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Conserved domains on  [gi|24642321|ref|NP_573083|]
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ubiquitin like 3, isoform A [Drosophila melanogaster]

Protein Classification

ubiquitin family protein( domain architecture ID 13018376)

ubiquitin family protein belongs to an diverse class of protein modifier and gene expression regulatory proteins that participate in a number of cellular processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ubl_UBL3 cd17048
ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins; ...
 236-317 6.39e-59

ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins; UBL3, also termed membrane-anchored ubiquitin-fold protein (MUB), or protein HCG-1, belongs to a newly described MUB protein family with structural homology with ubiquitin. MUB proteins have a beta-grasp ubiquitin-like (Ubl) domain with longer N- and C-termini and extended loops. The Ubl domain contains a C-terminal CAAX-box, a canonical motif for protein prenylation, which is modified through protein lipidation with a hydrophobic membrane anchor. The lipidation and membrane localization inhibit attachment of MUBs to target proteins.


:

Pssm-ID: 340568  Cd Length: 82  Bit Score: 184.50  E-value: 6.39e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642321 236 INLRLILVSGKTKEFIFSPSDSAGDIAQTVFDNWPEDWTHETVSKAEILRLIYQGRFLHCNVTLGALGLPLGKTTVMHLV 315
Cdd:cd17048   1 INLRLILVSGKTKEFLFSPNDSAADIAQHVFDNWPEDWEEEQVSSANILRLIYQGRFLHGNVTLGALQLPLGKTTVMHLV 80


                ..
gi 24642321 316 PR 317
Cdd:cd17048  81 AR 82
 
Name Accession Description Interval E-value
Ubl_UBL3 cd17048
ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins; ...
 236-317 6.39e-59

ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins; UBL3, also termed membrane-anchored ubiquitin-fold protein (MUB), or protein HCG-1, belongs to a newly described MUB protein family with structural homology with ubiquitin. MUB proteins have a beta-grasp ubiquitin-like (Ubl) domain with longer N- and C-termini and extended loops. The Ubl domain contains a C-terminal CAAX-box, a canonical motif for protein prenylation, which is modified through protein lipidation with a hydrophobic membrane anchor. The lipidation and membrane localization inhibit attachment of MUBs to target proteins.


Pssm-ID: 340568  Cd Length: 82  Bit Score: 184.50  E-value: 6.39e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642321 236 INLRLILVSGKTKEFIFSPSDSAGDIAQTVFDNWPEDWTHETVSKAEILRLIYQGRFLHCNVTLGALGLPLGKTTVMHLV 315
Cdd:cd17048   1 INLRLILVSGKTKEFLFSPNDSAADIAQHVFDNWPEDWEEEQVSSANILRLIYQGRFLHGNVTLGALQLPLGKTTVMHLV 80


                ..
gi 24642321 316 PR 317
Cdd:cd17048  81 AR 82
Rad60-SLD_2 pfam13881
Ubiquitin-2 like Rad60 SUMO-like;
234-340 1.62e-37

Ubiquitin-2 like Rad60 SUMO-like;


Pssm-ID: 372780  Cd Length: 111  Bit Score: 130.50  E-value: 1.62e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642321   234 DKINLRLILVSGK-TKEFIFSPSDSAGDIAQTVFDNWPEDWThETVSKAEILRLIYQGRFLHCNVTLGALGLPLGKT--- 309
Cdd:pfam13881   1 DQIELKFRLVDGSdIGPFVFSPATTVADLKEKVIAQWPKDKE-NGPKTVNDVKLINAGKILENNKTLGECRLPVGETpgg 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 24642321   310 -TVMHLVPRDNLPEPNSQDQRQNSKGGSGRCC 340
Cdd:pfam13881  80 vTTMHVVVRPNLPEPNSEKKANKPKQNGCGCC 111
 
Name Accession Description Interval E-value
Ubl_UBL3 cd17048
ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins; ...
 236-317 6.39e-59

ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins; UBL3, also termed membrane-anchored ubiquitin-fold protein (MUB), or protein HCG-1, belongs to a newly described MUB protein family with structural homology with ubiquitin. MUB proteins have a beta-grasp ubiquitin-like (Ubl) domain with longer N- and C-termini and extended loops. The Ubl domain contains a C-terminal CAAX-box, a canonical motif for protein prenylation, which is modified through protein lipidation with a hydrophobic membrane anchor. The lipidation and membrane localization inhibit attachment of MUBs to target proteins.


Pssm-ID: 340568  Cd Length: 82  Bit Score: 184.50  E-value: 6.39e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642321 236 INLRLILVSGKTKEFIFSPSDSAGDIAQTVFDNWPEDWTHETVSKAEILRLIYQGRFLHCNVTLGALGLPLGKTTVMHLV 315
Cdd:cd17048   1 INLRLILVSGKTKEFLFSPNDSAADIAQHVFDNWPEDWEEEQVSSANILRLIYQGRFLHGNVTLGALQLPLGKTTVMHLV 80


                ..
gi 24642321 316 PR 317
Cdd:cd17048  81 AR 82
Rad60-SLD_2 pfam13881
Ubiquitin-2 like Rad60 SUMO-like;
234-340 1.62e-37

Ubiquitin-2 like Rad60 SUMO-like;


Pssm-ID: 372780  Cd Length: 111  Bit Score: 130.50  E-value: 1.62e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642321   234 DKINLRLILVSGK-TKEFIFSPSDSAGDIAQTVFDNWPEDWThETVSKAEILRLIYQGRFLHCNVTLGALGLPLGKT--- 309
Cdd:pfam13881   1 DQIELKFRLVDGSdIGPFVFSPATTVADLKEKVIAQWPKDKE-NGPKTVNDVKLINAGKILENNKTLGECRLPVGETpgg 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 24642321   310 -TVMHLVPRDNLPEPNSQDQRQNSKGGSGRCC 340
Cdd:pfam13881  80 vTTMHVVVRPNLPEPNSEKKANKPKQNGCGCC 111
Ubl_MUBs_plant cd01814
ubiquitin-like (Ubl) domain found in plant membrane-anchored ubiquitin-fold proteins (MUBs); ...
 236-317 5.25e-05

ubiquitin-like (Ubl) domain found in plant membrane-anchored ubiquitin-fold proteins (MUBs); The plant MUBs belong to a family of ubiquitin-fold proteins that are plasma membrane-anchored by prenylation. They may serve as docking site to facilitate the association of specific E2s to the plasma membrane. MUBs contain a ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold.


Pssm-ID: 340512  Cd Length: 89  Bit Score: 41.21  E-value: 5.25e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642321 236 INLRLILVSG-KTKEFIFSPSDSAGDIAQTVFDNWPEDWTHETVSKAEiLRLIYQGRFLHCNVTLG----ALGLPLGKTT 310
Cdd:cd01814   2 IEIKFRLTDGsDIGPFRYSSATTVATLKEKVIAEWPKDKENGPKSIND-VKLIYAGKVLENGKTLAdsrtPGKVPPGGVI 80


                ....*..
gi 24642321 311 VMHLVPR 317
Cdd:cd01814  81 TMHVVVR 87
Ubl_TMUB1_like cd17057
ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing ...
 236-313 4.35e-04

ubiquitin-like (Ubl) domain found in transmembrane and ubiquitin-like domain-containing proteins TMUB1, TMUB2, and similar proteins; TMUB1, also termed dendritic cell-derived ubiquitin-like protein (DULP), or hepatocyte odd protein shuttling protein, or ubiquitin-like protein SB144, or HOPS, is highly expressed in the nervous system. It is involved in the termination of liver regeneration and plays a negative role in interleukin-6-induced hepatocyte proliferation. The overexpression of Tmub1 has been shown to play a role in the inhibition of cell proliferation. TMUB1 has been implicated in the regulation of locomotor activity and wakefulness in mice, perhaps acting through its interaction with CAMLG. It also facilitates the recycling of AMPA receptors into synaptic membrane in cultured primary neurons. TMUB1 contains transmembrane domains and a ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold. TMUB2 is an uncharacterized transmembrane domain and Ubl domain-containing protein that shows high sequence similarity to TMUB1.


Pssm-ID: 340577  Cd Length: 74  Bit Score: 38.36  E-value: 4.35e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24642321 236 INLRLILVSGKTKEFIFSPSDSAGDIAQTVFdnwpedwtHETVSKAEILRLIYQGRFLHCNV-TLGALGLPLGktTVMH 313
Cdd:cd17057   2 ITIRLKFLNETERVVYARPEDTVGDFKRRHF--------PDELAQGKRVRLIYQGQLLRDDSrTLSSYGIQDG--SVIH 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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