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Conserved domains on  [gi|18859995|ref|NP_572978|]
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uncharacterized protein Dmel_CG9519 [Drosophila melanogaster]

Protein Classification

GMC family oxidoreductase( domain architecture ID 11455227)

GMC (glucose-methanol-choline) family oxidoreductase is a flavoprotein that catalyzes the oxidation of an alcohol moiety to the corresponding aldehyde with the concomitant reduction of flavin adenine dinucleotide (FAD)

EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0050660
PubMed:  23578136|1542121
SCOP:  3000055

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 59-619 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


:

Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 544.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  59 TTKYDFIVVGAGTAGCALAARLSENPRWRVLLLEAGGPENYAM-DIPI-VAHLLQLGEINWKYKTEPSnsycLAMNNNRC 136
Cdd:COG2303   2 LEEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLiRMPAgYAKLLGNPRYDWRYETEPQ----PGLNGRRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 137 NWPRGKVMGGSSVLNYMMYTRGNRRDYDRWARLGNPGWSYEEVLPYFKKYEGSVVPDADenLVGRNGPVKVSYSETRTRI 216
Cdd:COG2303  78 YWPRGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGADA--YHGRSGPLPVSDPPLPNPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 217 ADAFVGATQDAGLPRG-DYNGDKQIRVSYLQANIYNETRWSSNRAYLYPIKgKRRNLHVKKNALVTKILIDpqTKSAFGI 295
Cdd:COG2303 156 SDAFIEAAEELGIPRAdDFNGGACEGCGFCQVTCRNGARWSAARAYLPPAL-KRPNLTVRTGALVTRILFD--GGRATGV 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 296 IVKMDGKMQKILARKEVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLADL-AVGYNLQDHIAPAISFLCN-VSSLQTS 373
Cdd:COG2303 233 EYRDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLpGVGRNLQDHLEVSVVFRFKePVTLNKS 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 374 EMFRSEAMSDFLKGRGVLRIpGGVEAISFYALDDARnpdAWADMELFVVGGGlqtnlalrlalgiqsniYETMFGELERQ 453
Cdd:COG2303 313 LRKARIGLQYLLTRSGPLTS-NVAEAGGFFRSDPGL---ERPDLQFHFLPLG-----------------LTPRWGKKALH 371

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 454 SANGFLIFPMILRAKSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQAVSLLDMPAFKAIgahllekRIPNCAK 533
Cdd:COG2303 372 DGHGFTAHVEQLRPESRGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPY-------RGEEILP 444

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 534 YKWKSSAYWACYARHFTFTIYHYSGTAKMGPrsDPSAVVDARLRVHGIDKLRVVDASIMPYLISGHPNGPVYLIAEKAAD 613
Cdd:COG2303 445 GPDVQSDEELAFIRARAYTIYHPVGTCRMGT--DPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAAD 522


                ....*.
gi 18859995 614 MIKEDH 619
Cdd:COG2303 523 MILGDY 528
 
Name Accession Description Interval E-value
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 59-619 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 544.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  59 TTKYDFIVVGAGTAGCALAARLSENPRWRVLLLEAGGPENYAM-DIPI-VAHLLQLGEINWKYKTEPSnsycLAMNNNRC 136
Cdd:COG2303   2 LEEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLiRMPAgYAKLLGNPRYDWRYETEPQ----PGLNGRRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 137 NWPRGKVMGGSSVLNYMMYTRGNRRDYDRWARLGNPGWSYEEVLPYFKKYEGSVVPDADenLVGRNGPVKVSYSETRTRI 216
Cdd:COG2303  78 YWPRGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGADA--YHGRSGPLPVSDPPLPNPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 217 ADAFVGATQDAGLPRG-DYNGDKQIRVSYLQANIYNETRWSSNRAYLYPIKgKRRNLHVKKNALVTKILIDpqTKSAFGI 295
Cdd:COG2303 156 SDAFIEAAEELGIPRAdDFNGGACEGCGFCQVTCRNGARWSAARAYLPPAL-KRPNLTVRTGALVTRILFD--GGRATGV 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 296 IVKMDGKMQKILARKEVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLADL-AVGYNLQDHIAPAISFLCN-VSSLQTS 373
Cdd:COG2303 233 EYRDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLpGVGRNLQDHLEVSVVFRFKePVTLNKS 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 374 EMFRSEAMSDFLKGRGVLRIpGGVEAISFYALDDARnpdAWADMELFVVGGGlqtnlalrlalgiqsniYETMFGELERQ 453
Cdd:COG2303 313 LRKARIGLQYLLTRSGPLTS-NVAEAGGFFRSDPGL---ERPDLQFHFLPLG-----------------LTPRWGKKALH 371

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 454 SANGFLIFPMILRAKSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQAVSLLDMPAFKAIgahllekRIPNCAK 533
Cdd:COG2303 372 DGHGFTAHVEQLRPESRGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPY-------RGEEILP 444

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 534 YKWKSSAYWACYARHFTFTIYHYSGTAKMGPrsDPSAVVDARLRVHGIDKLRVVDASIMPYLISGHPNGPVYLIAEKAAD 613
Cdd:COG2303 445 GPDVQSDEELAFIRARAYTIYHPVGTCRMGT--DPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAAD 522


                ....*.
gi 18859995 614 MIKEDH 619
Cdd:COG2303 523 MILGDY 528
PRK02106 PRK02106
choline dehydrogenase; Validated
 59-616 3.06e-141

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 422.32  E-value: 3.06e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   59 TTKYDFIVVGAGTAGCALAARLSENPRWRVLLLEAGGPeNYAMDIPI-----VAHLLQLGEINWKYKTEPSNSyclaMNN 133
Cdd:PRK02106   3 TMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGP-DYRWDFFIqmpaaLAFPLQGKRYNWAYETEPEPH----MNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  134 NRCNWPRGKVMGGSSVLNYMMYTRGNRRDYDRWARL-GNPGWSYEEVLPYFKKYEGSVVPDADenLVGRNGPVKVSYSET 212
Cdd:PRK02106  78 RRMECPRGKVLGGSSSINGMVYIRGNAMDYDNWAELpGLEGWSYADCLPYFKKAETRDGGEDD--YRGGDGPLSVTRGKP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  213 RTR-IADAFVGATQDAGLPR-GDYNGDKQIRVSYLQANIYNETRWSSNRAYLYPIKgKRRNLHVKKNALVTKILIDPqtK 290
Cdd:PRK02106 156 GTNpLFQAFVEAGVQAGYPRtDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPAL-KRPNLTIVTHALTDRILFEG--K 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  291 SAFGIIVKMDGKMQKILARKEVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLADLA-VGYNLQDHIAPAISFLCN--V 367
Cdd:PRK02106 233 RAVGVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPgVGENLQDHLEVYIQYECKqpV 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  368 SSLQTSEMFRSEAM-------------SDFLKGRGVLRIPGGVE--AISFYAL-----DDARNPdawadmelfVVGGGLQ 427
Cdd:PRK02106 313 SLYPALKWWNKPKIgaewlftgtglgaSNHFEAGGFIRSRAGVDwpNIQYHFLpvairYDGSNA---------VKGHGFQ 383

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  428 tnlalrlalgiqsniyetmfgelerqsangFLIFPMilRAKSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQA 507
Cdd:PRK02106 384 ------------------------------AHVGPM--RSPSRGSVKLKSADPRAHPSILFNYMSTEQDWREFRDAIRLT 431

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  508 VSLLDMPAFKAI-------GAHLlekripncakykwKSSAYWACYARHFTFTIYHYSGTAKMGPrsDPSAVVDARLRVHG 580
Cdd:PRK02106 432 REIMAQPALDPYrgreispGADV-------------QTDEEIDAFVREHAETAYHPSCTCKMGT--DPMAVVDPEGRVHG 496

                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 18859995  581 IDKLRVVDASIMPYLISGHPNGPVYLIAEKAADMIK 616
Cdd:PRK02106 497 VEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIR 532
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 63-616 4.51e-113

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 348.79  E-value: 4.51e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995    63 DFIVVGAGTAGCALAARLSENPRWRVLLLEAGGPEnYAMDIPI-----VAHLLQLGEINWKYKTEPSNSyclaMNNNRCN 137
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGSD-YPWDLLIqmpaaLAYPAGNKRYNWIYETEPEPH----MNNRRVG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   138 WPRGKVMGGSSVLNYMMYTRGNRRDYDRWAR-LGNPGWSYEEVLPYFKKYEGSVVpdADENLVGRNGPVKVSYSETRTRI 216
Cdd:TIGR01810  76 HARGKVLGGSSSINGMIYQRGNPMDYEKWAKpEGMESWDYADCLPYYKRLETTFG--GEKPYRGHDGPIKVRRGPADNPL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   217 ADAFVGATQDAGLPRG-DYNGDKQIRVSYLQANIYNETRWSSNRAYLYPIKgKRRNLHVKKNALVTKILIDpqTKSAFGI 295
Cdd:TIGR01810 154 FQAFIEAGVEAGYNKTpDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAM-KRPNLEVQTRAFVTKINFE--GNRATGV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   296 IVKMDGKMQKILARKEVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLADL-AVGYNLQDHIAPAISFLCNVS-SLQTS 373
Cdd:TIGR01810 231 EFKKGGRKEHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLpGVGENLQDHLEVYVQHACKQPvSLYPS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   374 --EMFRSEAMSDFLKGRGVLRIPGGVEAISFY-ALDDARNPDawadmelfvvgggLQTNLalrLALGIQSNIYETMfgel 450
Cdd:TIGR01810 311 lnWLKQPFIGAQWLFGRKGAGASNHFEGGGFVrSNDDVDYPN-------------IQYHF---LPVAIRYDGTKAP---- 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   451 erqSANGFLIFPMILRAKSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQAVSLLDMPAFKAIGAHLLEKRiPN 530
Cdd:TIGR01810 371 ---KAHGFQVHVGPMYSNSRGHVKIKSKDPFEKPEIVFNYMSHEEDWREFREAIRVTREILKQKALDPYRGGEISPG-PE 446

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   531 CakykwKSSAYWACYARHFTFTIYHYSGTAKMGPRSDPSAVVDARLRVHGIDKLRVVDASIMPYLISGHPNGPVYLIAEK 610
Cdd:TIGR01810 447 V-----QTDEEIDEFVRRHGETALHPCGTCKMGPASDEMSVVDPETRVHGMEGLRVVDASIMPRITNGNLNAPVIMMGEK 521


                  ....*.
gi 18859995   611 AADMIK 616
Cdd:TIGR01810 522 AADIIR 527
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 132-356 2.19e-46

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 162.84  E-value: 2.19e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   132 NNNRCNWPRGKVMGGSSVLNYMMYTRGNRRDYDRWARL-GNPGWSYEEVLPYFKKYEG--SVVPDADENLvGRNgpvkvs 208
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWASEfGLEGWGYDDYLPYMDKVEGplGVTTKGIEES-PLN------ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   209 ysetrtriaDAFVGATQDAGLP----RGDYNGDKQIRVSYLQANiyNETRWSSNRAYLYPikGKRRNLHVKKNALVTKIL 284
Cdd:pfam00732  88 ---------QALLKAAEELGYPveavPRNSNGCHYCGFCGLGCP--TGAKQSTARTWLRP--ALERNLRILTGAKAEKII 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18859995   285 IDPQTKSAFGI-IVKMDGK-MQKILARKEVILSAGAINTPQLLMLSGVGPAKHlremgikpladlAVGYNLQDH 356
Cdd:pfam00732 155 ILGRGGRAVGVeARDGGGGiKRLITAAKEVVVAAGALNTPPLLLRSGLGKNPH------------PVGKNLQLH 216
 
Name Accession Description Interval E-value
BetA COG2303
Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General ...
 59-619 0e+00

Choline dehydrogenase or related flavoprotein [Lipid transport and metabolism, General function prediction only]; Choline dehydrogenase or related flavoprotein is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 441878 [Multi-domain]  Cd Length: 531  Bit Score: 544.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  59 TTKYDFIVVGAGTAGCALAARLSENPRWRVLLLEAGGPENYAM-DIPI-VAHLLQLGEINWKYKTEPSnsycLAMNNNRC 136
Cdd:COG2303   2 LEEYDYVIVGAGSAGCVLANRLSEDAGLRVLLLEAGGRDDDPLiRMPAgYAKLLGNPRYDWRYETEPQ----PGLNGRRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 137 NWPRGKVMGGSSVLNYMMYTRGNRRDYDRWARLGNPGWSYEEVLPYFKKYEGSVVPDADenLVGRNGPVKVSYSETRTRI 216
Cdd:COG2303  78 YWPRGKVLGGSSSINGMIYVRGQPEDFDLWAQLGNQGWGYDDVLPYFKRAEDNERGADA--YHGRSGPLPVSDPPLPNPL 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 217 ADAFVGATQDAGLPRG-DYNGDKQIRVSYLQANIYNETRWSSNRAYLYPIKgKRRNLHVKKNALVTKILIDpqTKSAFGI 295
Cdd:COG2303 156 SDAFIEAAEELGIPRAdDFNGGACEGCGFCQVTCRNGARWSAARAYLPPAL-KRPNLTVRTGALVTRILFD--GGRATGV 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 296 IVKMDGKMQKILARKEVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLADL-AVGYNLQDHIAPAISFLCN-VSSLQTS 373
Cdd:COG2303 233 EYRDDGEEHTVRAAREVILAAGAINSPQLLLLSGIGPASHLREHGIPVVHDLpGVGRNLQDHLEVSVVFRFKePVTLNKS 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 374 EMFRSEAMSDFLKGRGVLRIpGGVEAISFYALDDARnpdAWADMELFVVGGGlqtnlalrlalgiqsniYETMFGELERQ 453
Cdd:COG2303 313 LRKARIGLQYLLTRSGPLTS-NVAEAGGFFRSDPGL---ERPDLQFHFLPLG-----------------LTPRWGKKALH 371

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 454 SANGFLIFPMILRAKSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQAVSLLDMPAFKAIgahllekRIPNCAK 533
Cdd:COG2303 372 DGHGFTAHVEQLRPESRGRVTLDSADPLGAPLIRPNYLSDENDRRVLVAGVRLAREIAAQPALAPY-------RGEEILP 444

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995 534 YKWKSSAYWACYARHFTFTIYHYSGTAKMGPrsDPSAVVDARLRVHGIDKLRVVDASIMPYLISGHPNGPVYLIAEKAAD 613
Cdd:COG2303 445 GPDVQSDEELAFIRARAYTIYHPVGTCRMGT--DPDSVVDPRLRVHGVENLRVVDASVMPTITSGNTNAPTIMLAEKAAD 522


                ....*.
gi 18859995 614 MIKEDH 619
Cdd:COG2303 523 MILGDY 528
PRK02106 PRK02106
choline dehydrogenase; Validated
 59-616 3.06e-141

choline dehydrogenase; Validated


Pssm-ID: 235000 [Multi-domain]  Cd Length: 560  Bit Score: 422.32  E-value: 3.06e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   59 TTKYDFIVVGAGTAGCALAARLSENPRWRVLLLEAGGPeNYAMDIPI-----VAHLLQLGEINWKYKTEPSNSyclaMNN 133
Cdd:PRK02106   3 TMEYDYIIIGAGSAGCVLANRLSEDPDVSVLLLEAGGP-DYRWDFFIqmpaaLAFPLQGKRYNWAYETEPEPH----MNN 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  134 NRCNWPRGKVMGGSSVLNYMMYTRGNRRDYDRWARL-GNPGWSYEEVLPYFKKYEGSVVPDADenLVGRNGPVKVSYSET 212
Cdd:PRK02106  78 RRMECPRGKVLGGSSSINGMVYIRGNAMDYDNWAELpGLEGWSYADCLPYFKKAETRDGGEDD--YRGGDGPLSVTRGKP 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  213 RTR-IADAFVGATQDAGLPR-GDYNGDKQIRVSYLQANIYNETRWSSNRAYLYPIKgKRRNLHVKKNALVTKILIDPqtK 290
Cdd:PRK02106 156 GTNpLFQAFVEAGVQAGYPRtDDLNGYQQEGFGPMDRTVTNGRRWSAARAYLDPAL-KRPNLTIVTHALTDRILFEG--K 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  291 SAFGIIVKMDGKMQKILARKEVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLADLA-VGYNLQDHIAPAISFLCN--V 367
Cdd:PRK02106 233 RAVGVEYERGGGRETARARREVILSAGAINSPQLLQLSGIGPAEHLKELGIPVVHDLPgVGENLQDHLEVYIQYECKqpV 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  368 SSLQTSEMFRSEAM-------------SDFLKGRGVLRIPGGVE--AISFYAL-----DDARNPdawadmelfVVGGGLQ 427
Cdd:PRK02106 313 SLYPALKWWNKPKIgaewlftgtglgaSNHFEAGGFIRSRAGVDwpNIQYHFLpvairYDGSNA---------VKGHGFQ 383

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  428 tnlalrlalgiqsniyetmfgelerqsangFLIFPMilRAKSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQA 507
Cdd:PRK02106 384 ------------------------------AHVGPM--RSPSRGSVKLKSADPRAHPSILFNYMSTEQDWREFRDAIRLT 431

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  508 VSLLDMPAFKAI-------GAHLlekripncakykwKSSAYWACYARHFTFTIYHYSGTAKMGPrsDPSAVVDARLRVHG 580
Cdd:PRK02106 432 REIMAQPALDPYrgreispGADV-------------QTDEEIDAFVREHAETAYHPSCTCKMGT--DPMAVVDPEGRVHG 496

                        570       580       590
                 ....*....|....*....|....*....|....*.
gi 18859995  581 IDKLRVVDASIMPYLISGHPNGPVYLIAEKAADMIK 616
Cdd:PRK02106 497 VEGLRVVDASIMPTITNGNLNAPTIMIAEKAADLIR 532
betA TIGR01810
choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied ...
 63-616 4.51e-113

choline dehydrogenase; Choline dehydrogenase catalyzes the conversion of exogenously supplied choline into the intermediate glycine betaine aldehyde, as part of a two-step oxidative reaction leading to the formation of osmoprotectant betaine. This enzymatic system can be found in both gram-positive and gram-negative bacteria. As in Escherichia coli, Staphylococcus xylosus, and Sinorhizobium meliloti, this enzyme is found associated in a transciptionally co-induced gene cluster with betaine aldehyde dehydrogenase, the second catalytic enzyme in this reaction. Other gram-positive organisms have been shown to employ a different enzymatic system, utlizing a soluable choline oxidase or type III alcohol dehydrogenase instead of choline dehydrogenase. This enzyme is a member of the GMC oxidoreductase family (pfam00732 and pfam05199), sharing a common evoluntionary origin and enzymatic reaction with alcohol dehydrogenase. Outgrouping from this model, Caulobacter crescentus shares sequence homology with choline dehydrogenase, yet other genes participating in this enzymatic reaction have not currently been identified. [Cellular processes, Adaptations to atypical conditions]


Pssm-ID: 273814 [Multi-domain]  Cd Length: 532  Bit Score: 348.79  E-value: 4.51e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995    63 DFIVVGAGTAGCALAARLSENPRWRVLLLEAGGPEnYAMDIPI-----VAHLLQLGEINWKYKTEPSNSyclaMNNNRCN 137
Cdd:TIGR01810   1 DYIIIGGGSAGSVLAGRLSEDVSNSVLVLEAGGSD-YPWDLLIqmpaaLAYPAGNKRYNWIYETEPEPH----MNNRRVG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   138 WPRGKVMGGSSVLNYMMYTRGNRRDYDRWAR-LGNPGWSYEEVLPYFKKYEGSVVpdADENLVGRNGPVKVSYSETRTRI 216
Cdd:TIGR01810  76 HARGKVLGGSSSINGMIYQRGNPMDYEKWAKpEGMESWDYADCLPYYKRLETTFG--GEKPYRGHDGPIKVRRGPADNPL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   217 ADAFVGATQDAGLPRG-DYNGDKQIRVSYLQANIYNETRWSSNRAYLYPIKgKRRNLHVKKNALVTKILIDpqTKSAFGI 295
Cdd:TIGR01810 154 FQAFIEAGVEAGYNKTpDVNGFRQEGFGPMDSTVHNGRRVSAARAYLHPAM-KRPNLEVQTRAFVTKINFE--GNRATGV 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   296 IVKMDGKMQKILARKEVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLADL-AVGYNLQDHIAPAISFLCNVS-SLQTS 373
Cdd:TIGR01810 231 EFKKGGRKEHTEANKEVILSAGAINSPQLLQLSGIGDAEHLRELGIEPRIHLpGVGENLQDHLEVYVQHACKQPvSLYPS 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   374 --EMFRSEAMSDFLKGRGVLRIPGGVEAISFY-ALDDARNPDawadmelfvvgggLQTNLalrLALGIQSNIYETMfgel 450
Cdd:TIGR01810 311 lnWLKQPFIGAQWLFGRKGAGASNHFEGGGFVrSNDDVDYPN-------------IQYHF---LPVAIRYDGTKAP---- 370

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   451 erqSANGFLIFPMILRAKSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQAVSLLDMPAFKAIGAHLLEKRiPN 530
Cdd:TIGR01810 371 ---KAHGFQVHVGPMYSNSRGHVKIKSKDPFEKPEIVFNYMSHEEDWREFREAIRVTREILKQKALDPYRGGEISPG-PE 446

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   531 CakykwKSSAYWACYARHFTFTIYHYSGTAKMGPRSDPSAVVDARLRVHGIDKLRVVDASIMPYLISGHPNGPVYLIAEK 610
Cdd:TIGR01810 447 V-----QTDEEIDEFVRRHGETALHPCGTCKMGPASDEMSVVDPETRVHGMEGLRVVDASIMPRITNGNLNAPVIMMGEK 521


                  ....*.
gi 18859995   611 AADMIK 616
Cdd:TIGR01810 522 AADIIR 527
Rv0697 TIGR03970
dehydrogenase, Rv0697 family; This model describes a set of dehydrogenases belonging to the ...
 63-615 3.02e-80

dehydrogenase, Rv0697 family; This model describes a set of dehydrogenases belonging to the glucose-methanol-choline oxidoreductase (GMC oxidoreductase) family. Members of the present family are restricted to Actinobacterial genome contexts containing also members of families TIGR03962 and TIGR03969 (the mycofactocin system), and are proposed to be uniform in function.


Pssm-ID: 274888 [Multi-domain]  Cd Length: 487  Bit Score: 261.67  E-value: 3.02e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995    63 DFIVVGAGTAGCALAARLSENPRWRVLLLEAGGPENYAMDIP-IVAHLLQL-----GEINWKYKTE----PSNSYCLAmn 132
Cdd:TIGR03970   2 DVLIVGAGSAGSVLAARLSEDPSCTVTVLEAGPGYRDPSRLPaQLTDGLRLpigpaSPVVWRYGVEltdgPRRASQIV-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   133 nnrcnwpRGKVMGGSSVLNYMMYTRGNRRDYDRWARlgnPGWSYEEVLPYFKKYEGSVvpDADENLVGRNGPVKVSYSET 212
Cdd:TIGR03970  80 -------RGRVLGGSGAVNGGYFCRALPADFDAWPI---PGWSWDDVLPHFRAIETDL--DFDGPLHGTAGPIPVRRTAE 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   213 RTRIADAFVGATQDAGLP-RGDYNGDKQIRVSYLQA---NIYNETRWSSNRAYLYPiKGKRRNLHVKKNALVTKILIDPQ 288
Cdd:TIGR03970 148 LDGISAAFVAAALGAGFGwIADLNGSGPGLPGGVGAvplNVDGGRRVSTAVAYLLP-ALKRPNLTVEADTRVVRILFSGT 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   289 TksAFGIIVKMDGKMQKILARKeVILSAGAINTPQLLMLSGVGPAKHLREMGIKPLADLAVGYNLQDHiaPAISFLCNVS 368
Cdd:TIGR03970 227 R--AVGVEVLGDGGPRTLRADR-VVLCAGAVESAHLLLLSGIGPAEQLRAAGIAVVLDLPVGSDFVDH--PEWVLPYRWR 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   369 SlqtsemfrseamsdflkgrgVLRIPGGVEAISfYALDDarnpdawADMEL------FV--VGGGLQTNLALRLALgiqs 440
Cdd:TIGR03970 302 P--------------------THDRPPTSPVLE-TVLNT-------ADIEIrpytagFTalVPGSPRDDPHLGVAL---- 349

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   441 niyetmfgelerqsangflifpmiLRAKSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQAVSLLdmpafkaiG 520
Cdd:TIGR03970 350 ------------------------MRPHSRGRIRLASADPADPPRIEHRYDSSAADRAALRAGAALAHELL--------G 397

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   521 AHLLEKRIPNCAKykwKSSAYWacyARHFTFTIYHYSGTAKMGPRSDPSAVVDARLRVHGIDKLRVVDASIMPYLISGHP 600
Cdd:TIGR03970 398 SPELGPLLEPAVR---EGEASW---VLARLATSQHLCGSCRMGGRDDPGAVVDARCRVRGVEGLWVVDGSILPVIPSRGP 471

                         570
                  ....*....|....*
gi 18859995   601 NGPVYLIAEKAADMI 615
Cdd:TIGR03970 472 HATAVMVAERAAEFL 486
GMC_oxred_N pfam00732
GMC oxidoreductase; This family of proteins bind FAD as a cofactor.
 132-356 2.19e-46

GMC oxidoreductase; This family of proteins bind FAD as a cofactor.


Pssm-ID: 366272 [Multi-domain]  Cd Length: 218  Bit Score: 162.84  E-value: 2.19e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   132 NNNRCNWPRGKVMGGSSVLNYMMYTRGNRRDYDRWARL-GNPGWSYEEVLPYFKKYEG--SVVPDADENLvGRNgpvkvs 208
Cdd:pfam00732  15 NGRRMILPAGSTVGGGSSVNWSACIRTPAAVLDEWASEfGLEGWGYDDYLPYMDKVEGplGVTTKGIEES-PLN------ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   209 ysetrtriaDAFVGATQDAGLP----RGDYNGDKQIRVSYLQANiyNETRWSSNRAYLYPikGKRRNLHVKKNALVTKIL 284
Cdd:pfam00732  88 ---------QALLKAAEELGYPveavPRNSNGCHYCGFCGLGCP--TGAKQSTARTWLRP--ALERNLRILTGAKAEKII 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18859995   285 IDPQTKSAFGI-IVKMDGK-MQKILARKEVILSAGAINTPQLLMLSGVGPAKHlremgikpladlAVGYNLQDH 356
Cdd:pfam00732 155 ILGRGGRAVGVeARDGGGGiKRLITAAKEVVVAAGALNTPPLLLRSGLGKNPH------------PVGKNLQLH 216
GMC_oxred_C pfam05199
GMC oxidoreductase; This domain found associated with pfam00732.
 468-611 3.72e-42

GMC oxidoreductase; This domain found associated with pfam00732.


Pssm-ID: 398739 [Multi-domain]  Cd Length: 143  Bit Score: 148.70  E-value: 3.72e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   468 KSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQAVSLLDMPAFkAIGAHLLEKRIPNCAKYKWKSSAYWACYAR 547
Cdd:pfam05199   2 RSRGRVTLSSSDPTGLPVIDPNYLSDPADLAALRAALRLARRILAAAGL-VLGVELTPGPVPEVSDAAVTSDDELLAYIR 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18859995   548 HFTFTIYHYSGTAKMGPRSDPSaVVDARLRVHGIDKLRVVDASIMPYLISGHPNGPVYLIAEKA 611
Cdd:pfam05199  81 AAASTSYHPMGTCRMGADPDDA-VVDPDLRVHGVDNLRVVDASVFPSSPSGNPTLTIYALAERA 143
PLN02785 PLN02785
Protein HOTHEAD
 62-591 1.33e-29

Protein HOTHEAD


Pssm-ID: 215420 [Multi-domain]  Cd Length: 587  Bit Score: 123.76  E-value: 1.33e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995   62 YDFIVVGAGTAGCALAARLSENprWRVLLLEAGGPENYAMDIPivahLLQLGEINWKYKTEPSNSYCLAMNNNRCNwPRG 141
Cdd:PLN02785  56 YDYIVVGGGTAGCPLAATLSQN--FSVLLLERGGVPFGNANVS----FLENFHIGLADTSPTSASQAFISTDGVIN-ARA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  142 KVMGGSSVLNYMMYTRGNRRDYDRwarlgnPGWsyeevlpyfkkyegsvvpdaDENLVGRngpvkvSYSETRTRIAD--- 218
Cdd:PLN02785 129 RVLGGGTCINAGFYSRASTRFIQK------AGW--------------------DAKLVNE------SYPWVERQIVHwpk 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  219 ------AFVGATQDAGL-PRGDYNGDkQIRVSYLQANIYNETRWSSNRAYLYPiKGKRRNLHVKKNALVTKILIDPQTKS 291
Cdd:PLN02785 177 vapwqaALRDSLLEVGVsPFNGFTYD-HVYGTKVGGTIFDEFGRRHTAAELLA-AGNPNKLRVLLHATVQKIVFDTSGKR 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  292 --AFGIIVKMD--GKMQKILARK---EVILSAGAINTPQLLMLSGVGPAKHLREMGIK-PLADLAVGYNLQDHIAPAIsF 363
Cdd:PLN02785 255 prATGVIFKDEngNQHQAFLSNNkgsEIILSAGAIGSPQMLLLSGIGPKKELKKHKIPvVLHNEHVGKGMADNPMNSI-F 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  364 L-----CNVSSLQTSEMFRS----EAMSDFLKGRGVLRIPGGVEAISFYALD----DARNPDAwadmelfvvggglqtnl 430
Cdd:PLN02785 334 VpskapVEQSLIQTVGITKMgvyiEASSGFGQSPDSIHCHHGIMSAEIGQLStippKQRTPEA----------------- 396

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  431 alrlalgIQSNIYETMFgeLERQSANGFLIFPMILRAKSRGRIKLKSRNPEEHPRIYANYFANPYDMNITVRGIEQAVSL 510
Cdd:PLN02785 397 -------IQAYIHRKKN--LPHEAFNGGFILEKIAGPISTGHLSLINTNVDDNPSVTFNYFKHPQDLQRCVYGIRTIEKI 467

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859995  511 LDMPAFKAI---GAHLLEKRIP-------NCAKYKWKSSAYWACYARHFTFTIYHYSGTAKMGprsdpsAVVDARLRVHG 580
Cdd:PLN02785 468 VKTNHFTNFtqcDKQTMEKVLNmsvkaniNLIPKHTNDTKSLEQFCKDTVITIWHYHGGCHVG------KVVDQNYKVLG 541

                        570
                 ....*....|.
gi 18859995  581 IDKLRVVDASI 591
Cdd:PLN02785 542 VSRLRVIDGST 552
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
59-93 1.65e-05

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 47.45  E-value: 1.65e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18859995  59 TTKYDFIVVGAGTAGCALAARLSENPRWRVLLLEA 93
Cdd:COG0579   2 MEMYDVVIIGAGIVGLALARELSRYEDLKVLVLEK 36
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
60-96 1.18e-04

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 44.90  E-value: 1.18e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 18859995  60 TKYDFIVVGAGTAGCALAARLSENpRWRVLLLEAGGP 96
Cdd:COG0665   1 ATADVVVIGGGIAGLSTAYHLARR-GLDVTVLERGRP 36
Lycopene_cycl pfam05834
Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. ...
 63-99 1.42e-04

Lycopene cyclase protein; This family consists of lycopene beta and epsilon cyclase proteins. Carotenoids with cyclic end groups are essential components of the photosynthetic membranes in all plants, algae, and cyanobacteria. These lipid-soluble compounds protect against photo-oxidation, harvest light for photosynthesis, and dissipate excess light energy absorbed by the antenna pigments. The cyclization of lycopene (psi, psi-carotene) is a key branch point in the pathway of carotenoid biosynthesis. Two types of cyclic end groups are found in higher plant carotenoids: the beta and epsilon rings. Carotenoids with two beta rings are ubiquitous, and those with one beta and one epsilon ring are common; however, carotenoids with two epsilon rings are rare.


Pssm-ID: 310433 [Multi-domain]  Cd Length: 380  Bit Score: 44.33  E-value: 1.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18859995    63 DFIVVGAGTAGCALAARLSEN-PRWRVLLLEAG----GPENY 99
Cdd:pfam05834   1 DVVIIGAGPAGLSLAARLAAAkPGLSVVLIEPGpsllRPNNY 42
PTZ00367 PTZ00367
squalene epoxidase; Provisional
 62-116 2.56e-04

squalene epoxidase; Provisional


Pssm-ID: 240384 [Multi-domain]  Cd Length: 567  Bit Score: 44.07  E-value: 2.56e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 18859995   62 YDFIVVGAGTAGCALAARLSENPRwRVLLLE---AGGPENyamdipIVAHLLQLGEIN 116
Cdd:PTZ00367  34 YDVIIVGGSIAGPVLAKALSKQGR-KVLMLErdlFSKPDR------IVGELLQPGGVN 84
GG-red-SF TIGR02032
geranylgeranyl reductase family; This model represents a subfamily which includes ...
 62-92 3.70e-04

geranylgeranyl reductase family; This model represents a subfamily which includes geranylgeranyl reductases involved in chlorophyll and bacteriochlorophyll biosynthesis as well as other related enzymes which may also act on geranylgeranyl groups or related substrates. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273936 [Multi-domain]  Cd Length: 295  Bit Score: 42.69  E-value: 3.70e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 18859995    62 YDFIVVGAGTAGCALAARLSENPRwRVLLLE 92
Cdd:TIGR02032   1 YDVVVVGAGPAGASAAYRLADKGL-RVLLLE 30
carotene-cycl TIGR01790
lycopene cyclase family protein; This family includes lycopene beta and epsilion cyclases ...
 63-99 5.88e-04

lycopene cyclase family protein; This family includes lycopene beta and epsilion cyclases (which form beta and delta carotene, respectively) from bacteria and plants as well as the plant capsanthin/capsorubin and neoxanthin cyclases which appear to have evolved from the plant lycopene cyclases. The plant lycopene epsilon cyclases also transform neurosporene to alpha zeacarotene.


Pssm-ID: 130850 [Multi-domain]  Cd Length: 388  Bit Score: 42.42  E-value: 5.88e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 18859995    63 DFIVVGAGTAGCALAARLSEnPRWRVLLLEA----GGPENY 99
Cdd:TIGR01790   1 DLAVIGGGPAGLAIALELAR-PGLRVQLIEPhppiPGNHTY 40
PRK06370 PRK06370
FAD-containing oxidoreductase;
59-92 3.33e-03

FAD-containing oxidoreductase;


Pssm-ID: 235787 [Multi-domain]  Cd Length: 463  Bit Score: 40.19  E-value: 3.33e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 18859995   59 TTKYDFIVVGAGTAGCALAARLSENPrWRVLLLE 92
Cdd:PRK06370   3 AQRYDAIVIGAGQAGPPLAARAAGLG-MKVALIE 35
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 63-94 4.77e-03

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 39.69  E-value: 4.77e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 18859995    63 DFIVVGAGTAGCALAARLSENPrWRVLLLEAG 94
Cdd:pfam01266   1 DVVVIGGGIVGLSTAYELARRG-LSVTLLERG 31
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 63-93 7.27e-03

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 39.44  E-value: 7.27e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 18859995   63 DFIVVGAGTAGCALAARLSEnpR-WRVLLLEA 93
Cdd:PRK01747 262 DAAIIGGGIAGAALALALAR--RgWQVTLYEA 291
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
66-94 8.91e-03

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 35.20  E-value: 8.91e-03
                          10        20
                  ....*....|....*....|....*....
gi 18859995    66 VVGAGTAGCALAARLSENPRwRVLLLEAG 94
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF-RVLVLEKR 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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