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Conserved domains on  [gi|24639092|ref|NP_569912|]
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uncharacterized protein Dmel_CG14785 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4734 pfam15881
Domain of unknown function (DUF4734); This domain family is found in species of Drosophila, ...
 359-450 5.97e-27

Domain of unknown function (DUF4734); This domain family is found in species of Drosophila, and is approximately 90 amino acids in length. The family is found in association with pfam07707.


:

Pssm-ID: 434992  Cd Length: 91  Bit Score: 103.50  E-value: 5.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639092   359 RVIHSPGVQRLIAAGLEDAITLKSKPRFSGAAlHRQRKHQEERLLVRDWIVDTECSHHHKSHCEQFVYPTYDAFKEYLAR 438
Cdd:pfam15881   1 EILQLPEVQALINEGLSYSTALMFEDKDPGFR-PLLEIFKVELPQQRRWIYDDGCPYHHDIKCPNTRYLTYEEFKSYLAR 79

                          90
                  ....*....|..
gi 24639092   439 IICCAPNCWRTF 450
Cdd:pfam15881  80 LQTQGPDYWDTL 91
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 256-345 7.45e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


:

Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 70.06  E-value: 7.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639092    256 YHPQARILCELMLTRISRVFLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAEV 335
Cdd:smart00875   9 DAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEHV 88

                           90
                   ....*....|
gi 24639092    336 HFALMPTWYL 345
Cdd:smart00875  89 RLPLLSPDYL 98
 
Name Accession Description Interval E-value
DUF4734 pfam15881
Domain of unknown function (DUF4734); This domain family is found in species of Drosophila, ...
 359-450 5.97e-27

Domain of unknown function (DUF4734); This domain family is found in species of Drosophila, and is approximately 90 amino acids in length. The family is found in association with pfam07707.


Pssm-ID: 434992  Cd Length: 91  Bit Score: 103.50  E-value: 5.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639092   359 RVIHSPGVQRLIAAGLEDAITLKSKPRFSGAAlHRQRKHQEERLLVRDWIVDTECSHHHKSHCEQFVYPTYDAFKEYLAR 438
Cdd:pfam15881   1 EILQLPEVQALINEGLSYSTALMFEDKDPGFR-PLLEIFKVELPQQRRWIYDDGCPYHHDIKCPNTRYLTYEEFKSYLAR 79

                          90
                  ....*....|..
gi 24639092   439 IICCAPNCWRTF 450
Cdd:pfam15881  80 LQTQGPDYWDTL 91
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 256-345 7.45e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 70.06  E-value: 7.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639092    256 YHPQARILCELMLTRISRVFLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAEV 335
Cdd:smart00875   9 DAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEHV 88

                           90
                   ....*....|
gi 24639092    336 HFALMPTWYL 345
Cdd:smart00875  89 RLPLLSPDYL 98
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 263-345 7.65e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 64.49  E-value: 7.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639092   263 LCELMLTRISRVFLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAEVHFALMPT 342
Cdd:pfam07707  16 LAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLSAVRLPLLSP 95


                  ...
gi 24639092   343 WYL 345
Cdd:pfam07707  96 QYL 98
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 271-334 7.37e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 38.69  E-value: 7.37e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24639092 271 ISRVFLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAE 334
Cdd:cd18483  29 IRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKREMHLPEIFAK 92
 
Name Accession Description Interval E-value
DUF4734 pfam15881
Domain of unknown function (DUF4734); This domain family is found in species of Drosophila, ...
 359-450 5.97e-27

Domain of unknown function (DUF4734); This domain family is found in species of Drosophila, and is approximately 90 amino acids in length. The family is found in association with pfam07707.


Pssm-ID: 434992  Cd Length: 91  Bit Score: 103.50  E-value: 5.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639092   359 RVIHSPGVQRLIAAGLEDAITLKSKPRFSGAAlHRQRKHQEERLLVRDWIVDTECSHHHKSHCEQFVYPTYDAFKEYLAR 438
Cdd:pfam15881   1 EILQLPEVQALINEGLSYSTALMFEDKDPGFR-PLLEIFKVELPQQRRWIYDDGCPYHHDIKCPNTRYLTYEEFKSYLAR 79

                          90
                  ....*....|..
gi 24639092   439 IICCAPNCWRTF 450
Cdd:pfam15881  80 LQTQGPDYWDTL 91
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 256-345 7.45e-15

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 70.06  E-value: 7.45e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639092    256 YHPQARILCELMLTRISRVFLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAEV 335
Cdd:smart00875   9 DAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHLPELLEHV 88

                           90
                   ....*....|
gi 24639092    336 HFALMPTWYL 345
Cdd:smart00875  89 RLPLLSPDYL 98
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 263-345 7.65e-13

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 64.49  E-value: 7.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639092   263 LCELMLTRISRVFLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAEVHFALMPT 342
Cdd:pfam07707  16 LAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHLPELLSAVRLPLLSP 95


                  ...
gi 24639092   343 WYL 345
Cdd:pfam07707  96 QYL 98
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 271-334 7.37e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 38.69  E-value: 7.37e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24639092 271 ISRVFLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAE 334
Cdd:cd18483  29 IRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKREMHLPEIFAK 92
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 275-324 1.28e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 38.06  E-value: 1.28e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 24639092 275 FLCIVGSPFFLYFTEHELTHILRNCYLSVnSEIEIFLSVVLWLEHNWLER 324
Cdd:cd18489  34 FSQIAQSPVLFELTKEYLIEALQSDFLQA-SELDILKAVLKWGEHQLIKR 82
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 275-345 4.08e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 37.06  E-value: 4.08e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24639092 275 FLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERGDCAERILAEVHFALMPTWYL 345
Cdd:cd18446  33 FSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLPLLPRVLENVRLPLLDPWYF 103
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 273-340 7.83e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 36.04  E-value: 7.83e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24639092 273 RVFLCIVGSPFFLYFTEHELTHILRNCYLSVNSEIEIFLSVVLWLEHNWLERgDCAERILAEVHFALM 340
Cdd:cd18465  31 RHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHDPSRR-ASASHVLCHIRFPLM 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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