NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|18859545|ref|NP_571483|]
View 

vascular endothelial growth factor A-A isoform 1 precursor [Danio rerio]

Protein Classification

PDGF and VEGF_C domain-containing protein( domain architecture ID 11255541)

PDGF and VEGF_C domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 47-129 1.26e-31

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


:

Pssm-ID: 197537  Cd Length: 83  Bit Score: 109.43  E-value: 1.26e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859545     47 SACKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDEALECVPTETRNVTMEVLRVKQRVSQHNFQLSFTEHTKCE 126
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 18859545    127 CRP 129
Cdd:smart00141  81 CRP 83
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 141-188 1.63e-21

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


:

Pssm-ID: 405273  Cd Length: 49  Bit Score: 82.74  E-value: 1.63e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18859545   141 CEPCSERRKRLYVQDPLTCKCSCKFTQMQCKSRQLELNERTCRCEKPR 188
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPR 48
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 47-129 1.26e-31

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 109.43  E-value: 1.26e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859545     47 SACKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDEALECVPTETRNVTMEVLRVKQRVSQHNFQLSFTEHTKCE 126
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 18859545    127 CRP 129
Cdd:smart00141  81 CRP 83
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 8-130 2.76e-29

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 105.47  E-value: 2.76e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859545    8 IQLFLAALLHLSAVKAAHIPKEGGKSKNDVIPFMDVYKKSACKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDE 87
Cdd:PHA02661   7 LQFAVALLLCMYNVPWCFSGSTGSSSASSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDE 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 18859545   88 ALECVPTETRNVTMEVLRVKQRVS---QHNFQ-LSFTEHTKCECRPK 130
Cdd:PHA02661  87 SQICTPTETSNVTVTVMLTSVSGStgaTSNFQtISVEEHTKCKCEFK 133
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 47-130 1.99e-27

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 98.98  E-value: 1.99e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859545  47 SACKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDEALECVPTETRNVTMEVLRVKQRVSQHNF--QLSFTEHTK 124
Cdd:cd00135   1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKRKPRSKlvEISFEEHTE 80


                ....*.
gi 18859545 125 CECRPK 130
Cdd:cd00135  81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
49-127 7.85e-27

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 97.36  E-value: 7.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859545    49 CKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDEALECVPTETRNVTMEVLRVKQ---RVSQHNFQLSFTEHTKC 125
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYaprRPSPELVEVSFEEHVQC 80


                  ..
gi 18859545   126 EC 127
Cdd:pfam00341  81 EC 82
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 141-188 1.63e-21

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 82.74  E-value: 1.63e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18859545   141 CEPCSERRKRLYVQDPLTCKCSCKFTQMQCKSRQLELNERTCRCEKPR 188
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPR 48
 
Name Accession Description Interval E-value
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 47-129 1.26e-31

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 109.43  E-value: 1.26e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859545     47 SACKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDEALECVPTETRNVTMEVLRVKQRVSQHNFQLSFTEHTKCE 126
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETNFLFKPPCVTVKRCGGCCNDEGLECVPTETSNVTMQLLEISRPLSQHLVEVSFEEHTKCE 80


                   ...
gi 18859545    127 CRP 129
Cdd:smart00141  81 CRP 83
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 8-130 2.76e-29

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 105.47  E-value: 2.76e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859545    8 IQLFLAALLHLSAVKAAHIPKEGGKSKNDVIPFMDVYKKSACKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDE 87
Cdd:PHA02661   7 LQFAVALLLCMYNVPWCFSGSTGSSSASSLSSWLDTSDKSSCQPRDTVVQLSDEYPGNTNDRYNPRCVTVRRCGGCCNDE 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 18859545   88 ALECVPTETRNVTMEVLRVKQRVS---QHNFQ-LSFTEHTKCECRPK 130
Cdd:PHA02661  87 SQICTPTETSNVTVTVMLTSVSGStgaTSNFQtISVEEHTKCKCEFK 133
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 47-130 1.99e-27

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 98.98  E-value: 1.99e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859545  47 SACKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDEALECVPTETRNVTMEVLRVKQRVSQHNF--QLSFTEHTK 124
Cdd:cd00135   1 SSCKPRETLVEISEELPDETNTIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKRKPRSKlvEISFEEHTE 80


                ....*.
gi 18859545 125 CECRPK 130
Cdd:cd00135  81 CECRPR 86
PDGF pfam00341
PDGF/VEGF domain;
49-127 7.85e-27

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 97.36  E-value: 7.85e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18859545    49 CKTRELLVDIIQEYPDEIEHTYIPSCVVLMRCAGCCNDEALECVPTETRNVTMEVLRVKQ---RVSQHNFQLSFTEHTKC 125
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFKPSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYaprRPSPELVEVSFEEHVQC 80


                  ..
gi 18859545   126 EC 127
Cdd:pfam00341  81 EC 82
VEGF_C pfam14554
VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been ...
 141-188 1.63e-21

VEGF heparin-binding domain; This short domain is found at the C-terminus of VEGF. It has been shown to have heparin binding activity.


Pssm-ID: 405273  Cd Length: 49  Bit Score: 82.74  E-value: 1.63e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18859545   141 CEPCSERRKRLYVQDPLTCKCSCKFTQMQCKSRQLELNERTCRCEKPR 188
Cdd:pfam14554   1 CSTCSERRKRLFVQDPETCKCSCKHTDADCKSRQLELNERTCRCDKPR 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH