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Conserved domains on  [gi|18423398|ref|NP_568773|]
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Fibrillarin family protein [Arabidopsis thaliana]

Protein Classification

fibrillarin-like rRNA/tRNA 2'-O-methyltransferase( domain architecture ID 10472635)

fibrillarin-like rRNA/tRNA 2'-O-methyltransferase is a S-adenosyl-L-methionine (SAM)-dependent methyltransferase that is involved in pre-rRNA and tRNA processing, utilizing SAM as a methyl donor to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrillarin pfam01269
Fibrillarin;
61-289 9.07e-133

Fibrillarin;


:

Pssm-ID: 396019  Cd Length: 227  Bit Score: 375.40  E-value: 9.07e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398    61 VTPH-RHAGVFVAK-SKADA-LVTKNLVPGEIIYNEKRIFVQNEdrstvEYRVWNPHRSKLADAITTGVDNIWIKPGVKV 137
Cdd:pfam01269   1 VEPHeRFEGVYIVKlGDGDArLATKNLVPGESVYGEKLIKVEGE-----EYRVWNPFRSKLAAAILKGLKEIPIKPGSKV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398   138 LYLGASSGYTVSHVSDIVGPEGCVYAVEHSDICGKVLMNMAEKRTNVIPIIEDARHPAKYRMLVGMVDIIFSDVNHPEQA 217
Cdd:pfam01269  76 LYLGAASGTTVSHVSDIVGPEGVVYAVEFSPRVGRELINVAKKRPNIVPILEDARHPQKYRMLVEMVDVIFADVAQPDQA 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18423398   218 NILSLNASYFLKSGGHFMISIKANSIDSTIAAETVYQMEVEKLQMEELRPTEILHLDSCEEKHACVFGGYRL 289
Cdd:pfam01269 156 RILALNARYFLKEGGYFMISIKARSIDVTKEPEEVFKREVRKLKEEGFKPIEQVHLEPYEKDHAMVVGKYKR 227
 
Name Accession Description Interval E-value
Fibrillarin pfam01269
Fibrillarin;
61-289 9.07e-133

Fibrillarin;


Pssm-ID: 396019  Cd Length: 227  Bit Score: 375.40  E-value: 9.07e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398    61 VTPH-RHAGVFVAK-SKADA-LVTKNLVPGEIIYNEKRIFVQNEdrstvEYRVWNPHRSKLADAITTGVDNIWIKPGVKV 137
Cdd:pfam01269   1 VEPHeRFEGVYIVKlGDGDArLATKNLVPGESVYGEKLIKVEGE-----EYRVWNPFRSKLAAAILKGLKEIPIKPGSKV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398   138 LYLGASSGYTVSHVSDIVGPEGCVYAVEHSDICGKVLMNMAEKRTNVIPIIEDARHPAKYRMLVGMVDIIFSDVNHPEQA 217
Cdd:pfam01269  76 LYLGAASGTTVSHVSDIVGPEGVVYAVEFSPRVGRELINVAKKRPNIVPILEDARHPQKYRMLVEMVDVIFADVAQPDQA 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18423398   218 NILSLNASYFLKSGGHFMISIKANSIDSTIAAETVYQMEVEKLQMEELRPTEILHLDSCEEKHACVFGGYRL 289
Cdd:pfam01269 156 RILALNARYFLKEGGYFMISIKARSIDVTKEPEEVFKREVRKLKEEGFKPIEQVHLEPYEKDHAMVVGKYKR 227
PTZ00146 PTZ00146
fibrillarin; Provisional
 37-292 6.57e-128

fibrillarin; Provisional


Pssm-ID: 240291  Cd Length: 293  Bit Score: 365.60  E-value: 6.57e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398   37 GRGrgpgrvKSESDGGIKGG---------SKVLVTPHRHAGVFVAKSKADALVTKNLVPGEIIYNEKRIFVQNED-RSTV 106
Cdd:PTZ00146  32 GGG------RGRGRGGGGGGrgggggggpGKVIVVPHRFPGVFIAKGKSDALVTKNMVPGESVYGEKRISVEDAEgGEKI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398  107 EYRVWNPHRSKLADAITTGVDNIWIKPGVKVLYLGASSGYTVSHVSDIVGPEGCVYAVEHSDICGKVLMNMAEKRTNVIP 186
Cdd:PTZ00146 106 EYRVWNPFRSKLAAAIIGGVANIPIKPGSKVLYLGAASGTTVSHVSDLVGPEGVVYAVEFSHRSGRDLTNMAKKRPNIVP 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398  187 IIEDARHPAKYRMLVGMVDIIFSDVNHPEQANILSLNASYFLKSGGHFMISIKANSIDSTIAAETVYQMEVEKLQMEELR 266
Cdd:PTZ00146 186 IIEDARYPQKYRMLVPMVDVIFADVAQPDQARIVALNAQYFLKNGGHFIISIKANCIDSTAKPEVVFASEVQKLKKEGLK 265

                        250       260
                 ....*....|....*....|....*.
gi 18423398  267 PTEILHLDSCEEKHACVFGGYRLPRK 292
Cdd:PTZ00146 266 PKEQLTLEPFERDHAVVIGVYRPVKK 291
NOP1 COG1889
Fibrillarin-like rRNA 2'-O-methylase NOP1 [Translation, ribosomal structure and biogenesis];
68-288 7.85e-82

Fibrillarin-like rRNA 2'-O-methylase NOP1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441493  Cd Length: 222  Bit Score: 245.88  E-value: 7.85e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398  68 GVF-VAKSKADALVTKNLVPGEIIYNEKRIFVQNedrstVEYRVWNPHRSKLADAITTGVDNIWIKPGVKVLYLGASSGY 146
Cdd:COG1889   7 GVYrVEFDGEKRLATKNLVPGKRVYGERLIKIEG-----VEYREWDPRRSKLAAAILKGLKELPIKEGSKVLYLGAASGT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398 147 TVSHVSDIVgPEGCVYAVEHSDICGKVLMNMAEKRTNVIPIIEDARHPAKYRMLVGMVDIIFSDVNHPEQANILSLNASY 226
Cdd:COG1889  82 TVSHVSDIV-PEGPVYAVEFAPRVMRDLLEVAESRPNIIPILADARKPEEYAHVVEKVDVIYQDVAQPNQAEIAIKNADF 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18423398 227 FLKSGGHFMISIKANSIDSTIAAETVYQMEVEKLQMEELRPTEILHLDSCEEKHACVFGGYR 288
Cdd:COG1889 161 FLKKGGYLLLAIKARSIDVTKDPKEIFKEEIRKLEERGFEILEIIDLEPYHKDHLMVVARKK 222
 
Name Accession Description Interval E-value
Fibrillarin pfam01269
Fibrillarin;
61-289 9.07e-133

Fibrillarin;


Pssm-ID: 396019  Cd Length: 227  Bit Score: 375.40  E-value: 9.07e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398    61 VTPH-RHAGVFVAK-SKADA-LVTKNLVPGEIIYNEKRIFVQNEdrstvEYRVWNPHRSKLADAITTGVDNIWIKPGVKV 137
Cdd:pfam01269   1 VEPHeRFEGVYIVKlGDGDArLATKNLVPGESVYGEKLIKVEGE-----EYRVWNPFRSKLAAAILKGLKEIPIKPGSKV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398   138 LYLGASSGYTVSHVSDIVGPEGCVYAVEHSDICGKVLMNMAEKRTNVIPIIEDARHPAKYRMLVGMVDIIFSDVNHPEQA 217
Cdd:pfam01269  76 LYLGAASGTTVSHVSDIVGPEGVVYAVEFSPRVGRELINVAKKRPNIVPILEDARHPQKYRMLVEMVDVIFADVAQPDQA 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18423398   218 NILSLNASYFLKSGGHFMISIKANSIDSTIAAETVYQMEVEKLQMEELRPTEILHLDSCEEKHACVFGGYRL 289
Cdd:pfam01269 156 RILALNARYFLKEGGYFMISIKARSIDVTKEPEEVFKREVRKLKEEGFKPIEQVHLEPYEKDHAMVVGKYKR 227
PTZ00146 PTZ00146
fibrillarin; Provisional
 37-292 6.57e-128

fibrillarin; Provisional


Pssm-ID: 240291  Cd Length: 293  Bit Score: 365.60  E-value: 6.57e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398   37 GRGrgpgrvKSESDGGIKGG---------SKVLVTPHRHAGVFVAKSKADALVTKNLVPGEIIYNEKRIFVQNED-RSTV 106
Cdd:PTZ00146  32 GGG------RGRGRGGGGGGrgggggggpGKVIVVPHRFPGVFIAKGKSDALVTKNMVPGESVYGEKRISVEDAEgGEKI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398  107 EYRVWNPHRSKLADAITTGVDNIWIKPGVKVLYLGASSGYTVSHVSDIVGPEGCVYAVEHSDICGKVLMNMAEKRTNVIP 186
Cdd:PTZ00146 106 EYRVWNPFRSKLAAAIIGGVANIPIKPGSKVLYLGAASGTTVSHVSDLVGPEGVVYAVEFSHRSGRDLTNMAKKRPNIVP 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398  187 IIEDARHPAKYRMLVGMVDIIFSDVNHPEQANILSLNASYFLKSGGHFMISIKANSIDSTIAAETVYQMEVEKLQMEELR 266
Cdd:PTZ00146 186 IIEDARYPQKYRMLVPMVDVIFADVAQPDQARIVALNAQYFLKNGGHFIISIKANCIDSTAKPEVVFASEVQKLKKEGLK 265

                        250       260
                 ....*....|....*....|....*.
gi 18423398  267 PTEILHLDSCEEKHACVFGGYRLPRK 292
Cdd:PTZ00146 266 PKEQLTLEPFERDHAVVIGVYRPVKK 291
NOP1 COG1889
Fibrillarin-like rRNA 2'-O-methylase NOP1 [Translation, ribosomal structure and biogenesis];
68-288 7.85e-82

Fibrillarin-like rRNA 2'-O-methylase NOP1 [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441493  Cd Length: 222  Bit Score: 245.88  E-value: 7.85e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398  68 GVF-VAKSKADALVTKNLVPGEIIYNEKRIFVQNedrstVEYRVWNPHRSKLADAITTGVDNIWIKPGVKVLYLGASSGY 146
Cdd:COG1889   7 GVYrVEFDGEKRLATKNLVPGKRVYGERLIKIEG-----VEYREWDPRRSKLAAAILKGLKELPIKEGSKVLYLGAASGT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398 147 TVSHVSDIVgPEGCVYAVEHSDICGKVLMNMAEKRTNVIPIIEDARHPAKYRMLVGMVDIIFSDVNHPEQANILSLNASY 226
Cdd:COG1889  82 TVSHVSDIV-PEGPVYAVEFAPRVMRDLLEVAESRPNIIPILADARKPEEYAHVVEKVDVIYQDVAQPNQAEIAIKNADF 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18423398 227 FLKSGGHFMISIKANSIDSTIAAETVYQMEVEKLQMEELRPTEILHLDSCEEKHACVFGGYR 288
Cdd:COG1889 161 FLKKGGYLLLAIKARSIDVTKDPKEIFKEEIRKLEERGFEILEIIDLEPYHKDHLMVVARKK 222
PRK04266 PRK04266
fibrillarin-like rRNA/tRNA 2'-O-methyltransferase;
61-288 1.31e-77

fibrillarin-like rRNA/tRNA 2'-O-methyltransferase;


Pssm-ID: 235267  Cd Length: 226  Bit Score: 235.55  E-value: 1.31e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398   61 VTPHRHAGVFVAKSKADA--LVTKNLVPGEIIYNEKRIFVQNedrstVEYRVWNPHRSKLADAITTGVDNIWIKPGVKVL 138
Cdd:PRK04266   3 KKKEIFEGVYEVEFEDGSkrLATKNLVPGKRVYGERLIKWEG-----VEYREWNPRRSKLAAAILKGLKNFPIKKGSKVL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398  139 YLGASSGYTVSHVSDIVGpEGCVYAVEHSDICGKVLMNMAEKRTNVIPIIEDARHPAKYRMLVGMVDIIFSDVNHPEQAN 218
Cdd:PRK04266  78 YLGAASGTTVSHVSDIVE-EGVVYAVEFAPRPMRELLEVAEERKNIIPILADARKPERYAHVVEKVDVIYQDVAQPNQAE 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398  219 ILSLNASYFLKSGGHFMISIKANSIDSTIAAETVYQMEVEKLQMEELRPTEILHLDSCEEKHACVFGGYR 288
Cdd:PRK04266 157 IAIDNAEFFLKDGGYLLLAIKARSIDVTKDPKEIFKEEIRKLEEGGFEILEVVDLEPYHKDHAAVVARKK 226
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
131-192 8.38e-04

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 39.66  E-value: 8.38e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18423398   131 IKPGVKVLYLGASSGYTVSHVSDIVGPEGCVYAVEHSdicgKVLMNMAEKR------TNVIPIIEDAR 192
Cdd:pfam01135  71 LKPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHI----PELVEIARRNleklglENVIVVVGDGR 134
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 131-236 1.26e-03

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 39.37  E-value: 1.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18423398 131 IKPGVKVLYLGASSGYTVSHVSDIVGPEGCVYAVE----HSDICGKVL--MNMAEkrtNVIPIIEDARHPakyrMLVGMV 204
Cdd:COG2519  89 IFPGARVLEAGTGSGALTLALARAVGPEGKVYSYErredFAEIARKNLerFGLPD---NVELKLGDIREG----IDEGDV 161

                        90       100       110
                ....*....|....*....|....*....|...
gi 18423398 205 DIIFSDVNHPEQAnilsLNASY-FLKSGGHFMI 236
Cdd:COG2519 162 DAVFLDMPDPWEA----LEAVAkALKPGGVLVA 190
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 131-190 1.62e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 38.84  E-value: 1.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18423398  131 IKPGVKVLYLGASSGYTVSHVSDIVGPEGCVYAVEHSdicgKVLMNMAEKR------TNVIPIIED 190
Cdd:PRK13942  74 LKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERI----PELAEKAKKTlkklgyDNVEVIVGD 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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