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Conserved domains on  [gi|18777778|ref|NP_571988|]
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xaa-Pro aminopeptidase 1 isoform 2 [Rattus norvegicus]

Protein Classification

aminopeptidase P family protein( domain architecture ID 11114206)

aminopeptidase P family protein (metallopeptidase M24) cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
329-551 4.95e-143

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


:

Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 413.88  E-value: 4.95e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 329 GMRRAHIKDAVALCELFNWLEQEVPKGG-VTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPIPETNRTLS 407
Cdd:cd01085   1 GMRAAHIRDGVALVEFLAWLEQEVPKGEtITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 408 LDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGT 487
Cdd:cd01085  81 PDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGT 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18777778 488 GHGVGSFLNVHEGPCGIsYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKTKYNF 551
Cdd:cd01085 161 GHGVGSFLNVHEGPQSI-SPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFG 223
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
157-326 2.37e-65

Creatinase/Prolidase N-terminal domain;


:

Pssm-ID: 465053  Cd Length: 159  Bit Score: 211.20  E-value: 2.37e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   157 DRPERPCKPLLTLGLDYTGISWKEKVADLRLKMAERSIVWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLERIMLF 236
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEATLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   237 IDGDRIDaPGVKQHLlldlgleAEYKIQVLPYKSILSELKTLCADlsprEKVWV-SDKASYAVSEAIPKDHRCCMPYTPI 315
Cdd:pfam16189  81 VDPEKLS-DEVRAHL-------EENGVEIRPYDDIYEDLAALAAG----KKVLLdPSRTSYALYSALPAGAKVVEAPSPI 148
                         170
                  ....*....|.
gi 18777778   316 CIAKAVKNSAE 326
Cdd:pfam16189 149 TLMKAVKNETE 159
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
557-619 9.16e-26

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


:

Pssm-ID: 465052  Cd Length: 63  Bit Score: 100.18  E-value: 9.16e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18777778   557 LTFEPLTLVPIQTKMIDVDALTDKECDWLNSYHQTCRDVIGKELQTQGrqEALEWLLRETEPI 619
Cdd:pfam16188   3 LGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
10-154 1.09e-09

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


:

Pssm-ID: 460159  Cd Length: 128  Bit Score: 56.54  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778    10 LRQLRQAMRNSEcvaepIQAYIIPSGDahqseyiapcdcRRAFVSGFDGSAGTAI-ITEEHAAMWTD-GRYFLQAAKQmd 87
Cdd:pfam01321   2 LEKLRKLMEEKG-----LDAALVTSPE------------NLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAES-- 62
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18777778    88 nnWTLMKM-GLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAghHLVPVkENLVDKI 154
Cdd:pfam01321  63 --APDFDVvPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
329-551 4.95e-143

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 413.88  E-value: 4.95e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 329 GMRRAHIKDAVALCELFNWLEQEVPKGG-VTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPIPETNRTLS 407
Cdd:cd01085   1 GMRAAHIRDGVALVEFLAWLEQEVPKGEtITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 408 LDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGT 487
Cdd:cd01085  81 PDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGT 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18777778 488 GHGVGSFLNVHEGPCGIsYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKTKYNF 551
Cdd:cd01085 161 GHGVGSFLNVHEGPQSI-SPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFG 223
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
183-566 5.55e-72

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 233.94  E-value: 5.55e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 183 ADLRLKMAERSIVWFVVTALDEIAWLFNLRGSdvehnPVFFSYAIIGLE-RIMLFIDGdridapgvkqhllldlgLEAEY 261
Cdd:COG0006   1 ARLRALMAEAGLDALLLTDPSNFAYLTGFRGS-----PERLAALLVTADgEPVLFVDE-----------------LEAER 58
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 262 KIQVLPykSILSELKtlcadlsprekvwvsdkasyavseaipkdhrccmpytpiciakAVKNSAESAGMRRAHIKDAVAL 341
Cdd:COG0006  59 ELVDAS--DLLEELR-------------------------------------------AIKSPEEIELMRKAARIADAAH 93
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 342 CELFNWLEQevpkgGVTEISAADKAEEFRRQQaDFVDLSFPTISSTGPNGAIIHYAPipeTNRTLSLDEVYLIDSGAQYK 421
Cdd:COG0006  94 EAALAALRP-----GVTEREVAAELEAAMRRR-GAEGPSFDTIVASGENAAIPHYTP---TDRPLKPGDLVLIDAGAEYD 164
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 422 DGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVfPTGTKGHLLDSFARSALWDSGL--DYLHGTGHGVGsfLNVHE 499
Cdd:COG0006 165 GYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPGVTGGEVDAAARDVLAEAGYgeYFPHGTGHGVG--LDVHE 241
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18777778 500 GPcgiSYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKtkynfnnrgsltFEPLTLVP 566
Cdd:COG0006 242 GP---QISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTEDG------------AEVLTRLP 293
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
157-326 2.37e-65

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 211.20  E-value: 2.37e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   157 DRPERPCKPLLTLGLDYTGISWKEKVADLRLKMAERSIVWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLERIMLF 236
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEATLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   237 IDGDRIDaPGVKQHLlldlgleAEYKIQVLPYKSILSELKTLCADlsprEKVWV-SDKASYAVSEAIPKDHRCCMPYTPI 315
Cdd:pfam16189  81 VDPEKLS-DEVRAHL-------EENGVEIRPYDDIYEDLAALAAG----KKVLLdPSRTSYALYSALPAGAKVVEAPSPI 148
                         170
                  ....*....|.
gi 18777778   316 CIAKAVKNSAE 326
Cdd:pfam16189 149 TLMKAVKNETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
328-544 1.20e-62

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 205.94  E-value: 1.20e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   328 AGMRRAHIKDAVALCELFNWLeqevpKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPipeTNRTLS 407
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAI-----RPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIP---NDRVLK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   408 LDEVYLIDSGAQYKDG-TTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGLD--YL 484
Cdd:pfam00557  73 PGDLVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGLGeyFP 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18777778   485 HGTGHGVGsfLNVHEGPcgISYKTFSDEPLEAGMIVTDEPGYYE-DGAFGIRIENVVLVVP 544
Cdd:pfam00557 152 HGLGHGIG--LEVHEGP--YISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
557-619 9.16e-26

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 100.18  E-value: 9.16e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18777778   557 LTFEPLTLVPIQTKMIDVDALTDKECDWLNSYHQTCRDVIGKELQTQGrqEALEWLLRETEPI 619
Cdd:pfam16188   3 LGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
PRK09795 PRK09795
aminopeptidase; Provisional
356-544 4.75e-19

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 89.23  E-value: 4.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  356 GVTEISAADKAEEFRRQQADfVDLSFPTISSTGPNGAIIHYAPipeTNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF-- 433
Cdd:PRK09795 157 GMSEREIAAELEWFMRQQGA-EKASFDTIVASGWRGALPHGKA---SDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVng 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  434 -GTPTAYEKECFTY--VLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGL-DYL-HGTGHGVGsfLNVHEGPcgiSYKT 508
Cdd:PRK09795 233 eGVSAESHPLFNVYqiVLQAQLAAISAIRP-GVRCQQVDDAARRVITEAGYgDYFgHNTGHAIG--IEVHEDP---RFSP 306
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 18777778  509 FSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVP 544
Cdd:PRK09795 307 RDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTP 342
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
10-154 1.09e-09

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 56.54  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778    10 LRQLRQAMRNSEcvaepIQAYIIPSGDahqseyiapcdcRRAFVSGFDGSAGTAI-ITEEHAAMWTD-GRYFLQAAKQmd 87
Cdd:pfam01321   2 LEKLRKLMEEKG-----LDAALVTSPE------------NLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAES-- 62
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18777778    88 nnWTLMKM-GLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAghHLVPVkENLVDKI 154
Cdd:pfam01321  63 --APDFDVvPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
 
Name Accession Description Interval E-value
APP cd01085
X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline ...
329-551 4.95e-143

X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide.


Pssm-ID: 238518 [Multi-domain]  Cd Length: 224  Bit Score: 413.88  E-value: 4.95e-143
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 329 GMRRAHIKDAVALCELFNWLEQEVPKGG-VTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPIPETNRTLS 407
Cdd:cd01085   1 GMRAAHIRDGVALVEFLAWLEQEVPKGEtITELSAADKLEEFRRQQKGYVGLSFDTISGFGPNGAIVHYSPTEESNRKIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 408 LDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSFARSALWDSGLDYLHGT 487
Cdd:cd01085  81 PDGLYLIDSGGQYLDGTTDITRTVHLGEPTAEQKRDYTLVLKGHIALARAKFPKGTTGSQLDALARQPLWKAGLDYGHGT 160
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18777778 488 GHGVGSFLNVHEGPCGIsYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKTKYNF 551
Cdd:cd01085 161 GHGVGSFLNVHEGPQSI-SPAPNNVPLKAGMILSNEPGYYKEGKYGIRIENLVLVVEAETTEFG 223
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
183-566 5.55e-72

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 233.94  E-value: 5.55e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 183 ADLRLKMAERSIVWFVVTALDEIAWLFNLRGSdvehnPVFFSYAIIGLE-RIMLFIDGdridapgvkqhllldlgLEAEY 261
Cdd:COG0006   1 ARLRALMAEAGLDALLLTDPSNFAYLTGFRGS-----PERLAALLVTADgEPVLFVDE-----------------LEAER 58
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 262 KIQVLPykSILSELKtlcadlsprekvwvsdkasyavseaipkdhrccmpytpiciakAVKNSAESAGMRRAHIKDAVAL 341
Cdd:COG0006  59 ELVDAS--DLLEELR-------------------------------------------AIKSPEEIELMRKAARIADAAH 93
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 342 CELFNWLEQevpkgGVTEISAADKAEEFRRQQaDFVDLSFPTISSTGPNGAIIHYAPipeTNRTLSLDEVYLIDSGAQYK 421
Cdd:COG0006  94 EAALAALRP-----GVTEREVAAELEAAMRRR-GAEGPSFDTIVASGENAAIPHYTP---TDRPLKPGDLVLIDAGAEYD 164
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 422 DGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVfPTGTKGHLLDSFARSALWDSGL--DYLHGTGHGVGsfLNVHE 499
Cdd:COG0006 165 GYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAAL-KPGVTGGEVDAAARDVLAEAGYgeYFPHGTGHGVG--LDVHE 241
                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18777778 500 GPcgiSYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKtkynfnnrgsltFEPLTLVP 566
Cdd:COG0006 242 GP---QISPGNDRPLEPGMVFTIEPGIYIPGIGGVRIEDTVLVTEDG------------AEVLTRLP 293
Creatinase_N_2 pfam16189
Creatinase/Prolidase N-terminal domain;
157-326 2.37e-65

Creatinase/Prolidase N-terminal domain;


Pssm-ID: 465053  Cd Length: 159  Bit Score: 211.20  E-value: 2.37e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   157 DRPERPCKPLLTLGLDYTGISWKEKVADLRLKMAERSIVWFVVTALDEIAWLFNLRGSDVEHNPVFFSYAIIGLERIMLF 236
Cdd:pfam16189   1 DRPALPANPVFVLPLKYAGESAAEKLARLREALKEKGADALVLSALDEIAWLLNLRGSDVPYNPVFLSYALVTDDEATLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   237 IDGDRIDaPGVKQHLlldlgleAEYKIQVLPYKSILSELKTLCADlsprEKVWV-SDKASYAVSEAIPKDHRCCMPYTPI 315
Cdd:pfam16189  81 VDPEKLS-DEVRAHL-------EENGVEIRPYDDIYEDLAALAAG----KKVLLdPSRTSYALYSALPAGAKVVEAPSPI 148
                         170
                  ....*....|.
gi 18777778   316 CIAKAVKNSAE 326
Cdd:pfam16189 149 TLMKAVKNETE 159
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
328-544 1.20e-62

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 205.94  E-value: 1.20e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   328 AGMRRAHIKDAVALCELFNWLeqevpKGGVTEISAADKAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPipeTNRTLS 407
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAI-----RPGVTERELAAELEAARLRRGGARGPAFPPIVASGPNAAIPHYIP---NDRVLK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778   408 LDEVYLIDSGAQYKDG-TTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGLD--YL 484
Cdd:pfam00557  73 PGDLVLIDVGAEYDGGyCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKP-GVTGGDVDAAAREVLEEAGLGeyFP 151
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18777778   485 HGTGHGVGsfLNVHEGPcgISYKTFSDEPLEAGMIVTDEPGYYE-DGAFGIRIENVVLVVP 544
Cdd:pfam00557 152 HGLGHGIG--LEVHEGP--YISRGGDDRVLEPGMVFTIEPGIYFiPGWGGVRIEDTVLVTE 208
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
333-542 3.09e-41

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 148.43  E-value: 3.09e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 333 AHIKDAVAL-CELFNWLEqEVPKGGVTEISAADKAE-EFRRQQADfvDLSFPTISSTGPNGAIIHYAPipeTNRTLSLDE 410
Cdd:cd01092   2 ELLRKAARIaDKAFEELL-EFIKPGMTEREVAAELEyFMRKLGAE--GPSFDTIVASGPNSALPHGVP---SDRKIEEGD 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 411 VYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGL-DYL-HGTG 488
Cdd:cd01092  76 LVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKP-GVTAKEVDKAARDVIEEAGYgEYFiHRTG 154
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 18777778 489 HGVGsfLNVHEGPcGISykTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLV 542
Cdd:cd01092 155 HGVG--LEVHEAP-YIS--PGSDDVLEEGMVFTIEPGIYIPGKGGVRIEDDVLV 203
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
328-547 9.86e-36

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 133.35  E-value: 9.86e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 328 AGMRRAHIKDAVALCELFNWLeqevpKGGVTEISAAdkAEEFRRQQADFVDLSFPTISSTGPNGAIIHYAPipeTNRTLS 407
Cdd:cd01066   2 ARLRKAAEIAEAAMAAAAEAI-----RPGVTEAEVA--AAIEQALRAAGGYPAGPTIVGSGARTALPHYRP---DDRRLQ 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 408 LDEVYLIDSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGL--DYLH 485
Cdd:cd01066  72 EGDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRP-GVTAEEVDAAAREVLEEHGLgpNFGH 150
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18777778 486 GTGHGVGsfLNVHEGPcgiSYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVPAKT 547
Cdd:cd01066 151 RTGHGIG--LEIHEPP---VLKAGDDTVLEPGMVFAVEPGLYLPGGGGVRIEDTVLVTEDGP 207
Peptidase_M24_C pfam16188
C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of ...
557-619 9.16e-26

C-terminal region of peptidase_M24; This is a short region at the C-terminus of a number of metallo-peptidases of the M24 family.


Pssm-ID: 465052  Cd Length: 63  Bit Score: 100.18  E-value: 9.16e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18777778   557 LTFEPLTLVPIQTKMIDVDALTDKECDWLNSYHQTCRDVIGKELQTQGrqEALEWLLRETEPI 619
Cdd:pfam16188   3 LGFETLTLVPIDRKLIDVSLLTEEEIEWLNAYHARVREKLSPLLEEEE--DALEWLKRATRPI 63
PRK09795 PRK09795
aminopeptidase; Provisional
356-544 4.75e-19

aminopeptidase; Provisional


Pssm-ID: 182080 [Multi-domain]  Cd Length: 361  Bit Score: 89.23  E-value: 4.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  356 GVTEISAADKAEEFRRQQADfVDLSFPTISSTGPNGAIIHYAPipeTNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF-- 433
Cdd:PRK09795 157 GMSEREIAAELEWFMRQQGA-EKASFDTIVASGWRGALPHGKA---SDKIVAAGEFVTLDFGALYQGYCSDMTRTLLVng 232
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  434 -GTPTAYEKECFTY--VLKGHIAVSAAVFPtGTKGHLLDSFARSALWDSGL-DYL-HGTGHGVGsfLNVHEGPcgiSYKT 508
Cdd:PRK09795 233 eGVSAESHPLFNVYqiVLQAQLAAISAIRP-GVRCQQVDDAARRVITEAGYgDYFgHNTGHAIG--IEVHEDP---RFSP 306
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 18777778  509 FSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLVVP 544
Cdd:PRK09795 307 RDTTTLQPGMLLTVEPGIYLPGQGGVRIEDVVLVTP 342
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
368-542 3.48e-18

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 84.16  E-value: 3.48e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 368 EFRRQQADfvdLSFPTISSTGPNGAIIHYApipETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF-GTPTAYEKECFTY 446
Cdd:cd01087  38 EFRSRGAR---LAYSYIVAAGSNAAILHYV---HNDQPLKDGDLVLIDAGAEYGGYASDITRTFPVnGKFTDEQRELYEA 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778 447 VLKGHIAVSAAVFPtGTK---GHLL-DSFARSALWDSGLD----------------YLHGTGHGVGsfLNVHEgpCGISY 506
Cdd:cd01087 112 VLAAQKAAIAACKP-GVSyedIHLLaHRVLAEGLKELGILkgdvdeivesgayakfFPHGLGHYLG--LDVHD--VGGYL 186
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 18777778 507 KTFS-DEPLEAGMIVTDEPGYY---EDGAF-------GIRIENVVLV 542
Cdd:cd01087 187 RYLRrARPLEPGMVITIEPGIYfipDLLDVpeyfrggGIRIEDDVLV 233
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
322-542 1.15e-11

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 67.06  E-value: 1.15e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  322 KNSAESAGMRRA-------HIKdAVALCE--LFNW-LEQEVpkggvteisaadkAEEFRRQQADFVdlSFPTISSTGPNG 391
Cdd:PRK10879 174 KSPEEIAVLRRAgeisalaHTR-AMEKCRpgMFEYqLEGEI-------------HHEFNRHGARYP--SYNTIVGSGENG 237
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  392 AIIHYApipETNRTLSLDEVYLIDSGAQYKDGTTDVTRTMHF-GTPTAYEKECFTYVLKGhIAVSAAVFPTGT------- 463
Cdd:PRK10879 238 CILHYT---ENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVnGKFTPAQREIYDIVLES-LETSLRLYRPGTsirevtg 313
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  464 ----------------KG---HLLDSFARSALwdsgldYLHGTGHGVGsfLNVHEgpCGiSYKTFSDEPLEAGMIVTDEP 524
Cdd:PRK10879 314 evvrimvsglvklgilKGdvdQLIAENAHRPF------FMHGLSHWLG--LDVHD--VG-VYGQDRSRILEPGMVLTVEP 382
                        250       260
                 ....*....|....*....|....*..
gi 18777778  525 GYY---------EDGAFGIRIENVVLV 542
Cdd:PRK10879 383 GLYiapdadvpeQYRGIGIRIEDDIVI 409
Creatinase_N pfam01321
Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic ...
10-154 1.09e-09

Creatinase/Prolidase N-terminal domain; This family includes the N-terminal non-catalytic domains from creatinase and prolidase. The exact function of this domain is uncertain.


Pssm-ID: 460159  Cd Length: 128  Bit Score: 56.54  E-value: 1.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778    10 LRQLRQAMRNSEcvaepIQAYIIPSGDahqseyiapcdcRRAFVSGFDGSAGTAI-ITEEHAAMWTD-GRYFLQAAKQmd 87
Cdd:pfam01321   2 LEKLRKLMEEKG-----LDAALVTSPE------------NLRYLTGFTGSRGLLLlVTADGALLLVDaLEYERAAAES-- 62
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18777778    88 nnWTLMKM-GLKDTPTQEDWLVSVLPEGSRVGVDPLIIPTDYWKKMAKVLRSAghHLVPVkENLVDKI 154
Cdd:pfam01321  63 --APDFDVvPYRDYEALADLLKELGAGGKRVGFEADALTVAFYEALKEALPGA--ELVDV-SGLIERL 125
PRK15173 PRK15173
peptidase; Provisional
359-542 7.12e-07

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 51.64  E-value: 7.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  359 EISAADKAEEFRRQQADFVDLSFPTIsstgpnGAIIHYAPIPETNRTLSLDEVYLiDSGAQYKDGTTDVTRTMHFGTPTA 438
Cdd:PRK15173 130 ELTAAYKAAVMSKSETHFSRFHLISV------GADFSPKLIPSNTKACSGDLIKF-DCGVDVDGYGADIARTFVVGEPPE 202
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  439 YEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSfARSALWDSGL-DYLHG-TGHGVGSFLNVHEGPCgisYKTFSDEPLEA 516
Cdd:PRK15173 203 ITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDS-TMEVIKKSGLpNYNRGhLGHGNGVFLGLEESPF---VSTHATESFTS 278
                        170       180
                 ....*....|....*....|....*.
gi 18777778  517 GMIVTDEPGYYEDGAFGIRIENVVLV 542
Cdd:PRK15173 279 GMVLSLETPYYGYNLGSIMIEDMILI 304
PRK14575 PRK14575
putative peptidase; Provisional
359-542 1.22e-06

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 51.25  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  359 EISAADKAEEFRRQQADFVDLSFPTIsstgpnGAIIHYAPIPETNRTLSLDEVYLiDSGAQYKDGTTDVTRTMHFGTPTA 438
Cdd:PRK14575 213 ELTAAYKAAVMSKSETHFSRFHLISV------GADFSPKLIPSNTKACSGDLIKF-DCGVDVDGYGADIARTFVVGEPPE 285
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  439 YEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSfARSALWDSGL-DYLHG-TGHGVGSFLNVHEGPcgiSYKTFSDEPLEA 516
Cdd:PRK14575 286 ITRKIYQTIRTGHEHMLSMVAPGVKMKDVFDS-TMEVIKKSGLpNYNRGhLGHGNGVFLGLEESP---FVSTHATESFTS 361
                        170       180
                 ....*....|....*....|....*.
gi 18777778  517 GMIVTDEPGYYEDGAFGIRIENVVLV 542
Cdd:PRK14575 362 GMVLSLETPYYGYNLGSIMIEDMILI 387
PRK14576 PRK14576
putative endopeptidase; Provisional
415-542 1.84e-04

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 44.24  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18777778  415 DSGAQYKDGTTDVTRTMHFGTPTAYEKECFTYVLKGHIAVSAAVFPTGTKGHLLDSfARSALWDSGLDYLH--GTGHGVG 492
Cdd:PRK14576 261 DCGIDVAGYGADLARTFVLGEPDKLTQQIYDTIRTGHEHMLSMVAPGVKLKAVFDS-TMAVIKTSGLPHYNrgHLGHGDG 339
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 18777778  493 SFLNVHEGPcgiSYKTFSDEPLEAGMIVTDEPGYYEDGAFGIRIENVVLV 542
Cdd:PRK14576 340 VFLGLEEVP---FVSTQATETFCPGMVLSLETPYYGIGVGSIMLEDMILI 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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