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Conserved domains on  [gi|24640525|ref|NP_572453|]
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uncharacterized protein Dmel_CG18262 [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10604042)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-288 5.96e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.96e-04
                          10        20
                  ....*....|....*....|....*.
gi 24640525   263 NMMRHRQRHSGIKPHKCPECDATFYT 288
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5236 super family cl28715
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
222-313 9.77e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5236:

Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 41.54  E-value: 9.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640525 222 YKCNEEACNQTFRTERDLRGH-RWKHTGIFCDICGKP----------FTQSGnMMRHRQ---RHSGIKPH-KCPECDATF 286
Cdd:COG5236 152 FKCPKSKCHRRCGSLKELKKHyKAQHGFVLCSECIGNkkdfwneirlFRSST-LRDHKNgglEEEGFKGHpLCIFCKIYF 230

                        90       100
                ....*....|....*....|....*...
gi 24640525 287 YTQKELSSHsiCHTGRMPC-ICEVCGRP 313
Cdd:COG5236 231 YDDDELRRH--CRLRHEAChICDMVGPI 256
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-342 1.00e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|...
gi 24640525   320 LTAHMRRHTGERPAKCEVCGKAF 342
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 389-411 2.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.64e-03
                          10        20
                  ....*....|....*....|...
gi 24640525   389 YACKLCGKTFAQSGGLNAHMRSH 411
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-288 5.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.96e-04
                          10        20
                  ....*....|....*....|....*.
gi 24640525   263 NMMRHRQRHSGIKPHKCPECDATFYT 288
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
222-313 9.77e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 41.54  E-value: 9.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640525 222 YKCNEEACNQTFRTERDLRGH-RWKHTGIFCDICGKP----------FTQSGnMMRHRQ---RHSGIKPH-KCPECDATF 286
Cdd:COG5236 152 FKCPKSKCHRRCGSLKELKKHyKAQHGFVLCSECIGNkkdfwneirlFRSST-LRDHKNgglEEEGFKGHpLCIFCKIYF 230

                        90       100
                ....*....|....*....|....*...
gi 24640525 287 YTQKELSSHsiCHTGRMPC-ICEVCGRP 313
Cdd:COG5236 231 YDDDELRRH--CRLRHEAChICDMVGPI 256
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-342 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|...
gi 24640525   320 LTAHMRRHTGERPAKCEVCGKAF 342
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-380 2.15e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640525 168 KDMLFQCDQCDRAYNTKRSLQSHrrlkhseanggsldkSASERNSKKRKGPPKVYKCNEeaCNQTFRTERDLR------- 240
Cdd:COG5048 251 SDSSSSASESPRSSLPTASSQSS---------------SPNESDSSSEKGFSLPIKSKQ--CNISFSRSSPLTrhlrsvn 313

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640525 241 --GHRWKHTGIFCDICGKPFTQSGNMMRHRQRHSGIKPHKCPECDATFY---------TQKELSSHSICHTGRMPCICEV 309
Cdd:COG5048 314 hsGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKfspllnnepPQSLQQYKDLKNDKKSETLSNS 393

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24640525 310 CGRPCRDRGVLTAHMRRHTGERPA--KCEVCGKAFYSFHDLNVHAVSHTNLRPFVCDVCGSTFQRKKALRVHK 380
Cdd:COG5048 394 CIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 389-411 2.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.64e-03
                          10        20
                  ....*....|....*....|...
gi 24640525   389 YACKLCGKTFAQSGGLNAHMRSH 411
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-288 5.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.96e-04
                          10        20
                  ....*....|....*....|....*.
gi 24640525   263 NMMRHRQRHSGIKPHKCPECDATFYT 288
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
222-313 9.77e-04

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 41.54  E-value: 9.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640525 222 YKCNEEACNQTFRTERDLRGH-RWKHTGIFCDICGKP----------FTQSGnMMRHRQ---RHSGIKPH-KCPECDATF 286
Cdd:COG5236 152 FKCPKSKCHRRCGSLKELKKHyKAQHGFVLCSECIGNkkdfwneirlFRSST-LRDHKNgglEEEGFKGHpLCIFCKIYF 230

                        90       100
                ....*....|....*....|....*...
gi 24640525 287 YTQKELSSHsiCHTGRMPC-ICEVCGRP 313
Cdd:COG5236 231 YDDDELRRH--CRLRHEAChICDMVGPI 256
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-342 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|...
gi 24640525   320 LTAHMRRHTGERPAKCEVCGKAF 342
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
168-380 2.15e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640525 168 KDMLFQCDQCDRAYNTKRSLQSHrrlkhseanggsldkSASERNSKKRKGPPKVYKCNEeaCNQTFRTERDLR------- 240
Cdd:COG5048 251 SDSSSSASESPRSSLPTASSQSS---------------SPNESDSSSEKGFSLPIKSKQ--CNISFSRSSPLTrhlrsvn 313

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640525 241 --GHRWKHTGIFCDICGKPFTQSGNMMRHRQRHSGIKPHKCPECDATFY---------TQKELSSHSICHTGRMPCICEV 309
Cdd:COG5048 314 hsGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKfspllnnepPQSLQQYKDLKNDKKSETLSNS 393

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24640525 310 CGRPCRDRGVLTAHMRRHTGERPA--KCEVCGKAFYSFHDLNVHAVSHTNLRPFVCDVCGSTFQRKKALRVHK 380
Cdd:COG5048 394 CIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 389-411 2.64e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.64e-03
                          10        20
                  ....*....|....*....|...
gi 24640525   389 YACKLCGKTFAQSGGLNAHMRSH 411
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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