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Conserved domains on  [gi|145357786|ref|NP_568194|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD repeat KATNB1 family protein( domain architecture ID 10078096)

WD repeat KATNB1 family protein similar to Mus musculus katanin p80 WD40 repeat-containing subunit B1 (KATNB1) that participates in a complex which severs microtubules in an ATP-dependent manner

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-245 8.41e-65

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.48  E-value: 8.41e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   9 LQEFVAHSAAVNCLKIgRKSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDL 88
Cdd:COG2319  155 LRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  89 EEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVK 168
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145357786 169 VWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCG 245
Cdd:COG2319  314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 677-832 1.78e-48

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


:

Pssm-ID: 464044  Cd Length: 160  Bit Score: 168.95  E-value: 1.78e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  677 QHDQFVSSMHSRLAKLQVVRRYWERNDIKNSISSIEKMADNAVIADVLLIVNERPEILTLDTCTSLLPLLTALLGSNMDS 756
Cdd:pfam13925   2 DHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYER 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145357786  757 HLSVCLDLLLKLVRMYGSQIYSSLSA-PSSVGVDIEAEQRMERYSCCFVEFEKIKACLPSLARRGNLVAKTLHELNL 832
Cdd:pfam13925  82 YIIVGLDFLRLILKNFGPVIKSALSApPSSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNL 158
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-245 8.41e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.48  E-value: 8.41e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   9 LQEFVAHSAAVNCLKIgRKSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDL 88
Cdd:COG2319  155 LRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  89 EEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVK 168
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145357786 169 VWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCG 245
Cdd:COG2319  314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-261 1.85e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 214.89  E-value: 1.85e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   9 LQEFVAHSAAVNCLKIGRkSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDL 88
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  89 EEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVK 168
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 169 VWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCGLQE 248
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250
                 ....*....|....
gi 145357786 249 -SLKIFSWEPIRCH 261
Cdd:cd00200  241 gTIRVWDLRTGECV 254
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 677-832 1.78e-48

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 168.95  E-value: 1.78e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  677 QHDQFVSSMHSRLAKLQVVRRYWERNDIKNSISSIEKMADNAVIADVLLIVNERPEILTLDTCTSLLPLLTALLGSNMDS 756
Cdd:pfam13925   2 DHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYER 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145357786  757 HLSVCLDLLLKLVRMYGSQIYSSLSA-PSSVGVDIEAEQRMERYSCCFVEFEKIKACLPSLARRGNLVAKTLHELNL 832
Cdd:pfam13925  82 YIIVGLDFLRLILKNFGPVIKSALSApPSSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNL 158
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-171 3.47e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.78  E-value: 3.47e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 145357786   135 CIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWD 171
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-171 7.63e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.66  E-value: 7.63e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145357786  135 CIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWD 171
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 41-209 1.13e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  41 VNLWAIGKPNAILSLYGHSSGIDSVTFDASE-GLVAAGAASGTIKLWDLEEAKVVRTLTGhRSNCVSVNF-HPFGEFFAS 118
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 119 GSLDTNLKIWDIRK-KGCIHTYKGHTRGVNVLRFTpDGRWIVSGGEDNVVKVWDLTAG------KLLHEFKSHEGKIQSL 191
Cdd:PLN00181 636 GSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFV 714

                        170
                 ....*....|....*...
gi 145357786 192 DFHPHEFLLATGSADKTV 209
Cdd:PLN00181 715 GLSVSDGYIATGSETNEV 732
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
9-245 8.41e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 222.48  E-value: 8.41e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   9 LQEFVAHSAAVNCLKIgRKSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDL 88
Cdd:COG2319  155 LRTLTGHSGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  89 EEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVK 168
Cdd:COG2319  234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145357786 169 VWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCG 245
Cdd:COG2319  314 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
9-245 4.66e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 220.55  E-value: 4.66e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   9 LQEFVAHSAAVNCLKIGRkSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDL 88
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  89 EEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVK 168
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145357786 169 VWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCG 245
Cdd:COG2319  272 LWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-261 1.85e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 214.89  E-value: 1.85e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   9 LQEFVAHSAAVNCLKIGRkSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDL 88
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  89 EEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVK 168
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 169 VWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCGLQE 248
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250
                 ....*....|....
gi 145357786 249 -SLKIFSWEPIRCH 261
Cdd:cd00200  241 gTIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
9-245 2.13e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.63  E-value: 2.13e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   9 LQEFVAHSAAVNCLKIGRkSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDL 88
Cdd:COG2319   71 LATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  89 EEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVK 168
Cdd:COG2319  150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145357786 169 VWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCG 245
Cdd:COG2319  230 LWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASG 306
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-213 5.81e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 5.81e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   8 KLQEFVAHSAAVNCLKIgRKSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWD 87
Cdd:cd00200   85 CVRTLTGHTSYVSSVAF-SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  88 LEEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVV 167
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTI 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 145357786 168 KVWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWD 213
Cdd:cd00200  244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
9-216 8.20e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 203.22  E-value: 8.20e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   9 LQEFVAHSAAVNCLKIGRkSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDL 88
Cdd:COG2319  197 LRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  89 EEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVK 168
Cdd:COG2319  276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 145357786 169 VWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLET 216
Cdd:COG2319  356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
28-245 3.86e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.29  E-value: 3.86e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  28 SSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDLEEAKVVRTLTGHRSNCVSV 107
Cdd:COG2319   47 DGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 108 NFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWDLTAGKLLHEFKSHEGK 187
Cdd:COG2319  127 AFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 145357786 188 IQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCG 245
Cdd:COG2319  207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264
Katanin_con80 pfam13925
con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein ...
 677-832 1.78e-48

con80 domain of Katanin; The con80 domain of katanin is the C-terminal region of the protein that binds to the N-terminal domain of katanin-p60, the catalytic ATPase. The complex associates with a specific subregion of the mitotic spindle leading to increased microtubule disassembly and targeting of p60 to the spindle poles. The assembly and function of the mitotic spindle requires the activity of a number of microtubule-binding proteins. Katanin, a heterodimeric microtubule-severing ATPase, is found localized at mitotic spindle poles. A proposed model is that katanin is targeted to spindle poles through a combination of direct microtubule binding by the p60 subunit and through interactions between the WD40 domain and an unknown protein.


Pssm-ID: 464044  Cd Length: 160  Bit Score: 168.95  E-value: 1.78e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  677 QHDQFVSSMHSRLAKLQVVRRYWERNDIKNSISSIEKMADNAVIADVLLIVNERPEILTLDTCTSLLPLLTALLGSNMDS 756
Cdd:pfam13925   2 DHDTMLSVLQSRLLKLQVVRTLWRRNDIKGAIEAAVRMQDPSVLVDVLSVLQLKPELITLDLCVDLLPLLKELLKSKYER 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 145357786  757 HLSVCLDLLLKLVRMYGSQIYSSLSA-PSSVGVDIEAEQRMERYSCCFVEFEKIKACLPSLARRGNLVAKTLHELNL 832
Cdd:pfam13925  82 YIIVGLDFLRLILKNFGPVIKSALSApPSSVGVDLSREERLEKCNECFKELQKIRQILKKLARRSGKLGELARELNL 158
WD40 COG2319
WD40 repeat [General function prediction only];
28-245 8.92e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 169.32  E-value: 8.92e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  28 SSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDLEEAKVVRTLTGHRSNCVSV 107
Cdd:COG2319    5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 108 NFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWDLTAGKLLHEFKSHEGK 187
Cdd:COG2319   85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 145357786 188 IQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFNPDGKSVLCG 245
Cdd:COG2319  165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
67-245 1.58e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.02  E-value: 1.58e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  67 FDASEGLVAAGAASGTIKLWDLEEAKVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRGV 146
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 147 NVLRFTPDGRWIVSGGEDNVVKVWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTE 226
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                        170
                 ....*....|....*....
gi 145357786 227 TTGVRCLTFNPDGKSVLCG 245
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASG 180
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-294 5.73e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 5.73e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 135 CIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDL 214
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 215 ETFELIGSGGTETTGVRCLTFNPDGKSVL-CGLQESLKIFSWEP------IRCH-DGV-DVGWSnlsdmnvHEGKLLGCS 285
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSsSSRDKTIKVWDVETgkclttLRGHtDWVnSVAFS-------PDGTFVASS 153


                 ....*....
gi 145357786 286 YNQNCVGVW 294
Cdd:cd00200  154 SQDGTIKLW 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-171 3.47e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 55.78  E-value: 3.47e-10
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 145357786   135 CIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWD 171
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
135-171 7.63e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.66  E-value: 7.63e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 145357786  135 CIHTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWD 171
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 41-209 1.13e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 1.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  41 VNLWAIGKPNAILSLYGHSSGIDSVTFDASE-GLVAAGAASGTIKLWDLEEAKVVRTLTGhRSNCVSVNF-HPFGEFFAS 118
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 119 GSLDTNLKIWDIRK-KGCIHTYKGHTRGVNVLRFTpDGRWIVSGGEDNVVKVWDLTAG------KLLHEFKSHEGKIQSL 191
Cdd:PLN00181 636 GSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFMGHTNVKNFV 714

                        170
                 ....*....|....*...
gi 145357786 192 DFHPHEFLLATGSADKTV 209
Cdd:PLN00181 715 GLSVSDGYIATGSETNEV 732
PTZ00421 PTZ00421
coronin; Provisional
 97-233 1.25e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 61.45  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  97 LTGHRSNCVSVNFHPFG--EFFaSGSLDTNLKIWDIRKKGC-------IHTYKGHTRGVNVLRFTPDGRWIV-SGGEDNV 166
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDpqKLF-TASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMNVLaSAGADMV 149

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145357786 167 VKVWDLTAGKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTG--VRCL 233
Cdd:PTZ00421 150 VNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksQRCL 218
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-213 2.18e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 2.18e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 145357786   175 GKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWD 213
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 59-243 5.31e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 59.58  E-value: 5.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  59 SSGIDSVTFDASEGLVA------AGAASGTIKLWDLEEAKVVRTLTGHRSNCVSVNFHP-FGEFFASGSLDTNLKIWDIR 131
Cdd:PTZ00420  26 SRVIDSCGIACSSGFVAvpweveGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIP 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 132 KKG----------CIhtYKGHTRGVNVLRFTPDGRWIV-SGGEDNVVKVWDLTAGKLLHEFKSHEgKIQSLDFHPHEFLL 200
Cdd:PTZ00420 106 HNDesvkeikdpqCI--LKGHKKKISIIDWNPMNYYIMcSSGFDSFVNIWDIENEKRAFQINMPK-KLSSLKWNIKGNLL 182

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 145357786 201 ATGSADKTVKFWDLETFE-----LIGSGGTETTGVRCLTFNPDGKSVL 243
Cdd:PTZ00420 183 SGTCVGKHMHIIDPRKQEiassfHIHDGGKNTKNIWIDGLGGDDNYIL 230
WD40 pfam00400
WD domain, G-beta repeat;
175-213 2.44e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 2.44e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 145357786  175 GKLLHEFKSHEGKIQSLDFHPHEFLLATGSADKTVKFWD 213
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 102-245 4.18e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 4.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 102 SNCV-SVNFHPFGEFFASGSLDTNLKIWD----IRKKGCIH----TYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWDL 172
Cdd:PLN00181 483 SNLVcAIGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHypvvELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDV 562

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 145357786 173 TAGKLLHEFKSHEGKIQSLDFHPHE-FLLATGSADKTVKFWDLETFELIGSGGTETTgVRCLTFNPD-GKSVLCG 245
Cdd:PLN00181 563 ARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFG 636
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-129 1.15e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 145357786    92 KVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWD 129
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
92-129 4.56e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 4.56e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 145357786   92 KVVRTLTGHRSNCVSVNFHPFGEFFASGSLDTNLKIWD 129
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 2-170 1.04e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.40  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   2 NTKRAYKLQEFVAHSAAVNCLKIGRKSSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSgIDSVTFDASEGL-VAAGAAS 80
Cdd:PLN00181 561 DVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESGRsLAFGSAD 639

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  81 GTIKLWDLEEAKV-VRTLTGHRSNCVSVNFHPfGEFFASGSLDTNLKIWDIR------KKGCIHTYKGHTRGVNVLRFTP 153
Cdd:PLN00181 640 HKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGHTNVKNFVGLSV 718

                        170
                 ....*....|....*..
gi 145357786 154 DGRWIVSGGEDNVVKVW 170
Cdd:PLN00181 719 SDGYIATGSETNEVFVY 735
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 74-214 1.75e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 1.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  74 VAAGAASGTIKLWDLEEAKVVRTLTGHRSNCVSVNFHPFG-EFFASGSLDTNLKIWDIRKKGCIHTYKGHTrGVNVLRFT 152
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKA-NICCVQFP 626

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 145357786 153 PD-GRWIVSGGEDNVVKVWDLTAGKL-LHEFKSHEGKIQSLDFHPHEFLLATgSADKTVKFWDL 214
Cdd:PLN00181 627 SEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
52-87 2.30e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 145357786   52 ILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWD 87
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 67-180 3.22e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 42.65  E-value: 3.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786   67 FDASEGLVAAGAASGTIKLWDLEeAKVVRTLTGHRSNCVSvnFHPFGEFFAS---GSLDTNLKIWDIRKKGCIHTYKgHT 143
Cdd:pfam08662  69 PNGKEFAVIYGYMPAKVSFFDLK-GNVIHSFGEQPRNTIF--WSPFGRLVLLagfGNLAGDIEFWDVVNKKKIATAE-AS 144

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 145357786  144 RGVnVLRFTPDGRWIVSGGE------DNVVKVWDLTaGKLLHE 180
Cdd:pfam08662 145 NAT-LCEWSPDGRYFLTATTaprlrvDNGFKIWHYN-GALVYK 185
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 52-87 3.94e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.94e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 145357786    52 ILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWD 87
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 32-145 7.38e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 7.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  32 LVTGGEDHKVNLWAI---GKPNAILS----LYGHSSGIDSVTFDAS-EGLVAAGAASGTIKLWDLEEAKVVRTLTGHRSN 103
Cdd:PTZ00421  91 LFTASEDGTIMGWGIpeeGLTQNISDpivhLQGHTKKVGIVSFHPSaMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 145357786 104 CVSVNFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGHTRG 145
Cdd:PTZ00421 171 ITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
28-217 1.52e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  28 SSRVLVTGGEDHKVNLWAIGKPNAILSLYGHSSGIDSVTFDASEG--LVAAGAASGTIKLWDLEEAKVVRTLTGHrSNCV 105
Cdd:COG3391   35 PLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGrrLYVANSGSGRVSVIDLATGKVVATIPVG-GGPR 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786 106 SVNFHPFGEF-FASGSLDTNLKIWDIRKKGCIHTYK--GHTRGVnvlRFTPDGRWI-VSGGEDN----VVKVWDLTAGKL 177
Cdd:COG3391  114 GLAVDPDGGRlYVADSGNGRVSVIDTATGKVVATIPvgAGPHGI---AVDPDGKRLyVANSGSNtvsvIVSVIDTATGKV 190

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 145357786 178 LHEFKSHEGkIQSLDFHPHEFLL--------ATGSADKTVKFWDLETF 217
Cdd:COG3391  191 VATIPVGGG-PVGVAVSPDGRRLyvanrgsnTSNGGSNTVSVIDLATL 237
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 126-193 2.82e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.64  E-value: 2.82e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 145357786  126 KIWDIrkkgcihTYKGHTRGVNVLRFTPDGRWIVSGGEDNVVKVWDLTAGKLLHEFKSHEGKIQSLDF 193
Cdd:pfam12894  28 RVWTL-------SPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 24-133 4.80e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 39.90  E-value: 4.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145357786  24 IGRKSSRVLVTGGEDHKVNLWAIG---KPnaILSLYGHSSGIDSVTFDASEGLVAAGAASGTIKLWDLEEAKVVRTLTGH 100
Cdd:cd22857  187 LSKDDHRKIVTGTGYHQVRLYDTRaqrRP--VVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGK 264

                         90       100       110
                 ....*....|....*....|....*....|....
gi 145357786 101 RSNCV-SVNFHPFGEFFASGSLDTNLKIWDIRKK 133
Cdd:cd22857  265 CGGSIrSIARHPELPLIASCGLDRYLRIWDTETR 298
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 9-44 9.58e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 9.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 145357786     9 LQEFVAHSAAVNCLKIgRKSSRVLVTGGEDHKVNLW 44
Cdd:smart00320   5 LKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 168-236 9.65e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.10  E-value: 9.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 145357786  168 KVWDLTAGKllhefksHEGKIQSLDFHPHEFLLATGSADKTVKFWDLETFELIGSGGTETTGVRCLTFN 236
Cdd:pfam12894  28 RVWTLSPDK-------EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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