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Conserved domains on  [gi|18421605|ref|NP_568545|]
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HIT-type Zinc finger family protein [Arabidopsis thaliana]

Protein Classification

zinc finger HIT domain-containing protein( domain architecture ID 19137923)

zinc finger HIT domain-containing protein may be involved in Box C/D snoRNP Biogenesis

CATH:  3.30.60.190
Gene Ontology:  GO:0046872
PubMed:  27139642

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-HIT_ZNHIT1_like cd21437
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ...
 125-166 2.85e-20

HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion.


:

Pssm-ID: 467791  Cd Length: 43  Bit Score: 78.82  E-value: 2.85e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18421605 125 PSSSSRRYFCSVCGYIAGYNCCLCGMRFCSIRCQNIHKDTRC 166
Cdd:cd21437   1 PSRLPPRKFCSVCGYWGKYTCVRCGARYCSLKCLETHNETRC 42
 
Name Accession Description Interval E-value
zf-HIT_ZNHIT1_like cd21437
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ...
 125-166 2.85e-20

HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion.


Pssm-ID: 467791  Cd Length: 43  Bit Score: 78.82  E-value: 2.85e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18421605 125 PSSSSRRYFCSVCGYIAGYNCCLCGMRFCSIRCQNIHKDTRC 166
Cdd:cd21437   1 PSRLPPRKFCSVCGYWGKYTCVRCGARYCSLKCLETHNETRC 42
zf-HIT pfam04438
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ...
 130-159 1.31e-07

HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor.


Pssm-ID: 461310  Cd Length: 30  Bit Score: 45.70  E-value: 1.31e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 18421605   130 RRYFCSVCGYIAGYNCCLCGMRFCSIRCQN 159
Cdd:pfam04438   1 PRKLCSVCGNPSKYRCPRCGVRYCSLECYK 30
 
Name Accession Description Interval E-value
zf-HIT_ZNHIT1_like cd21437
HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar ...
 125-166 2.85e-20

HIT zinc finger found in zinc finger HIT domain-containing protein 1 (ZNHIT1) and similar proteins; The family includes ZNHIT1 and its yeast counterpart, the vacuolar protein sorting-associated protein 71 (Vps71p). ZNHIT1, also known as cyclin-G1-binding protein 1 (CGBP1), zinc finger protein subfamily 4A member 1 (ZNFN4A1), or p18 Hamlet, may have a role in inducing apoptosis through p53 signaling. It binds to Rev-erb beta and releases its inhibitory effect on the transcription of apolipoprotein C3 (APOC3) without affecting its DNA-binding activity. The yeast counterpart Vps71p, also referred to as SWR complex protein 6 (Swc6p), plays a role in the exchange of histone H2A for the H2A variant HZT1, a euchromatin-specific factor, leading to chromatin remodeling and transcriptional changes of targeted genes. It is indirectly involved in vacuolar protein sorting. Members of this family contain a zf-HIT domain characterized by a "treble-clef" fold through interleaved CCCC and CCHC zinc finger motifs, both of which bind a zinc ion.


Pssm-ID: 467791  Cd Length: 43  Bit Score: 78.82  E-value: 2.85e-20
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 18421605 125 PSSSSRRYFCSVCGYIAGYNCCLCGMRFCSIRCQNIHKDTRC 166
Cdd:cd21437   1 PSRLPPRKFCSVCGYWGKYTCVRCGARYCSLKCLETHNETRC 42
zf-HIT pfam04438
HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could ...
 130-159 1.31e-07

HIT zinc finger; This presumed zinc finger contains up to 6 cysteine residues that could coordinate zinc. The domain is named after the HIT protein. This domain is also found in the Thyroid receptor interacting protein 3 (TRIP-3) that specifically interact with the ligand binding domain of the thyroid receptor.


Pssm-ID: 461310  Cd Length: 30  Bit Score: 45.70  E-value: 1.31e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 18421605   130 RRYFCSVCGYIAGYNCCLCGMRFCSIRCQN 159
Cdd:pfam04438   1 PRKLCSVCGNPSKYRCPRCGVRYCSLECYK 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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