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Conserved domains on  [gi|18859873|ref|NP_572995|]
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doppelganger von brummer [Drosophila melanogaster]

Protein Classification

patatin-like phospholipase domain-containing protein; patatin-like phospholipase family protein( domain architecture ID 10163430)

patatin-like phospholipase domain-containing protein may function as a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids| patatin-like phospholipase family protein may catalyze the cleavage of fatty acids from membrane lipids

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Pat_iPLA2 cd07218
Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2; Calcium-independent ...
7-253 8.58e-164

Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2; Calcium-independent phospholipase A2; otherwise known as Group IVA-1 PLA2. It contains the lipase consensus sequence (Gly-X-Ser-X-Gly);mutagenesis experiments confirm the role of this serine as a nucleophile. Some members of this group show triacylglycerol lipase activity (EC 3:1:1:3). Members include iPLA-1, iPLA-2, and iPLA-3 from Aedes aegypti and show acylglycerol transacylase/lipase activity. Also includes putative iPLA2-eta from Pediculus humanus corporis which shows patatin-like phospholipase activity.


:

Pssm-ID: 132857  Cd Length: 245  Bit Score: 462.20  E-value: 8.58e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   7 RSLSFSGCGFLGIYHVGVAVCLRQHAPQLLLERIAGASAGALAACCLICDLPLECMAGDFLRVVQEIQRHSLGAFSPWFN 86
Cdd:cd07218   1 MNLSFAGCGFLGIYHVGVAVCLKKYAPHLLLNKISGASAGALAACCLLCDLPLGEMTSDFLRVVREARRHSLGPFSPSFN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  87 LPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGAF 166
Cdd:cd07218  81 IQTCLLEGLQKFLPDDAHERVSGRLHISLTRVSDGKNVIVSEFESREELLQALLCSCFIPVFSGLLPPKFRGVRYMDGGF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 167 SDNLPLLDEHTVTVSPFCGESDICPRDQNPHLlqLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQF 246
Cdd:cd07218 161 SDNLPTLDENTITVSPFCGESDICPRDNSSQL--FHINWANTSIELSRQNIYRLVRILFPPRPEVLSSLCQQGFDDALRF 238

                ....*..
gi 18859873 247 LRRNSLL 253
Cdd:cd07218 239 LHRNNLI 245
 
Name Accession Description Interval E-value
Pat_iPLA2 cd07218
Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2; Calcium-independent ...
7-253 8.58e-164

Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2; Calcium-independent phospholipase A2; otherwise known as Group IVA-1 PLA2. It contains the lipase consensus sequence (Gly-X-Ser-X-Gly);mutagenesis experiments confirm the role of this serine as a nucleophile. Some members of this group show triacylglycerol lipase activity (EC 3:1:1:3). Members include iPLA-1, iPLA-2, and iPLA-3 from Aedes aegypti and show acylglycerol transacylase/lipase activity. Also includes putative iPLA2-eta from Pediculus humanus corporis which shows patatin-like phospholipase activity.


Pssm-ID: 132857  Cd Length: 245  Bit Score: 462.20  E-value: 8.58e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   7 RSLSFSGCGFLGIYHVGVAVCLRQHAPQLLLERIAGASAGALAACCLICDLPLECMAGDFLRVVQEIQRHSLGAFSPWFN 86
Cdd:cd07218   1 MNLSFAGCGFLGIYHVGVAVCLKKYAPHLLLNKISGASAGALAACCLLCDLPLGEMTSDFLRVVREARRHSLGPFSPSFN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  87 LPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGAF 166
Cdd:cd07218  81 IQTCLLEGLQKFLPDDAHERVSGRLHISLTRVSDGKNVIVSEFESREELLQALLCSCFIPVFSGLLPPKFRGVRYMDGGF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 167 SDNLPLLDEHTVTVSPFCGESDICPRDQNPHLlqLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQF 246
Cdd:cd07218 161 SDNLPTLDENTITVSPFCGESDICPRDNSSQL--FHINWANTSIELSRQNIYRLVRILFPPRPEVLSSLCQQGFDDALRF 238

                ....*..
gi 18859873 247 LRRNSLL 253
Cdd:cd07218 239 LHRNNLI 245
YjjU COG4667
Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];
96-249 1.15e-08

Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];


Pssm-ID: 443704 [Multi-domain]  Cd Length: 281  Bit Score: 56.33  E-value: 1.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  96 RSWLPED-AHLLASGR-LHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVppQVRGVRYMDGAFSDNLPLL 173
Cdd:COG4667  95 NELLPFDfETFKASPReFYVVATNADTGEAEYFSKKDDDYDLLDALRASSALPLLYPPV--EIDGKRYLDGGVADSIPVR 172
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 174 -------DEHTV--TVspfcgesdicPRDQnphllqlninwantciRLSRRNLRRMVRILV---PGRADFMANFCQQgYD 241
Cdd:COG4667 173 eairdgaDKIVVilTR----------PRGY----------------RKKPSKFKRLLRRLYrkyPKLVEALLNRHER-YN 225

                ....*...
gi 18859873 242 DTLQFLRR 249
Cdd:COG4667 226 ETLEFIEQ 233
Patatin pfam01734
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ...
9-174 1.61e-07

Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 396341  Cd Length: 190  Bit Score: 51.46  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873     9 LSFSGCGFLGIYHVGVAVCLRQHAPQ-----------LLLeriagasagalaaCCLICDLPLECMAGDFLRVVQE----- 72
Cdd:pfam01734   1 LVLSGGGARGAYHLGVLKALGEAGIRfdvisgtsagaINA-------------ALLALGRDPEEIEDLLLELDLNlflsl 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873    73 IQRHSLGAFSPWFNL--------PECLLEGMRSWLPEDA--HLLASGRLHISLTRVSDRRNVVMS-----------EFSS 131
Cdd:pfam01734  68 IRKRALSLLALLRGLigegglfdGDALRELLRKLLGDLTleELAARLSLLLVVALRALLTVISTAlgtrarillpdDLDD 147
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 18859873   132 RQELLQALMCSCFIPGLsgLVPPQVRGVRYMDGAFSDNLPLLD 174
Cdd:pfam01734 148 DEDLADAVLASSALPGV--FPPVRLDGELYVDGGLVDNVPVEA 188
 
Name Accession Description Interval E-value
Pat_iPLA2 cd07218
Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2; Calcium-independent ...
7-253 8.58e-164

Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2; Calcium-independent phospholipase A2; otherwise known as Group IVA-1 PLA2. It contains the lipase consensus sequence (Gly-X-Ser-X-Gly);mutagenesis experiments confirm the role of this serine as a nucleophile. Some members of this group show triacylglycerol lipase activity (EC 3:1:1:3). Members include iPLA-1, iPLA-2, and iPLA-3 from Aedes aegypti and show acylglycerol transacylase/lipase activity. Also includes putative iPLA2-eta from Pediculus humanus corporis which shows patatin-like phospholipase activity.


Pssm-ID: 132857  Cd Length: 245  Bit Score: 462.20  E-value: 8.58e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   7 RSLSFSGCGFLGIYHVGVAVCLRQHAPQLLLERIAGASAGALAACCLICDLPLECMAGDFLRVVQEIQRHSLGAFSPWFN 86
Cdd:cd07218   1 MNLSFAGCGFLGIYHVGVAVCLKKYAPHLLLNKISGASAGALAACCLLCDLPLGEMTSDFLRVVREARRHSLGPFSPSFN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  87 LPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGAF 166
Cdd:cd07218  81 IQTCLLEGLQKFLPDDAHERVSGRLHISLTRVSDGKNVIVSEFESREELLQALLCSCFIPVFSGLLPPKFRGVRYMDGGF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 167 SDNLPLLDEHTVTVSPFCGESDICPRDQNPHLlqLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTLQF 246
Cdd:cd07218 161 SDNLPTLDENTITVSPFCGESDICPRDNSSQL--FHINWANTSIELSRQNIYRLVRILFPPRPEVLSSLCQQGFDDALRF 238

                ....*..
gi 18859873 247 LRRNSLL 253
Cdd:cd07218 239 LHRNNLI 245
Pat_PNPLA_like cd07204
Patatin-like phospholipase domain containing protein family; Members of this family share a ...
8-249 2.82e-110

Patatin-like phospholipase domain containing protein family; Members of this family share a patain domain, initially discovered in potato tubers. PNPLA protein members show non-specific hydrolase activity with a variety of substrates such as triacylglycerol, phospholipids, and retinylesters. It contains the lipase consensus sequence (Gly-X-Ser-X-Gly). Nomenclature of PNPLA family could be misleading as some of the mammalian members of this family show hydrolase, but no phospholipase activity.


Pssm-ID: 132843 [Multi-domain]  Cd Length: 243  Bit Score: 326.23  E-value: 2.82e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   8 SLSFSGCGFLGIYHVGVAVCLRQHAPQLLL--ERIAGASAGALAACCLICDLPLECMAGDFLRVVQEIQRHSLGAFSPWF 85
Cdd:cd07204   1 NLSFSGCGFLGIYHVGVASALREHAPRLLQnaRRIAGASAGAIVAAVVLCGVSMEEACSFILKVVSEARRRSLGPLHPSF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  86 NLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGA 165
Cdd:cd07204  81 NLLKILRQGLEKILPDDAHELASGRLHISLTRVSDGENVLVSEFDSKEELIQALVCSCFIPFYCGLIPPKFRGVRYIDGG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 166 FSDNLPLL-DEHTVTVSPFCGESDICPRDQNPHLLQLNInwANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTL 244
Cdd:cd07204 161 LSDNLPILdDENTITVSPFSGESDICPQDKSSNLLEVNI--ANTSIQLSLENLYRLNRALFPPSLEILSRMCQQGYLDAL 238

                ....*
gi 18859873 245 QFLRR 249
Cdd:cd07204 239 RFLER 243
Pat_PNPLA2 cd07220
Patatin-like phospholipase domain containing protein 2; PNPLA2 plays a key role in hydrolysis ...
8-250 1.54e-91

Patatin-like phospholipase domain containing protein 2; PNPLA2 plays a key role in hydrolysis of stored triacylglecerols and is also known as adipose triglyceride lipase (ATGL). Members of this family share a patain domain, initially discovered in potato tubers. ATGL is expressed in white and brown adipose tissue in high mRNA levels. Mutations in PNPLA2 encoding adipose triglyceride lipase (ATGL) leads to neutral lipid storage disease (NLSD) which is characterized by the accumulation of triglycerides in multiple tissues. ATGL mutations are also commonly associated with severe forms of skeletal- and cardio-myopathy. This family includes patatin-like proteins: TTS-2.2 (transport-secretion protein 2.2), PNPLA2 (Patatin-like phospholipase domain-containing protein 2), and iPLA2-zeta (Calcium-independent phospholipase A2) from Homo sapiens.


Pssm-ID: 132859  Cd Length: 249  Bit Score: 278.55  E-value: 1.54e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   8 SLSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDLPLECMAGDFLRVVQEIQRHSLGAFSPWF 85
Cdd:cd07220   6 NISFAGCGFLGVYHVGVASCLLEHAPFLVanARKIYGASAGALTATALVTGVCLGECGASVIRVAKEARKRFLGPLHPSF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  86 NLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGA 165
Cdd:cd07220  86 NLVKILRDGLLRTLPENAHELASGRLGISLTRVSDGENVLVSDFNSKEELIQALVCSCFIPVYCGLIPPTLRGVRYVDGG 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 166 FSDNLPLLD-EHTVTVSPFCGESDICPRDQNPHLLQLNINwaNTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTL 244
Cdd:cd07220 166 ISDNLPQYElKNTITVSPFSGESDICPRDSSTNFHELRFT--NTSIQFNLRNLYRLSKALFPPEPQVLAEMCKQGYRDAL 243

                ....*.
gi 18859873 245 QFLRRN 250
Cdd:cd07220 244 RFLKEN 249
Pat_PNPLA3 cd07221
Patatin-like phospholipase domain containing protein 3; PNPLA3 is a triacylglycerol lipase ...
8-254 2.71e-76

Patatin-like phospholipase domain containing protein 3; PNPLA3 is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes and is an indicator of the nutritional state. PNPLA3 is also known as adiponutrin (ADPN) or iPLA2-epsilon. Human adiponutrins are bound to the cell membrane of adipocytes and show transacylase, TG hydrolase, and PLA2 activity. This family includes patatin-like proteins: ADPN (adiponutrin) from mammals, PNPLA3 (Patatin-like phospholipase domain-containing protein 3), and iPLA2-epsilon (Calcium-independent phospholipase A2) from Homo sapiens.


Pssm-ID: 132860  Cd Length: 252  Bit Score: 239.68  E-value: 2.71e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   8 SLSFSGCGFLGIYHVGVAVCLRQHAPQLLLE-RIAGASAGALAACC-LICDLPLECMAGDFLRVVQEIQRHSLGAFSPWF 85
Cdd:cd07221   2 SLSFAGCGFLGFYHVGVTRCLSERAPHLLRDaRMFFGASAGALHCVtFLSGLPLDQILQILMDLVRSARSRNIGILHPSF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  86 NLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGA 165
Cdd:cd07221  82 NLSKHLRDGLQRHLPDNVHQLISGKMCISLTRVSDGENVLVSDFHSKDEVVDALVCSCFIPFFSGLIPPSFRGVRYVDGG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 166 FSDNLPLLD-EHTVTVSPFCGESDICPRDQNPHLLQLNInwANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTL 244
Cdd:cd07221 162 VSDNVPFFDaKTTITVSPFYGEYDICPKVKSTNFLHVDF--TKLSLRLCTENLYLLTRALFPPDVKVLGEICLRGYLDAF 239
                       250
                ....*....|
gi 18859873 245 QFLRRNSLLN 254
Cdd:cd07221 240 RFLEENGICN 249
Pat_PNPLA5-mammals cd07223
Patatin-like phospholipase domain containing protein 5; PNPLA5, also known as GS2L (GS2-like), ...
8-255 3.73e-65

Patatin-like phospholipase domain containing protein 5; PNPLA5, also known as GS2L (GS2-like), plays a role in regulation of adipocyte differentiation. PNPLA5 is expressed in brain tissue in high mRNA levels and low levels in liver tissue. There is no concrete evidence in support of the enzymatic activity of GS2L. This family includes patatin-like proteins: GS2L (GS2-like) and PNPLA5 (Patatin-like phospholipase domain-containing protein 5) reported exclusively in mammals.


Pssm-ID: 132862  Cd Length: 405  Bit Score: 215.55  E-value: 3.73e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   8 SLSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDLPLECMAGDFLRVVQEIQRHSLGAFSPWF 85
Cdd:cd07223  11 NLSFSGAGYLGLYHVGVTECLRQRAPRLLqgARRIYGSSSGALNAVSIVCGKSADFCCSNLLGMVKHLERLSLGIFHPAY 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  86 NLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGA 165
Cdd:cd07223  91 APIEHIRQQLQESLPPNIHILASQRLGISMTRWPDGRNFIVTDFATRDELIQALICTLYFPFYCGIIPPEFRGERYIDGA 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 166 FSDNLPLLD-EHTVTVSPFCGESDICPRDQNPHLLQLNInwANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDTL 244
Cdd:cd07223 171 LSNNLPFSDcPSTITVSPFHGTVDICPQSTSANLHELNA--FNASFQISTRNFFLGLKCLIPPKPEVVADNCRQGYLDAL 248
                       250
                ....*....|.
gi 18859873 245 QFLRRNSLLNE 255
Cdd:cd07223 249 RFLERRGLTKE 259
Pat_PNPLA4 cd07222
Patatin-like phospholipase domain containing protein 4; PNPLA4, also known as GS2 (gene ...
9-250 4.03e-65

Patatin-like phospholipase domain containing protein 4; PNPLA4, also known as GS2 (gene sequence-2), shows both lipase and transacylation activities. GS2 lipase is expressed in various tissues, predominantly in muscle and adipocytes tissue. It is also expressed in keratinocytes and shows retinyl ester hydrolase, acylglycerol, TG hydrolase, and PLA2 activity. This family includes patatin-like proteins: GS2 from mammals, PNPLA4 (Patatin-like phospholipase domain-containing protein 4), and iPLA2-eta (Calcium-independent phospholipase A2) from Homo sapiens.


Pssm-ID: 132861 [Multi-domain]  Cd Length: 246  Bit Score: 210.26  E-value: 4.03e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   9 LSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDlP--LECMAGDFLRVVQEIQRHSLGAFSPW 84
Cdd:cd07222   2 LSFAACGFLGIYHLGAAKALLRHGKKLLkrVKRFAGASAGSLVAAVLLTA-PekIEECKEFTYKFAEEVRKQRFGAMTPG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  85 FNLPECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDG 164
Cdd:cd07222  81 YDFMARLRKGIESILPTDAHELANDRLHVSITNLKTRKNYLVSNFTSREDLIKVLLASCYVPVYAGLKPVEYKGQKWIDG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 165 AFSDNLPLL-DEHTVTVSPFCGESDICPRDqnPHLLQLNINWANTCIRLSRRNLRRMVRILVPGRADFMANFCQQGYDDT 243
Cdd:cd07222 161 GFTNSLPVLpVGRTITVSPFSGRADICPQD--KGQLDLYVRFANQDIMLSLANLVRLNQALFPPNRRKLESYYQMGFDDA 238

                ....*..
gi 18859873 244 LQFLRRN 250
Cdd:cd07222 239 VRFLKKE 245
Pat_PNPLA1 cd07219
Patatin-like phospholipase domain containing protein 1; Members of this family share a patatin ...
5-251 1.38e-59

Patatin-like phospholipase domain containing protein 1; Members of this family share a patatin domain, initially discovered in potato tubers. Some members of PNPLA1 subfamily do not have the lipase consensus sequence Gly-X-Ser-X-Gly which is essential for hydrolase activity. This family includes PNPLA1 from Homo sapiens and Gallus gallus. Currently, there is no literature available on the physiological role, structure, or enzymatic activity of PNPLA1. It is expressed in various human tissues in low mRNA levels.


Pssm-ID: 132858  Cd Length: 382  Bit Score: 200.50  E-value: 1.38e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   5 TRRSLSFSGCGFLGIYHVGVAVCLRQHAPQLL--LERIAGASAGALAACCLICDLPLEcmagDFLRV----VQEIQRHSL 78
Cdd:cd07219  11 TPHSISFSGSGFLSFYQAGVVDALRDLAPRMLetAHRVAGTSAGSVIAALVVCGISMD----EYLRVlnvgVAEVRKSFL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  79 GAFSPwfnlpEC-LLEGMRSWL----PEDAHLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVP 153
Cdd:cd07219  87 GPLSP-----SCkMVQMMRQFLyrvlPEDSYKVATGKLHVSLTRVTDGENVVVSEFTSKEELIEALYCSCFVPVYCGLIP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 154 PQVRGVRYMDGAFSDNLPL-LDEHTVTVSPFCGESDICPRDqNPHLLQlNINWANTCIRLSRRNLRRMVRILVPGRADFM 232
Cdd:cd07219 162 PTYRGVRYIDGGFTGMQPCsFWTDSITISTFSGQQDICPRD-CPAIFH-DFRIFNCSFQFSLENIARMTHALFPPDLMVL 239
                       250
                ....*....|....*....
gi 18859873 233 ANFCQQGYDDTLQFLRRNS 251
Cdd:cd07219 240 HDYYYRGYQDTVLYLRRLN 258
Patatin cd07198
Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows ...
9-182 3.69e-45

Patatin-like phospholipase; Patatin is a storage protein of the potato tuber that shows Phospholipase A2 activity (PLA2; EC 3.1.1.4). Patatin catalyzes the nonspecific hydrolysis of phospholipids, glycolipids, sulfolipids, and mono- and diacylglycerols, thereby showing lipid acyl hydrolase activity. The active site includes an oxyanion hole with a conserved GGxR motif; it is found in almost all the members of this family. The catalytic dyad is formed by a serine and an aspartate. Patatin belongs to the alpha-beta hydrolase family which is identified by a characteristic nucleophile elbow with a consensus sequence of Sm-X-Nu-Sm (Sm = small residue, X = any residue and Nu = nucleophile). Members of this family have been found also in vertebrates. This family includes PNPLA (1-9), TGL (3-5), ExoU-like, and SDP1-like subfamilies. There are some additional hypothetical proteins included in this family.


Pssm-ID: 132837 [Multi-domain]  Cd Length: 172  Bit Score: 155.58  E-value: 3.69e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   9 LSFSGCGFLGIYHVGVAVCLRQHAPqlLLERIAGASAGALAACCLICDLPLECMAGDFLRVVQEIQRHSLGAFSPWFNLP 88
Cdd:cd07198   1 LVLSGGGALGIYHVGVAKALRERGP--LIDIIAGTSAGAIVAALLASGRDLEEALLLLLRLSREVRLRFDGAFPPTGRLL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  89 ECLLEGMRSWLPEDAHLLASGRLHISLTRVSDRRNVVMSeFSSRQELLQALMCSCFIPGLSGLVPPQVRGVRYMDGAFSD 168
Cdd:cd07198  79 GILRQPLLSALPDDAHEDASGKLFISLTRLTDGENVLVS-DTSKGELWSAVRASSSIPGYFGPVPLSFRGRRYGDGGLSN 157
                       170
                ....*....|....*
gi 18859873 169 NLPLLD-EHTVTVSP 182
Cdd:cd07198 158 NLPVAElGNTINVSP 172
Patatin_and_cPLA2 cd01819
Patatins and Phospholipases; Patatin-like phospholipase. This family consists of various ...
9-182 5.91e-25

Patatins and Phospholipases; Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates. This family also includes the catalytic domain of cytosolic phospholipase A2 (PLA2; EC 3.1.1.4) hydrolyzes the sn-2-acyl ester bond of phospholipids to release arachidonic acid. At the active site, cPLA2 contains a serine nucleophile through which the catalytic mechanism is initiated. The active site is partially covered by a solvent-accessible flexible lid. cPLA2 displays interfacial activation as it exists in both "closed lid" and "open lid" forms.


Pssm-ID: 132836 [Multi-domain]  Cd Length: 155  Bit Score: 100.57  E-value: 5.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   9 LSFSGCGFLGIYHVGVAVCLRQHAPQLLLERIAGASAGALAACCLicdLPLECMAGDFLRVVQEiqrhslgafspwfnlp 88
Cdd:cd01819   1 LSFSGGGFRGMYHAGVLSALAERGLLDCVTYLAGTSGGAWVAATL---YPPSSSLDNKPRQSLE---------------- 61
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  89 ecllegmrswlpedahLLASGRLHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVPPQV----------RG 158
Cdd:cd01819  62 ----------------EALSGKLWVSFTPVTAGENVLVSRFVSKEELIRALFASGSWPSYFGLIPPAElytsksnlkeKG 125
                       170       180       190
                ....*....|....*....|....*....|
gi 18859873 159 VRYMDGAFSDNLPLL------DEHTVTVSP 182
Cdd:cd01819 126 VRLVDGGVSNNLPAPvllrpgRGVTLTISP 155
Pat_like cd07224
Patatin-like phospholipase; Patatin-like phospholipase. This family consists of various ...
10-206 5.21e-22

Patatin-like phospholipase; Patatin-like phospholipase. This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 132863  Cd Length: 233  Bit Score: 94.33  E-value: 5.21e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  10 SFSGCGFLGIYHVGVAVCL------RQHAPqlllerIAGASAGALAACCLICDLPLEcmagDFLRVVQEIQR--HSLGAf 81
Cdd:cd07224   3 SFSAAGLLFPYHLGVLSLLieagviNETTP------LAGASAGSLAAACSASGLSPE----EALEATEELAEdcRSNGT- 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  82 spWFNLPECLLEGMRSWLPEDAH-LLASGRLHISLTRVSDR-RNVVMSEFSSRQELLQALMCSCFIPGLSGLVPP-QVRG 158
Cdd:cd07224  72 --AFRLGGVLRDELDKTLPDDAHeRCNRGRIRVAVTQLFPVpRGLLVSSFDSKSDLIDALLASCNIPGYLAPWPAtMFRG 149
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18859873 159 VRYMDGAFSDNLPLLD--EHTVTVSPFCGES------DICPRDQNPH---LLQLnINWA 206
Cdd:cd07224 150 KLCVDGGFALFIPPTTaaDRTVRVCPFPASRssikgqNLDNDDTEDVpysRRQL-LNWA 207
YjjU COG4667
Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];
96-249 1.15e-08

Predicted phospholipase, patatin/cPLA2 family [Lipid transport and metabolism];


Pssm-ID: 443704 [Multi-domain]  Cd Length: 281  Bit Score: 56.33  E-value: 1.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  96 RSWLPED-AHLLASGR-LHISLTRVSDRRNVVMSEFSSRQELLQALMCSCFIPGLSGLVppQVRGVRYMDGAFSDNLPLL 173
Cdd:COG4667  95 NELLPFDfETFKASPReFYVVATNADTGEAEYFSKKDDDYDLLDALRASSALPLLYPPV--EIDGKRYLDGGVADSIPVR 172
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 174 -------DEHTV--TVspfcgesdicPRDQnphllqlninwantciRLSRRNLRRMVRILV---PGRADFMANFCQQgYD 241
Cdd:COG4667 173 eairdgaDKIVVilTR----------PRGY----------------RKKPSKFKRLLRRLYrkyPKLVEALLNRHER-YN 225

                ....*...
gi 18859873 242 DTLQFLRR 249
Cdd:COG4667 226 ETLEFIEQ 233
Patatin pfam01734
Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. ...
9-174 1.61e-07

Patatin-like phospholipase; This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids. Members of this family have been found also in vertebrates.


Pssm-ID: 396341  Cd Length: 190  Bit Score: 51.46  E-value: 1.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873     9 LSFSGCGFLGIYHVGVAVCLRQHAPQ-----------LLLeriagasagalaaCCLICDLPLECMAGDFLRVVQE----- 72
Cdd:pfam01734   1 LVLSGGGARGAYHLGVLKALGEAGIRfdvisgtsagaINA-------------ALLALGRDPEEIEDLLLELDLNlflsl 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873    73 IQRHSLGAFSPWFNL--------PECLLEGMRSWLPEDA--HLLASGRLHISLTRVSDRRNVVMS-----------EFSS 131
Cdd:pfam01734  68 IRKRALSLLALLRGLigegglfdGDALRELLRKLLGDLTleELAARLSLLLVVALRALLTVISTAlgtrarillpdDLDD 147
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 18859873   132 RQELLQALMCSCFIPGLsgLVPPQVRGVRYMDGAFSDNLPLLD 174
Cdd:pfam01734 148 DEDLADAVLASSALPGV--FPPVRLDGELYVDGGLVDNVPVEA 188
RssA COG1752
Predicted acylesterase/phospholipase RssA, containd patatin domain [General function ...
1-249 5.52e-05

Predicted acylesterase/phospholipase RssA, containd patatin domain [General function prediction only];


Pssm-ID: 441358 [Multi-domain]  Cd Length: 261  Bit Score: 44.89  E-value: 5.52e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873   1 MKIRTRRSLSFSGCGFLGIYHVGVAVCLRQHapQLLLERIAGASAGALAACCLICDLPLEcmagDFLRVVQEIQRHSLGA 80
Cdd:COG1752   1 APARPKIGLVLSGGGARGAAHIGVLKALEEA--GIPPDVIAGTSAGAIVGALYAAGYSAD----ELEELWRSLDRRDLFD 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  81 FSPWFNLPECLL----------EGMRSWLpeDAHLLAS--GRLHISL----TRVSDRRNVVMSEFssrqELLQALMCSCF 144
Cdd:COG1752  75 LSLPRRLLRLDLglspgglldgDPLRRLL--ERLLGDRdfEDLPIPLavvaTDLETGREVVFDSG----PLADAVRASAA 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873 145 IPGLsgLVPPQVRGVRYMDGAFSDNLPL--LDEHT------VTVSPfcgesdicPRDQNPHLLQLNINWANTCIR---LS 213
Cdd:COG1752 149 IPGV--FPPVEIDGRLYVDGGVVNNLPVdpARALGadrviaVDLNP--------PLRKLPSLLDILGRALEIMFNsilRR 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 18859873 214 RRNLRRMVRILVPGRADF-MANF------CQQGYDDTLQFLRR 249
Cdd:COG1752 219 ELALEPADILIEPDLSGIsLLDFsraeelIEAGYEAARRALDE 261
Pat_hypo_Ecoli_Z1214_like cd07209
Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase ...
91-172 9.07e-04

Hypothetical patatin similar to Z1214 protein of Escherichia coli; Patatin-like phospholipase similar to Z1214 protein of Escherichia coli. This family predominantly consists of bacterial patatin glycoproteins and some representatives from eukaryotes and archaea. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers. Patatin is a storage protein, but it also has the enzymatic activity of a lipid acyl hydrolase, catalyzing the cleavage of fatty acids from membrane lipids. Members of this family have also been found in vertebrates.


Pssm-ID: 132848 [Multi-domain]  Cd Length: 215  Bit Score: 40.74  E-value: 9.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859873  91 LLEGMRSWLPED---AHLLASGRLHISLTRVSDRRNVVMSEfSSRQELLQALMCSCFIPGlsGLVPPQVRGVRYMDGAFS 167
Cdd:cd07209  68 LRGLLDRALDFDtlrLLAILFAGLVIVAVNVLTGEPVYFDD-IPDGILPEHLLASAALPP--FFPPVEIDGRYYWDGGVV 144

                ....*
gi 18859873 168 DNLPL 172
Cdd:cd07209 145 DNTPL 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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