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Conserved domains on  [gi|563580275|ref|NP_571311|]
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transcription factor GATA-4 [Danio rerio]

Protein Classification

GATA-type transcription factor( domain architecture ID 12062858)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0006355|GO:0008270|GO:0043565|GO:0000981
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-158 3.30e-57

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


:

Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 183.40  E-value: 3.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275    1 MYQGVTMAANHGAASY---ESGFLHNS-TSPVYVTPTRVTPMIQALPYLQ---APQQSSPASGHSGWAQPGVETTSYNSS 73
Cdd:pfam05349   1 MYQSLALAANHGQAAYdhdSGGFLHSAaSSPVYVPTTRVPSMLPTLPYLQgcgSSQQSHPVSSHSGWAQAGAESSSYNPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275   74 TGHhhsPVSRFTFSTSPPLTSG--RDtATYTS--------REHFGS--RALSGSYHSGYPAYVSPNIGASWTASHFDSSV 141
Cdd:pfam05349  81 SPH---PSPRFSYSHSPPGSNGtsRD-AAYQSpllisaggREQYGAlgRPLGGSYPSPYPAYVSPEMAPSWTAGPFDSSV 156

                         170
                  ....*....|....*...
gi 563580275  142 LHSLQTGGAA-AARHPNL 158
Cdd:pfam05349 157 LHSLQGRGAPlPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 169-219 4.66e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 74.33  E-value: 4.66e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 563580275 169 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLVKPQRRLSASRR 219
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 223-274 2.79e-16

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 72.02  E-value: 2.79e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 563580275 223 SCTNCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKEG-IQTRKRK 274
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-158 3.30e-57

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 183.40  E-value: 3.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275    1 MYQGVTMAANHGAASY---ESGFLHNS-TSPVYVTPTRVTPMIQALPYLQ---APQQSSPASGHSGWAQPGVETTSYNSS 73
Cdd:pfam05349   1 MYQSLALAANHGQAAYdhdSGGFLHSAaSSPVYVPTTRVPSMLPTLPYLQgcgSSQQSHPVSSHSGWAQAGAESSSYNPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275   74 TGHhhsPVSRFTFSTSPPLTSG--RDtATYTS--------REHFGS--RALSGSYHSGYPAYVSPNIGASWTASHFDSSV 141
Cdd:pfam05349  81 SPH---PSPRFSYSHSPPGSNGtsRD-AAYQSpllisaggREQYGAlgRPLGGSYPSPYPAYVSPEMAPSWTAGPFDSSV 156

                         170
                  ....*....|....*...
gi 563580275  142 LHSLQTGGAA-AARHPNL 158
Cdd:pfam05349 157 LHSLQGRGAPlPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 169-219 4.66e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 74.33  E-value: 4.66e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 563580275 169 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLVKPQRRLSASRR 219
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 223-274 2.79e-16

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 72.02  E-value: 2.79e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 563580275 223 SCTNCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKEG-IQTRKRK 274
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
165-210 7.62e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.13  E-value: 7.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 563580275   165 GEGRECVNCGAMSTPLWRRDGTGH-YLCNACGLYHKMNGI-NRPLVKP 210
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLK 48
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
221-268 7.93e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 62.44  E-value: 7.93e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 563580275   221 GLSCTNCQTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMKKEGI 268
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 170-202 1.12e-11

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 58.87  E-value: 1.12e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 563580275  170 CVNCGAMSTPLWRRDGTGHY-LCNACGLYHKMNG 202
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
80-332 2.50e-10

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 61.43  E-value: 2.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275  80 PVSRFTFSTSPPLTSGRDTATYTSREHfgSRALSGSYHSGYPAYVSPNIGAS--WTASHFDSSVL-HSLQTGGAAAARHP 156
Cdd:COG5641   70 PSGNASISGSPRFVNRIQEHRASSRQS--SISSLSDFPISSSSSTSNAASPStnYTDESNQQFSSyNTTLNPGGTSSLNP 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275 157 NLEFFDDLGEGRECVNCGAMSTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLVKPQRRLSASRRVGLSCTNCQT-T 230
Cdd:COG5641  148 NNNQSDNSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSnG 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275 231 TTTLWRRNAEGEPVCNACGLYMKLHGvpRPLAMKKEGIQTRKRKPKNISKTKPGSSegqsaisavnssptEETRPIKTEP 310
Cdd:COG5641  228 ENANTESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKSPLLEGLMGS--------------TSLQPVSTPK 291

                        250       260
                 ....*....|....*....|..
gi 563580275 311 DTTPLYTHHNIHTQVSAFPAYM 332
Cdd:COG5641  292 LVLPSDKKRSTLTTSTATPLWR 313
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 224-258 1.37e-09

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 52.71  E-value: 1.37e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 563580275  224 CTNCQTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 258
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
 
Name Accession Description Interval E-value
GATA-N pfam05349
GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell ...
 1-158 3.30e-57

GATA-type transcription activator, N-terminal; GATA transcription factors mediate cell differentiation in a diverse range of tissues. Mutation are often associated with certain congenital human disorders. The six classical vertebrate GATA proteins, GATA-1 to GATA-6, are highly homologous and have two tandem zinc fingers. The classical GATA transcription factors function transcription activators. In lower metazoans GATA proteins carry a single canonical zinc finger. This family represents the N-terminal domain of the family of GATA transcription activators.


Pssm-ID: 461628 [Multi-domain]  Cd Length: 174  Bit Score: 183.40  E-value: 3.30e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275    1 MYQGVTMAANHGAASY---ESGFLHNS-TSPVYVTPTRVTPMIQALPYLQ---APQQSSPASGHSGWAQPGVETTSYNSS 73
Cdd:pfam05349   1 MYQSLALAANHGQAAYdhdSGGFLHSAaSSPVYVPTTRVPSMLPTLPYLQgcgSSQQSHPVSSHSGWAQAGAESSSYNPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275   74 TGHhhsPVSRFTFSTSPPLTSG--RDtATYTS--------REHFGS--RALSGSYHSGYPAYVSPNIGASWTASHFDSSV 141
Cdd:pfam05349  81 SPH---PSPRFSYSHSPPGSNGtsRD-AAYQSpllisaggREQYGAlgRPLGGSYPSPYPAYVSPEMAPSWTAGPFDSSV 156

                         170
                  ....*....|....*...
gi 563580275  142 LHSLQTGGAA-AARHPNL 158
Cdd:pfam05349 157 LHSLQGRGAPlPGRRPNL 174
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 169-219 4.66e-17

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 74.33  E-value: 4.66e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 563580275 169 ECVNCGAMSTPLWRRDG-TGHYLCNACGLYHKMNGINRPLVKPQRRLSASRR 219
Cdd:cd00202    1 ACSNCGTTTTPLWRRGPsGGSTLCNACGLYWKKHGVMRPLSKRKKDQIKRRN 52
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 223-274 2.79e-16

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 72.02  E-value: 2.79e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 563580275 223 SCTNCQTTTTTLWRRN-AEGEPVCNACGLYMKLHGVPRPLAMKKEG-IQTRKRK 274
Cdd:cd00202    1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
165-210 7.62e-14

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 65.13  E-value: 7.62e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 563580275   165 GEGRECVNCGAMSTPLWRRDGTGH-YLCNACGLYHKMNGI-NRPLVKP 210
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGlKRPLSLK 48
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
221-268 7.93e-13

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 62.44  E-value: 7.93e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 563580275   221 GLSCTNCQTTTTTLWRRNAEGE-PVCNACGLYMKLHGVP-RPLAMKKEGI 268
Cdd:smart00401   3 GRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGGLkRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 170-202 1.12e-11

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 58.87  E-value: 1.12e-11
                          10        20        30
                  ....*....|....*....|....*....|....
gi 563580275  170 CVNCGAMSTPLWRRDGTGHY-LCNACGLYHKMNG 202
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKG 34
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
80-332 2.50e-10

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 61.43  E-value: 2.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275  80 PVSRFTFSTSPPLTSGRDTATYTSREHfgSRALSGSYHSGYPAYVSPNIGAS--WTASHFDSSVL-HSLQTGGAAAARHP 156
Cdd:COG5641   70 PSGNASISGSPRFVNRIQEHRASSRQS--SISSLSDFPISSSSSTSNAASPStnYTDESNQQFSSyNTTLNPGGTSSLNP 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275 157 NLEFFDDLGEGRECVNCGAMSTPLWRRD-----GTGHYLCNACGLYHKMNGINRPLVKPQRRLSASRRVGLSCTNCQT-T 230
Cdd:COG5641  148 NNNQSDNSNQPHVCSNCKTTSTPLWRRAssessLPGNNLCNACGLYLKLHGSPRAPISLKSDSIKSRSSRSSHNNNDSnG 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275 231 TTTLWRRNAEGEPVCNACGLYMKLHGvpRPLAMKKEGIQTRKRKPKNISKTKPGSSegqsaisavnssptEETRPIKTEP 310
Cdd:COG5641  228 ENANTESIGNSSASKLTKSWEERPQG--RQLLSDAGSLSPRSNNPKSPLLEGLMGS--------------TSLQPVSTPK 291

                        250       260
                 ....*....|....*....|..
gi 563580275 311 DTTPLYTHHNIHTQVSAFPAYM 332
Cdd:COG5641  292 LVLPSDKKRSTLTTSTATPLWR 313
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 224-258 1.37e-09

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 52.71  E-value: 1.37e-09
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 563580275  224 CTNCQTTTTTLWRRNAEGEP-VCNACGLYMKLHGVP 258
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKKGLK 36
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
172-305 1.35e-06

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 49.87  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275 172 NCGAMSTPLWRR-DGTGHYLCNACGLYHKMNGINRPLvkPQRRLSASRRVGLSCTNCQTTTTTLWRrnaEGEPVCNACGL 250
Cdd:COG5641  303 LTTSTATPLWRRtSDKSSFSCNASGSALKPPGSKRPL--LPKPDPNSKRSNATCMNCSSTPTNKIL---SPPTTSNSPGA 377

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580275 251 YMKLHGVPRPLAMKKEGIQTRKRKPKNI-----SKTKPGSSEGQSAISAVNSSPTEETRP 305
Cdd:COG5641  378 QVKLPNQTRSTGATKKKITRRRMNSGKIpalssSMKNPVPKEFSPLIPQSTESETPSQSK 437
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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