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Conserved domains on  [gi|18858833|ref|NP_571191|]
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homeobox protein Hox-B2a [Danio rerio]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10441114)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
159-215 9.85e-30

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 109.13  E-value: 9.85e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858833   159 RRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKR 215
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PRK11907 super family cl36084
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
237-320 2.97e-03

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


The actual alignment was detected with superfamily member PRK11907:

Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 39.84  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858833  237 TDASSPYSSQSLEVSGSGSAAPSESETCPTTAAYTNSSDKSQ-PTPEEGQASQPEPASVPDTAVHSPPYPTPTADNPTTM 315
Cdd:PRK11907  29 EEIVTTTPATSTEAEQTTPVESDATEEADNTETPVAATTAAEaPSSSETAETSDPTSEATDTTTSEARTVTPAATETSKP 108


                 ....*
gi 18858833  316 AEGRA 320
Cdd:PRK11907 109 VEGQT 113
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
159-215 9.85e-30

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 109.13  E-value: 9.85e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858833   159 RRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKR 215
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 158-214 5.05e-27

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 101.94  E-value: 5.05e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858833    158 SRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHK 214
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 159-216 5.16e-26

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 99.24  E-value: 5.16e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 18858833 159 RRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQ 216
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
147-245 1.14e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858833 147 EIQGGLDNVSGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTTHHRDGQEG 226
Cdd:COG5576  40 KLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPG 119

                        90
                ....*....|....*....
gi 18858833 227 EPSGfDLLEGTDASSPYSS 245
Cdd:COG5576 120 EEEA-DLAKIGSLSTGQIS 137
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
237-320 2.97e-03

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 39.84  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858833  237 TDASSPYSSQSLEVSGSGSAAPSESETCPTTAAYTNSSDKSQ-PTPEEGQASQPEPASVPDTAVHSPPYPTPTADNPTTM 315
Cdd:PRK11907  29 EEIVTTTPATSTEAEQTTPVESDATEEADNTETPVAATTAAEaPSSSETAETSDPTSEATDTTTSEARTVTPAATETSKP 108


                 ....*
gi 18858833  316 AEGRA 320
Cdd:PRK11907 109 VEGQT 113
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
159-215 9.85e-30

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 109.13  E-value: 9.85e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858833   159 RRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKR 215
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 158-214 5.05e-27

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 101.94  E-value: 5.05e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 18858833    158 SRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHK 214
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 159-216 5.16e-26

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 99.24  E-value: 5.16e-26
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 18858833 159 RRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQ 216
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
147-245 1.14e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 1.14e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858833 147 EIQGGLDNVSGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQVKVWFQNRRMKHKRQTTHHRDGQEG 226
Cdd:COG5576  40 KLERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRSGKVEQRPG 119

                        90
                ....*....|....*....
gi 18858833 227 EPSGfDLLEGTDASSPYSS 245
Cdd:COG5576 120 EEEA-DLAKIGSLSTGQIS 137
PRK11907 PRK11907
bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;
237-320 2.97e-03

bifunctional 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase;


Pssm-ID: 237019 [Multi-domain]  Cd Length: 814  Bit Score: 39.84  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858833  237 TDASSPYSSQSLEVSGSGSAAPSESETCPTTAAYTNSSDKSQ-PTPEEGQASQPEPASVPDTAVHSPPYPTPTADNPTTM 315
Cdd:PRK11907  29 EEIVTTTPATSTEAEQTTPVESDATEEADNTETPVAATTAAEaPSSSETAETSDPTSEATDTTTSEARTVTPAATETSKP 108


                 ....*
gi 18858833  316 AEGRA 320
Cdd:PRK11907 109 VEGQT 113
PRK06975 PRK06975
bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed
 265-312 4.31e-03

bifunctional uroporphyrinogen-III synthetase/uroporphyrin-III C-methyltransferase; Reviewed


Pssm-ID: 235899 [Multi-domain]  Cd Length: 656  Bit Score: 39.32  E-value: 4.31e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 18858833  265 PTTAAyTNSSDKSQPTPEEGQASQPEPASVPDTAVHSPPYPTPTADNP 312
Cdd:PRK06975 272 PATAA-PAPSRMTDTNDSKSVTSQPAAAAAAPAPPPNPPATPPEPPAR 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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