BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  32 FVDVTLACEGQQVHCHRLVLAACSTYFEAILAEH-PCKHPVIILPrEIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAE 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILP-DVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                ....*.
gi 18859953 111 QLQIRG 116
Cdd:cd18315  80 LLQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  32 FVDVTLACEGQQVHCHRLVLAACSTYFEAILAEH-PCKHPVIILPrEIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAE 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILP-DVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                ....*.
gi 18859953 111 QLQIRG 116
Cdd:cd18315  80 LLQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953     34 DVTLACEGQQVHCHRLVLAACSTYFEAILAEHPC--KHPVIILPrEIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAEQ 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLD-DVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                   ....*.
gi 18859953    112 LQIRGL 117
Cdd:smart00225  80 LQIPGL 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  32 FVDVTLACEGQQVHCHRLVLAACSTYFEAILAEH-PCKHPVIILPrEIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAE 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILP-DVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79

                ....*.
gi 18859953 111 QLQIRG 116
Cdd:cd18315  80 LLQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953     34 DVTLACEGQQVHCHRLVLAACSTYFEAILAEHPC--KHPVIILPrEIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAEQ 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLD-DVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                   ....*.
gi 18859953    112 LQIRGL 117
Cdd:smart00225  80 LQIPGL 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  22 AFPQLLAGQR---FVDVTLACEGQQVHCHRLVLAACSTYFEAILA--EHPCKHPVIILPREIKLWEIQALVDFMYKGEVN 96
Cdd:cd18293   2 AFLQLHRQQNsgvFCDVLLQAEGESVPAHCCVLSACSPYLTERLSsePPPAGQKVVLELQGLKAHTLLKLVDFLYTSELE 81

                        90       100
                ....*....|....*....|...
gi 18859953  97 VTQAGLGQLLRCAEQLQIRGLYG 119
Cdd:cd18293  82 VSSEEAQDVLAAARRLQISELES 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  14 SHLGSIGAAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAI--------LAEHPCKHPViilPREIklweIQA 85
Cdd:cd18250   3 AHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMfagelresRADRVVLHGV---SAEI----LGL 75

                        90       100
                ....*....|....*....|....*...
gi 18859953  86 LVDFMYKGEVNVTQAGLGQLLRCAEQLQ 113
Cdd:cd18250  76 LLDFSYTGRVTVTQDNVEALLRAADLFQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  32 FVDVTLAC-EGQQVHCHRLVLAACSTYFEAIL-AEHPCKHPVIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCA 109
Cdd:cd18252  21 FTDITLQCaSGQIFHCHKAALAACSSYFKVMFtADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAA 100

                ....
gi 18859953 110 EQLQ 113
Cdd:cd18252 101 DLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  34 DVTLACEGQQVHCHRLVLAACSTYFEAI----LAEHPCKHPVIilpREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCA 109
Cdd:cd18235  23 DVILVADGVEIPAHRVVLASCSPYFHAMftgdLSESRANRVTL---QDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAA 99

                ....*
gi 18859953 110 EQLQI 114
Cdd:cd18235 100 NLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953   7 EFCVrwNSHLGSIGAAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHpvIILPREIKLWE---I 83
Cdd:cd18259   9 DFCL--PSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVES--ISARVEIKDVDpavM 84

                        90       100       110
                ....*....|....*....|....*....|
gi 18859953  84 QALVDFMYKGEVNVTQAGLGQLLRCAEQLQ 113
Cdd:cd18259  85 ESLIDFAYTGKLTINQGNVEALIRTSNRLQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  32 FVDVTLACEGQQVHCHRLVLAACSTYFEAILAEH-PCKHPVIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAE 110
Cdd:cd18265  23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHlKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASD 102

                ....*...
gi 18859953 111 QLQIRGLY 118
Cdd:cd18265 103 LLQVSKLR 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  34 DVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHPVIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAEQLQ 113
Cdd:cd18278  33 DVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIQEVIRCAEFLR 112

                ....*..
gi 18859953 114 IRGLYGS 120
Cdd:cd18278 113 MHNLEDS 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  15 HLGSIGAAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAIL----AEHPCKhpVIILpREIKLWEIQALVDFM 90
Cdd:cd18287   5 HVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmRESQQS--EIEL-KDTNAEAFKALLKYI 81

                ....*...
gi 18859953  91 YKGEVNVT 98
Cdd:cd18287  82 YTGRLTLT 89

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  34 DVTLACEGQQVHCHRLVLAACSTYFEAI----LAEhpCKHpviilpREIKLWEI-----QALVDFMYKGEVNVTQAGLGQ 104
Cdd:cd18247  21 DVTLKVGDQKFSAHRIVLAATIPYFHAMfthdMVE--SKQ------DEITMQGIepsalEALINFAYSGRIAIDTSNVQS 92

                        90
                ....*....|
gi 18859953 105 LLRCAEQLQI 114
Cdd:cd18247  93 LLVGASFLQL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  14 SHLGSIGAAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHPV-IILPREIKLWEIQALVDFMYK 92
Cdd:cd18339   3 AHMKKAFKVMNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAkKIEIKDVDGQTLSKLIDYIYT 82

                        90       100
                ....*....|....*....|..
gi 18859953  93 GEVNVTQAGLGQLLRCAEQLQI 114
Cdd:cd18339  83 AEIEVTEENVQVLLPAASLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  32 FVDVTLACEGQQVHCHRLVLAACSTYFEAILAehpCKHPVIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAEQ 111
Cdd:cd18208  25 FCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLL---LGYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQSEALQILTAASI 101

                ....
gi 18859953 112 LQIR 115
Cdd:cd18208 102 LQIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  21 AAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPC--KHPVIILPrEIKlWEI-QALVDFMYKGEV-- 95
Cdd:cd18297   1 RIDPHYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTeaQTPVIEIP-DIR-YDIfQLMMQYLYTGGVes 78

                        90       100
                ....*....|....*....|...
gi 18859953  96 -NVTQAGLGQLLRCAEQLQIRGL 117
Cdd:cd18297  79 lDVAQDDALELLRAASFFQLDGL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  30 QRFVDVTLACEGQQVHCHRLVLAACSTYFEAI----LAEHPCKHpviILPREIKLWEIQALVDFMYKGEVNVTQAGLGQL 105
Cdd:cd18270  24 QLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMfmsgLSESKQTH---VHLRNVDAATLQIIITYAYTGNLAINDSTVEQL 100

                ....*....
gi 18859953 106 LRCAEQLQI 114
Cdd:cd18270 101 YETACFLQV 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  30 QRFVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHPVIILPreIKLWEIQA-----LVDFMYKGEVNVTQAGLGQ 104
Cdd:cd18245  12 PHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYK--IELEGISVevmeeILDYIYTGQIKLSEDNIQD 89

                ....*...
gi 18859953 105 LLRCAEQL 112
Cdd:cd18245  90 IVQAADLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  34 DVTLACEGQQVHCHRLVLAACSTYFEAI----LAEhpcKHPVIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCA 109
Cdd:cd18236  26 DVILCVDSQEFSCHRVVLAAASNYFRAMfcndLKE---KYEEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVLEAA 102

                ....*
gi 18859953 110 EQLQI 114
Cdd:cd18236 103 SLFQF 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  27 LAGQR----FVDVTLACEGQQVHCHRLVLAACSTYFEAILAehpCKHPVIILPREIKLWEIQALVDFMYKGEVNVTQAGL 102
Cdd:cd18229   9 LNAQRlgghFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLL---LGHSEIEVPPVVPAQTVRQLVEFMYSGSLVVAQSEA 85

                        90
                ....*....|...
gi 18859953 103 GQLLRCAEQLQIR 115
Cdd:cd18229  86 LQILTAASILQIK 98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  14 SHLGSIGAAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAILAE------------HPCKHPVIilpreiklw 81
Cdd:cd18254   4 SHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNglresldstvnfHDSLHPEV--------- 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 18859953  82 eIQALVDFMYKGEVNVTQAGLGQLLRCAEQLQIRGLYGSEAPINYKKL 129
Cdd:cd18254  75 -LELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 121

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  15 HLGSIGAAFPQLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHPVIILPREIKLWEiqALVDFMYKGE 94
Cdd:cd18262   1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLGSNGPLPPLSLEVTPVGWE--AVLTFAYTGV 78

                        90
                ....*....|....*...
gi 18859953  95 VNVTQAGLGQLLRCAEQL 112
Cdd:cd18262  79 LGRNPATVGDILVAAEAL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  25 QLLAGQRFVDVTLACEGQ----QVHCHRLVLAACSTYFEAILAE--HPCKHPVIILpREIKLWEIQALVDFMYKGEVNVT 98
Cdd:cd18248  14 ELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSglRECGMEVVPI-EGVHPCVMSRLIEFAYTASISVG 92

                        90
                ....*....|....*.
gi 18859953  99 QAGLGQLLRCAEQLQI 114
Cdd:cd18248  93 EKCVLHVLPGAVMYQM 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  34 DVTLACEGQQVHCHRLVLAACSTYFEAI----LAEhpcKHPVIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCA 109
Cdd:cd18249  25 DVVLVVGAKKIYAHRVILSACSPYFRAMftgeLAE---SRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAA 101

                ....*
gi 18859953 110 EQLQI 114
Cdd:cd18249 102 CLLQL 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  31 RFVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHpvIILPREIKlWEIQALVDFMYKGEVNVTQAGLGQLLRCAE 110
Cdd:cd18232  17 QYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGS--VVLPESFA-EVFGLLLDFFYTGELALTRENRDRVLLAAK 93

                ....
gi 18859953 111 QLQI 114
Cdd:cd18232  94 ELRV 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  22 AFPQLLAGQR----FVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHPVIILPREIKLWEIQALVDFMYKGEVNV 97
Cdd:cd18204   4 VFLKTLNEQRlegeFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFLRSDIFEEVLNYMYTAKISV 83

                        90       100
                ....*....|....*....|
gi 18859953  98 TQAGLGQLLRCAEQLQIRGL 117
Cdd:cd18204  84 KKEDVNLMMSSGQILGIRFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  34 DVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHPVIILPREIKLWE-IQALVDFMYKGEVNVTQAGLGQLLRCAEQL 112
Cdd:cd18326  27 DVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEaLTALLDFAYTATLTVSTSNVGDILSAARLL 106

                ..
gi 18859953 113 QI 114
Cdd:cd18326 107 EI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  25 QLLAGQRFVDVTLACEGQQVHCHRLVLAACSTYFEAILAehpCKHPVIILPREIKLWEIQALV-----DFMYKGEVNVTQ 99
Cdd:cd18207  20 QRKSGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFS---AQEGDGGTPRELEMHTISSKVfgdilDFAYTSRIVVRL 96

                        90
                ....*....|....*...
gi 18859953 100 AGLGQLLRCAEQLQIRGL 117
Cdd:cd18207  97 ESFPELMTAAKFLLMRSV 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  32 FVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCK-HPVIILPREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAE 110
Cdd:cd18272  32 FADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEaRNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVAD 111

                ....*...
gi 18859953 111 QLQIRGLY 118
Cdd:cd18272 112 MYQLTALF 119

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  29 GQRFV------DVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHPVIILPREIKLWEI-QALVDFMYKGEVNVTQAG 101
Cdd:cd18352   4 GEQYVnnatlsDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVfELMMRFIYTGSVDITNDI 83

                        90
                ....*....|....*.
gi 18859953 102 LGQLLRCAEQLQIRGL 117
Cdd:cd18352  84 AKDLLRAADQYLLEGL 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859953  32 FVDVTLACEGQQVHCHRLVLAACSTYFEAILAEHPCKHPVIIlpREIKLWEIQALVDFMYKGEVNVTQAGLGQLLRCAEQ 111
Cdd:cd18226  22 FCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNTDAVTL--DHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAAKF 99

                ...
gi 18859953 112 LQI 114
Cdd:cd18226 100 LDI 102