mucosal addressin cell adhesion molecule 1 isoform a precursor [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||
| IgI_MAdCAM-1 | cd20942 | Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of ... |
25-112 | 4.74e-50 | |||
Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of the I-set of IgSF domains; The members here include the immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1). MadCAM-1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. MadCAM-1 is expressed primarily on HEV of Peyer's patches and on venules in small intestinal lamina propria, on the marginal sinus of the spleen, and on HEV of embryonic lymph nodes. It is a member of the immunoglobulin superfamily (IgSF), which is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of MAdCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand. : Pssm-ID: 409535 Cd Length: 88 Bit Score: 162.99 E-value: 4.74e-50
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| Adhes-Ig_like | pfam09085 | Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal ... |
113-224 | 3.07e-49 | |||
Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues. : Pssm-ID: 430399 Cd Length: 110 Bit Score: 161.50 E-value: 3.07e-49
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| MSA-2c super family | cl13647 | Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this ... |
228-290 | 2.12e-06 | |||
Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this family are typically between 263 and 318 amino acids in length. There is a conserved SFT sequence motif. MSA-2 is a plasma membrane glycoprotein which can be found in Babesia bovis species. The actual alignment was detected with superfamily member pfam12238: Pssm-ID: 289042 Cd Length: 216 Bit Score: 48.21 E-value: 2.12e-06
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| Name | Accession | Description | Interval | E-value | ||||
| IgI_MAdCAM-1 | cd20942 | Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of ... |
25-112 | 4.74e-50 | ||||
Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of the I-set of IgSF domains; The members here include the immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1). MadCAM-1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. MadCAM-1 is expressed primarily on HEV of Peyer's patches and on venules in small intestinal lamina propria, on the marginal sinus of the spleen, and on HEV of embryonic lymph nodes. It is a member of the immunoglobulin superfamily (IgSF), which is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of MAdCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand. Pssm-ID: 409535 Cd Length: 88 Bit Score: 162.99 E-value: 4.74e-50
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| Adhes-Ig_like | pfam09085 | Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal ... |
113-224 | 3.07e-49 | ||||
Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues. Pssm-ID: 430399 Cd Length: 110 Bit Score: 161.50 E-value: 3.07e-49
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| MSA-2c | pfam12238 | Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this ... |
228-290 | 2.12e-06 | ||||
Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this family are typically between 263 and 318 amino acids in length. There is a conserved SFT sequence motif. MSA-2 is a plasma membrane glycoprotein which can be found in Babesia bovis species. Pssm-ID: 289042 Cd Length: 216 Bit Score: 48.21 E-value: 2.12e-06
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| PRK15313 | PRK15313 | intestinal colonization autotransporter adhesin MisL; |
222-295 | 2.45e-06 | ||||
intestinal colonization autotransporter adhesin MisL; Pssm-ID: 237940 [Multi-domain] Cd Length: 955 Bit Score: 49.80 E-value: 2.45e-06
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| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
188-360 | 4.76e-06 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.78 E-value: 4.76e-06
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| rad23 | TIGR00601 | UV excision repair protein Rad23; All proteins in this family for which functions are known ... |
226-279 | 3.27e-04 | ||||
UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273167 [Multi-domain] Cd Length: 378 Bit Score: 42.57 E-value: 3.27e-04
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| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
193-320 | 6.15e-04 | ||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.06 E-value: 6.15e-04
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| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
122-319 | 9.20e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 38.38 E-value: 9.20e-03
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| Name | Accession | Description | Interval | E-value | ||||
| IgI_MAdCAM-1 | cd20942 | Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of ... |
25-112 | 4.74e-50 | ||||
Immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1); member of the I-set of IgSF domains; The members here include the immunoglobulin-like domain of Mucosal addressin cell-adhesion molecule (MAdCAM-1). MadCAM-1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. MadCAM-1 is expressed primarily on HEV of Peyer's patches and on venules in small intestinal lamina propria, on the marginal sinus of the spleen, and on HEV of embryonic lymph nodes. It is a member of the immunoglobulin superfamily (IgSF), which is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of MAdCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand. Pssm-ID: 409535 Cd Length: 88 Bit Score: 162.99 E-value: 4.74e-50
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| Adhes-Ig_like | pfam09085 | Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal ... |
113-224 | 3.07e-49 | ||||
Adhesion molecule, immunoglobulin-like; Members of this family are found in a set of mucosal cellular adhesion proteins and adopt an immunoglobulin-like beta-sandwich structure, with seven strands arranged in two beta-sheets in a Greek-key topology. They are essential for recruitment of lymphocytes to specific tissues. Pssm-ID: 430399 Cd Length: 110 Bit Score: 161.50 E-value: 3.07e-49
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| MSA-2c | pfam12238 | Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this ... |
228-290 | 2.12e-06 | ||||
Merozoite surface antigen 2c; This family of proteins is found in eukaryotes. Proteins in this family are typically between 263 and 318 amino acids in length. There is a conserved SFT sequence motif. MSA-2 is a plasma membrane glycoprotein which can be found in Babesia bovis species. Pssm-ID: 289042 Cd Length: 216 Bit Score: 48.21 E-value: 2.12e-06
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| PRK15313 | PRK15313 | intestinal colonization autotransporter adhesin MisL; |
222-295 | 2.45e-06 | ||||
intestinal colonization autotransporter adhesin MisL; Pssm-ID: 237940 [Multi-domain] Cd Length: 955 Bit Score: 49.80 E-value: 2.45e-06
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| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
188-360 | 4.76e-06 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.78 E-value: 4.76e-06
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| IgI_1_NCAM-1_like | cd04977 | First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, and similar ... |
26-112 | 7.50e-06 | ||||
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1, and similar domains; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1. NCAM-1 plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-nonNCAM) interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves the Ig1, Ig2, and Ig3 domains. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. Also included in this group is NCAM-2 (also known as OCAM/mamFas II and RNCAM). NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand. Pssm-ID: 409366 Cd Length: 95 Bit Score: 44.16 E-value: 7.50e-06
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| PRK13042 | PRK13042 | superantigen-like protein SSL4; Reviewed; |
220-307 | 2.83e-05 | ||||
superantigen-like protein SSL4; Reviewed; Pssm-ID: 183854 [Multi-domain] Cd Length: 291 Bit Score: 45.39 E-value: 2.83e-05
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| rad23 | TIGR00601 | UV excision repair protein Rad23; All proteins in this family for which functions are known ... |
226-279 | 3.27e-04 | ||||
UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273167 [Multi-domain] Cd Length: 378 Bit Score: 42.57 E-value: 3.27e-04
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| PLN02328 | PLN02328 | lysine-specific histone demethylase 1 homolog |
226-312 | 3.72e-04 | ||||
lysine-specific histone demethylase 1 homolog Pssm-ID: 215187 [Multi-domain] Cd Length: 808 Bit Score: 42.67 E-value: 3.72e-04
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| Atrophin-1 | pfam03154 | Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
193-320 | 6.15e-04 | ||||
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity. Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.06 E-value: 6.15e-04
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| IgI_VCAM-1 | cd20943 | First immunoglobulin-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1), ... |
31-112 | 9.63e-04 | ||||
First immunoglobulin-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1), and similar domains; member of the I-set of IgSF domains; The members here include the first immunoglobulin-like domain of vascular endothelial cell adhesion molecule-1 (VCAM-1; also known as Cluster of Differentiation 106 (CD106)) and similar proteins. During the inflammation process, these molecules recruit leukocytes onto the vascular endothelium before extravasation to the injured tissues. The interaction of VCAM-1 binding to the beta1 integrin very late antigen (VLA-4) expressed by lymphocytes and monocytes mediates the adhesion of leucocytes to blood vessel walls, and regulates migration across the endothelium. During metastasis, some circulating cancer cells extravasate to a secondary site by a similar process. VCAM-1 may be involved in organ targeted tumor metastasis and may also act as host receptors for viruses and parasites. VCAM-1 contains seven Ig domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The first Ig-like domain of VCAM-1 is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, the A strand of the I-set is discontinuous, but lacks a C" strand. Pssm-ID: 409536 Cd Length: 89 Bit Score: 38.03 E-value: 9.63e-04
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| PTZ00144 | PTZ00144 | dihydrolipoamide succinyltransferase; Provisional |
226-296 | 9.78e-04 | ||||
dihydrolipoamide succinyltransferase; Provisional Pssm-ID: 240289 [Multi-domain] Cd Length: 418 Bit Score: 40.82 E-value: 9.78e-04
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| IgI_Perlecan_like | cd05754 | Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of ... |
28-109 | 1.63e-03 | ||||
Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the third immunoglobulin (Ig)-like domain found in Perlecan. Perlecan is a large multi-domain heparin sulfate proteoglycan, important in tissue development and organogenesis. Perlecan can be represented as 5 major portions; its fourth major portion (domain IV) is a tandem repeat of immunoglobulin-like domains (Ig2-Ig15) which can vary in size due to alternative splicing. Perlecan binds many cellular and extracellular ligands. Its domain IV region has many binding sites. Some of these have been mapped at the level of individual Ig-like domains, including a site restricted to the Ig5 domain for heparin/sulfatide, a site restricted to the Ig3 domain for nidogen-1 and nidogen-2, a site restricted to Ig4-5 for fibronectin, and sites restricted to Ig2 and to Ig13-15 for fibulin-2. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand. Pssm-ID: 409412 Cd Length: 85 Bit Score: 37.15 E-value: 1.63e-03
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| Trypan_PARP | pfam05887 | Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ... |
230-275 | 1.73e-03 | ||||
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated. Pssm-ID: 368653 Cd Length: 134 Bit Score: 38.23 E-value: 1.73e-03
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| ig | pfam00047 | Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ... |
30-97 | 1.81e-03 | ||||
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. Pssm-ID: 395002 Cd Length: 86 Bit Score: 37.17 E-value: 1.81e-03
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| Herpes_BLLF1 | pfam05109 | Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
225-313 | 1.99e-03 | ||||
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo. Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 40.28 E-value: 1.99e-03
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| PRK10856 | PRK10856 | cytoskeleton protein RodZ; |
219-316 | 3.41e-03 | ||||
cytoskeleton protein RodZ; Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 39.24 E-value: 3.41e-03
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| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
197-314 | 4.95e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 39.15 E-value: 4.95e-03
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| DUF6550 | pfam20187 | Family of unknown function (DUF6550); This family of proteins is functionally uncharacterized. ... |
219-279 | 5.55e-03 | ||||
Family of unknown function (DUF6550); This family of proteins is functionally uncharacterized. This family of proteins is found in Firmicutes. Proteins in this family are approximately 180 amino acids in length. There are two conserved sequence motifs at the C-terminal: FGW/I and I/VGxM. Pssm-ID: 466338 [Multi-domain] Cd Length: 190 Bit Score: 37.60 E-value: 5.55e-03
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| DUF4045 | pfam13254 | Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ... |
219-314 | 6.11e-03 | ||||
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length. Pssm-ID: 433066 [Multi-domain] Cd Length: 415 Bit Score: 38.61 E-value: 6.11e-03
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| PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
122-319 | 9.20e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 38.38 E-value: 9.20e-03
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| rad23 | TIGR00601 | UV excision repair protein Rad23; All proteins in this family for which functions are known ... |
228-284 | 9.39e-03 | ||||
UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273167 [Multi-domain] Cd Length: 378 Bit Score: 37.95 E-value: 9.39e-03
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| Blast search parameters | ||||
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