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Conserved domains on  [gi|18424859|ref|NP_568993|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 8.09e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.27  E-value: 8.09e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  10 EAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWDV 89
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  90 STGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRshSVEPVQIIDTFLDTVMSVVLTKTE--IIGGSVDGT 167
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 168 VRTFDMRIGREMSDNLG--QPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHisKSFKTDCCLTNSDAHVIG 245
Cdd:cd00200 159 IKLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAFSPDGYLLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 18424859 246 GSEDGLVFFWDLVDAKVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVWK 298
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 8.09e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.27  E-value: 8.09e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  10 EAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWDV 89
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  90 STGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRshSVEPVQIIDTFLDTVMSVVLTKTE--IIGGSVDGT 167
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 168 VRTFDMRIGREMSDNLG--QPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHisKSFKTDCCLTNSDAHVIG 245
Cdd:cd00200 159 IKLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAFSPDGYLLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 18424859 246 GSEDGLVFFWDLVDAKVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVWK 298
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-297 2.92e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 199.75  E-value: 2.92e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   8 TKEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYW 87
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  88 DVSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRShsVEPVQIIDTFLDTVMSVVLT---KTeIIGGSV 164
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRSVAFSpdgRL-LASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 165 DGTVRTFDMRIGREMS--DNLGQPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHISKSfkTDCCLTNSDAH 242
Cdd:COG2319 267 DGTVRLWDLATGELLRtlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV--RSVAFSPDGKT 344

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18424859 243 VIGGSEDGLVFFWDLVDAKVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVW 297
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 14-130 4.66e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 4.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   14 LKGHEGAVLAARFNGDGNYALTCGKDR-TIRLWNPHRGILIKTYKSHGrEVRDVHVTSDNAKFCSCG-GDRQVYYWDVST 91
Cdd:PLN00181 571 MKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVSIGTIKTKA-NICCVQFPSESGRSLAFGsADHKVYYYDLRN 649

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 18424859   92 GRV-IRKFRGHDGEVNAVKFNDSSSvVVSAGFDRSLRVWD 130
Cdd:PLN00181 650 PKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-130 7.33e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 7.33e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18424859     91 TGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWD 130
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
92-130 1.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18424859    92 GRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWD 130
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-298 8.09e-67

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 210.27  E-value: 8.09e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  10 EAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWDV 89
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  90 STGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRshSVEPVQIIDTFLDTVMSVVLTKTE--IIGGSVDGT 167
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGtfVASSSQDGT 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 168 VRTFDMRIGREMSDNLG--QPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHisKSFKTDCCLTNSDAHVIG 245
Cdd:cd00200 159 IKLWDLRTGKCVATLTGhtGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH--ENGVNSVAFSPDGYLLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 18424859 246 GSEDGLVFFWDLVDAKVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVWK 298
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-297 2.92e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 199.75  E-value: 2.92e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   8 TKEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYW 87
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  88 DVSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRShsVEPVQIIDTFLDTVMSVVLT---KTeIIGGSV 164
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRSVAFSpdgRL-LASGSA 266

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 165 DGTVRTFDMRIGREMS--DNLGQPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHISKSfkTDCCLTNSDAH 242
Cdd:COG2319 267 DGTVRLWDLATGELLRtlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV--RSVAFSPDGKT 344

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18424859 243 VIGGSEDGLVFFWDLVDAKVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVW 297
Cdd:COG2319 345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
3-297 7.02e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.80  E-value: 7.02e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   3 ATELPTKEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDR 82
Cdd:COG2319  63 LDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  83 QVYYWDVSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRSHsvEPVQIIDTFLDTVMSVVLT---KTeI 159
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSpdgKL-L 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 160 IGGSVDGTVRTFDMRIGREMS--DNLGQPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHISKSfkTDCCLT 237
Cdd:COG2319 220 ASGSADGTVRLWDLATGKLLRtlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV--NSVAFS 297

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 238 NSDAHVIGGSEDGLVFFWDLVDAKVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVW 297
Cdd:COG2319 298 PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
10-297 3.40e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 3.40e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  10 EAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWDV 89
Cdd:COG2319  28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  90 STGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDcrSHSVEPVQIIDTFLDTVMSVVLTK--TEIIGGSVDGT 167
Cdd:COG2319 108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTSVAFSPdgKLLASGSDDGT 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 168 VRTFDMRIGREMSDNLG--QPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHISKSfkTDCCLTNSDAHVIG 245
Cdd:COG2319 186 VRLWDLATGKLLRTLTGhtGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV--RSVAFSPDGRLLAS 263

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 18424859 246 GSEDGLVFFWDLVDAKVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVW 297
Cdd:COG2319 264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
9-215 4.96e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 146.59  E-value: 4.96e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   9 KEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWD 88
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  89 VSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRSHsvEPVQIIDTFLDTVMSVVLT--KTEIIGGSVDG 166
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSpdGKTLASGSDDG 352

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 18424859 167 TVRTFDMRIGREMSDNLG--QPVNCISISNDGNCVLAGCLDSTLRLLDRTT 215
Cdd:COG2319 353 TVRLWDLATGELLRTLTGhtGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-210 6.02e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.54  E-value: 6.02e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   9 KEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWD 88
Cdd:cd00200  84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  89 VSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRshSVEPVQIIDTFLDTVMSVVLTKTE--IIGGSVDG 166
Cdd:cd00200 164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNSVAFSPDGylLASGSEDG 241

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 18424859 167 TVRTFDMRIGREMSDNLG--QPVNCISISNDGNCVLAGCLDSTLRL 210
Cdd:cd00200 242 TIRVWDLRTGECVQTLSGhtNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
25-297 1.48e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 1.48e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  25 RFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWDVSTGRVIRKFRGHDGE 104
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 105 VNAVKFNDSSSVVVSAGFDRSLRVWDCRSHsvEPVQIIDTFLDTVMSVVLTK--TEIIGGSVDGTVRTFDMRIGREMS-- 180
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRtl 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859 181 DNLGQPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHisKSFKTDCCLTNSDAHVIGGSEDGLVFFWDLVDA 260
Cdd:COG2319 159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH--TGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 18424859 261 KVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVW 297
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-172 2.39e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.21  E-value: 2.39e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   9 KEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWD 88
Cdd:cd00200 126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  89 VSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDcrSHSVEPVQIIDTFLDTVMSVVL--TKTEIIGGSVDG 166
Cdd:cd00200 206 LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD--LRTGECVQTLSGHTNSVTSLAWspDGKRLASGSADG 283


                ....*.
gi 18424859 167 TVRTFD 172
Cdd:cd00200 284 TIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 14-130 4.66e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 4.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   14 LKGHEGAVLAARFNGDGNYALTCGKDR-TIRLWNPHRGILIKTYKSHGrEVRDVHVTSDNAKFCSCG-GDRQVYYWDVST 91
Cdd:PLN00181 571 MKEHEKRVWSIDYSSADPTLLASGSDDgSVKLWSINQGVSIGTIKTKA-NICCVQFPSESGRSLAFGsADHKVYYYDLRN 649

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 18424859   92 GRV-IRKFRGHDGEVNAVKFNDSSSvVVSAGFDRSLRVWD 130
Cdd:PLN00181 650 PKLpLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-130 7.33e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 7.33e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18424859     91 TGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWD 130
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 14-177 4.58e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.66  E-value: 4.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   14 LKGHEGAVLAARFNGDGNYAL-TCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWDVSTG 92
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   93 RVIRKFRGHDG-EVNAVKFNDSSSVVVSAGFD----RSLRVWDCRSHSvEPVQIIDtfLDTVMSVVL------TKTEIIG 161
Cdd:PTZ00421 201 TIVSSVEAHASaKSQRCLWAKRKDLIITLGCSksqqRQIMLWDTRKMA-SPYSTVD--LDQSSALFIpffdedTNLLYIG 277

                        170
                 ....*....|....*.
gi 18424859  162 GSVDGTVRTFDMRIGR 177
Cdd:PTZ00421 278 SKGEGNIRCFELMNER 293
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 12-46 6.60e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 6.60e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 18424859     12 HILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWN 46
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
92-130 1.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18424859    92 GRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWD 130
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
9-46 2.39e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 2.39e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18424859     9 KEAHILKGHEGAVLAARFNGDGNYALTCGKDRTIRLWN 46
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 13-136 9.48e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 9.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859   13 ILKGHEGAVLAARFNG-DGNYALTCGKDRTIRLWN-PHRGIL------IKTYKSHGREVRDV--HVTSDNAkFCSCGGDR 82
Cdd:PTZ00421  70 ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTqnisdpIVHLQGHTKKVGIVsfHPSAMNV-LASAGADM 148

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 18424859   83 QVYYWDVSTGRVIRKFRGHDGEVNAVKFNDSSSVVVSAGFDRSLRVWDCRSHSV 136
Cdd:PTZ00421 149 VVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTI 202
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 261-298 2.37e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.37e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 18424859    261 KVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVWK 298
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
261-297 2.74e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 2.74e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 18424859   261 KVLSKFRAHDLVVTSVSYHPKEDCMLTSSVDGTIRVW 297
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 105-297 4.41e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 4.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  105 VNAVKFNDSSSVVVSAGFDRSLRVWDCRShsvepvqIIDTFLDTVMSVV---------------LTKTEIIGGSVDGTVR 169
Cdd:PLN00181 486 VCAIGFDRDGEFFATAGVNKKIKIFECES-------IIKDGRDIHYPVVelasrsklsgicwnsYIKSQVASSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424859  170 TFDM---RIGREMSDNlGQPVNCISISNDGNCVLA-GCLDSTLRLLDRTTGellqVYKGHIsKSFKTDCCL---TNSDAH 242
Cdd:PLN00181 559 VWDVarsQLVTEMKEH-EKRVWSIDYSSADPTLLAsGSDDGSVKLWSINQG----VSIGTI-KTKANICCVqfpSESGRS 632

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 18424859  243 VIGGSEDGLVFFWDLVDAKV-LSKFRAHDLVVTSVSYhPKEDCMLTSSVDGTIRVW 297
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 50-88 2.00e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.00e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 18424859     50 GILIKTYKSHGREVRDVHVTSDNAKFCSCGGDRQVYYWD 88
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Nsa1 cd22858
Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from ...
 67-130 5.14e-03

Ribosome Biogenesis Protein Nsa1; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi is an essential factor for ribosome assembly. In cooperation with the assembly factor Rix7, Nsa1 participates in an early cleavage of the pre-rRNA processing pathway. Rix7 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1 from nucleolar pre-60S particles. The release of Nsa1 from a discrete preribosomal particle may trigger the progression of 60S ribosome biogenesis. Nsa1 is essential for cell viability in yeast. It contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439304  Cd Length: 399  Bit Score: 37.97  E-value: 5.14e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18424859  67 HVTSDNAKFCSCGGdrqvyywdvSTGRVIRKFRGHD--GEVNAVkFNDSSSVVVSAGFDRSLRVWD 130
Cdd:cd22858 279 LITTDSKKSVSAGD---------GKGRLLGKYGGGDitGAVSAV-DVFEDKYLATGGLDRYLRVFD 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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