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Conserved domains on  [gi|24640759|ref|NP_572536|]
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uncharacterized protein Dmel_CG12106 [Drosophila melanogaster]

Protein Classification

COMM domain-containing protein 3( domain architecture ID 10140830)

COMM domain-containing protein 3 (COMMD3) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes, down-regulate activation of NF-kappa-B, and modulate Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits

Gene Symbol:  COMMD3
Gene Ontology:  GO:0006814
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 112-210 4.73e-33

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240099  Cd Length: 95  Bit Score: 114.37  E-value: 4.73e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640759 112 DELSRVYEDSRKDLILRQLQIGHSFPHITDIQWRIVCDVKSstsdCSTGAACFHINLGNFRQSSGERVTIVEFVCNAEEL 191
Cdd:cd04751   1 EIFAKQYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSS----KHLGKVNQPIYLIQLSTENGENKPDINFTCTLEQL 76

                        90
                ....*....|....*....
gi 24640759 192 QSLINRLKEIERHCQQMAV 210
Cdd:cd04751  77 QDLVNKLKDAAKNIERAAQ 95
 
Name Accession Description Interval E-value
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 112-210 4.73e-33

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240099  Cd Length: 95  Bit Score: 114.37  E-value: 4.73e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640759 112 DELSRVYEDSRKDLILRQLQIGHSFPHITDIQWRIVCDVKSstsdCSTGAACFHINLGNFRQSSGERVTIVEFVCNAEEL 191
Cdd:cd04751   1 EIFAKQYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSS----KHLGKVNQPIYLIQLSTENGENKPDINFTCTLEQL 76

                        90
                ....*....|....*....
gi 24640759 192 QSLINRLKEIERHCQQMAV 210
Cdd:cd04751  77 QDLVNKLKDAAKNIERAAQ 95
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 135-201 7.63e-08

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 47.54  E-value: 7.63e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640759   135 SFPHITDIQWRIvcDVKSSTSDCS-TGAACFHINLgNFRQSSGERVTiVEFVCNAEELQSLINRLKEI 201
Cdd:pfam07258   1 SLPQLVDLDWRL--DVQLSSSSLSkVNEPVVLLEL-KLSDGDGSSEE-VTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 112-210 4.73e-33

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240099  Cd Length: 95  Bit Score: 114.37  E-value: 4.73e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640759 112 DELSRVYEDSRKDLILRQLQIGHSFPHITDIQWRIVCDVKSstsdCSTGAACFHINLGNFRQSSGERVTIVEFVCNAEEL 191
Cdd:cd04751   1 EIFAKQYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSS----KHLGKVNQPIYLIQLSTENGENKPDINFTCTLEQL 76

                        90
                ....*....|....*....
gi 24640759 192 QSLINRLKEIERHCQQMAV 210
Cdd:cd04751  77 QDLVNKLKDAAKNIERAAQ 95
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 135-201 7.63e-08

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 47.54  E-value: 7.63e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24640759   135 SFPHITDIQWRIvcDVKSSTSDCS-TGAACFHINLgNFRQSSGERVTiVEFVCNAEELQSLINRLKEI 201
Cdd:pfam07258   1 SLPQLVDLDWRL--DVQLSSSSLSkVNEPVVLLEL-KLSDGDGSSEE-VTFELSKEQLQDLLNELEEA 64
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 137-202 7.19e-03

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 34.59  E-value: 7.19e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24640759 137 PHITDIQWRIvcDVKSSTSDCS---TGAACFHINLGNFRQSSGERVTiveFVCNAEELQSLINRLKEIE 202
Cdd:cd04748  21 PQLVDFDWRL--DVQISSSSLAkvkQPTILVQLKLQVGDNNSSEKIC---FEMTKEELQNFLNKLKKIK 84
Commd5_HCaRG cd04753
COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated ...
 111-155 7.39e-03

COMM_Domain containing protein 5, also called HCaRG (hypertension-related, calcium-regulated gene). HCaRG is a nuclear protein that might be involved in cell proliferation; it is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240101  Cd Length: 110  Bit Score: 35.11  E-value: 7.39e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 24640759 111 VDELSRVYEDSRKDLILRQL-QIGHSFPHITDIQWRIvcDVKSSTS 155
Cdd:cd04753   9 ITDLASVVYGQRRPLLESGAlQKGVRLPHLEDFKWRV--DVAISTS 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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