|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
7-974 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 1949.36 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 7 FSLPTPTTTLLSPSSPHQLNTLFFTRRRRRLISPSRLNSIFSQrrfsfsAAASGNNVFTSPETSKTFDFSSEEKIYKWWE 86
Cdd:PLN02943 1 MALSRPSSALLSCSSIRRLNPLLLSACRRRAWAPRRAARRFCA------AAASENDVFTSPETAKSFDFTSEERIYNWWE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 87 SQGYFKPNFDQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHAGIATQLVVEKMLASEGI 166
Cdd:PLN02943 75 SQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKMLASEGI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 167 KRVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDKGLIYQGSYMVNWSPNLQ 246
Cdd:PLN02943 155 KRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQ 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 247 TAVSDLEVEYSEEPGFLYHIKYRVAGSP-DFLTIATTRPETLFGDVALAVHPEDDRYSKYVGQTAIVPMTYGRHVPIIAD 325
Cdd:PLN02943 235 TAVSDLEVEYSEEPGTLYYIKYRVAGGSeDFLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMTYGRHVPIIAD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 326 KYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDATLNDVAGLFcgldRFEVREKLWADLEEIGLAVKKEPHTL 405
Cdd:PLN02943 315 RYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAGLY----WFEAREKLWSDLEETGLAVKKEPHTL 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 406 RVPRSQRGGEVIEPLVSKQWFVHMDPLAEKALLAVENKELTIIPERFEKIYNHWLTNIKDWCISRQLWWGHRIPVWYVVG 485
Cdd:PLN02943 391 RVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIPVWYIVG 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 486 KDCEEDYIVAKSAEEALEKALEKYGKDVEIYQDPDVLDTWFSSSLWPFSTLGWPDVAAKDFNNFYPTNMLETGHDILFFW 565
Cdd:PLN02943 471 KDCEEDYIVARSAEEALEKAREKYGKDVEIYQDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLETGHDILFFW 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 566 VARMVMMGIEFTGTVPFSHVYLHGLIRDSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIALGTAGQDLNLSTERLTANK 645
Cdd:PLN02943 551 VARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTAGQDLNLSTERLTSNK 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 646 AFTNKLWNAGKFVLHSLPSLSDTSAWENLLDLKLDKEETLLSLPLPECWAVSKLHILIDSVTASYEKLFFGDVGRETYDF 725
Cdd:PLN02943 631 AFTNKLWNAGKFVLQNLPSQSDTSAWEHILACKFDKEESLLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDF 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 726 FWSDFADWYIEASKSRLYGSGGNSVSLASQAVLLYVFENILKLLHPFMPFVTEDLWQALPYRKEALIVSPWPQNSLPRNV 805
Cdd:PLN02943 711 FWSDFADWYIEASKTRLYHSGDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYRKEALIVSPWPQTSLPKDL 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 806 ESIKRFENLQALTRAIRNARAEYSVEPVKRISASVVGSAEVIEYISKEKEVLALLSRLDLNNVHFSNAPPGDANLSVHLV 885
Cdd:PLN02943 791 KSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVASAEVIEYISKEKEVLALLSRLDLQNVHFTDSPPGDANQSVHLV 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 886 ASEGLEAYLPLAAMVDISSEVQRISKRLSKMQTEYDALITRLSSPKFVEKAPEEVVRGVKEQVEELEEKIKLTKARLDFL 965
Cdd:PLN02943 871 ASEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAEAEEKIKLTKNRLAFL 950
|
....*....
gi 334187718 966 KStTSLVSQ 974
Cdd:PLN02943 951 KS-TSLVSQ 958
|
|
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
70-966 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1402.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 70 SKTFDFSS-EEKIYKWWESQGYFKPNFDQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDH 148
Cdd:COG0525 4 PKTYDPKEvEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTDH 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 149 AGIATQLVVEKMLASEGIKRVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHD 228
Cdd:COG0525 84 AGIATQAVVERQLAEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYE 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 229 KGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGFLYHIKYRVAGSPDFLTIATTRPETLFGDVALAVHPEDDRYSKYVGQ 308
Cdd:COG0525 164 KGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADGSGYIVVATTRPETMLGDTAVAVHPEDERYKHLIGK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 309 TAIVPMTyGRHVPIIADKYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDATLNDVAGLFCGLDRFEVREKLW 388
Cdd:COG0525 244 TVILPLV-GREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKYRGLDRFEARKAIV 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 389 ADLEEIGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVHMDPLAEKALLAVENKELTIIPERFEKIYNHWLTNIKDWCI 468
Cdd:COG0525 323 ADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDGEIKFVPERWEKTYFHWMENIRDWCI 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 469 SRQLWWGHRIPVWYvvgkdCEE-DYIVAKSAEEALEKAlekygKDVEIYQDPDVLDTWFSSSLWPFSTLGWPDvAAKDFN 547
Cdd:COG0525 403 SRQLWWGHRIPAWY-----CPDgEVYVARTEPEACAKA-----GSVNLTQDEDVLDTWFSSALWPFSTLGWPE-KTEDLK 471
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 548 NFYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVYLHGLIRDSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIAL 627
Cdd:COG0525 472 YFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAA 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 628 G-TAGQDLNLSTERLTANKAFTNKLWNAGKFVLHslpslsdtsaweNLLDLKLDKEETLLSLPLPECWAVSKLHILIDSV 706
Cdd:COG0525 552 LaSPGRDIKFDEERVEGYRNFANKLWNASRFVLM------------NLEGFDPGLDPDPEELSLADRWILSRLNKTIAEV 619
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 707 TASYEKLFFGDVGRETYDFFWSDFADWYIEASKSRLYGsGGNSVSLASQAVLLYVFENILKLLHPFMPFVTEDLWQALPY 786
Cdd:COG0525 620 TEALEKYRFDEAAQALYDFVWNEFCDWYLELAKPRLYG-GDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPP 698
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 787 RK--EALIVSPWPQ-NSLPRNVESIKRFENLQALTRAIRNARAEYSVEPVKRISASVVG-SAEVIEYISKEKEVLALLSR 862
Cdd:COG0525 699 RKegESIMLAPWPEaDEELIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGaDEADRARLEENAAYIKRLAR 778
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 863 LDlnNVHF-SNAPPGDAnlsVHLVAsEGLEAYLPLAAMVDISSEVQRISKRLSKMQTEYDALITRLSSPKFVEKAPEEVV 941
Cdd:COG0525 779 LE--EITIlVDEKPEGA---ASAVV-GGAEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVV 852
|
890 900
....*....|....*....|....*
gi 334187718 942 RGVKEQVEELEEKIKLTKARLDFLK 966
Cdd:COG0525 853 EKEREKLAEAEAKLEKLEEQLARLK 877
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
65-967 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1350.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 65 TSPETSKTFDFSS-EEKIYKWWESQGYFKPNfDQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWL 143
Cdd:PRK05729 1 MMMELPKTYDPKEvEAKWYQKWEEKGYFKPD-DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 144 PGTDHAGIATQLVVEKMLASEGIKRVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAF 223
Cdd:PRK05729 80 PGTDHAGIATQMVVERQLAAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 224 VKLHDKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGFLYHIKYRVAGSPDFLTIATTRPETLFGDVALAVHPEDDRYS 303
Cdd:PRK05729 160 VRLYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADGSDYLVVATTRPETMLGDTAVAVNPEDERYK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 304 KYVGQTAIVPMTyGRHVPIIADKYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDATLNDVAGLFCGLDRFEV 383
Cdd:PRK05729 240 HLIGKTVILPLV-GREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGLDRFEA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 384 REKLWADLEEIGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVHMDPLAEKALLAVENKELTIIPERFEKIYNHWLTNI 463
Cdd:PRK05729 319 RKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENGEIKFVPERWEKTYFHWMENI 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 464 KDWCISRQLWWGHRIPVWYvvGKDCEEdyIVAKSAEEALEKALekygkdveIYQDPDVLDTWFSSSLWPFSTLGWPDvAA 543
Cdd:PRK05729 399 QDWCISRQLWWGHRIPAWY--DEDGEV--YVGREEPEAREKAL--------LTQDEDVLDTWFSSALWPFSTLGWPE-KT 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 544 KDFNNFYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVYLHGLIRDSQGRKMSKSLGNVIDPLDTIKDFGTDALRF 623
Cdd:PRK05729 466 EDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRF 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 624 TIALG-TAGQDLNLSTERLTANKAFTNKLWNAGKFVLhslpslsdtsawENLLDLKLDKEETLLSLPLPECWAVSKLHIL 702
Cdd:PRK05729 546 TLAALaSPGRDIRFDEERVEGYRNFANKLWNASRFVL------------MNLEGADVGELPDPEELSLADRWILSRLNRT 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 703 IDSVTASYEKLFFGDVGRETYDFFWSDFADWYIEASKSRLYGSGGNsvslASQAVLLYVFENILKLLHPFMPFVTEDLWQ 782
Cdd:PRK05729 614 VAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELAKPVLQEAAKR----ATRATLAYVLEQILRLLHPFMPFITEELWQ 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 783 ALPYR--KEALIVSPWPQNSLPRNVESIKRFENLQALTRAIRNARAEYSVEPVKRISASVVG-SAEVIEYISKEKEVLAL 859
Cdd:PRK05729 690 KLAPLgiEESIMLAPWPEADEAIDEAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGaDAEDRARLEANEAYIKR 769
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 860 LSRLD-LNNVHFSNAPPGDANLSVhlvaSEGLEAYLPLAAMVDISSEVQRISKRLSKMQTEYDALITRLSSPKFVEKAPE 938
Cdd:PRK05729 770 LARLEsLEILADDEEAPEGAASAV----VGGAELFLPLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPE 845
|
890 900
....*....|....*....|....*....
gi 334187718 939 EVVRGVKEQVEELEEKIKLTKARLDFLKS 967
Cdd:PRK05729 846 EVVEKEREKLAEYEEKLAKLKERLARLKA 874
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
71-949 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1060.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 71 KTFDFSS-EEKIYKWWESQGYFKPNFDQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHA 149
Cdd:TIGR00422 3 KDYDPHEvEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 150 GIATQLVVEKMLASEGIKRVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDK 229
Cdd:TIGR00422 83 GIATQVKVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 230 GLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGFLYHIKYRVA-GSPDFLTIATTRPETLFGDVALAVHPEDDRYSKYVGQ 308
Cdd:TIGR00422 163 GLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLAnGSKDYLVVATTRPETMFGDTAVAVHPEDERYKHLIGK 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 309 TAIVPMTyGRHVPIIADKYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDATLNDVAGLFCGLDRFEVREKLW 388
Cdd:TIGR00422 243 KVILPLT-GRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKIV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 389 ADLEEIGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVHMDPLAEKALLAVENKELTIIPERFEKIYNHWLTNIKDWCI 468
Cdd:TIGR00422 322 EDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEGEIKFVPKRMEKRYLNWLRNIKDWCI 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 469 SRQLWWGHRIPVWYVvgKDCEEdYIVAKsaEEALEKALEKYGKDVEIYQDPDVLDTWFSSSLWPFSTLGWPDVaAKDFNN 548
Cdd:TIGR00422 402 SRQLIWGHRIPVWYC--KECGE-VYVAK--EEPLPDDKTNTGPSVELEQDTDVLDTWFSSSLWPFSTLGWPDE-TKDLKK 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 549 FYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVYLHGLIRDSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIA-L 627
Cdd:TIGR00422 476 FYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLAsL 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 628 GTAGQDLNLSTERLTANKAFTNKLWNAGKFVLHslpslsdtsawenLLDLKLDKEETLLSLPLPECWAVSKLHILIDSVT 707
Cdd:TIGR00422 556 VTPGDDINFDWKRVESARNFLNKLWNASRFVLM-------------NLSDDLELSGGEEKLSLADRWILSKLNRTIKEVR 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 708 ASYEKLFFGDVGRETYDFFWSDFADWYIEASKSRLYGsGGNSVSLASQAVLLYVFENILKLLHPFMPFVTEDLWQALPYR 787
Cdd:TIGR00422 623 KALDKYRFAEAAKALYEFIWNDFCDWYIELVKYRLYN-GNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEG 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 788 KEALIVSPWPQ-NSLPRNVESIKRFENLQALTRAIRNARAEYSVEPVKRISASVVGS-AEVIEYISKEKEVLALLsrLDL 865
Cdd:TIGR00422 702 ADSIMLQSYPVvDAEFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTeAETAERLKLNAVDIKGA--INF 779
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 866 NNVHF-SNAPPGDANLsvhLVASEGLEAYLPLAAMVDISSEVQRISKRLSKMQTEYDALITRLSSPKFVEKAPEEVVRGV 944
Cdd:TIGR00422 780 SEVEVvIEKPEVTEAV---VELVPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKE 856
|
....*
gi 334187718 945 KEQVE 949
Cdd:TIGR00422 857 KEKLE 861
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
67-958 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1027.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 67 PETSKTFDFSS-EEKIYKWWESQGYFKPNFDQG----GSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTL 141
Cdd:PTZ00419 22 SSMAASYDPKEvESGWYEWWEKSGFFKPAEDAKslnsGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 142 WLPGTDHAGIATQLVVEKMLA-SEGIKRVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVV 220
Cdd:PTZ00419 102 WVPGTDHAGIATQVVVEKKLMkEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 221 EAFVKLHDKGLIYQGSYMVNWSPNLQTAVSDLEVEYSE----------------EPGFLYHIKYRVAGSPDF-LTIATTR 283
Cdd:PTZ00419 182 EAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEiekptkitipgydkkvEVGVLWHFAYPLEDSGQEeIVVATTR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 284 PETLFGDVALAVHPEDDRYSKYVGQTAIVPMTYGRHVPIIAD-KYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVM 362
Cdd:PTZ00419 262 IETMLGDVAVAVHPKDERYKKLHGKELIHPFIPDRKIPIIADdELVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIF 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 363 NKDATLNDVAGLFCGLDRFEVREKLWADLEEIGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVHMDPLAEKALLAVEN 442
Cdd:PTZ00419 342 TLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRN 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 443 KELTIIPERFEKIYNHWLTNIKDWCISRQLWWGHRIPVWYVVGKDC------EEDYIVAKSAEEALEKALEKYG---KDV 513
Cdd:PTZ00419 422 GELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGPetdpsdEEPWVVARSEEEALEKAKKKFGlseEDF 501
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 514 EIYQDPDVLDTWFSSSLWPFSTLGWPDvAAKDFNNFYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVYLHGLIRD 593
Cdd:PTZ00419 502 ELEQDEDVLDTWFSSGLFPFSTLGWPD-QTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHAMVRD 580
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 594 SQGRKMSKSLGNVIDPLDTI------------------------------KDF-------GTDALRFTI-ALGTAGQDLN 635
Cdd:PTZ00419 581 SQGEKMSKSKGNVIDPLEVIegislqdlnqklyegnlpekeikraielqkKEFpngipecGTDALRFGLlAYTQQGRNIN 660
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 636 LSTERLTANKAFTNKLWNAGKFVLHSLPSLsdtsawENLLDLKLDKEETLLSLPLPECWAVSKLHILIDSVTASYEKLFF 715
Cdd:PTZ00419 661 LDINRVVGYRHFCNKLWNAVKFALMKLLKD------FNLPNSTLFKPNNVESLPWEDKWILHRLNVAIKEVTEGFKEYDF 734
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 716 GDVGRETYDFFWSDFADWYIEASKSRLYGSGGNSVSLASQAVLLYVFENILKLLHPFMPFVTEDLWQALP---YRKEALI 792
Cdd:PTZ00419 735 SEATQATYNFWLYELCDVYLELIKPRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPnylRKSESIS 814
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 793 VSPWPQNSLPRNVESI-KRFENLQALTRAIRNARAEYSVEPVKRISASVVG-SAEVIEYISKEKEVLALLSRL------- 863
Cdd:PTZ00419 815 IAKYPQPNPGWNNEALdEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAkDAELIELIESAENLISTLAKIgsvsvip 894
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 864 DLNNVHfsNAPPGdanLSVHLVASEgLEAYLPLAAMVDISSEVQRISKRLSKMQTEYDALITRLSSPKFVEKAPEEVVRG 943
Cdd:PTZ00419 895 PIEEEA--EVPKG---CGFDVVDNK-VIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVRKL 968
|
970
....*....|....*
gi 334187718 944 VKEQVEELEEKIKLT 958
Cdd:PTZ00419 969 NDEKIDELNEEIKQL 983
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
68-963 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 887.80 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 68 ETSKTFDFSS-EEKIYKWWESQGYFKPN-FDQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPG 145
Cdd:PRK14900 14 ELAKGYEHREvEARWYPFWQERGYFHGDeHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 146 TDHAGIATQLVVEKML-ASEGIKRVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFV 224
Cdd:PRK14900 94 TDHAGIATQMIVEKELkKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 225 KLHDKGLIYQGSYMVNWSPNLQTAVSDLEVEYSE-EPGFLYHIKYRVAGSPDFLTIATTRPETLFGDVALAVHPEDDRYS 303
Cdd:PRK14900 174 RLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEaHQGELWSFAYPLADGSGEIVVATTRPETMLGDTAVAVHPLDPRYM 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 304 KYVGQTAIVPMTyGRHVPIIADK-YVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDATLNDVAGLFCGLDRFE 382
Cdd:PRK14900 254 ALHGKKVRHPIT-GRTFPIVADAiLVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFE 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 383 VREKLWADLEEIGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVHMDPLAEKALLAVENKELTIIPERFEKIYNHWLTN 462
Cdd:PRK14900 333 ARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVEQGRTRFIPEQWTNTYMAWMRN 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 463 IKDWCISRQLWWGHRIPVWYvvgkdCEEDY-IVAKSAEEALEKAlekyGKdVEIYQDPDVLDTWFSSSLWPFSTLGWPDv 541
Cdd:PRK14900 413 IHDWCISRQLWWGHQIPAWY-----CPDGHvTVARETPEACSTC----GK-AELRQDEDVLDTWFSSGLWPFSTMGWPE- 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 542 AAKDFNNFYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVYLHGLIRDSQGRKMSKSLGNVIDPLDTIKDFGTDAL 621
Cdd:PRK14900 482 QTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADAL 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 622 RFTIALGTA-GQDLNLSTERLTANKAFTNKLWNAGKFVLHslpslsdtsaweNLLDLKLDKEE-TLLSLPLPECWAVSKL 699
Cdd:PRK14900 562 RFTLAALTAqGRDIKLAKERIEGYRAFANKLWNASRFALM------------NLSGYQERGEDpARLARTPADRWILARL 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 700 HILIDSVTASYEKLFFGDVGRETYDFFWSDFADWYIEASKSRLYGSGGNSVSlASQAVLLYVFENILKLLHPFMPFVTED 779
Cdd:PRK14900 630 QRAVNETVEALEAFRFNDAANAVYAFVWHELCDWYIELAKEALASEDPEARR-SVQAVLVHCLQTSYRLLHPFMPFITEE 708
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 780 LWQALPYRKEAlivSPWPQNSL----PR----NVESIKRFENLQALTRAIRNARAEYSVEPvkrisASVVGSAEVIEYIS 851
Cdd:PRK14900 709 LWHVLRAQVGA---SAWADSVLaaeyPRkgeaDEAAEAAFRPVLGIIDAVRNIRGEMGIPW-----KVKLGAQAPVEIAV 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 852 KEKEVLALLSRLDLNNVH----------FSNAPPGDANLSVHLVASeGLEAYLPLAAMVDISSEVQRISKRLSKMQTEYD 921
Cdd:PRK14900 781 ADPALRDLLQAGELARVHrvagvegsrlVVAAATAPAPQSAVGVGP-GFEVRVPLAGVIDLAAETARVDKEIGKVDQDLA 859
|
890 900 910 920
....*....|....*....|....*....|....*....|..
gi 334187718 922 ALITRLSSPKFVEKAPEEVVRGVKEQVEELEEKikltKARLD 963
Cdd:PRK14900 860 VLERKLQNPSFVQNAPPAVVEKDRARAEELREK----RGKLE 897
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
59-968 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 751.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 59 SGNNVFTSPETSKTFDFSSEEKI-YKWWESQGYFKPNFDQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNG 137
Cdd:PLN02381 86 FGQKKRLSSQMAKQYSPSAVEKSwYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSG 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 138 RPTLWLPGTDHAGIATQLVVEKMLASE-GIKRVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLS 216
Cdd:PLN02381 166 YNALWVPGVDHAGIATQVVVEKKLMRErHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRS 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 217 RAVVEAFVKLHDKGLIYQGSYMVNWSPNLQTAVSDLEVEYSE----------------EPGFLYHIKYRVAGSPDFLTIA 280
Cdd:PLN02381 246 KAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDikertllkvpgydkpvEFGVLTSFAYPLEGGLGEIVVA 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 281 TTRPETLFGDVALAVHPEDDRYSKYVGQTAIVPMTyGRHVPIIADK-YVDKDFGTGVLKISPGHDHNDYLLARKLGLPIL 359
Cdd:PLN02381 326 TTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPFN-GRKLPIICDAiLVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFI 404
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 360 NVMNKDATLNDVAGL-FCGLDRFEVREKLWADLEEIGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVHMDPLAEKALL 438
Cdd:PLN02381 405 NIFTDDGKINSNGGSeFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALD 484
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 439 AV---ENKELTIIPERFEKIYNHWLTNIKDWCISRQLWWGHRIPVWYVVGKDCEED--------YIVAKSAEEALEKALE 507
Cdd:PLN02381 485 AAidgENKKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLEDDQLKelgsyndhWVVARNESDALLEASQ 564
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 508 KY-GKDVEIYQDPDVLDTWFSSSLWPFSTLGWPDVAAkDFNNFYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVY 586
Cdd:PLN02381 565 KFpGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTD-DLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVY 643
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 587 LHGLIRDSQGRKMSKSLGNVIDPLDTI------------------------------KDF-------GTDALRFTIALGT 629
Cdd:PLN02381 644 LHPMIRDAHGRKMSKSLGNVIDPLEVIngisleglhkrleegnldpkelvvakegqkKDFpngiaecGTDALRFALVSYT 723
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 630 AGQD-LNLSTERLTANKAFTNKLWNAGKFVLHSLPslSDTSAWENLldlkldkeeTLLSLPlPEC-WAVSKLHILIDSVT 707
Cdd:PLN02381 724 AQSDkINLDILRVVGYRQWCNKLWNAVRFAMSKLG--DDYTPPATL---------SVETMP-FSCkWILSVLNKAISKTV 791
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 708 ASYEKLFFGDVGRETYDFFWSDFADWYIEASKSRLYGSGGN--SVSLASQAVLLYVFENILKLLHPFMPFVTEDLWQALP 785
Cdd:PLN02381 792 SSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNPEfaSERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLP 871
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 786 -----YRKEALIVSPWPQNSLPRNVESIK-RFENLQALTRAIRNARAE-YSVEPVKRISASVVGSAEVIEYI--SKEKEV 856
Cdd:PLN02381 872 qpkdhTRKDSIMISEYPSAVEAWTNEKVEyEMDLVLSTVKCLRSLRAEvLEKQKNERLPAFALCRNQEIAAIikSHQLEI 951
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 857 LAL--LSRLDLNNVHFSNAPPGDANLSVhlvaSEGLEAYLPLAAMVDISSEVQRISKRLSKMQTEYDALITRLSSPKFVE 934
Cdd:PLN02381 952 LTLanLSSLKVLLSENDAPPAGCAFENV----NENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKE 1027
|
970 980 990
....*....|....*....|....*....|....*...
gi 334187718 935 KAP----EEVVRGVKEQVEELeEKIKLTKARLDFLKST 968
Cdd:PLN02381 1028 KVPaniqEEDARKLTKLLQEL-EFFEKESKRLEAETSN 1064
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
80-637 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 703.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 80 KIYKWWESQGYFKPNF--DQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHAGIATQLVV 157
Cdd:pfam00133 1 QIYEFWDEQGYFKPELekRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 158 EKMLASEGIK-RVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDKGLIYQGS 236
Cdd:pfam00133 81 EKKLGIKEKKtRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 237 YMVNWSPNLQTAVSDLEVEYSEEPGFLYHIKYRVAGSPDF-LTIATTRPETLFGDVALAVHPE----------------- 298
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGAsLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyilaeall 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 299 --------------DDRYSKYVGQTAIVPMTyGRHVPIIADKYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNK 364
Cdd:pfam00133 241 kslykkgtdkkileDFRGKELEGKEAIHPFV-NREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDD 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 365 DATLNDVAGLFCGLDRFEVREKLWADLEEIGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVHMDPLAEKALLAVENke 444
Cdd:pfam00133 320 DGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVEK-- 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 445 LTIIPERFEKIYNHWLTNIKDWCISRQLWWGHRIPVWYVvgKDCEE--------DYIVAKSAEEALEKALEKYGKDV--- 513
Cdd:pfam00133 398 VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVS--KDTEEvvcrgelfELVAGRFEEEGSIKWLHREAKDKlgy 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 514 ---EIYQDPDVLDTWFSSSLWPFSTLGWPDVAAKDFNNFYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVYLHGL 590
Cdd:pfam00133 476 gkgTLEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGL 555
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 334187718 591 IRDSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIALGTAGQDLNLS 637
Cdd:pfam00133 556 VRDEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANSDYGRDINLS 602
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
65-864 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 604.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 65 TSPETSKTFDFSS-EEKIYKWWESQGYFKPNFDQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWL 143
Cdd:PRK13208 2 MMPELPKKYDPEElEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 144 PGTDHAGIATQLVVEKMLaseGIKRVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEqLSRAVV-EA 222
Cdd:PRK13208 82 QGWDDNGLPTERKVEKYY---GIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISP-EYRRISqKS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 223 FVKLHDKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEEPGFLYHIKYRVAGSPDfLTIATTRPETLFGDVALAVHPEDDRY 302
Cdd:PRK13208 158 FLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDGEE-IEIATTRPELLPACVAVVVHPDDERY 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 303 SKYVGQTAIVPMtYGRHVPIIADKYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDATLNDVAGLFCGLDRFE 382
Cdd:PRK13208 237 KHLVGKTAIVPL-FGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEE 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 383 VREKLWADLEEIGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVHMDPLAEKALLAVenKELTIIPERFEKIYNHWLTN 462
Cdd:PRK13208 316 ARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERG--KEINWYPEHMRVRLENWIEG 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 463 IK-DWCISRQLWWGHRIPVWYVvgKDC-------EEDYIVAKSAEEALEKALEKYGKDvEIYQDPDVLDTWFSSSLWPFS 534
Cdd:PRK13208 394 LNwDWCISRQRYFGTPIPVWYC--KDCghpilpdEEDLPVDPTKDEPPGYKCPQCGSP-GFEGETDVMDTWATSSITPLI 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 535 TLGWPDvAAKDFNNFYPTNMLETGHDILFFW----VARMVMMgiefTGTVPFSHVYLHGLIRDSQGRKMSKSLGNVIDPL 610
Cdd:PRK13208 471 VTGWER-DEDLFEKVFPMDLRPQGHDIIRTWlfytILRAYLL----TGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPE 545
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 611 DTIKDFGTDALRFTIALGTAGQDLNLSTERLTANKAFTNKLWNAGKFVLHslpsLSDTSAWENLLDLK-LDKeetllslp 689
Cdd:PRK13208 546 ELLEKYGADAVRYWAASARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLH----FSADPEPDKAEVLEpLDR-------- 613
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 690 lpecWAVSKLHILIDSVTASYEKLFFGDVGRETYDFFWSDFADWYIEASKSRLYGSGGNSVSLASQAVLLYVFENILKLL 769
Cdd:PRK13208 614 ----WILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAYGEDEEEEQKSARYTLYTVLDTLLRLL 689
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 770 HPFMPFVTEDLWQALpyRKEALIVSPWPQ-NSLPRNVESIKRFENLQALTRAIRNARAEYSV---EPVKRIsasVVGSAE 845
Cdd:PRK13208 690 APFLPFITEEVWSWL--YGGSVHRASWPEpDEELIDEEDEELGELAKEILSAVRKYKSEAGLslnAPLKKV---EVYGPA 764
|
810
....*....|....*....
gi 334187718 846 VIEYISKEKEVLALLSRLD 864
Cdd:PRK13208 765 DLELLEAAEEDLKAAGNIE 783
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
101-636 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 585.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 101 PFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHAGIATQLVVEKMLASEGIKRVDLGRDEFTKRV 180
Cdd:cd00817 2 VFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHDLGREEFLEKC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 181 WEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDKGLIYQGSYMVNWSPNLQTAVSDLEVEYseep 260
Cdd:cd00817 82 WEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEVCS---- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 261 gflyhikyrvagspdfltiattrpetlfgdvalavhpeddryskyvgqtaivpmtygrhvpiiadkyvdkdfgtgvlkis 340
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 341 pghdhndyllarklglpilnvmnkdatlndvaglfcgldrfevreklwadleeiglavkkephtlrvprsqRGGEVIEPL 420
Cdd:cd00817 158 -----------------------------------------------------------------------RSGDVIEPL 166
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 421 VSKQWFVHMDPLAEKALLAVENKELTIIPERFEKIYNHWLTNIKDWCISRQLWWGHRIPVWYVvgKDCEeDYIVAKSAEE 500
Cdd:cd00817 167 LKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYC--KDGG-HWVVAREEDE 243
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 501 ALEKALEK---YGKDVEIYQDPDVLDTWFSSSLWPFSTLGWPDvAAKDFNNFYPTNMLETGHDILFFWVARMVMMGIEFT 577
Cdd:cd00817 244 AIDKAAPEacvPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPE-ETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLT 322
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 578 GTVPFSHVYLHGLIRDSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIALGTA-GQDLNL 636
Cdd:cd00817 323 GKLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATqGRDINL 382
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
78-863 |
1.28e-116 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 379.81 E-value: 1.28e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 78 EEKIYKWWESQGYFKPNFDQ--GGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTD-HaGIATQ 154
Cdd:COG0060 22 EPEILKFWEENDIYEKSREAraGRPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-GLPIE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 155 LVVEKMLaseGIKRVD---LGRDEFTKR----VWEWKEKYggtiTNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLH 227
Cdd:COG0060 101 LKVEKEL---GIKKKDiekVGIAEFREKcreyALKYVDEQ----REDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLY 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 228 DKGLIYQGSYMVNWSPNLQTAVSDLEVEYSEepgflyH------IKYRVAGSPD-------FLTIATTRPETLFGDVALA 294
Cdd:COG0060 174 EKGLLYKGLKPVPWCPRCGTALAEAEVEYKD------VtspsiyVKFPVKDEKAlllledaYLVIWTTTPWTLPANLAVA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 295 VHPE----------DDRY---------------------------SKYVGQTAIVPM----TYGRHVPIIADKYVDKDFG 333
Cdd:COG0060 248 VHPDidyvlvevtgGERLilaealveavlkelgiedyevlatfkgAELEGLRYEHPFyyvvGYDRAHPVILGDYVTTEDG 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 334 TGVLKISPGHDHNDYLLARKLGLPILNVMNKDATLNDVAGLFCGLDRFEVREKLWADLEEIGLAVKKEPHTLRVP---RS 410
Cdd:COG0060 328 TGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKITHSYPhcwRC 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 411 QrggeviEPLV---SKQWFVHMDPLAEKALlaVENKELTIIPE----RFEKiynhWLTNIKDWCISRQLWWGHRIPVWYv 483
Cdd:COG0060 408 K------TPLIyraTPQWFISMDKLRDRAL--EAIEKVNWIPEwgegRFGN----MLENRPDWCISRQRYWGVPIPIWV- 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 484 vGKDCEEDYIVAKSAEeALEKALEKYGKDV-------EIYQD---------------PDVLDTWFSSSLWPFSTL----- 536
Cdd:COG0060 475 -CEDCGELHRTEEVIG-SVAELLEEEGADAwfeldlhRPFLDetlkcpkcggtmrrvPDVLDVWFDSGSMHFAVLenree 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 537 -GWP-DvaakdfnnFYptnmLEtGHD--------------ILFfwvarmvmmgieftGTVPFSHVYLHGLIRDSQGRKMS 600
Cdd:COG0060 553 lHFPaD--------FY----LE-GSDqtrgwfysslltstALF--------------GRAPYKNVLTHGFVLDEDGRKMS 605
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 601 KSLGNVIDPLDTIKDFGTDALRFTIALGTAGQDLNLSTERLTANKAFTNKLWNAGKFVlhsLPSLSDTSAWENLLDLKld 680
Cdd:COG0060 606 KSLGNVVDPQEVIDKYGADILRLWVASSDYWGDLRFSDEILKEVRDVYRRLRNTYRFL---LANLDDFDPAEDAVPYE-- 680
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 681 keetllSLPLPECWAVSKLHILIDSVTASYEKLFFGDVGRETYDFFWSDFADWYIEASKSRLYGSGGNSVS-LASQAVLL 759
Cdd:COG0060 681 ------DLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKDRLYTEAADSLDrRAAQTTLY 754
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 760 YVFENILKLLHPFMPFVTEDLWQALPYRKEALI-VSPWPQ-NSLPRNVESIKRFENLQAL----TRAIRNARAEysvepv 833
Cdd:COG0060 755 EVLETLVRLLAPILPFTAEEIWQNLPGEAEESVhLADWPEvDEELIDEELEAKWDLVREVrsavLKALEAARKE------ 828
|
890 900 910
....*....|....*....|....*....|
gi 334187718 834 KRISASVvgSAEVIEYISkeKEVLALLSRL 863
Cdd:COG0060 829 KLIRQPL--EAAVVLYAD--EELAAALESL 854
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
78-797 |
3.59e-77 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 272.42 E-value: 3.59e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 78 EEKIYKWWESQGYFKPNFDQG-GSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHAGIATQLV 156
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDRNnGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 157 VEKMLASEgiKRVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDKGLIYQGS 236
Cdd:PLN02843 89 VLQSLDQE--ARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 237 YMVNWSPNLQTAVSDLEVEYSEEpgflyHIK------YRVAGSPD-------------FLTIATTRPETLFGDVALAVHP 297
Cdd:PLN02843 167 KPVHWSPSSRTALAEAELEYPEG-----HVSksiyvaFPVVSPSEtspeeleeflpglSLAIWTTTPWTMPANAAVAVND 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 298 EDDrYS---------------------------KYVGQTAIV----------------------------------PMtY 316
Cdd:PLN02843 242 KLQ-YSvvevqsfsedestsggnkkkrpgnvlkEQQKLFLIVatdlvpaleakwgvklvvlktfpgsdlegcryihPL-Y 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 317 GRHVPIIAD-KYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDATLNDVAGLFCGLDRF-EVREKLWADLEEI 394
Cdd:PLN02843 320 NRESPVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLgEGNAAVVEALDEA 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 395 GLAVKKEPHTLRVPRSQRggeVIEPLV---SKQWFVHMDPLAEKALLAVENkeLTIIPERFEKIYNHWLTNIKDWCISRQ 471
Cdd:PLN02843 400 GSLLMEEAYGHKYPYDWR---TKKPTIfraTEQWFASVEGFRQAALDAIDK--VKWIPAQGENRIRAMVSGRSDWCISRQ 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 472 LWWGHRIPVWYVVGKD---CEEDYI------VAKSAEEA-----LEKAL-EKY-GKDVEIYQDPDVLDTWFSSSlwpfST 535
Cdd:PLN02843 475 RTWGVPIPVFYHVETKeplMNEETIahvksiVAQKGSDAwwymdVEDLLpEKYrDKASDYEKGTDTMDVWFDSG----SS 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 536 lgWPDVAAKDFNNFYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVYLHGLIRDSQGRKMSKSLGNVIDPLDTI-- 613
Cdd:PLN02843 551 --WAGVLGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIeg 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 614 -KD------FGTDALRFTIALGTAGQDLNLSTERLTANKAFTNKLWNAGKFVLhslpslsdtsawENLLDLKLDKEETLL 686
Cdd:PLN02843 629 gKNqkqepaYGADVLRLWVASVDYTGDVLIGPQILKQMSDIYRKLRGTLRYLL------------GNLHDWKPDNAVPYE 696
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 687 SLPLPECWAVSKLHILIDSVTASYEKLFFGDVGRETYDFFWSDFADWYIEASKSRLYGSGGNSVSLAS-QAVLLYVFENI 765
Cdd:PLN02843 697 DLPSIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLYVGGTTSFTRRScQTVLAAHLLSL 776
|
810 820 830
....*....|....*....|....*....|....*..
gi 334187718 766 LKLLHPFMPFVTEDLWQALPYRK-----EALIVSPWP 797
Cdd:PLN02843 777 LRAIAPILPHLAEDAWQNLPFQEdgsaaESVFEAGWP 813
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
101-636 |
1.31e-71 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 239.63 E-value: 1.31e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 101 PFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHAGIATQLVVEKMLaseGIKRVDLGRDEFTKRV 180
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKG---GRKKKTIWIEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 181 WEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDKGLIYQGsymvnwspnlqtavsdleveyseep 260
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRG------------------------- 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 261 gflyhiKYRVAGSPdfltiattrpetlfgdvalavhpeddryskyvgqtaivpmtygrhvpiiadkyvdkdfgtgvlkis 340
Cdd:cd00668 133 ------THPVRITE------------------------------------------------------------------ 140
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 341 pghdhndyllarklglpilnvmnkdatlndvaglfcgldrfevreklwadleeiglavkkephtlrvprsqrggeviepl 420
Cdd:cd00668 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 421 vskQWFVHMDPLAEKALLAveNKELTIIPERFEKIYNHWLTNIKDWCISRQLWWGHRIPvwyvvgkdceedyivaksaee 500
Cdd:cd00668 141 ---QWFFDMPKFKEKLLKA--LRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP--------------------- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 501 alekalekygkdveiyqdPDVLDTWFSSSLWPFSTLGWPDVaAKDFNNFYPTNMLETGHDILFFWVARMVMMGIEFTGTV 580
Cdd:cd00668 195 ------------------EDVFDVWFDSGIGPLGSLGYPEE-KEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEI 255
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 334187718 581 PFSHVYLHGLIRDSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTI-ALGTAGQDLNL 636
Cdd:cd00668 256 PPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVVEKYGADALRYYLtSLAPYGDDIRL 312
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
115-855 |
2.06e-51 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 195.47 E-value: 2.06e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 115 LHMGHAMFVTLEDIMVRYNRMNGRPTLWlP------GTDHAGIAtqlvvekmlasEGIKRvdlgRDEFTkrVWEWKEKYG 188
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLF-PmafhvtGTPILGIA-----------ERIAR----GDPET--IELYKSLYG 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 189 --------------------GTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDKGLIYQGSYMVNWSPNLQTA 248
Cdd:PRK12300 63 ipeeelekfkdpeyiveyfsEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNP 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 249 VSDLEVEYSEEPGFL--YHIKYRVAGSPDFLTiATTRPETLFGDVALAVHPE--------DDRY---------------- 302
Cdd:PRK12300 143 VGDHDLLDGEEPEIVeyTLIKFEESEDLILPA-ATLRPETIFGVTNLWVNPDatyvkaevDGEKwivskeaaeklsfqdr 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 303 ----------SKYVGQTAIVPMTyGRHVPIIADKYVDKDFGTGVLKISPGHDHNDYLLARKLG-----------LPILNV 361
Cdd:PRK12300 222 dveiieeikgSELIGKKVKNPVT-GKEVPILPADFVDPDNGTGVVMSVPAHAPYDYVALRDLKknkelldviepIPLIEV 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 362 --------------MN---------KDAT------------LNDVAGLFCGLDRFEVREKLWADLEEIGLAVK-----KE 401
Cdd:PRK12300 301 egygefpakevvekLGiksqedpelEEATkevyraefhkgvLKENTGEYAGKPVREAREKITKDLIEKGIADImyefsNR 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 402 PHTLRVprsqrGGEVIEPLVSKQWFV-HMDP-LAEKALLAVENkeLTIIPERFEKIYNHWLTNIKDWCISRQLWWGHRIP 479
Cdd:PRK12300 381 PVYCRC-----GTECVVKVVKDQWFIdYSDPeWKELAHKALDN--MEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLP 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 480 vW--------------YVVGkdceedYIVAksaeealeKALEKYGKDVEIYqDPDVLDTWFssslwpfstLGWPDVAA-- 543
Cdd:PRK12300 454 -WdeewiieslsdstiYMAY------YTIA--------HKIREYGIKPEQL-TPEFFDYVF---------LGKGDPEEvs 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 544 --------------KDFNNFYPTNMLETGHD-----ILFF------------WVARMVmmgieftgtvpfshvyLHGLIR 592
Cdd:PRK12300 509 kktgipkeileemrEEFLYWYPVDWRHSGKDlipnhLTFFifnhvaifpeekWPRGIV----------------VNGFVL 572
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 593 dSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIAlGTAG--QDLNlsterltankaFTNKLWNAGKFVLHSLPSLSdtsa 670
Cdd:PRK12300 573 -LEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLT-SSAEllQDAD-----------WREKEVESVRRQLERFYELA---- 635
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 671 wENLLDLKLDKEETllslpLPECWAVSKLHILIDSVTASYEKLFFGDVGRETYDFFWSDFaDWYIEasksrlygSGGNSV 750
Cdd:PRK12300 636 -KELIEIGGEEELR-----FIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDL-RWYLR--------RVGEAN 700
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 751 SlasqAVLLYVFENILKLLHPFMPFVTEDLWQALpyRKEALIV-SPWPQNS-LPRNVESIKRFENLQALTRAIRNARAEY 828
Cdd:PRK12300 701 N----KVLREVLEIWIRLLAPFTPHLAEELWHKL--GGEGFVSlEKWPEPDeSKIDEEAELAEEYVKRLIEDIREILKVA 774
|
890 900 910 920
....*....|....*....|....*....|....*....|.
gi 334187718 829 SVEPVK--------------RISASVVGSAEVIEYISKEKE 855
Cdd:PRK12300 775 KIKPKKvyiyvapdwkyevlEIAAENGDVKEAIKELMKDEE 815
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
636-784 |
3.41e-48 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 167.35 E-value: 3.41e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 636 LSTERLTANKAFTNKLWNAGKFVLHSLPSLSDTSAWENlldlkldkeetllSLPLPECWAVSKLHILIDSVTASYEKLFF 715
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPE-------------SLSLADRWILSRLNKTVEEVTEALENYRF 67
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 334187718 716 GDVGRETYDFFWSDFADWYIEASKSRLYGsGGNSVSLASQAVLLYVFENILKLLHPFMPFVTEDLWQAL 784
Cdd:cd07962 68 SEAATALYEFFWNDFCDWYLELVKPRLYG-EDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
71-874 |
1.21e-43 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 172.22 E-value: 1.21e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 71 KTFDF-SSEEKIYKWWESQGYFKPNF--DQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTD 147
Cdd:PLN02882 6 KDFSFpKQEEKILSLWSEIDAFKTQLkrTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 148 HAGIATQLVVEKMLaseGIKRVD----LGRDEF--------TKRVWEWkEKyggtitnQIKRLGASCDWSRERFTLDEQL 215
Cdd:PLN02882 86 CHGLPVEYEIDKKL---GIKRRDdvlkMGIDKYneecrsivTRYSKEW-EK-------TVTRTGRWIDFENDYKTMDPKF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 216 SRAVVEAFVKLHDKGLIYQGSYMVNWSPNLQTAVSDLEV--EYSEEPGFLYHIKYRVAGSPD--FLTIATTRPETLFGDV 291
Cdd:PLN02882 155 MESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNYKDVSDPAVMVSFPIVGDPDnaSFVAWTTTPWTLPSNL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 292 ALAVHPE------DDRYSKYV---------------------GQTAIVPMTYG-------------RHVPI--------- 322
Cdd:PLN02882 235 ALCVNPNftyvkvRNKYTGKVyivaesrlsalptakpkskkgSKPENAAEGYEvlakvpgsslvgkKYEPLfdyfsefsd 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 323 -----IADKYVDKDFGTGVLKISPGHDHNDY--LLARKlglpilnVMNKDATLN---DVAGLFC-------GLDRFEVRE 385
Cdd:PLN02882 315 tafrvVADDYVTDDSGTGVVHCAPAFGEDDYrvCLANG-------IIEKGGNLPvpvDDDGCFTekvtdfsGRYVKDADK 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 386 KLWADLEEIGLAVKKEPHTLRVPRSQRGGeviEPLVSK---QWFVHMDPLAEKALlavENKELTI-IPERF-EKIYNHWL 460
Cdd:PLN02882 388 DIIAAIKAKGRLVKSGSITHSYPFCWRSD---TPLIYRavpSWFVKVEEIKDRLL---ENNKQTYwVPDYVkEKRFHNWL 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 461 TNIKDWCISRQLWWGHRIPVWyvVGKDCEEdYIVAKSAEEaLEKA-------LEKYGKD-VEI--YQDP---------DV 521
Cdd:PLN02882 462 ENARDWAVSRSRFWGTPLPIW--ISDDGEE-VVVIGSIAE-LEKLsgvkvtdLHRHFIDhITIpsSRGPefgvlrrvdDV 537
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 522 LDTWFSSSLWPFSTLGWPDVAAKDFNNFYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVYLHGLIRDSQGRKMSK 601
Cdd:PLN02882 538 FDCWFESGSMPYAYIHYPFENKELFEKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSK 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 602 SLGNVIDPLDTIKDFGTDALRFTIALGTA--GQDLNLSTER-LTANKAFTNKLWNAGKFVLHSLPSLSDtsawENLLDLK 678
Cdd:PLN02882 618 SLKNYPDPNEVIDKYGADALRLYLINSPVvrAEPLRFKEEGvFGVVKDVFLPWYNAYRFLVQNAKRLEV----EGGAPFV 693
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 679 -LDKEETLLSLPLPECWAVSKLHILIDSVTASYEKLFFGDVGRETYDFFwSDFADWYIEASKSRLYGSGGNSVSLASQAV 757
Cdd:PLN02882 694 pLDLAKLQNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKFI-DNLTNIYVRFNRKRLKGRTGEEDCRTALST 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 758 LLYVFENILKLLHPFMPFVTEDLWQ----ALPYRKEALIVSPWPQNSL----PRNVESIKRFENLQALTRAIRNARAEYS 829
Cdd:PLN02882 773 LYNVLLTSCKVMAPFTPFFTEVLYQnlrkVLPGSEESIHYCSFPQVDEgeldERIEQSVSRMQTVIELARNIRERHNKPL 852
|
890 900 910 920
....*....|....*....|....*....|....*....|....*.
gi 334187718 830 VEPVKRISAsVVGSAEVIEYISKE-KEVlaLLSRLDLNNVHFSNAP 874
Cdd:PLN02882 853 KTPLKEMVV-VHPDAEFLDDITGKlKEY--VLEELNVRSLVPCNDP 895
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
70-798 |
7.28e-43 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 168.69 E-value: 7.28e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 70 SKTFDFSSEEKiyKW---WESQGYFKPNFDQGGSPF-VIPM-PPPnvTGSLHMGHAMFVTLEDIMVRYNRMNGRPTL--- 141
Cdd:COG0495 2 QERYNPKEIEK--KWqkyWEENGTFKADEDSSKPKYyVLDMfPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLhpm 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 142 -W----LPGTDHAgiatqlvvekmlasegIKRvdlGRDEFtkrvwEWKEKYGGTITNQIKRLGASCDWSRERFTLD---- 212
Cdd:COG0495 78 gWdafgLPAENAA----------------IKN---GVHPA-----EWTYENIANMRRQLKRLGLSYDWSREIATCDpeyy 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 213 --EQ-LsravveaFVKLHDKGLIYQGSYMVNWSPNLQTaV-------------SDLEVE-------------YSEEpgfL 263
Cdd:COG0495 134 kwTQwI-------FLQLYEKGLAYRKEAPVNWCPVDQT-VlaneqvidgrcwrCGAPVEkkelpqwflkitdYADE---L 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 264 Y---------------------------HIKYRVAGSPDFLTIATTRPETLFGD--VALAV-HP---------EDDRYSK 304
Cdd:COG0495 203 LddldkldgwpekvktmqrnwigrsegaEVDFPVEGSDEKITVFTTRPDTLFGAtfMVLAPeHPlvkelatpeQNAAVAA 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 305 YV-----------------------GQTAIVPMTyGRHVPI-IADkYVDKDFGTG----VlkisPGHDHNDYLLARKLGL 356
Cdd:COG0495 283 FIeeakkkseiertsetkektgvftGLYAINPLT-GEKIPIwIAD-YVLMDYGTGavmaV----PAHDQRDFEFAKKYGL 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 357 PILNVM-NKDATLNDVA-------------GLFCGLDRFEVREKLWADLEEIGLAVKKephtlrvprsqrggevieplvs 422
Cdd:COG0495 357 PIKQVIaPEDGDDPDILeeaytgdgvlinsGEFDGLDSEEAKEAIIEWLEEKGLGKRK---------------------- 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 423 kqwfvhmdplaekallavenkeltiiperfekiynhwlTN--IKDWCISRQLWWGHRIPVWYvvgkdCEEDYIVA----- 495
Cdd:COG0495 415 --------------------------------------VNyrLRDWLISRQRYWGEPIPIIH-----CEDCGVVPvpedq 451
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 496 -------------------KSAEEALEKALEKYGKDVEiyQDPDVLDTWFSSSlW-------------PFStlgwPDVAA 543
Cdd:COG0495 452 lpvelpedvdfdptggsplARAPEWVNVTCPKCGGPAR--RETDTMDTFVDSS-WyylrytdphndeaPFD----PEAAN 524
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 544 K----DfnnFYptnmleTG---HDIL------FFWvarMVM--MGI----EftgtvPFSHVYLHGLIRD--------SQG 596
Cdd:COG0495 525 YwlpvD---QY------IGgieHAILhllyarFFT---KVLrdLGLvsfdE-----PFKRLLTQGMVLEvgkdgvviGGI 587
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 597 RKMSKSLGNVIDPLDTIKDFGTDALR-FTIALGTAGQDLNLSTERLTANKAFTNKLWN-AGKFVLHSLPSLSDTSAwenl 674
Cdd:COG0495 588 EKMSKSKGNVVDPDEIIEKYGADTLRlFEMFAGPPERDLEWSDSGVEGAYRFLNRVWRlVVDEAEALKLDVADLSE---- 663
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 675 LDLKLDKeetllslplpecwavsKLHILIDSVTASYEKLFFGDVGRETYDFFwsdfadwyieaskSRLYGSGGNSVslAS 754
Cdd:COG0495 664 ADKELRR----------------ALHKTIKKVTEDIERLRFNTAIAALMELV-------------NALYKAKDSGE--AD 712
|
890 900 910 920
....*....|....*....|....*....|....*....|....
gi 334187718 755 QAVLLYVFENILKLLHPFMPFVTEDLWQALPYrKEALIVSPWPQ 798
Cdd:COG0495 713 RAVLREALETLVLLLAPFAPHIAEELWERLGH-EGSVADAPWPE 755
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
108-626 |
2.29e-42 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 158.16 E-value: 2.29e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 108 PPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHAGIATQLVVEKMLASEGIKRVD-LGRDEFTKRVWEWKEK 186
Cdd:cd00818 9 PPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKDIEkMGIAEFNAKCREFALR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 187 YGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDKGLIYQGSYMVNWspnlqtavsdleveyseepgflyhi 266
Cdd:cd00818 89 YVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW------------------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 267 kyrvagspdfltiattrpetlfgdvalavhpeddryskyvgqtaivpmtygrhvPIIadkyvdkdfgtgvlkispghdhn 346
Cdd:cd00818 144 ------------------------------------------------------PLI----------------------- 146
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 347 dyllarklglpilnvmnkdatlndvaglfcgldrfevreklwadleeiglavkkephtLRVprsqrggevieplvSKQWF 426
Cdd:cd00818 147 ----------------------------------------------------------YRA--------------TPQWF 154
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 427 VHMDPLAEKALlaVENKELTIIPERFEKIYNHWLTNIKDWCISRQLWWGHRIPVWYvvGKDCEEdYIVAKSaeealekal 506
Cdd:cd00818 155 IRVTKIKDRLL--EANDKVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWY--CEDCGE-VLVRRV--------- 220
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 507 ekygkdveiyqdPDVLDTWFSSSLWPFSTLGWPDvAAKDFNNFYPTNMLETGHDILFFWVARMVMMGIEFTGTVPFSHVY 586
Cdd:cd00818 221 ------------PDVLDVWFDSGSMPYAQLHYPF-ENEDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVI 287
|
490 500 510 520
....*....|....*....|....*....|....*....|
gi 334187718 587 LHGLIRDSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIA 626
Cdd:cd00818 288 VHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVA 327
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
694-832 |
3.91e-40 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 144.85 E-value: 3.91e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 694 WAVSKLHILIDSVTASYEKLFFGDVGRETYDFFWSDFADWYIEASKSRLYGSGGNSvslASQAVLLYVFENILKLLHPFM 773
Cdd:pfam08264 3 WILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDS---RAQTTLYEVLETLLRLLAPFM 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 334187718 774 PFVTEDLWQalpyrKEALIVSPWPQNSLPRNVESIKRFENLQALTRAIRNARAEYSVEP 832
Cdd:pfam08264 80 PFITEELWQ-----KESIHLAPWPEDAELEEAELEEAFELRQEIVQAIRKLRSELKIKK 133
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
66-874 |
1.30e-39 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 159.75 E-value: 1.30e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 66 SPETSKTFDFSS--------EEKIYKWWESQGYFKPN--FDQGGSPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRM 135
Cdd:PTZ00427 58 AEMVTVTFTGVSenpniveeEEKVLKYWKSIDAFNTSnkLAKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQ 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 136 NGRPTLWLPGTDHAGIATQLVVEK---MLASEGIkrVDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLD 212
Cdd:PTZ00427 138 CGFSVERKFGWDCHGLPIEYEIEKennINKKEDI--LKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMD 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 213 EQLSRAVVEAFVKLHDKGLIYQGSYMVNWSPNLQTAVSDLEVE--YSEEP------------------------------ 260
Cdd:PTZ00427 216 KTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTPISNFELNlnYKDTPdpsiiisfvlcsdfpkveeecnieedkqll 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 261 ----GFLYHIKYR--------------VAGSPDFLTIATTrPETLFGDVALAV----------HPEDDRY---------- 302
Cdd:PTZ00427 296 gekySVLYNNKREnsnngnnnstnnvcYAQHSEILAWTTT-PWTLPSNLALCVnehftylrihHVKSNRVvivgecrlew 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 303 -------------------SKYVGQTAIVPMT---YGRH------VPIIADKYVDKDFGTGVLKISPGHDHNDYLLARKL 354
Cdd:PTZ00427 375 imkelkwnvedlkivnrfkGKELKGLRYKPLFtnfYEKYnfkeraYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKN 454
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 355 GL--PILNVMNKDAtlnDVAGLFCglDRFEVREKLWadLEEIGLAVKKepHTLRVPRSQRGGEVIE----------PLVS 422
Cdd:PTZ00427 455 GVidPEKNIFIDPL---DANGYFT--NEVEEVQNLY--IKEADNVIKK--KLKNENRLLSNNTIVHsypfcwrsdtPLIY 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 423 KQ---WFVHMDPLAEKAllaVENKELTI-IPERF-EKIYNHWLTNIKDWCISRQLWWGHRIPVWyvvgkdCEE--DYIVA 495
Cdd:PTZ00427 526 RAipaWFIRVSNSTNEL---VKNNETTYwIPAHIkEKKFHNWIKDAKDWCISRNRYWGTPIPIW------ADEkmETVIC 596
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 496 KSAEEALEKA--------LEKY-----------GKDV-EIYQDPDVLDTWFSSSLWPFSTLGWP-DVAAKDFNNFYPTNM 554
Cdd:PTZ00427 597 VESIKHLEELsgvknindLHRHfidhieiknpkGKTYpKLKRIPEVFDCWFESGSMPYAKVHYPfSTEKEDFHKIFPADF 676
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 555 LETGHDILFFWVARMVMMGIEFTGTVPFSHVYLHGLIRDSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIALGTAGQDL 634
Cdd:PTZ00427 677 IAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAE 756
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 635 NLSTERLTAN---KAFTNKLWNAGKFVLHSLPSLSDTSAWENLLDLK-LDKEETLLslplpECWAVSKLHILIDSVTASY 710
Cdd:PTZ00427 757 NLKFQEKGVNevvKSFILPFYHSFRFFSQEVTRYECLNKKQFLFNTDyIYKNDNIM-----DQWIFSSVQSLTKSVHTEM 831
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 711 EKLFFGDVGRETYDFFwSDFADWYIEASKSRLYGSGGNSVSLASQAVLLYVFENILKLLHPFMPFVTEDLWQALPYRK-- 788
Cdd:PTZ00427 832 KAYKLYNVLPKLLQFI-ENLTNWYIRLNRDRMRGSLGEENCLQSLCTTYRTLHLFTVLMAPFTPFITEYIYQQLRRVKst 910
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 789 ----EALIVSPWPQNSLPRNV------------------------ESIKRFENLQALTRAIRNARAEYSVEPVKRIS--- 837
Cdd:PTZ00427 911 nehnENNETGNTKEGDLNRGVihksvhfimlpqvdekyiidyeiiELIEKMKDVILLGRVLRERRKVASKKPLKSITilh 990
|
970 980 990 1000
....*....|....*....|....*....|....*....|
gi 334187718 838 ---ASVVGSAEVIEYISKEKEVLALLSRLDLNNVHFSNAP 874
Cdd:PTZ00427 991 pneSYFKNFDQISNYIKEELNVLNVECSNDTSCLDFSAIP 1030
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-798 |
1.93e-26 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 116.85 E-value: 1.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 9 LPTPTTTLLSPSSPHQLNTLFFTRRRRRLISPSRLNSIFSQRRFSFSAAASGNNVFTSPETSKTFDFSS-EEKIYKWWES 87
Cdd:PLN02563 16 FRFTSLRLSLFLVVSSAQTPASASSYFRRSRRGGVSRSLTRRAFAAPSALTSTTAKTTPAAKRAYPFHEiEPKWQRYWEE 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 88 QGYF---------KPNFdqggspFVIPM-PPPNVTGsLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHAGI-ATQLV 156
Cdd:PLN02563 96 NRTFrtpddvdtsKPKF------YVLDMfPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLpAEQYA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 157 VEKmlaseGIKRvdlgRDEFTKRVWEWKEkyggtitnQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDKGLIYQGS 236
Cdd:PLN02563 169 IET-----GTHP----KITTLKNIARFRS--------QLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 237 YMVNWSPNLQTAVSDLEV-------------------------EY---------------------------SEEPGFLY 264
Cdd:PLN02563 232 VPVNWCPALGTVLANEEVvdglsergghpvirkpmrqwmlkitAYadrlledlddldwpesikemqrnwigrSEGAELDF 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 265 HIKYRVAGSPDF-LTIATTRPETLFGDVALAVHPE--------DDRYSKYV---------------------------GQ 308
Cdd:PLN02563 312 SVLDGEGKERDEkITVYTTRPDTLFGATYLVVAPEhpllssltTAEQKEAVeeyvdaasrksdlertelqkektgvftGS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 309 TAIVPMTyGRHVPI-IADkYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDATLNDVAGL------------- 374
Cdd:PLN02563 392 YAINPAT-GEAIPIwVAD-YVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPADGNEDDAEKaytgegvivnsss 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 375 ----FCGLDRFEVREKLWADLEEIGLAVKKEPHTLR---VPRSQRGGEVIePLVSKQWFVHMDPLAEkALLAVENKEL-- 445
Cdd:PLN02563 470 sgldINGLSSKEAAKKVIEWLEETGNGKKKVNYKLRdwlFARQRYWGEPI-PVVFLEDSGEPVPVPE-SDLPLTLPELdd 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 446 ---TIIPErfekiynHWLTNIKDWC----------ISRQL-----WWGhriPVWYVVgkdceeDYIVAKSAEEALEKALE 507
Cdd:PLN02563 548 ftpTGTGE-------PPLAKAVSWVntvdpssgkpARRETntmpqWAG---SCWYYL------RFMDPKNSNALVDKEKE 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 508 KYGKDVEIY---QDPDVL-------------DTWFSSSLWPFS-------TLGwpDVAAKDFNNFYPTNMLETGHDilff 564
Cdd:PLN02563 612 KYWMPVDLYvggAEHAVLhllyarfwhkvlyDIGVVSTKEPFQclvnqgmILG--EVEYTAFKDSDGEYVSADTAD---- 685
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 565 wvarmvMMGIEFTGTVPFSHVYLHG----LIRDSQGR------KMSKSLGNVIDPLDTIKDFGTDALR-FTIALGTAGQD 633
Cdd:PLN02563 686 ------RLGELQQEKIPEEKVIKSGdsfvLKDDPSIRliarahKMSKSRGNVVNPDDVVSEYGADSLRlYEMFMGPLRDS 759
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 634 LNLSTERLTANKAFTNKLWNagkfvLHSLPSLSDTSAWENLL--DLKLDKEETLLslplpecwavskLHILIDSVTASYE 711
Cdd:PLN02563 760 KTWSTSGVEGVHRFLGRTWR-----LVVGAPLPDGSFRDGTVvtDEEPSLEQLRL------------LHKCIAKVTEEIE 822
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 712 KLFFGDVGRETYDFfwsdfadwyIEAsksrLYGSGGNSVSLASQAVLlyvfenilkLLHPFMPFVTEDLWQALPYrKEAL 791
Cdd:PLN02563 823 STRFNTAISAMMEF---------TNA----AYKWDKVPREAIEPFVL---------LLSPYAPHLAEELWFRLGH-SNSL 879
|
....*..
gi 334187718 792 IVSPWPQ 798
Cdd:PLN02563 880 AYEPWPE 886
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
101-784 |
2.43e-26 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 114.83 E-value: 2.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 101 PFVI--PMPPPNvtGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTD-H----------AGIATQLVVEKMlasegik 167
Cdd:COG0143 2 KFLVttAIPYAN--GPPHIGHLYTYIPADILARYQRLRGHDVLFVTGTDeHgtkielaaekEGITPQELVDRI------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 168 rvdlgRDEFtKRVWewkekyggtitnqiKRLGASCD-WSRerfTLDEQLSRAVVEAFVKLHDKGLIYQGSYmvnwspnlq 246
Cdd:COG0143 73 -----HAEF-KELF--------------EKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGEY--------- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 247 tavsdlEVEYSeepgflyhikyrvagspdfltiattrpetlfgdvalavhPEDDRYskyvgqtaivpmtygrhvpiIADK 326
Cdd:COG0143 121 ------EGWYC---------------------------------------PECERF--------------------LPDR 135
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 327 YVDkdfGTgvlkiSPgHDHNDyllarklglpilnvmnkdatlnDVAGLFCgldrfevrEKLWADLEeiglavkkePHTLR 406
Cdd:COG0143 136 YVE---GT-----CP-KCGAE----------------------DAYGDQC--------ENCGATLE---------PTELI 167
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 407 VPRSQRGGEVIEPLVSKQWFVHMDPLAEKaLLA-VENKElTIIPERFEKIYNhWLTN-IKDWCISRQLWWGHRIP----- 479
Cdd:COG0143 168 NPRSAISGAPPELREEEHYFFRLSKYQDR-LLEwIEENP-DIQPEVRNEVLS-WLKEgLQDLSISRDFDWGIPVPgdpgk 244
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 480 VWYV-----VGkdceedYIvakSAeealekaLEKYGKDVEIYQDpdvLDTWfssslwpfstlgWPDVAAKDFNnFYptnm 554
Cdd:COG0143 245 VFYVwfdalIG------YI---SA-------TKGYADDRGLPED---FEKY------------WPAPDTELVH-FI---- 288
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 555 letGHDILFF----WVArmVMMGIEFTgtVPfSHVYLHG-LIRDsqGRKMSKSLGNVIDPLDTIKDFGTDALR-FTIALG 628
Cdd:COG0143 289 ---GKDIIRFhaiiWPA--MLMAAGLP--LP-KKVFAHGfLTVE--GEKMSKSRGNVIDPDDLLDRYGPDALRyYLLREV 358
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 629 TAGQDLNLSTERLT-------ANK---------AFTNKLWNaGKfvlhsLPSLSDTSawenlldlklDKEETLLslplpe 692
Cdd:COG0143 359 PFGQDGDFSWEDFVarvnsdlANDlgnlasrtlSMIHKYFD-GK-----VPEPGELT----------EADEELL------ 416
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 693 cwavSKLHILIDSVTASYEKLFFGDVGRETYDFfwSDFADWYIEAS------KSrlygsgGNSVSLASQ-AVLLYVFENI 765
Cdd:COG0143 417 ----AEAEAALEEVAEAMEAFEFRKALEEIMAL--ARAANKYIDETapwklaKD------EDPERLATVlYTLLEALRIL 484
|
730
....*....|....*....
gi 334187718 766 LKLLHPFMPFVTEDLWQAL 784
Cdd:COG0143 485 AILLKPFLPETAEKILEQL 503
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
102-653 |
6.01e-22 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 99.29 E-value: 6.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 102 FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHAGIATQLVVEKmlasEGIKrvdlgrdeftkrvw 181
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEK----EGIT-------------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 182 ewKEKYGGTITNQIKRLGASCDWSRERF--TLDEQLSRAVVEAFVKLHDKGLIYQGSYmvnwspnlqtavsdlEVEYSee 259
Cdd:pfam09334 63 --PEELVDRYHEIHREDFKKFNISFDDYgrTTSERHHELVQEFFLKLYENGYIYEKEI---------------EQFYC-- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 260 pgflyhikyrvagspdfltiattrpetlfgdvalavhPEDDRYskyvgqtaivpmtygrhvpiIADKYVDkdfGTGvlki 339
Cdd:pfam09334 124 -------------------------------------PSDERF--------------------LPDRYVE---GTC---- 139
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 340 spghDHNDYLLARklglpilnvmnKDATLNdvaglfCGldrfevreklwadleeiglaVKKEPHTLRVPRSQRGGEVIEP 419
Cdd:pfam09334 140 ----PHCGSEDAR-----------GDQCEN------CG--------------------RHLEPTELINPKCVICGTTPEV 178
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 420 LVSKQWFVHMDPLAE--KALLAVENKELtiiPERFEKIYNHWLTN-IKDWCISRQLWWGHRIP--------VWY--VVGk 486
Cdd:pfam09334 179 KETEHYFFDLSKFQDklREWIEENNPEW---PENVKNMVLEWLKEgLKDRAISRDLDWGIPVPgaegkvfyVWLdaPIG- 254
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 487 dceedYIVAKSAEEALEKALEKY---GKDVEIYQdpdvldtwfssslwpfstlgwpdVAAKDFNNFyptnmletgHDIlf 563
Cdd:pfam09334 255 -----YISATKELSGNEEKWKEWwpnDPDTELVH-----------------------FIGKDIIYF---------HTI-- 295
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 564 FWVArmVMMGIEFtgTVPfSHVYLHGLIrDSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIA-LGTAGQDLNLSTERLT 642
Cdd:pfam09334 296 FWPA--MLLGAGY--RLP-TTVFAHGYL-TYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLArNRPETKDTDFSWEDFV 369
|
570
....*....|...
gi 334187718 643 A--NKAFTNKLWN 653
Cdd:pfam09334 370 ErvNSELADDLGN 382
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
102-814 |
7.87e-18 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 88.20 E-value: 7.87e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 102 FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDHAGIATQLVVEKmlasegikrvdLGRDeftkrvw 181
Cdd:TIGR00398 1 ILITTALPYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQ-----------EGLT------- 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 182 ewKEKYGGTITNQIKRLGASCDWSRERF--TLDEQLSRAVVEAFVKLHDKGLIYQGSYMVNWSPNLQTavsdleveysee 259
Cdd:TIGR00398 63 --PKELVDKYHEEFKDDWKWLNISFDRFirTTDEEHKEIVQKIFQKLKENGYIYEKEIKQLYCPECEM------------ 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 260 pgfLYHIKYRVAGSPDfltiattrpetlfgdvalavHPEDDRYSkyvgqtaivpmtygrhvpiiadkyvdkdfgtgvlki 339
Cdd:TIGR00398 129 ---FLPDRYVEGTCPK--------------------CGSEDARG------------------------------------ 149
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 340 spGHDHNdyllarklglpilnvmnkdatlndvaglfCGLdrfevreklwadleeiglavKKEPHTLRVPRSQRGGEVIEP 419
Cdd:TIGR00398 150 --DHCEV-----------------------------CGR--------------------HLEPTELINPRCKICGAKPEL 178
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 420 LVSKQWFVHM----DPLAEKALLAVENKELtiiPERFEKIYNHWLTN-IKDWCISRQL-WWGHRIP--------VWYvvg 485
Cdd:TIGR00398 179 RDSEHYFFRLsafeKELEEWIRKNPESGSP---ASNVKNKAQNWLKGgLKDLAITRDLvYWGIPVPndpnkvvyVWF--- 252
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 486 kDCEEDYIVAKSAEEALEKALEKY---GKDVEIYQdpdvldtwfssslwpfstlgwpdVAAKDFNNFyptnmletgHDIl 562
Cdd:TIGR00398 253 -DALIGYISSLGILSGDTEDWKKWwnnDEDAELIH-----------------------FIGKDIVRF---------HTI- 298
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 563 fFWVArmVMMGIEFTgtvPFSHVYLHGLIRDsQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIALGTA-GQDLNLSTERL 641
Cdd:TIGR00398 299 -YWPA--MLMGLGLP---LPTQVFSHGYLTV-EGGKMSKSLGNVVDPSDLLARFGADILRYYLLKERPlGKDGDFSWEDF 371
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 642 --TANKAFTNKLWN--------AGKFVLHSLPS-LSDTSAWENLLDLKLDKEETLLSLplpecwavsklhilidsvtasY 710
Cdd:TIGR00398 372 veRVNADLANKLGNllnrtlgfIKKYFNGVLPSeDITDEEDKKLLKLINEALEQIDEA---------------------I 430
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 711 EKLFFGDVGREtydfFWS--DFADWYIEASKS-RLYGSGGNSVSLasQAVLLYVFENILKLLHPFMPFVTEDLWQALPYR 787
Cdd:TIGR00398 431 ESFEFRKALRE----IMKlaDRGNKYIDENKPwELFKQSPRLKEL--LAVCSMLIRVLSILLYPIMPKLSEKILKFLNFE 504
|
730 740
....*....|....*....|....*..
gi 334187718 788 KEalivspWPQNSLPRNVESIKRFENL 814
Cdd:TIGR00398 505 LE------WDFKLKLLEGHKLNKAEPL 525
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
650-821 |
2.22e-16 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 77.95 E-value: 2.22e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 650 KLWNAGKFVLHSL---PSLSDTSAWENLLDLklDKeetllslplpecWAVSKLHILIDSVTASYEKLFFGDVGRETYDFF 726
Cdd:cd07960 15 KIRNTFRFLLGNLndfDPAKDAVPYEELLEL--DR------------YALHRLNELIKEVREAYENYEFHKVYQALNNFC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 727 WSDFADWYIEASKSRLYGSGGNSVS-LASQAVLLYVFENILKLLHPFMPFVTEDLWQALPYRKEALIV--SPWPQ-NSLP 802
Cdd:cd07960 81 TVDLSAFYLDIIKDRLYCDAKDSLErRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEESVflEDWPElPEEW 160
|
170
....*....|....*....
gi 334187718 803 RNVESIKRFENLQALTRAI 821
Cdd:cd07960 161 KDEELEEKWEKLLALRDEV 179
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
102-241 |
6.15e-16 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 79.98 E-value: 6.15e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 102 FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTDhagiATQLVVEKMlaseGIKRvdlGRDEFTkrvw 181
Cdd:cd00812 2 FYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAENA----AIKI---GRDPED---- 66
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 182 eWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVKLHDKGLIYQGSYMVNW 241
Cdd:cd00812 67 -WTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
694-784 |
7.75e-16 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 76.44 E-value: 7.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 694 WAVSKLHILIDSVTASYEKLFFGDVGREtydffWSDFAD----WYIEASKSRLYGSGGNSVSLASQAVLLYVFENILKLL 769
Cdd:cd07961 51 WILSRLNSLIKEVTEEMEAYDLYTAVRA-----LLEFIDeltnWYIRRNRKRFWGEEGDDDKLAAYATLYEVLLTLSRLM 125
|
90
....*....|....*
gi 334187718 770 HPFMPFVTEDLWQAL 784
Cdd:cd07961 126 APFTPFITEEIYQNL 140
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
382-635 |
2.35e-14 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 75.26 E-value: 2.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 382 EVREKLWADLEEIGLAVKKEPHTLRVPRSQRG-GEVIEplvSKQWFVHMDPLAEKALLAVENKELTIIPERFEKIYNHWL 460
Cdd:cd00814 99 EIVQEFFKKLYENGYIYEGEYEGLYCVSCERFlPEWRE---EEHYFFRLSKFQDRLLEWLEKNPDFIWPENARNEVLSWL 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 461 TN-IKDWCISRQLW-WGHRIP-----VWYV-----VGkdceedYI-VAKSAEEALEKALEKYGKDVEIYQdpdvldtwfs 527
Cdd:cd00814 176 KEgLKDLSITRDLFdWGIPVPldpgkVIYVwfdalIG------YIsATGYYNEEWGNSWWWKDGWPELVH---------- 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 528 sslwpfstlgwpdVAAKDFNNFyptnmletgHDIlfFWVArmVMMGIEFTgtvPFSHVYLHGLIRDSqGRKMSKSLGNVI 607
Cdd:cd00814 240 -------------FIGKDIIRF---------HAI--YWPA--MLLGAGLP---LPTRIVAHGYLTVE-GKKMSKSRGNVV 289
|
250 260
....*....|....*....|....*....
gi 334187718 608 DPLDTIKDFGTDALR-FTIALGTAGQDLN 635
Cdd:cd00814 290 DPDDLLERYGADALRyYLLRERPEGKDSD 318
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
901-966 |
8.07e-14 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 66.91 E-value: 8.07e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 334187718 901 DISSEVQRISKRLSKMQTEYDALITRLSSPKFVEKAPEEVVRGVKEQVEELEEKIKLTKARLDFLK 966
Cdd:pfam10458 1 DVEKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKLG 66
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
534-623 |
5.08e-13 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 72.91 E-value: 5.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 534 STLGWPDVAAKDFNNFYPTNMLETGHDIL-F---FWVARMVMMGIEftgtvPFSHVYLHG-LIRDsqGRKMSKSLGNVID 608
Cdd:PRK12267 237 TALGYGSDDDELFKKFWPADVHLVGKDILrFhaiYWPIMLMALGLP-----LPKKVFAHGwWLMK--DGKMSKSKGNVVD 309
|
90
....*....|....*
gi 334187718 609 PLDTIKDFGTDALRF 623
Cdd:PRK12267 310 PEELVDRYGLDALRY 324
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
266-369 |
9.98e-13 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 67.57 E-value: 9.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 266 IKYRVAGSPDFLTIATTRPETLFGD--VALAV-HP-------EDDRYSKYV-----------------------GQTAIV 312
Cdd:pfam13603 12 ITFPVEGTDEKIEVFTTRPDTLMGVtfVALAPeHPlveklaeKNPEVAAFIeeckntseiertsetkekegvftGLYAIH 91
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 334187718 313 PMTyGRHVPI-IADkYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNV-MNKDATLN 369
Cdd:pfam13603 92 PIT-GEKIPIwIAN-FVLMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPViQPEDGDLD 148
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
513-641 |
1.31e-12 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 71.45 E-value: 1.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 513 VEIYQDPD-VLDTWFSSSLWPFSTLGWPD---VAAKDFNNFYPTNMLETGHDILFF----WVArMVMM-GIEFtgtvpFS 583
Cdd:PRK11893 212 IPVPGDPKhVIYVWFDALTNYLTALGYPDdeeLLAELFNKYWPADVHLIGKDILRFhavyWPA-FLMAaGLPL-----PK 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 334187718 584 HVYLHG-LIRDsqGRKMSKSLGNVIDPLDTIKDFGTDALRF----TIALgtaGQDLNLSTERL 641
Cdd:PRK11893 286 RVFAHGfLTLD--GEKMSKSLGNVIDPFDLVDEYGVDAVRYfllrEIPF---GQDGDFSREAF 343
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
459-784 |
7.22e-10 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 62.86 E-value: 7.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 459 WLTN-IKDWCISRQL-WWGHRIP-----VWYV-----VGkdceedYIvaKSAEEALEKA----LEKY---GKDVEIYQdp 519
Cdd:PRK00133 219 WLEEgLQDWDISRDApYFGFEIPgapgkVFYVwldapIG------YI--SSTKNLCDKRggldWDEYwkkDSDTELYH-- 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 520 dvldtwfssslwpFstLGwpdvaaKDFNNFyptnmletgHDIlfFWVArmVMMGIEFTgtVPfSHVYLHGLIRdSQGRKM 599
Cdd:PRK00133 289 -------------F--IG------KDIIYF---------HTL--FWPA--MLEGAGYR--LP-TNVFAHGFLT-VEGAKM 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 600 SKSLGNVIDPLDTIKDFGTDALRFTIA--LGTAGQDLNLSTERLTA--NKAFTNKLWN----AGKFVlhslpslsdTSAW 671
Cdd:PRK00133 331 SKSRGTFIWARTYLDHLDPDYLRYYLAakLPETIDDLDFNWEDFQQrvNSELVGKVVNfasrTAGFI---------NKRF 401
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 672 ENLLDLKLDKEETLlslplpecwavSKLHILIDSVTASYEKLFFGDVGRETYDFfwSDFADWYIEASKS-RLYGSGGNSV 750
Cdd:PRK00133 402 DGKLPDALADPELL-----------EEFEAAAEKIAEAYEAREFRKALREIMAL--ADFANKYVDDNEPwKLAKQDGERL 468
|
330 340 350
....*....|....*....|....*....|....*..
gi 334187718 751 slasQAVL---LYVFENILKLLHPFMPFVTEDLWQAL 784
Cdd:PRK00133 469 ----QAVCsvgLNLFRALAIYLKPVLPELAERAEAFL 501
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
67-797 |
7.36e-10 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 63.16 E-value: 7.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 67 PETSKTF---DF--SSEEKIYKWWESQGYFKPNFDQGGSP----FVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMNG 137
Cdd:PLN02959 3 AEGGKSTarrDRllEIEVAVQKWWEEEKVFEAEAGDEPPKpgekFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 138 RPTLwLPGTDH-AGI-----ATQLVVE-------------------------------------------KMLASEG--- 165
Cdd:PLN02959 83 ANVL-LPFAFHcTGMpikasADKLAREiqqygnppvfpeededeaaavaaakaeaeaaaappdkfkgkksKAVAKSGtqk 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 166 -----IKRVDLGRDEFTK--RVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDeqlSRAVVEAFV-----KLHDKGLIY 233
Cdd:PLN02959 162 yqweiMRSFGLPDSEIAKfqDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTD---VNPYYDAFVrwqfrKLKKKGKIV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 234 QGSYMVNWSPNLQTAVSD------------------LEVeYSEEPGFLYHIkyrvAGSPDFLTIATTRPETLFGDVALAV 295
Cdd:PLN02959 239 KDKRYTIYSPLDGQPCADhdrasgegvgpqeyvlikMEV-LPPFPGKLKAL----EGKKVFLAAATLRPETMYGQTNCWV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 296 HPEDDRYSKYVGQTAIVPMT--------YGRH--VP------------------------------------IIADKyvd 329
Cdd:PLN02959 314 LPDGKYGAYEINDTEVFILTaraalnlaYQNFskVPgkptclveltgydliglplksplafneviyalpmltILTDK--- 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 330 kdfGTGVLKISPGHDHNDYL----------LARKLG-----------LPILNVMN-------------KDATLNDVA--- 372
Cdd:PLN02959 391 ---GTGVVTSVPSDSPDDYMalsdlkakpaLRAKYGvkdewvlpfevVPIINIPEfgdksaekvcedlKIKSQNDKEkla 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 373 ------------------GLFCGLDRFEVREKLWADLEEIGLAV-KKEPHTLRVPRSqrGGEVIEPLvSKQWFVHMD--- 430
Cdd:PLN02959 468 eakrltylkgftdgtmlvGEYAGRKVQEAKPLIKKKLIEAGQAIlYSEPEKKVMSRS--GDECVVAL-TDQWYLTYGeee 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 431 --PLAEKALlavENKELTIIPERfeKIYNHWLTNIKDWCISRQLWWGHRIPvWyvvgkdcEEDYIVAKSAEEALEKA--- 505
Cdd:PLN02959 545 wkKKAEKCL---SKMNLYSDETR--HGFEHTLGWLNQWACSRSFGLGTRIP-W-------DEQFLIESLSDSTIYMAyyt 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 506 ----LEK---YGKD---VEIYQ-DPDVLDTWFSSSLWPFSTLGWPDVAAK---DFNNFYPTNMLETGHDIL-----FFWV 566
Cdd:PLN02959 612 vahlLQGgdmYGKDkssIKPEQmTDEVWDFVFCGGPLPKSSDIPAELLEKmkqEFEYWYPFDLRVSGKDLIqnhltFAIY 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 567 ARMVMM-------GIEFTGtvpfsHVYLHGlirdsqgRKMSKSLGNVIDPLDTIKDFGTDALRFtiALGTAG---QDLNL 636
Cdd:PLN02959 692 NHTAIWaeehwprGFRCNG-----HLMLNS-------EKMSKSTGNFLTLRQAIEEFSADATRF--ALADAGdgvDDANF 757
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 637 STErlTANKAftnklwnagkfvlhsLPSLSDTSAWenlLDLKLDKEETLLSLPlPECWA----VSKLHILIDSVTASYEK 712
Cdd:PLN02959 758 VFE--TANAA---------------ILRLTKEIAW---MEEVLAAESSLRTGP-PSTYAdrvfENEINIAIAETEKNYEA 816
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 713 LFFgdvgRETYDffwSDFADWYIEASKSRLY-GSGGNSVSLasqavLLYVFENILKLLHPFMPFVTEDLWQALpYRKEAL 791
Cdd:PLN02959 817 MMF----REALK---SGFYDLQAARDEYRLScGSGGMNRDL-----VWRFMDVQTRLITPICPHYAEHVWREI-LKKEGF 883
|
....*..
gi 334187718 792 IVS-PWP 797
Cdd:PLN02959 884 AVTaGWP 890
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
679-784 |
2.08e-09 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 56.06 E-value: 2.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 679 LDKEETLLSLPLPECWAVSKLHILIDSVTASYEKLFFGDVGRETYDFFWSDFaDWYIEASKSRlygsggnsvslASQAVL 758
Cdd:cd07959 24 IETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDL-DWYRERGGAG-----------MNKDLL 91
|
90 100
....*....|....*....|....*.
gi 334187718 759 LYVFENILKLLHPFMPFVTEDLWQAL 784
Cdd:cd07959 92 RRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
111-237 |
1.71e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 55.19 E-value: 1.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 111 VTGSLHMGHAMFVTLEDIMVRYNRMNGRPTLWLPGTD-H----------AGIATQLVVEKMlaSEGIKrvDLgrdeftkr 179
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDeHgqkiqqaaekAGKTPQEYVDEI--SAGFK--EL-------- 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 180 vweWKEkyggtitnqikrLGASCDwsreRF--TLDEQLSRAVVEAFVKLHDKGLIYQGSY 237
Cdd:PRK12267 83 ---WKK------------LDISYD----KFirTTDERHKKVVQKIFEKLYEQGDIYKGEY 123
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
639-773 |
2.07e-07 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 50.58 E-value: 2.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 639 ERLTANKAFTNKLWNAGKFVLHSLpsLSDTSAWENLLDLKLDKeetllslplpecWAVSKLHILIDSVTASYEKLFFGDV 718
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKAL--GGTQPKWDNELLEEADR------------ELLARLQEFIKRTTNALEALDPTTA 67
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 334187718 719 GRETYDFFWSDfaDWYIEASKSRLYGSGGNSvslASQAVLLYVFENILKLLHPFM 773
Cdd:cd07375 68 VQELFKFTNEL--NWYLDELKPALQTEELRE---AVLAVLRAALVVLTKLLAPFT 117
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
550-796 |
4.41e-07 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 53.95 E-value: 4.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 550 YPTNMLETGHDILFF----WVARMVMMGIEFTGTVpFSHVYLhglirDSQGRKMSKSLGNVIDPLDTIKDFGTDALR-FT 624
Cdd:PLN02224 320 WPASLHLIGKDILRFhavyWPAMLMSAGLELPKMV-FGHGFL-----TKDGMKMGKSLGNTLEPFELVQKFGPDAVRyFF 393
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 625 IALGTAGQDLNLSTERL--TANKAFTNKLWNAGKFVLHSLPSLSDTSawenlldLKLDKEETLLSLPLPEcwAVSKlhiL 702
Cdd:PLN02224 394 LREVEFGNDGDYSEDRFikIVNAHLANTIGNLLNRTLGLLKKNCEST-------LVEDSTVAAEGVPLKD--TVEK---L 461
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 703 IDSVTASYEKLFFGDVGRETYDF------FWSDFADWYieasksrLYGSGGNSVSLASQ--AVLLYVFENILKLLHPFMP 774
Cdd:PLN02224 462 VEKAQTNYENLSLSSACEAVLEIgnagntYMDQRAPWF-------LFKQGGVSAEEAAKdlVIILEVMRVIAVALSPIAP 534
|
250 260
....*....|....*....|..
gi 334187718 775 FVTEDLWQALPYRKEALIVSPW 796
Cdd:PLN02224 535 CLSLRIYSQLGYSEDQFNSITW 556
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
581-670 |
2.71e-05 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 47.79 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 334187718 581 PFSHVYLH-GLIRDSqGRKMSKSLGNVIDPLDTIKDFGTDALRFtiALGTA--GQDLNLSTERLTANKAFTNKLWNAGKF 657
Cdd:COG0215 248 PFARYWMHnGFLTVN-GEKMSKSLGNFFTVRDLLKKYDPEVLRF--FLLSAhyRSPLDFSEEALEEAEKALERLYNALRR 324
|
90
....*....|...
gi 334187718 658 VLHSLPSLSDTSA 670
Cdd:COG0215 325 LEEALGAADSSAE 337
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
753-784 |
1.09e-03 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 39.90 E-value: 1.09e-03
10 20 30
....*....|....*....|....*....|..
gi 334187718 753 ASQAVLLYVFENILKLLHPFMPFVTEDLWQAL 784
Cdd:cd07958 86 QHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
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| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
581-637 |
2.30e-03 |
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catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 40.64 E-value: 2.30e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 334187718 581 PFSHVYLH-GLIRdSQGRKMSKSLGNVIDPLDTIKDFGTDALRFTIALGTAGQDLNLS 637
Cdd:cd00672 157 PFARYWLHtGHLT-IDGEKMSKSLGNFITVRDALKKYDPEVLRLALLSSHYRSPLDFS 213
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