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Conserved domains on  [gi|24640291|ref|NP_572377|]
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uncharacterized protein Dmel_CG4593, isoform A [Drosophila melanogaster]

Protein Classification

CCDC25 family protein( domain architecture ID 10529311)

CCDC25 family protein such as vertebrate coiled-coil domain-containing protein 25 and yeast protein JLP2

PubMed:  32528174

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 1-112 8.77e-43

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


:

Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 139.67  E-value: 8.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640291     1 MVFYFKSNVVqppAMLYMGRDKHENEELIRWGWPE-DVWFHVHDLSSAHVYLRLRKGQtidDIPTDVLVDAAQLCKANSI 79
Cdd:pfam05670   1 KFYWFVSSEG---YLVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEGE---DIPPETLEEAAQLAKANSI 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 24640291    80 Q-GNKVNNLEVVYTMWENLKKTPD---MEPGQVAYHN 112
Cdd:pfam05670  75 AwGNKQNNISVWYTPASQVSKTGPsgyLDTGSFMFKG 111
GumC super family cl34566
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
120-198 3.10e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3206:

Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 38.07  E-value: 3.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640291 120 RLEKRINEIVNRLN--RTKTEEEHPDFRGLREARDAAERQDQKKIQRERREQEKEAAKQRELEAELRSYASLQKSENMRT 197
Cdd:COG3206 267 QLRAQLAELEAELAelSARYTPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAEL 346


                .
gi 24640291 198 N 198
Cdd:COG3206 347 P 347
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 1-112 8.77e-43

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 139.67  E-value: 8.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640291     1 MVFYFKSNVVqppAMLYMGRDKHENEELIRWGWPE-DVWFHVHDLSSAHVYLRLRKGQtidDIPTDVLVDAAQLCKANSI 79
Cdd:pfam05670   1 KFYWFVSSEG---YLVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEGE---DIPPETLEEAAQLAKANSI 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 24640291    80 Q-GNKVNNLEVVYTMWENLKKTPD---MEPGQVAYHN 112
Cdd:pfam05670  75 AwGNKQNNISVWYTPASQVSKTGPsgyLDTGSFMFKG 111
RqcH COG1293
Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) ...
 19-128 5.55e-07

Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440904 [Multi-domain]  Cd Length: 578  Bit Score: 49.07  E-value: 5.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640291  19 GRDKHENEELI-RWGWPEDVWFHVHDLSSAHVYLRLRKgqtiDDIPTDVLVDAAQLCKANSiQGNKVNNLEVVYTMWENL 97
Cdd:COG1293 472 GRNNRQNDELTkKYARKNDIWFHAKDIPGSHVIIKTEG----KEPPEETLEEAAQLAAYYS-KARKSGSVPVDYTEPKQV 546

                        90       100       110
                ....*....|....*....|....*....|.
gi 24640291  98 KKTPDMEPGQVAYHNEKAVrRIRLEKRINEI 128
Cdd:COG1293 547 SKPKGAKPGFVIYGNRKTL-YVTPDEEVEKL 576
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
120-198 3.10e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 38.07  E-value: 3.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640291 120 RLEKRINEIVNRLN--RTKTEEEHPDFRGLREARDAAERQDQKKIQRERREQEKEAAKQRELEAELRSYASLQKSENMRT 197
Cdd:COG3206 267 QLRAQLAELEAELAelSARYTPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAEL 346


                .
gi 24640291 198 N 198
Cdd:COG3206 347 P 347
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 143-202 4.18e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 37.54  E-value: 4.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24640291  143 DFRgLREARDAAERQDQKKIQRER------REQEKEAAKQRE-LEAELRSY------ASLQKSENMRTNYDAG 202
Cdd:PLN03086   2 DFE-LRRAREKLEREQRERKQRAKlklereRKAKEEAAKQREaIEAAQRSRrldaieAQIKADQQMQESLQAG 73
 
Name Accession Description Interval E-value
NFACT-R_1 pfam05670
NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as ...
 1-112 8.77e-43

NFACT protein RNA binding domain; This domain occurs in proteins that have been annotated as Fibronectin/fibrinogen binding protein by similarity. This annotation comes from Swiss:O34693 where the N-terminal region is involved in this activity. It is an RNA binding domain of the NFACT (NEMF, FbpA, Caliban, and Tae2) proteins. This NFACT-R family is found in two eukaryotic gene contexts: fused to the NFACT-N and NFACT-C domains in the NFACT protein involved in the ribosomal quality control pathway which contributes to CAT-tailing and as a standalone domain. Additionally this domain contains a conserved motif D/E-X-W/Y-X-H that may be functionally important.


Pssm-ID: 428576 [Multi-domain]  Cd Length: 111  Bit Score: 139.67  E-value: 8.77e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640291     1 MVFYFKSNVVqppAMLYMGRDKHENEELIRWGWPE-DVWFHVHDLSSAHVYLRLRKGQtidDIPTDVLVDAAQLCKANSI 79
Cdd:pfam05670   1 KFYWFVSSEG---YLVIGGRDKQENELLIKKYLEEgDLWFHADKHGSAHVYLKLPEGE---DIPPETLEEAAQLAKANSI 74

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 24640291    80 Q-GNKVNNLEVVYTMWENLKKTPD---MEPGQVAYHN 112
Cdd:pfam05670  75 AwGNKQNNISVWYTPASQVSKTGPsgyLDTGSFMFKG 111
RqcH COG1293
Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) ...
 19-128 5.55e-07

Ribosome quality control (RQC) protein RqcH, Rqc2/NEMF/Tae2 family, contains fibronectin-(FbpA) and RNA- (NFACT) binding domains [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440904 [Multi-domain]  Cd Length: 578  Bit Score: 49.07  E-value: 5.55e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640291  19 GRDKHENEELI-RWGWPEDVWFHVHDLSSAHVYLRLRKgqtiDDIPTDVLVDAAQLCKANSiQGNKVNNLEVVYTMWENL 97
Cdd:COG1293 472 GRNNRQNDELTkKYARKNDIWFHAKDIPGSHVIIKTEG----KEPPEETLEEAAQLAAYYS-KARKSGSVPVDYTEPKQV 546

                        90       100       110
                ....*....|....*....|....*....|.
gi 24640291  98 KKTPDMEPGQVAYHNEKAVrRIRLEKRINEI 128
Cdd:COG1293 547 SKPKGAKPGFVIYGNRKTL-YVTPDEEVEKL 576
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
120-198 3.10e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 38.07  E-value: 3.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640291 120 RLEKRINEIVNRLN--RTKTEEEHPDFRGLREARDAAERQDQKKIQRERREQEKEAAKQRELEAELRSYASLQKSENMRT 197
Cdd:COG3206 267 QLRAQLAELEAELAelSARYTPNHPDVIALRAQIAALRAQLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAEL 346


                .
gi 24640291 198 N 198
Cdd:COG3206 347 P 347
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 143-202 4.18e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 37.54  E-value: 4.18e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24640291  143 DFRgLREARDAAERQDQKKIQRER------REQEKEAAKQRE-LEAELRSY------ASLQKSENMRTNYDAG 202
Cdd:PLN03086   2 DFE-LRRAREKLEREQRERKQRAKlklereRKAKEEAAKQREaIEAAQRSRrldaieAQIKADQQMQESLQAG 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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