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Conserved domains on  [gi|18858497|ref|NP_571113|]
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gap junction alpha-1 protein [Danio rerio]

Protein Classification

Connexin and Connexin43 domain-containing protein( domain architecture ID 11981467)

Connexin and Connexin43 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
3-233 1.32e-124

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


:

Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 357.96  E-value: 1.32e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858497     3 DWSALGRLLDKVQAYSTAGGKVWLSVLFIFRILVLGTAVESAWGDEQSAFKCNTQQPGCENVCYDKSFPISHVRFWVLQI 82
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858497    83 IFVSTPTLLYLAHVFYLMRKEEKLNRKEEELKAVqndggdvelhlkkiELKKFKHGLEEHGKVKMKGSLLRTYIFSIIFK 162
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRREKEEEEMEE--------------ELYEEEGKKEAEPKVHIRGGLLWTYVLSLLFR 146
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18858497   163 SICEVVFLVIQWYLYGFSLSAVYTCERTPCPHRVDCFLSRPTEKTIFIIFMLVVSLFSLLLNIIELFYVLF 233
Cdd:pfam00029 147 IVLEVGFLVGQYYLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLGW 217
Connexin43 pfam03508
Gap junction alpha-1 protein (Cx43);
283-359 3.44e-51

Gap junction alpha-1 protein (Cx43);


:

Pssm-ID: 460950  Cd Length: 79  Bit Score: 165.58  E-value: 3.44e-51
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18858497   283 PPGYKLATGERTN-SCRNYNKQANEQNWANYSTEQNRLGQNGSTISNSHAQAFDYPDDTHEHKKLTPGHELQPLALID 359
Cdd:pfam03508   1 PPGYKLATGERNNsSCRNYNKQASEQNWANYSAEQNRLGQNGSTISNSHAQAFDFPEAPHNTKKLGSGHELQPLALLD 78
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
3-233 1.32e-124

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 357.96  E-value: 1.32e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858497     3 DWSALGRLLDKVQAYSTAGGKVWLSVLFIFRILVLGTAVESAWGDEQSAFKCNTQQPGCENVCYDKSFPISHVRFWVLQI 82
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858497    83 IFVSTPTLLYLAHVFYLMRKEEKLNRKEEELKAVqndggdvelhlkkiELKKFKHGLEEHGKVKMKGSLLRTYIFSIIFK 162
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRREKEEEEMEE--------------ELYEEEGKKEAEPKVHIRGGLLWTYVLSLLFR 146
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18858497   163 SICEVVFLVIQWYLYGFSLSAVYTCERTPCPHRVDCFLSRPTEKTIFIIFMLVVSLFSLLLNIIELFYVLF 233
Cdd:pfam00029 147 IVLEVGFLVGQYYLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLGW 217
Connexin43 pfam03508
Gap junction alpha-1 protein (Cx43);
283-359 3.44e-51

Gap junction alpha-1 protein (Cx43);


Pssm-ID: 460950  Cd Length: 79  Bit Score: 165.58  E-value: 3.44e-51
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18858497   283 PPGYKLATGERTN-SCRNYNKQANEQNWANYSTEQNRLGQNGSTISNSHAQAFDYPDDTHEHKKLTPGHELQPLALID 359
Cdd:pfam03508   1 PPGYKLATGERNNsSCRNYNKQASEQNWANYSAEQNRLGQNGSTISNSHAQAFDFPEAPHNTKKLGSGHELQPLALLD 78
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
166-231 5.71e-29

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 107.19  E-value: 5.71e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18858497    166 EVVFLVIQWYLYGFSLSAVYTCERTPCPHRVDCFLSRPTEKTIFIIFMLVVSLFSLLLNIIELFYV 231
Cdd:smart01089   2 EVGFLYGQYYLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
3-233 1.32e-124

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 357.96  E-value: 1.32e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858497     3 DWSALGRLLDKVQAYSTAGGKVWLSVLFIFRILVLGTAVESAWGDEQSAFKCNTQQPGCENVCYDKSFPISHVRFWVLQI 82
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18858497    83 IFVSTPTLLYLAHVFYLMRKEEKLNRKEEELKAVqndggdvelhlkkiELKKFKHGLEEHGKVKMKGSLLRTYIFSIIFK 162
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRREKEEEEMEE--------------ELYEEEGKKEAEPKVHIRGGLLWTYVLSLLFR 146
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18858497   163 SICEVVFLVIQWYLYGFSLSAVYTCERTPCPHRVDCFLSRPTEKTIFIIFMLVVSLFSLLLNIIELFYVLF 233
Cdd:pfam00029 147 IVLEVGFLVGQYYLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLCLLLNLLELFYLGW 217
Connexin43 pfam03508
Gap junction alpha-1 protein (Cx43);
283-359 3.44e-51

Gap junction alpha-1 protein (Cx43);


Pssm-ID: 460950  Cd Length: 79  Bit Score: 165.58  E-value: 3.44e-51
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18858497   283 PPGYKLATGERTN-SCRNYNKQANEQNWANYSTEQNRLGQNGSTISNSHAQAFDYPDDTHEHKKLTPGHELQPLALID 359
Cdd:pfam03508   1 PPGYKLATGERNNsSCRNYNKQASEQNWANYSAEQNRLGQNGSTISNSHAQAFDFPEAPHNTKKLGSGHELQPLALLD 78
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
166-231 5.71e-29

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 107.19  E-value: 5.71e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18858497    166 EVVFLVIQWYLYGFSLSAVYTCERTPCPHRVDCFLSRPTEKTIFIIFMLVVSLFSLLLNIIELFYV 231
Cdd:smart01089   2 EVGFLYGQYYLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAICILLNLLELFYL 67
CNX smart00037
Connexin homologues; Connexin channels participate in the regulation of signaling between ...
43-76 5.82e-22

Connexin homologues; Connexin channels participate in the regulation of signaling between developing and differentiated cell types.


Pssm-ID: 128352  Cd Length: 34  Bit Score: 87.50  E-value: 5.82e-22
                           10        20        30
                   ....*....|....*....|....*....|....
gi 18858497     43 SAWGDEQSAFKCNTQQPGCENVCYDKSFPISHVR 76
Cdd:smart00037   1 SVWGDEQSDFVCNTQQPGCENVCYDQAFPISHVR 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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