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Conserved domains on  [gi|24642830|ref|NP_573232|]
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integrator 2 [Drosophila melanogaster]

Protein Classification

INTS2 domain-containing protein( domain architecture ID 10631717)

INTS2 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
INTS2 pfam14750
Integrator complex subunit 2; This family of proteins are subunits of the integrator complex ...
24-1058 0e+00

Integrator complex subunit 2; This family of proteins are subunits of the integrator complex involved in snRNA transcription and processing.


:

Pssm-ID: 464296  Cd Length: 1047  Bit Score: 1459.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830     24 LASYPEAEIRPVLPSLVRMSLLSPLDNTESSMESRKEILAVLIGIEVVNSIVSYLQVNYHELENELKKELQARQKSAFFE 103
Cdd:pfam14750    1 LAKLSEKEIRPLLPCLVRMSLCSPLDQSESWAESRKRILKLLSGIEVVNSIVALLSIDFHALEVDVKKEQQLRQKLGGSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    104 GQQHEYG-LQSGIALGFERADVARKVRVVLSEIFNLQQQVSEQKP---AAHSEMLDDGIYLEEVVDILCIALAELPSLLN 179
Cdd:pfam14750   81 SESILIGsLQNGIALEFERSDPTRRLRLVLSELLRIQAQVSESNPefyIKSSELFDNEIYLEEVSDVLCIALAELPSLLP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    180 ILELTDALVHVPNGHRIICALVANFPDCYRDVVSHVIAN---CDEDGSDGKHRLMLLMGLSEMNPSQALANRSMCVDMLK 256
Cdd:pfam14750  161 ILEVAEALLHVKNGPWLICRLVANVPDSFEEVCQSLISNgerQDEESVGGRRRLDALRLLCSMNPSQALLIRAKCVELCR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    257 VPSFMLKLTLKHPE--------DLIAFLTGLLLGNDQNLRSWFAAYIRSSQKRKGD--ALNLVRVELLQKV---IQTTTN 323
Cdd:pfam14750  241 MPALAIALTLDHKNdvaegsaqDLVAFVSGLLLGNDQKVRSWFAQFIRNGQKRKDEstALKQLREELLEELqslLPTSED 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    324 AAELRDFNLQGAVLLRLYCALRGIGGLKFNDDEINALSQLVTSCPQATPSGVRFVTLALCMLIACPSLVSTIPLENKAVE 403
Cdd:pfam14750  321 STLPESSVVKASALLRLYCALRGIAGLKFTDEEVNSLLQLITSHPPPTPAGVRFVSLGLCMLLACPSLISTPEQEKKAVE 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    404 WLQWLIREDAFFCKRPGTSTSLGEMLLLLAIHFHSNQISAISEMVCSTLAMKIPIRPNSTNRIKQLFTQDLFTEQVVALH 483
Cdd:pfam14750  401 WLQWLVKEESYFESASGVSASFGEMLLLMAIHFHSNQLSAICELVCSTLGMKIPIRPNSLTRMKQIFTQEIFTEQVVTAH 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    484 AVRVPVTPNLNGTILCYLPVHCIQQLLKSRTFLKHKVPIKSWIFKQICSSVRPVHPVMPALVEVFVNTLIIPNPtgKVNI 563
Cdd:pfam14750  481 AVKVPVTPNLNANITGFLPIHCIYQLLKSRAFSKHKVPIKDWIYKQICNCVTPLHPVLPALIEVYVNSILVPAS--KTSF 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    564 DHMHRPFTEAEILHVFRTSKltffaeelppMAESQELNQIEVTCPLTAQLLMIYYLMLYEDTRLMNLSAL--GGRKQKEY 641
Cdd:pfam14750  559 EATNEPISEEEILNVFQGSI----------DVDSENVSEVEDKSSLTPQLLLLYYLLLYEDTRLSNMKTLasSGRKVKSY 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    642 SNNFLGGLPLKYLLQKAHHYHNDYLSLFHPLLRLIISNYPHLSMVDDWLEEHNLAQGNST--VVVSKHELKPETLDRALA 719
Cdd:pfam14750  629 SSEFLSQIPIKYLLQQAQRDQEEYGGLFSPLLRLLATHYPHLCLVDDWLCEEEDDQTIALllLTVVKVPISPEQLLEAFS 708
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    720 AIQTKPHLAIRVFKQLLQMPPETQAQYGQQLVKHLPMVFAKSVPRYVKDLYNDIWLRLNAVLPTTLWIMSLRAITNGSDT 799
Cdd:pfam14750  709 RIDENPSKAMRLLQRLLKLPPEELWPYAEPFISSLPLLLNECVPRRIQELYKKVWLRLNTVLPRSLWVMTVNALSPEQST 788
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    800 MDRRTFANESLLE-PMEVLSCPRFVFCSPYLLMILLRILKGSLAASKTYLNVHmqMQQKQVLDKNGMMQTDAIWEDLRTT 878
Cdd:pfam14750  789 KLRQPLTQEDLVVdPLQVLRCDERVFRCPPLLEIVLRILNAYLAASRTYLSRH--LQEKPLLDKTGQLTSESEREELKSA 866
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    879 LIASQESAAVHILLEV-LDYIASKATDRVSHLELREIQGIIGTYVHQAFISEPSLAKLVHFQTYPKSVIPMMVASVPSMH 957
Cdd:pfam14750  867 LIAAQESAAVQILLEIcLPTEEDQAKGSGLLSNLREVRCLICSHLHQMFIADPNLAKLVHFQGYPRELLPVTVAGIPSMH 946
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    958 ICIDFVHEFLNVTEMEKQIFTIDLTSHLVLNYSIPKSLGVSKFCLNVIQTTLSMLTASTKCRFLRNVMPAMVRFVETFPI 1037
Cdd:pfam14750  947 ICLDFIPELLSQPQLEKQIFAIDLASHLCLQYALPKSLSVARLCLNVLSTLLSVLTSDERLELFRPVLPALVRFCEAFPP 1026
                         1050      1060
                   ....*....|....*....|.
gi 24642830   1038 LADDCVNILMTTGRILHSQSS 1058
Cdd:pfam14750 1027 LAEDIVSLLIQLGRVCASQAA 1047
 
Name Accession Description Interval E-value
INTS2 pfam14750
Integrator complex subunit 2; This family of proteins are subunits of the integrator complex ...
24-1058 0e+00

Integrator complex subunit 2; This family of proteins are subunits of the integrator complex involved in snRNA transcription and processing.


Pssm-ID: 464296  Cd Length: 1047  Bit Score: 1459.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830     24 LASYPEAEIRPVLPSLVRMSLLSPLDNTESSMESRKEILAVLIGIEVVNSIVSYLQVNYHELENELKKELQARQKSAFFE 103
Cdd:pfam14750    1 LAKLSEKEIRPLLPCLVRMSLCSPLDQSESWAESRKRILKLLSGIEVVNSIVALLSIDFHALEVDVKKEQQLRQKLGGSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    104 GQQHEYG-LQSGIALGFERADVARKVRVVLSEIFNLQQQVSEQKP---AAHSEMLDDGIYLEEVVDILCIALAELPSLLN 179
Cdd:pfam14750   81 SESILIGsLQNGIALEFERSDPTRRLRLVLSELLRIQAQVSESNPefyIKSSELFDNEIYLEEVSDVLCIALAELPSLLP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    180 ILELTDALVHVPNGHRIICALVANFPDCYRDVVSHVIAN---CDEDGSDGKHRLMLLMGLSEMNPSQALANRSMCVDMLK 256
Cdd:pfam14750  161 ILEVAEALLHVKNGPWLICRLVANVPDSFEEVCQSLISNgerQDEESVGGRRRLDALRLLCSMNPSQALLIRAKCVELCR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    257 VPSFMLKLTLKHPE--------DLIAFLTGLLLGNDQNLRSWFAAYIRSSQKRKGD--ALNLVRVELLQKV---IQTTTN 323
Cdd:pfam14750  241 MPALAIALTLDHKNdvaegsaqDLVAFVSGLLLGNDQKVRSWFAQFIRNGQKRKDEstALKQLREELLEELqslLPTSED 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    324 AAELRDFNLQGAVLLRLYCALRGIGGLKFNDDEINALSQLVTSCPQATPSGVRFVTLALCMLIACPSLVSTIPLENKAVE 403
Cdd:pfam14750  321 STLPESSVVKASALLRLYCALRGIAGLKFTDEEVNSLLQLITSHPPPTPAGVRFVSLGLCMLLACPSLISTPEQEKKAVE 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    404 WLQWLIREDAFFCKRPGTSTSLGEMLLLLAIHFHSNQISAISEMVCSTLAMKIPIRPNSTNRIKQLFTQDLFTEQVVALH 483
Cdd:pfam14750  401 WLQWLVKEESYFESASGVSASFGEMLLLMAIHFHSNQLSAICELVCSTLGMKIPIRPNSLTRMKQIFTQEIFTEQVVTAH 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    484 AVRVPVTPNLNGTILCYLPVHCIQQLLKSRTFLKHKVPIKSWIFKQICSSVRPVHPVMPALVEVFVNTLIIPNPtgKVNI 563
Cdd:pfam14750  481 AVKVPVTPNLNANITGFLPIHCIYQLLKSRAFSKHKVPIKDWIYKQICNCVTPLHPVLPALIEVYVNSILVPAS--KTSF 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    564 DHMHRPFTEAEILHVFRTSKltffaeelppMAESQELNQIEVTCPLTAQLLMIYYLMLYEDTRLMNLSAL--GGRKQKEY 641
Cdd:pfam14750  559 EATNEPISEEEILNVFQGSI----------DVDSENVSEVEDKSSLTPQLLLLYYLLLYEDTRLSNMKTLasSGRKVKSY 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    642 SNNFLGGLPLKYLLQKAHHYHNDYLSLFHPLLRLIISNYPHLSMVDDWLEEHNLAQGNST--VVVSKHELKPETLDRALA 719
Cdd:pfam14750  629 SSEFLSQIPIKYLLQQAQRDQEEYGGLFSPLLRLLATHYPHLCLVDDWLCEEEDDQTIALllLTVVKVPISPEQLLEAFS 708
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    720 AIQTKPHLAIRVFKQLLQMPPETQAQYGQQLVKHLPMVFAKSVPRYVKDLYNDIWLRLNAVLPTTLWIMSLRAITNGSDT 799
Cdd:pfam14750  709 RIDENPSKAMRLLQRLLKLPPEELWPYAEPFISSLPLLLNECVPRRIQELYKKVWLRLNTVLPRSLWVMTVNALSPEQST 788
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    800 MDRRTFANESLLE-PMEVLSCPRFVFCSPYLLMILLRILKGSLAASKTYLNVHmqMQQKQVLDKNGMMQTDAIWEDLRTT 878
Cdd:pfam14750  789 KLRQPLTQEDLVVdPLQVLRCDERVFRCPPLLEIVLRILNAYLAASRTYLSRH--LQEKPLLDKTGQLTSESEREELKSA 866
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    879 LIASQESAAVHILLEV-LDYIASKATDRVSHLELREIQGIIGTYVHQAFISEPSLAKLVHFQTYPKSVIPMMVASVPSMH 957
Cdd:pfam14750  867 LIAAQESAAVQILLEIcLPTEEDQAKGSGLLSNLREVRCLICSHLHQMFIADPNLAKLVHFQGYPRELLPVTVAGIPSMH 946
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    958 ICIDFVHEFLNVTEMEKQIFTIDLTSHLVLNYSIPKSLGVSKFCLNVIQTTLSMLTASTKCRFLRNVMPAMVRFVETFPI 1037
Cdd:pfam14750  947 ICLDFIPELLSQPQLEKQIFAIDLASHLCLQYALPKSLSVARLCLNVLSTLLSVLTSDERLELFRPVLPALVRFCEAFPP 1026
                         1050      1060
                   ....*....|....*....|.
gi 24642830   1038 LADDCVNILMTTGRILHSQSS 1058
Cdd:pfam14750 1027 LAEDIVSLLIQLGRVCASQAA 1047
 
Name Accession Description Interval E-value
INTS2 pfam14750
Integrator complex subunit 2; This family of proteins are subunits of the integrator complex ...
24-1058 0e+00

Integrator complex subunit 2; This family of proteins are subunits of the integrator complex involved in snRNA transcription and processing.


Pssm-ID: 464296  Cd Length: 1047  Bit Score: 1459.83  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830     24 LASYPEAEIRPVLPSLVRMSLLSPLDNTESSMESRKEILAVLIGIEVVNSIVSYLQVNYHELENELKKELQARQKSAFFE 103
Cdd:pfam14750    1 LAKLSEKEIRPLLPCLVRMSLCSPLDQSESWAESRKRILKLLSGIEVVNSIVALLSIDFHALEVDVKKEQQLRQKLGGSS 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    104 GQQHEYG-LQSGIALGFERADVARKVRVVLSEIFNLQQQVSEQKP---AAHSEMLDDGIYLEEVVDILCIALAELPSLLN 179
Cdd:pfam14750   81 SESILIGsLQNGIALEFERSDPTRRLRLVLSELLRIQAQVSESNPefyIKSSELFDNEIYLEEVSDVLCIALAELPSLLP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    180 ILELTDALVHVPNGHRIICALVANFPDCYRDVVSHVIAN---CDEDGSDGKHRLMLLMGLSEMNPSQALANRSMCVDMLK 256
Cdd:pfam14750  161 ILEVAEALLHVKNGPWLICRLVANVPDSFEEVCQSLISNgerQDEESVGGRRRLDALRLLCSMNPSQALLIRAKCVELCR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    257 VPSFMLKLTLKHPE--------DLIAFLTGLLLGNDQNLRSWFAAYIRSSQKRKGD--ALNLVRVELLQKV---IQTTTN 323
Cdd:pfam14750  241 MPALAIALTLDHKNdvaegsaqDLVAFVSGLLLGNDQKVRSWFAQFIRNGQKRKDEstALKQLREELLEELqslLPTSED 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    324 AAELRDFNLQGAVLLRLYCALRGIGGLKFNDDEINALSQLVTSCPQATPSGVRFVTLALCMLIACPSLVSTIPLENKAVE 403
Cdd:pfam14750  321 STLPESSVVKASALLRLYCALRGIAGLKFTDEEVNSLLQLITSHPPPTPAGVRFVSLGLCMLLACPSLISTPEQEKKAVE 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    404 WLQWLIREDAFFCKRPGTSTSLGEMLLLLAIHFHSNQISAISEMVCSTLAMKIPIRPNSTNRIKQLFTQDLFTEQVVALH 483
Cdd:pfam14750  401 WLQWLVKEESYFESASGVSASFGEMLLLMAIHFHSNQLSAICELVCSTLGMKIPIRPNSLTRMKQIFTQEIFTEQVVTAH 480
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    484 AVRVPVTPNLNGTILCYLPVHCIQQLLKSRTFLKHKVPIKSWIFKQICSSVRPVHPVMPALVEVFVNTLIIPNPtgKVNI 563
Cdd:pfam14750  481 AVKVPVTPNLNANITGFLPIHCIYQLLKSRAFSKHKVPIKDWIYKQICNCVTPLHPVLPALIEVYVNSILVPAS--KTSF 558
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    564 DHMHRPFTEAEILHVFRTSKltffaeelppMAESQELNQIEVTCPLTAQLLMIYYLMLYEDTRLMNLSAL--GGRKQKEY 641
Cdd:pfam14750  559 EATNEPISEEEILNVFQGSI----------DVDSENVSEVEDKSSLTPQLLLLYYLLLYEDTRLSNMKTLasSGRKVKSY 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    642 SNNFLGGLPLKYLLQKAHHYHNDYLSLFHPLLRLIISNYPHLSMVDDWLEEHNLAQGNST--VVVSKHELKPETLDRALA 719
Cdd:pfam14750  629 SSEFLSQIPIKYLLQQAQRDQEEYGGLFSPLLRLLATHYPHLCLVDDWLCEEEDDQTIALllLTVVKVPISPEQLLEAFS 708
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    720 AIQTKPHLAIRVFKQLLQMPPETQAQYGQQLVKHLPMVFAKSVPRYVKDLYNDIWLRLNAVLPTTLWIMSLRAITNGSDT 799
Cdd:pfam14750  709 RIDENPSKAMRLLQRLLKLPPEELWPYAEPFISSLPLLLNECVPRRIQELYKKVWLRLNTVLPRSLWVMTVNALSPEQST 788
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    800 MDRRTFANESLLE-PMEVLSCPRFVFCSPYLLMILLRILKGSLAASKTYLNVHmqMQQKQVLDKNGMMQTDAIWEDLRTT 878
Cdd:pfam14750  789 KLRQPLTQEDLVVdPLQVLRCDERVFRCPPLLEIVLRILNAYLAASRTYLSRH--LQEKPLLDKTGQLTSESEREELKSA 866
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    879 LIASQESAAVHILLEV-LDYIASKATDRVSHLELREIQGIIGTYVHQAFISEPSLAKLVHFQTYPKSVIPMMVASVPSMH 957
Cdd:pfam14750  867 LIAAQESAAVQILLEIcLPTEEDQAKGSGLLSNLREVRCLICSHLHQMFIADPNLAKLVHFQGYPRELLPVTVAGIPSMH 946
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642830    958 ICIDFVHEFLNVTEMEKQIFTIDLTSHLVLNYSIPKSLGVSKFCLNVIQTTLSMLTASTKCRFLRNVMPAMVRFVETFPI 1037
Cdd:pfam14750  947 ICLDFIPELLSQPQLEKQIFAIDLASHLCLQYALPKSLSVARLCLNVLSTLLSVLTSDERLELFRPVLPALVRFCEAFPP 1026
                         1050      1060
                   ....*....|....*....|.
gi 24642830   1038 LADDCVNILMTTGRILHSQSS 1058
Cdd:pfam14750 1027 LAEDIVSLLIQLGRVCASQAA 1047
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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