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Conserved domains on  [gi|18859869|ref|NP_573213|]
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uncharacterized protein Dmel_CG5445, isoform A [Drosophila melanogaster]

Protein Classification

UBA domain-containing protein( domain architecture ID 10198748)

ubiquitin-associated (UBA) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBA_CF106 cd14349
UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family ...
 129-170 2.12e-17

UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family corresponds to a group of uncharacterized protein C6orf106 and its homologs mainly found in Metazoa. All family members contain a ubiquitin-associated (UBA)-like domain.


:

Pssm-ID: 270534  Cd Length: 41  Bit Score: 74.18  E-value: 2.12e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18859869 129 DHEDLISQFQSLMNNQmNRESARFYLEMSNWSLQTAVGCYLD 170
Cdd:cd14349   1 DHEELISQFQSILGAQ-NESEAAFFLEMNNWNLQAAVGAYFD 41
NBR1_like super family cl22423
Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has ...
 197-261 4.11e-13

Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has been characterized as a specific late endosomal protein, which might play a role in receptor (RTK) trafficking. Specifically, NBR1 was shown to inhibit ligand-mediated receptor internalization from the cell surface. The region covered by this domain model may be involved in that function, as the C-terminus (which contains a UBA domain) was shown to be essential but not sufficient by itself. In an earlier yeast two-hybrid study, the region in mouse NBR1 covered by this domain has been shown to interact with CIB (calcium and integrin-binding protein) and FEZ1 (fasciculation and elongation protein zeta-1). Thus, NBR1 may play a role in cellular signalling pathways and possibly in neural development.


The actual alignment was detected with superfamily member pfam16158:

Pssm-ID: 473955  Cd Length: 98  Bit Score: 64.14  E-value: 4.11e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18859869   197 LQNDGTERWPNNCYL-----TSPIQTQRINVPALRPGETCDILADMM-PTQP---PTMWRLCTSNGWYFGDAIW 261
Cdd:pfam16158  20 LRNSGNVAWPAGTSLrfvggDNMGNVSTVLVPPVAPGEEVDVSVELKaPSRPgryISYWRLKTPDGTPFGDRLW 93
 
Name Accession Description Interval E-value
UBA_CF106 cd14349
UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family ...
 129-170 2.12e-17

UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family corresponds to a group of uncharacterized protein C6orf106 and its homologs mainly found in Metazoa. All family members contain a ubiquitin-associated (UBA)-like domain.


Pssm-ID: 270534  Cd Length: 41  Bit Score: 74.18  E-value: 2.12e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18859869 129 DHEDLISQFQSLMNNQmNRESARFYLEMSNWSLQTAVGCYLD 170
Cdd:cd14349   1 DHEELISQFQSILGAQ-NESEAAFFLEMNNWNLQAAVGAYFD 41
N_BRCA1_IG pfam16158
Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human ...
 197-261 4.11e-13

Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human next to BRCA1 gene 1 protein Q14596 (NBR1_HUMAN) Distant homology and fold prediction analysis suggests this domain has an immunoglobulin like fold and is distantly homologous to domains involved in cell adhesion such as CARDB (PF07705). JCSG construct was crystalized confirming the domain boundaries


Pssm-ID: 465035  Cd Length: 98  Bit Score: 64.14  E-value: 4.11e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18859869   197 LQNDGTERWPNNCYL-----TSPIQTQRINVPALRPGETCDILADMM-PTQP---PTMWRLCTSNGWYFGDAIW 261
Cdd:pfam16158  20 LRNSGNVAWPAGTSLrfvggDNMGNVSTVLVPPVAPGEEVDVSVELKaPSRPgryISYWRLKTPDGTPFGDRLW 93
NBR1_like cd14947
Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has ...
 197-261 7.21e-13

Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has been characterized as a specific late endosomal protein, which might play a role in receptor (RTK) trafficking. Specifically, NBR1 was shown to inhibit ligand-mediated receptor internalization from the cell surface. The region covered by this domain model may be involved in that function, as the C-terminus (which contains a UBA domain) was shown to be essential but not sufficient by itself. In an earlier yeast two-hybrid study, the region in mouse NBR1 covered by this domain has been shown to interact with CIB (calcium and integrin-binding protein) and FEZ1 (fasciculation and elongation protein zeta-1). Thus, NBR1 may play a role in cellular signalling pathways and possibly in neural development.


Pssm-ID: 271343 [Multi-domain]  Cd Length: 112  Bit Score: 63.85  E-value: 7.21e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18859869 197 LQNDGTERWPNNCYL------TSPIQT-QRINVPALRPGETCDILADMM-PTQP---PTMWRLCTSNGWYFGDAIW 261
Cdd:cd14947  31 LRNTGTVPWPAGTLLrfvggdPGLLSApERVPVPSTVPGEEVDVSVELRaPSEPgryISYWRLVTPDGLPFGDRLW 106
UBA_4 pfam14555
UBA-like domain;
131-170 3.83e-08

UBA-like domain;


Pssm-ID: 464207  Cd Length: 43  Bit Score: 48.60  E-value: 3.83e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18859869   131 EDLISQFQSLMNnqMNRESARFYLEMSNWSLQTAVGCYLD 170
Cdd:pfam14555   1 DELIAQFQAITG--ADEEVARQYLEAHNWDLEAAVNAFFD 38
 
Name Accession Description Interval E-value
UBA_CF106 cd14349
UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family ...
 129-170 2.12e-17

UBA-like domain found in uncharacterized protein C6orf106 and similar proteins; The family corresponds to a group of uncharacterized protein C6orf106 and its homologs mainly found in Metazoa. All family members contain a ubiquitin-associated (UBA)-like domain.


Pssm-ID: 270534  Cd Length: 41  Bit Score: 74.18  E-value: 2.12e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18859869 129 DHEDLISQFQSLMNNQmNRESARFYLEMSNWSLQTAVGCYLD 170
Cdd:cd14349   1 DHEELISQFQSILGAQ-NESEAAFFLEMNNWNLQAAVGAYFD 41
N_BRCA1_IG pfam16158
Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human ...
 197-261 4.11e-13

Ig-like domain from next to BRCA1 gene; Domain present between positions 365-485 in the human next to BRCA1 gene 1 protein Q14596 (NBR1_HUMAN) Distant homology and fold prediction analysis suggests this domain has an immunoglobulin like fold and is distantly homologous to domains involved in cell adhesion such as CARDB (PF07705). JCSG construct was crystalized confirming the domain boundaries


Pssm-ID: 465035  Cd Length: 98  Bit Score: 64.14  E-value: 4.11e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18859869   197 LQNDGTERWPNNCYL-----TSPIQTQRINVPALRPGETCDILADMM-PTQP---PTMWRLCTSNGWYFGDAIW 261
Cdd:pfam16158  20 LRNSGNVAWPAGTSLrfvggDNMGNVSTVLVPPVAPGEEVDVSVELKaPSRPgryISYWRLKTPDGTPFGDRLW 93
NBR1_like cd14947
Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has ...
 197-261 7.21e-13

Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins; NBR1 has been characterized as a specific late endosomal protein, which might play a role in receptor (RTK) trafficking. Specifically, NBR1 was shown to inhibit ligand-mediated receptor internalization from the cell surface. The region covered by this domain model may be involved in that function, as the C-terminus (which contains a UBA domain) was shown to be essential but not sufficient by itself. In an earlier yeast two-hybrid study, the region in mouse NBR1 covered by this domain has been shown to interact with CIB (calcium and integrin-binding protein) and FEZ1 (fasciculation and elongation protein zeta-1). Thus, NBR1 may play a role in cellular signalling pathways and possibly in neural development.


Pssm-ID: 271343 [Multi-domain]  Cd Length: 112  Bit Score: 63.85  E-value: 7.21e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18859869 197 LQNDGTERWPNNCYL------TSPIQT-QRINVPALRPGETCDILADMM-PTQP---PTMWRLCTSNGWYFGDAIW 261
Cdd:cd14947  31 LRNTGTVPWPAGTLLrfvggdPGLLSApERVPVPSTVPGEEVDVSVELRaPSEPgryISYWRLVTPDGLPFGDRLW 106
UBA_4 pfam14555
UBA-like domain;
131-170 3.83e-08

UBA-like domain;


Pssm-ID: 464207  Cd Length: 43  Bit Score: 48.60  E-value: 3.83e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18859869   131 EDLISQFQSLMNnqMNRESARFYLEMSNWSLQTAVGCYLD 170
Cdd:pfam14555   1 DELIAQFQAITG--ADEEVARQYLEAHNWDLEAAVNAFFD 38
UBA_p47 cd14348
UBA-like domain found in NSFL1 cofactor p47 and similar proteins; p47, also called UBX ...
 131-170 1.27e-06

UBA-like domain found in NSFL1 cofactor p47 and similar proteins; p47, also called UBX domain-containing protein 2C, is a major cofactor of the cytosolic AAA ATPase p97. It is required for the p97-regulated membrane reassembly of the endoplasmic reticulum (ER), the nuclear envelope and the Golgi apparatus. p47, together with p97, forms the p97-p47 complex that plays an important role in regulation of membrane fusion events. p47 contains an N-terminal ubiquitin-associated (UBA)-like domain, a central SEP (named after shp1, eyc and p47) domain, and a ubiquitin-like (UBX) domain. UBA-like domain is responsible for forming a highly stable complex with ubiquitin. SEP domain and UBX domain may involve in p47 trimerization or forms a stable complex with the p97 N-terminal domain.


Pssm-ID: 270533  Cd Length: 40  Bit Score: 44.45  E-value: 1.27e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 18859869 131 EDLISQFQSLMNnqMNRESARFYLEMSNWSLQTAVGCYLD 170
Cdd:cd14348   1 DELIAQFVSVTG--ADEDRAKFFLESAGWDLEAALSSFFE 38
UBA_TAP-C_like cd14273
UBA-like domain found in the NXF family of mRNA nuclear export factors and similar proteins; ...
 137-169 7.71e-04

UBA-like domain found in the NXF family of mRNA nuclear export factors and similar proteins; This family includes nuclear RNA export factors (NXF1/NXF2), FAS-associated factors (FAF1/2), tyrosyl-DNA phosphodiesterase 2 (TDP2), OTU domain-containing proteins (OTU7A/OTU7B), NSFL1 cofactor p47, defective in cullin neddylation protein 1 (DCN1)-like protein (DCNL1/DCNL2), yeast defective in cullin neddylation protein 1 (DCN1) and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. FAF1 is an apoptotic signaling molecule that acts downstream in the Fas signal transduction pathway. It interacts with the cytoplasmic domain of Fas, but not to a Fas mutant that is deficient in signal transduction. FAF2 is the translation product of a highly expressed gene in the T-cells and eosinophils of atopic dermatitis patients compared with those of normal individuals. Its biological function remains unclear. TDP2 is a 5'-Tyr-DNA phosphodiesterase required for the efficient repair of topoisomerase II-induced DNA double strand breaks. OTU7A and OTU7B are zinc finger proteins that function as deubiquitinating enzymes. p47 is a major cofactor of the cytosolic AAA ATPase p97. It is required for the p97-regulated membrane reassembly of the endoplasmic reticulum (ER), the nuclear envelope and the Golgi apparatus. DCNL1 plays an essential role in the neddylation E3 complex and participates in the release of inhibitory effects of CAND1 on cullin-RING ligase E3 complex assembly and activity. The biological function of DCNL2 remains unclear. Yeast DCN1 is a scaffold-type E3 ligase for cullin neddylation. It can bind directly to cullins and the ubiquitin-like protein Nedd8-specific E2 (Ubc12), and regulate cullin neddylation and thus display ubiquitin ligase activity.


Pssm-ID: 270459  Cd Length: 31  Bit Score: 36.22  E-value: 7.71e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 18859869 137 FQSLMNnqMNRESARFYLEMSNWSLQTAVGCYL 169
Cdd:cd14273   1 FMEITG--ADPETARQYLESNNWDLEAAINLYF 31
UBA_DCN1 cd14352
UBA-like domain found in yeast defective in cullin neddylation protein 1 (DCN1) and similar ...
 132-165 1.09e-03

UBA-like domain found in yeast defective in cullin neddylation protein 1 (DCN1) and similar proteins; DCN1 is a scaffold-type E3 ligase for cullin neddylation. It can bind directly to cullins and the ubiquitin-like protein Nedd8-specific E2 (Ubc12), and regulate cullin neddylation and thus display ubiquitin ligase activity. It contains an N-terminal ubiquitin-associated (UBA)-like domain and a unique C-terminal PONY domain that is essential for the neddylation function of DCN1.


Pssm-ID: 270537  Cd Length: 36  Bit Score: 36.11  E-value: 1.09e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 18859869 132 DLISQFQSLMnnQMNRESARFYLEMSNWSLQTAV 165
Cdd:cd14352   1 ELIKQFREIT--ATSPEVARDYLQRSNWNLNYAV 32
UBA_Ubx5_like cd14346
UBA-like domain found in Saccharomyces cerevisiae UBX domain-containing protein 5 (Ubx5) and ...
 131-170 2.22e-03

UBA-like domain found in Saccharomyces cerevisiae UBX domain-containing protein 5 (Ubx5) and similar proteins; Ubx5 is a ubiquitin regulatory X (UBX) domain-containing protein encoded by the open reading frame (ORF) YDR330W in yeast. As the yeast ortholog of mammalian UBXD7, Ubx5 functions as the cofactor of AAA+ ATPase p97, also known as VCP or Cdc48. It binds only to the active, NEDD8- or Rub1-modified form of cullins. Ubx5 contains the ubiquitin-associated (UBA), ubiquitin-associating (UAS), ubiquitin regulatory X (UBX) and ubiquitin-interacting motif (UIM) domains and its UIM domain is required to promote UV-dependent degradation of polyubiquitinated Rpb1.


Pssm-ID: 270531  Cd Length: 39  Bit Score: 35.35  E-value: 2.22e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 18859869 131 EDLISQFQSLMNNQmNRESARFYLEMSNWSLQTAVGCYLD 170
Cdd:cd14346   1 DEQISTFLAITGSE-DAAVARQFLEMAGGDLETAVSLFFE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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