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Conserved domains on  [gi|62751911|ref|NP_571607|]
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homeobox protein Hox-A9a [Danio rerio]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11151457)

homeobox domain-containing protein similar to double homeobox protein that may act as a transcription factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hox9_act pfam04617
Hox9 activation region; This family constitutes the N termini of the paralogous homeobox ...
 1-171 1.10e-51

Hox9 activation region; This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.


:

Pssm-ID: 461369  Cd Length: 182  Bit Score: 166.41  E-value: 1.10e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62751911     1 MSTSGALTGYYVDSIVIPGSEE---TRFSSGLGLIQHRPTILPADLSDLGPCTFPAKQPVYGTSdWGHIPTHFSTGVPSV 77
Cdd:pfam04617   1 MSTSGTLSNYYVDSIISHESEDlyaPRFSSGPHVQQARQPSGVADHADFPSCSFQPKSPVFSTS-WSPVHPQSSAAVPSV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62751911    78 YQPHAQPPVVGD----YVQSWL-----LDSACGLpqtePPTVNHNHAKSDTNETNDDGTEYS--PHTILQPEVFTNGGcS 146
Cdd:pfam04617  80 YHPYVHQPHVPAsdgrYVRSWLepisgSVSFPGL----PSTGRHYGIKPEPLLGSKGGECTPleTHTRLLSSDYARGS-P 154

                         170       180
                  ....*....|....*....|....*...
gi 62751911   147 TKTEAESSRTAEKSGDIEG---KPGADP 171
Cdd:pfam04617 155 AKPTSESSSSSEAKDESEGkeeKPELDP 182
Homeodomain pfam00046
Homeodomain;
185-241 8.57e-30

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.05  E-value: 8.57e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 62751911   185 RKKRCPYTKHQILELEKEFLFNTYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKK 241
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
Hox9_act pfam04617
Hox9 activation region; This family constitutes the N termini of the paralogous homeobox ...
 1-171 1.10e-51

Hox9 activation region; This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.


Pssm-ID: 461369  Cd Length: 182  Bit Score: 166.41  E-value: 1.10e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62751911     1 MSTSGALTGYYVDSIVIPGSEE---TRFSSGLGLIQHRPTILPADLSDLGPCTFPAKQPVYGTSdWGHIPTHFSTGVPSV 77
Cdd:pfam04617   1 MSTSGTLSNYYVDSIISHESEDlyaPRFSSGPHVQQARQPSGVADHADFPSCSFQPKSPVFSTS-WSPVHPQSSAAVPSV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62751911    78 YQPHAQPPVVGD----YVQSWL-----LDSACGLpqtePPTVNHNHAKSDTNETNDDGTEYS--PHTILQPEVFTNGGcS 146
Cdd:pfam04617  80 YHPYVHQPHVPAsdgrYVRSWLepisgSVSFPGL----PSTGRHYGIKPEPLLGSKGGECTPleTHTRLLSSDYARGS-P 154

                         170       180
                  ....*....|....*....|....*...
gi 62751911   147 TKTEAESSRTAEKSGDIEG---KPGADP 171
Cdd:pfam04617 155 AKPTSESSSSSEAKDESEGkeeKPELDP 182
Homeodomain pfam00046
Homeodomain;
185-241 8.57e-30

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.05  E-value: 8.57e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 62751911   185 RKKRCPYTKHQILELEKEFLFNTYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKK 241
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 184-240 2.33e-27

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 99.63  E-value: 2.33e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 62751911    184 TRKKRCPYTKHQILELEKEFLFNTYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMK 240
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 185-241 7.71e-26

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 95.77  E-value: 7.71e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62751911 185 RKKRCPYTKHQILELEKEFLFNTYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKK 241
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
181-244 2.31e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.84  E-value: 2.31e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62751911 181 ASSTRKKRCPYTKHQILELEKEFLFNTYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKFNK 244
Cdd:COG5576  48 SSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Name Accession Description Interval E-value
Hox9_act pfam04617
Hox9 activation region; This family constitutes the N termini of the paralogous homeobox ...
 1-171 1.10e-51

Hox9 activation region; This family constitutes the N termini of the paralogous homeobox proteins HoxA9, HoxB9, HoxC9 and HoxD9. The N terminal region is found to act as a transcription activation region. Btg1 and Btg2 - the B-cell translocation gene products - may function as cofactors for Hoxb9-mediated transcription. The Btg proteins modulate Hoxb9 transcriptional activity by recruiting a multiprotein Ccr4-like complex.


Pssm-ID: 461369  Cd Length: 182  Bit Score: 166.41  E-value: 1.10e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62751911     1 MSTSGALTGYYVDSIVIPGSEE---TRFSSGLGLIQHRPTILPADLSDLGPCTFPAKQPVYGTSdWGHIPTHFSTGVPSV 77
Cdd:pfam04617   1 MSTSGTLSNYYVDSIISHESEDlyaPRFSSGPHVQQARQPSGVADHADFPSCSFQPKSPVFSTS-WSPVHPQSSAAVPSV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62751911    78 YQPHAQPPVVGD----YVQSWL-----LDSACGLpqtePPTVNHNHAKSDTNETNDDGTEYS--PHTILQPEVFTNGGcS 146
Cdd:pfam04617  80 YHPYVHQPHVPAsdgrYVRSWLepisgSVSFPGL----PSTGRHYGIKPEPLLGSKGGECTPleTHTRLLSSDYARGS-P 154

                         170       180
                  ....*....|....*....|....*...
gi 62751911   147 TKTEAESSRTAEKSGDIEG---KPGADP 171
Cdd:pfam04617 155 AKPTSESSSSSEAKDESEGkeeKPELDP 182
Homeodomain pfam00046
Homeodomain;
185-241 8.57e-30

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 106.05  E-value: 8.57e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 62751911   185 RKKRCPYTKHQILELEKEFLFNTYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKK 241
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 184-240 2.33e-27

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 99.63  E-value: 2.33e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 62751911    184 TRKKRCPYTKHQILELEKEFLFNTYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMK 240
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 185-241 7.71e-26

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 95.77  E-value: 7.71e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62751911 185 RKKRCPYTKHQILELEKEFLFNTYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKK 241
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
181-244 2.31e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 62.84  E-value: 2.31e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62751911 181 ASSTRKKRCPYTKHQILELEKEFLFNTYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKFNK 244
Cdd:COG5576  48 SSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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