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Conserved domains on  [gi|42568139|ref|NP_568527|]
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DENN (AEX-3) domain-containing protein [Arabidopsis thaliana]

Protein Classification

uDENN and DENN domain-containing protein( domain architecture ID 10506699)

protein containing domains uDENN, DENN, and dDENN

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 455-639 1.61e-30

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214823  Cd Length: 183  Bit Score: 118.45  E-value: 1.61e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139    455 KSKKNGSLQILCEYYQLKCPARGSTITFHPLEHLHPVEYHRPnevalhtpgsaidlrsCSTSLELaeahttlmaeeeaaa 534
Cdd:smart00799  29 PSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPGDLIELQRP----------------LDSSLPL--------------- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139    535 lSTWAVASLCGSLRLDNVLMILAGALLEKQIVFVCSNLGILAASVLSIIPVIRPFRWQSLLMPVLPDDMLEFLDAPVPYI 614
Cdd:smart00799  78 -IDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFI 156

                          170       180
                   ....*....|....*....|....*..
gi 42568139    615 VGVKNKTSEVQSKLTN--VIVVDILKN 639
Cdd:smart00799 157 IGVHSSYFEEVKELPDedVVVVDLDTG 183
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 160-237 5.74e-06

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


:

Pssm-ID: 460926  Cd Length: 59  Bit Score: 44.14  E-value: 5.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42568139   160 PQVLLVYPPDKQP-PIKYKDLHSFCFPGGIEVHaVERTPSmselseiilsqehlrpsdlSFVFRLQVADNSTLYGCCLL 237
Cdd:pfam03456   1 PEVLDRYPEDDWSdPPLPDGIPMFCFPEGLETL-SSREPT-------------------FFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 727-763 6.08e-05

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


:

Pssm-ID: 460925  Cd Length: 48  Bit Score: 41.03  E-value: 6.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 42568139   727 KESFIDSFPSRQRPFMKLFVDTQLFSvhtdlvlSFIQ 763
Cdd:pfam03455   3 KEAFLKSLPSDSRPFLSQFLETQMFN-------EFIE 32
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 455-639 1.61e-30

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 118.45  E-value: 1.61e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139    455 KSKKNGSLQILCEYYQLKCPARGSTITFHPLEHLHPVEYHRPnevalhtpgsaidlrsCSTSLELaeahttlmaeeeaaa 534
Cdd:smart00799  29 PSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPGDLIELQRP----------------LDSSLPL--------------- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139    535 lSTWAVASLCGSLRLDNVLMILAGALLEKQIVFVCSNLGILAASVLSIIPVIRPFRWQSLLMPVLPDDMLEFLDAPVPYI 614
Cdd:smart00799  78 -IDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFI 156

                          170       180
                   ....*....|....*....|....*..
gi 42568139    615 VGVKNKTSEVQSKLTN--VIVVDILKN 639
Cdd:smart00799 157 IGVHSSYFEEVKELPDedVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 547-639 2.21e-17

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 80.69  E-value: 2.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139   547 LRLDNVLMILAGALLEKQIVFVCSNLGILAASVLSIIPVIRPFRWQSLLMPVLPDDMLEFLDAPVPYIVGVKNKTSEVQS 626
Cdd:pfam02141  93 LSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLLE 172

                          90
                  ....*....|....
gi 42568139   627 K-LTNVIVVDILKN 639
Cdd:pfam02141 173 DpLDDVVLVDLDTG 186
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 160-237 5.74e-06

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 44.14  E-value: 5.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42568139   160 PQVLLVYPPDKQP-PIKYKDLHSFCFPGGIEVHaVERTPSmselseiilsqehlrpsdlSFVFRLQVADNSTLYGCCLL 237
Cdd:pfam03456   1 PEVLDRYPEDDWSdPPLPDGIPMFCFPEGLETL-SSREPT-------------------FFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 727-763 6.08e-05

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 41.03  E-value: 6.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 42568139   727 KESFIDSFPSRQRPFMKLFVDTQLFSvhtdlvlSFIQ 763
Cdd:pfam03455   3 KEAFLKSLPSDSRPFLSQFLETQMFN-------EFIE 32
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 712-752 1.47e-04

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 40.74  E-value: 1.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 42568139    712 ITNVQSNNDKVSLLLKESFIDSFPSRQRPFMKLFVDTQLFS 752
Cdd:smart00801  23 LRELRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFS 63
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 105-238 3.01e-04

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 40.40  E-value: 3.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139    105 PSRLFESVVVVGLHPncDIQALERQYiarksegssgrlrsalvsqnhsrvepslEPQVLLVYPP-DKQPPIKYKDLHSFC 183
Cdd:smart00800   1 PSRLFDYFVVVGLDS--DTGPLGRSY----------------------------KPEILQRYPEkDFEDFPLPDSIPLFC 50

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 42568139    184 FPGGIEVHavertpsmselseiilSQEHLRPSDlSFVFRLQVADNSTLYGCCLLV 238
Cdd:smart00800  51 FPEGLDFV----------------TQTSSKDPQ-FFSFVLTDIDGSRRYGFCLRF 88
 
Name Accession Description Interval E-value
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 455-639 1.61e-30

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 118.45  E-value: 1.61e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139    455 KSKKNGSLQILCEYYQLKCPARGSTITFHPLEHLHPVEYHRPnevalhtpgsaidlrsCSTSLELaeahttlmaeeeaaa 534
Cdd:smart00799  29 PSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPGDLIELQRP----------------LDSSLPL--------------- 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139    535 lSTWAVASLCGSLRLDNVLMILAGALLEKQIVFVCSNLGILAASVLSIIPVIRPFRWQSLLMPVLPDDMLEFLDAPVPYI 614
Cdd:smart00799  78 -IDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFI 156

                          170       180
                   ....*....|....*....|....*..
gi 42568139    615 VGVKNKTSEVQSKLTN--VIVVDILKN 639
Cdd:smart00799 157 IGVHSSYFEEVKELPDedVVVVDLDTG 183
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 547-639 2.21e-17

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 80.69  E-value: 2.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139   547 LRLDNVLMILAGALLEKQIVFVCSNLGILAASVLSIIPVIRPFRWQSLLMPVLPDDMLEFLDAPVPYIVGVKNKTSEVQS 626
Cdd:pfam02141  93 LSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFIIGVHSRYFDLLE 172

                          90
                  ....*....|....
gi 42568139   627 K-LTNVIVVDILKN 639
Cdd:pfam02141 173 DpLDDVVLVDLDTG 186
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 160-237 5.74e-06

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 44.14  E-value: 5.74e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 42568139   160 PQVLLVYPPDKQP-PIKYKDLHSFCFPGGIEVHaVERTPSmselseiilsqehlrpsdlSFVFRLQVADNSTLYGCCLL 237
Cdd:pfam03456   1 PEVLDRYPEDDWSdPPLPDGIPMFCFPEGLETL-SSREPT-------------------FFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 727-763 6.08e-05

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 41.03  E-value: 6.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 42568139   727 KESFIDSFPSRQRPFMKLFVDTQLFSvhtdlvlSFIQ 763
Cdd:pfam03455   3 KEAFLKSLPSDSRPFLSQFLETQMFN-------EFIE 32
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 712-752 1.47e-04

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 40.74  E-value: 1.47e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 42568139    712 ITNVQSNNDKVSLLLKESFIDSFPSRQRPFMKLFVDTQLFS 752
Cdd:smart00801  23 LRELRKEPGPVITFDKESFLKSRPSSERPFLSKFLETQMFS 63
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 105-238 3.01e-04

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 40.40  E-value: 3.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42568139    105 PSRLFESVVVVGLHPncDIQALERQYiarksegssgrlrsalvsqnhsrvepslEPQVLLVYPP-DKQPPIKYKDLHSFC 183
Cdd:smart00800   1 PSRLFDYFVVVGLDS--DTGPLGRSY----------------------------KPEILQRYPEkDFEDFPLPDSIPLFC 50

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 42568139    184 FPGGIEVHavertpsmselseiilSQEHLRPSDlSFVFRLQVADNSTLYGCCLLV 238
Cdd:smart00800  51 FPEGLDFV----------------TQTSSKDPQ-FFSFVLTDIDGSRRYGFCLRF 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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