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Conserved domains on  [gi|18423700|ref|NP_568819|]
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myb domain protein 120 [Arabidopsis thaliana]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 1000535)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein may be involved in the regulation of gene expression

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN03212 super family cl31985
Transcription repressor MYB5; Provisional
26-134 6.24e-47

Transcription repressor MYB5; Provisional


The actual alignment was detected with superfamily member PLN03212:

Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 163.71  E-value: 6.24e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423700   26 LKKGPWTAAEDEILAAYVRENGEGNWNAVQKNTGLARCGKSCRLRWANHLRPNLKKGSFTGDEERLIIQLHAQLGNKWAR 105
Cdd:PLN03212  23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSL 102
                         90       100       110
                 ....*....|....*....|....*....|
gi 18423700  106 MAAQLPGRTDNEIKNYWNTRL-KRLLRQGL 134
Cdd:PLN03212 103 IAGRIPGRTDNEIKNYWNTHLrKKLLRQGI 132
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
26-134 6.24e-47

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 163.71  E-value: 6.24e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423700   26 LKKGPWTAAEDEILAAYVRENGEGNWNAVQKNTGLARCGKSCRLRWANHLRPNLKKGSFTGDEERLIIQLHAQLGNKWAR 105
Cdd:PLN03212  23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSL 102
                         90       100       110
                 ....*....|....*....|....*....|
gi 18423700  106 MAAQLPGRTDNEIKNYWNTRL-KRLLRQGL 134
Cdd:PLN03212 103 IAGRIPGRTDNEIKNYWNTHLrKKLLRQGI 132
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
23-130 4.59e-18

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 87.15  E-value: 4.59e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423700  23 GVILKKGPWTAAEDEILAAYVRENGEGNWNAVQKNTGLaRCGKSCRLRWANHLRPNLKKGSFTGDEERLIIQLHAQLGNK 102
Cdd:COG5147  15 QTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ 93
                        90       100
                ....*....|....*....|....*...
gi 18423700 103 WARMAAQLPGRTDNEIKNYWNTRLKRLL 130
Cdd:COG5147  94 WSTIADYKDRRTAQQCVERYVNTLEDLS 121
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
81-126 2.77e-15

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 69.84  E-value: 2.77e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18423700    81 KGSFTGDEERLIIQLHAQLGNKWARMAAQLPGRTDNEIKNYWNTRL 126
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
81-128 3.15e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 61.09  E-value: 3.15e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 18423700     81 KGSFTGDEERLIIQLHAQLG-NKWARMAAQLPGRTDNEIKNYWNTRLKR 128
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
83-126 9.81e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 56.81  E-value: 9.81e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18423700  83 SFTGDEERLIIQLHAQLG-NKWARMAAQLPGRTDNEIKNYWNTRL 126
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
26-134 6.24e-47

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 163.71  E-value: 6.24e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423700   26 LKKGPWTAAEDEILAAYVRENGEGNWNAVQKNTGLARCGKSCRLRWANHLRPNLKKGSFTGDEERLIIQLHAQLGNKWAR 105
Cdd:PLN03212  23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSL 102
                         90       100       110
                 ....*....|....*....|....*....|
gi 18423700  106 MAAQLPGRTDNEIKNYWNTRL-KRLLRQGL 134
Cdd:PLN03212 103 IAGRIPGRTDNEIKNYWNTHLrKKLLRQGI 132
PLN03091 PLN03091
hypothetical protein; Provisional
26-132 4.51e-42

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 156.29  E-value: 4.51e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423700   26 LKKGPWTAAEDEILAAYVRENGEGNWNAVQKNTGLARCGKSCRLRWANHLRPNLKKGSFTGDEERLIIQLHAQLGNKWAR 105
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91
                         90       100
                 ....*....|....*....|....*..
gi 18423700  106 MAAQLPGRTDNEIKNYWNTRLKRLLRQ 132
Cdd:PLN03091  92 IAAQLPGRTDNEIKNLWNSCLKKKLRQ 118
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
23-130 4.59e-18

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 87.15  E-value: 4.59e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423700  23 GVILKKGPWTAAEDEILAAYVRENGEGNWNAVQKNTGLaRCGKSCRLRWANHLRPNLKKGSFTGDEERLIIQLHAQLGNK 102
Cdd:COG5147  15 QTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ 93
                        90       100
                ....*....|....*....|....*...
gi 18423700 103 WARMAAQLPGRTDNEIKNYWNTRLKRLL 130
Cdd:COG5147  94 WSTIADYKDRRTAQQCVERYVNTLEDLS 121
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
81-126 2.77e-15

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 69.84  E-value: 2.77e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 18423700    81 KGSFTGDEERLIIQLHAQLGNKWARMAAQLPGRTDNEIKNYWNTRL 126
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
81-128 3.15e-12

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 61.09  E-value: 3.15e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 18423700     81 KGSFTGDEERLIIQLHAQLG-NKWARMAAQLPGRTDNEIKNYWNTRLKR 128
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
28-75 3.08e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 58.28  E-value: 3.08e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18423700    28 KGPWTAAEDEILAAYVRENGeGNWNAVQKNTGLaRCGKSCRLRWANHL 75
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPG-RTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
28-77 5.10e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 57.62  E-value: 5.10e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 18423700     28 KGPWTAAEDEILAAYVRENGEGNWNAVQKNTGLaRCGKSCRLRWANHLRP 77
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPG-RTAEQCRERWRNLLKP 49
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
31-90 9.68e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 57.32  E-value: 9.68e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423700    31 WTAAEDEILAAYVRENGeGNWNAVQKNTGlARCGKSCRLRWANHLRPNLKKGSFTGDEER 90
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELG-RRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
83-126 9.81e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 56.81  E-value: 9.81e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18423700  83 SFTGDEERLIIQLHAQLG-NKWARMAAQLPGRTDNEIKNYWNTRL 126
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
30-75 3.93e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 55.27  E-value: 3.93e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 18423700  30 PWTAAEDEILAAYVRENGEGNWNAVQKNTGLaRCGKSCRLRWANHL 75
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPG-RTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
84-133 7.33e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 43.45  E-value: 7.33e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 18423700    84 FTGDEERLIIQLHAQLGNKWARMAAQLPGRTDNEIKNYWNTRLKRLLRQG 133
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRG 50
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
30-56 1.20e-03

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 36.78  E-value: 1.20e-03
                        10        20
                ....*....|....*....|....*..
gi 18423700  30 PWTAAEDEILAAYVRENGEGNWNAVQK 56
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWAKILK 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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