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Conserved domains on  [gi|18420460|ref|NP_568061|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11459274)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 122-298 3.56e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 85.94  E-value: 3.56e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 122 FEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLLI 201
Cdd:COG2956  31 LEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 202 RALHGLAMVMHKTHDTSvfdmliEAMEVARQGNRVTEER-NIQVLIGQMHIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQ 280
Cdd:COG2956 111 EALRLLAEIYEQEGDWE------KAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLL 184

                       170
                ....*....|....*...
gi 18420460 281 GIVYSLMDKKEEAAQQFE 298
Cdd:COG2956 185 AELYLEQGDYEEAIAALE 202
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 122-298 3.56e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 85.94  E-value: 3.56e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 122 FEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLLI 201
Cdd:COG2956  31 LEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 202 RALHGLAMVMHKTHDTSvfdmliEAMEVARQGNRVTEER-NIQVLIGQMHIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQ 280
Cdd:COG2956 111 EALRLLAEIYEQEGDWE------KAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLL 184

                       170
                ....*....|....*...
gi 18420460 281 GIVYSLMDKKEEAAQQFE 298
Cdd:COG2956 185 AELYLEQGDYEEAIAALE 202
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 120-306 1.32e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 56.25  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   120 KMFEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPL 199
Cdd:TIGR02917 520 QRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPD 599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   200 LIRALH--GLAMVMHKTHDT--SVFDMLIE------------------------AMEVARQG-NRVTEERNIQVLIGQMH 250
Cdd:TIGR02917 600 SPEAWLmlGRAQLAAGDLNKavSSFKKLLAlqpdsalalllladayavmknyakAITSLKRAlELKPDNTEAQIGLAQLL 679

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 18420460   251 IVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVPG 306
Cdd:TIGR02917 680 LAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPS 735
PknG_TPR pfam16918
Protein kinase G tetratricopeptide repeat; This domain is found at the C-terminus of protein ...
 250-337 1.68e-03

Protein kinase G tetratricopeptide repeat; This domain is found at the C-terminus of protein kinase G and contains a tetratricopeptide repeat (TPR).


Pssm-ID: 435652 [Multi-domain]  Cd Length: 340  Bit Score: 39.68  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   250 HIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVPGEFPQKgflddVALAAQAksrERL 329
Cdd:pfam16918 104 HLDLGDVAKARRLLDRLAPTVGGDWRLDWYRGIAELLAGDYEEAFAHFDEVLAALPGEIAPK-----LALAATA---ELA 175


                  ....*...
gi 18420460   330 QNTFKAKF 337
Cdd:pfam16918 176 GETDEHKY 183
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 122-298 3.56e-19

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 85.94  E-value: 3.56e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 122 FEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLLI 201
Cdd:COG2956  31 LEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDA 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 202 RALHGLAMVMHKTHDTSvfdmliEAMEVARQGNRVTEER-NIQVLIGQMHIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQ 280
Cdd:COG2956 111 EALRLLAEIYEQEGDWE------KAIEVLERLLKLGPENaHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLL 184

                       170
                ....*....|....*...
gi 18420460 281 GIVYSLMDKKEEAAQQFE 298
Cdd:COG2956 185 AELYLEQGDYEEAIAALE 202
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 119-306 4.44e-15

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 74.38  E-value: 4.44e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEAMK--AVVYkkMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKE 196
Cdd:COG2956  62 IRIHQKLLERDPDRAEALLelAQDY--LKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKL 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 197 QPLLIRALHGLAMVMHKTHDtsvFDMLIEAMEVARQGNRvtEERNIQVLIGQMHIVEGQFEEGLKIFQQMVNDNPRDFRP 276
Cdd:COG2956 140 GPENAHAYCELAELYLEQGD---YDEAIEALEKALKLDP--DCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPA 214

                       170       180       190
                ....*....|....*....|....*....|
gi 18420460 277 YLCQGIVYSLMDKKEEAAQQFEIYWSLVPG 306
Cdd:COG2956 215 LPRLAELYEKLGDPEEALELLRKALELDPS 244
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 119-298 2.45e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 72.07  E-value: 2.45e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQP 198
Cdd:COG2956  96 EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDP 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 199 LLIRALHGLAMVMHKTHDTSvfdmliEAMEVARQGNRVTEER-NIQVLIGQMHIVEGQFEEGLKIFQQMVNDNPRDfRPY 277
Cdd:COG2956 176 DCARALLLLAELYLEQGDYE------EAIAALERALEQDPDYlPALPRLAELYEKLGDPEEALELLRKALELDPSD-DLL 248

                       170       180
                ....*....|....*....|.
gi 18420460 278 LCQGIVYSLMDKKEEAAQQFE 298
Cdd:COG2956 249 LALADLLERKEGLEAALALLE 269
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
126-330 4.47e-13

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 4.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 126 LENEPENMEAM--KAVVYkkMRRGKNEDAVKYVEKLMKLEPHEVE-WKLLeALCYETMGELSKAKRLYKDILKEQPLLIR 202
Cdd:COG0457   1 LELDPDDAEAYnnLGLAY--RRLGRYEEAIEDYEKALELDPDDAEaLYNL-GLAYLRLGRYEEALADYEQALELDPDDAE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 203 ALHGLAMVMHKTHDTSvfdmliEAMEVARQGNRVtEERNIQVL--IGQMHIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQ 280
Cdd:COG0457  78 ALNNLGLALQALGRYE------EALEDYDKALEL-DPDDAEALynLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 18420460 281 GIVYSLMDKKEEAAQQFEIYWSLVPGEFPQKGFLDDVALAAQAKSRERLQ 330
Cdd:COG0457 151 GIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALL 200
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 119-217 7.80e-12

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 62.13  E-value: 7.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEA--MKAVVYkkMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKE 196
Cdd:COG4783  24 EALLEKALELDPDNPEAfaLLGEIL--LQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKL 101

                        90       100
                ....*....|....*....|.
gi 18420460 197 QPLLIRALHGLAMVMHKTHDT 217
Cdd:COG4783 102 DPEHPEAYLRLARAYRALGRP 122
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 167-307 5.21e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 59.82  E-value: 5.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 167 VEWKLLEALCYETMGELSKAKRLYKDILKEQPLLIRALHGLAMVMHKTHDTSvfdmliEAMEVARQGNRVT-EERNIQVL 245
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLD------EAIVLLHEALELDpDEPEARLN 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18420460 246 IGQMHIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVPGE 307
Cdd:COG4783  78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 144-298 9.07e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 9.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 144 MRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLLIRALHGLAMVMHKTHDtsvFDml 223
Cdd:COG2956  19 LLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGL---LD-- 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18420460 224 iEAMEVARQGNRvTEERNIQVL--IGQMHIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFE 298
Cdd:COG2956  94 -RAEELLEKLLE-LDPDDAEALrlLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALE 168
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 143-273 4.32e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 4.32e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 143 KMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLLIRALHGLAMVMHKTHDTSvfdm 222
Cdd:COG4783  14 LLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYD---- 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 18420460 223 liEAMEVARQGNRVTEER-NIQVLIGQMHIVEGQFEEGLKIFQQMVNDNPRD 273
Cdd:COG4783  90 --EALALLEKALKLDPEHpEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 122-216 1.24e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 52.70  E-value: 1.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 122 FEKLLENEPENMEA--MKAVVYkkMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPL 199
Cdd:COG4235   6 LRQALAANPNDAEGwlLLGRAY--LRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPD 83

                        90
                ....*....|....*..
gi 18420460 200 LIRALHGLAMVMHKTHD 216
Cdd:COG4235  84 NPEALYLLGLAAFQQGD 100
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 120-306 1.32e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 56.25  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   120 KMFEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPL 199
Cdd:TIGR02917 520 QRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADAAPD 599

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   200 LIRALH--GLAMVMHKTHDT--SVFDMLIE------------------------AMEVARQG-NRVTEERNIQVLIGQMH 250
Cdd:TIGR02917 600 SPEAWLmlGRAQLAAGDLNKavSSFKKLLAlqpdsalalllladayavmknyakAITSLKRAlELKPDNTEAQIGLAQLL 679

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 18420460   251 IVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVPG 306
Cdd:TIGR02917 680 LAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAPS 735
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
119-202 1.24e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.01  E-value: 1.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYvEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQP 198
Cdd:COG3063  12 EEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90


                ....
gi 18420460 199 LLIR 202
Cdd:COG3063  91 SALR 94
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 119-199 3.03e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.57  E-value: 3.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQP 198
Cdd:COG5010  74 LALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153


                .
gi 18420460 199 L 199
Cdd:COG5010 154 L 154
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 144-305 4.97e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 4.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 144 MRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLLIRALHGLAMVMHKThdtsvfdml 223
Cdd:COG3914  89 QALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRL--------- 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 224 ieamevarqgnrvteerniqvligqmhiveGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSL 303
Cdd:COG3914 160 ------------------------------GRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALEL 209


                ..
gi 18420460 304 VP 305
Cdd:COG3914 210 DP 211
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 122-232 8.24e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 50.76  E-value: 8.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 122 FEKLLENEPENMEAMK--AVVYkkMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPL 199
Cdd:COG3914 101 YRRALALNPDNAEALFnlGNLL--LALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPD 178

                        90       100       110
                ....*....|....*....|....*....|...
gi 18420460 200 LIRALHGLAMVMHKTHDTSvfdmliEAMEVARQ 232
Cdd:COG3914 179 NAEALNNLGNALQDLGRLE------EAIAAYRR 205
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 119-228 1.69e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.96  E-value: 1.69e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEA--MKAVVYkkMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKE 196
Cdd:COG2956 164 IEALEKALKLDPDCARAllLLAELY--LEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241

                        90       100       110
                ....*....|....*....|....*....|..
gi 18420460 197 QPLLIRALHGLAMVMHKTHDTSVFDMLIEAME 228
Cdd:COG2956 242 DPSDDLLLALADLLERKEGLEAALALLERQLR 273
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 122-298 2.69e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.31  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   122 FEKLLENEPENMEAMK-AVVYkkMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLL 200
Cdd:TIGR02917 726 YRKALKRAPSSQNAIKlHRAL--LASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDN 803

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   201 IRALHGLAMVMHKTHDTSVFDMLIEAMEVARQgnrvteerNIQVL--IGQMHIVEGQFEEGLKIFQQMVNDNPRDFRPYL 278
Cdd:TIGR02917 804 AVVLNNLAWLYLELKDPRALEYAERALKLAPN--------IPAILdtLGWLLVEKGEADRALPLLRKAVNIAPEAAAIRY 875

                         170       180
                  ....*....|....*....|
gi 18420460   279 CQGIVYSLMDKKEEAAQQFE 298
Cdd:TIGR02917 876 HLALALLATGRKAEARKELD 895
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 119-236 3.51e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 48.84  E-value: 3.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEAM--KAVVYKKMRRGknEDAVKYVEKLMKLEPHEVE-WKLLeALCYETMGELSKAKRLYKDILK 195
Cdd:COG3914 132 LAALRRALALNPDFAEAYlnLGEALRRLGRL--EEAIAALRRALELDPDNAEaLNNL-GNALQDLGRLEEAIAAYRRALE 208

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 18420460 196 EQPLLIRALHGLAMVMHKTHDTSVFDMLIEAMEVARQGNRV 236
Cdd:COG3914 209 LDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSE 249
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 119-198 4.91e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.57  E-value: 4.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEA--MKAVVYkkMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKE 196
Cdd:COG4783  58 IVLLHEALELDPDEPEArlNLGLAL--LKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALEL 135


                ..
gi 18420460 197 QP 198
Cdd:COG4783 136 DP 137
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 12-299 6.59e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 47.77  E-value: 6.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460    12 PAKFHHRREQSLIFTPTHLRNPNG-FQFRWRKSRPFA-------PRLAQPDNFAPPLPLIRSstsLLSSKDFVQML--AR 81
Cdd:TIGR02917 515 PDDAIQRFEKVLTIDPKNLRAILAlAGLYLRTGNEEEavawlekAAELNPQEIEPALALAQY---YLGKGQLKKALaiLN 591

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460    82 KAAillvgsfvfLGFCSSKPALALPTATVVSQAELEDE-KMFEKLLENEPENMEAMK--AVVYKKMRrgKNEDAVKYVEK 158
Cdd:TIGR02917 592 EAA---------DAAPDSPEAWLMLGRAQLAAGDLNKAvSSFKKLLALQPDSALALLllADAYAVMK--NYAKAITSLKR 660

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   159 LMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPL--LIRALHG-LAMVMHKthdtsvFDMLIEAMEVARQgnr 235
Cdd:TIGR02917 661 ALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKaaLGFELEGdLYLRQKD------YPAAIQAYRKALK--- 731

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18420460   236 vtEERNIQVLIGQMHIV--EGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEI 299
Cdd:TIGR02917 732 --RAPSSQNAIKLHRALlaSGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQT 795
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 119-198 7.33e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.00  E-value: 7.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEAM--KAVVYkkMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKE 196
Cdd:COG4235  37 LAAYEKALRLDPDNADALldLAEAL--LAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLAL 114


                ..
gi 18420460 197 QP 198
Cdd:COG4235 115 LP 116
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 144-216 1.05e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 42.25  E-value: 1.05e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18420460 144 MRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLLIRALHGLAMVMHKTHD 216
Cdd:COG5010  65 NKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQ 137
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 237-308 1.66e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.33  E-value: 1.66e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18420460 237 TEERNIQVLIGQMHIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVPGEF 308
Cdd:COG4783   1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEP 72
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
144-217 1.87e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.77  E-value: 1.87e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18420460 144 MRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRlYKDILKEQPLLIRALHGLAMVMHKTHDT 217
Cdd:COG3063   3 LKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDY 75
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 151-309 2.07e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 2.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 151 DAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLLIRALHGLAMVMHKTHDTsvfdmlieameva 230
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT------------- 67

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18420460 231 rqgnrvteerniqvligqmhivegqfEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVPGEFP 309
Cdd:COG4235  68 --------------------------EEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAP 120
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 171-298 2.98e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.02  E-value: 2.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 171 LLEALCYETMGELSKAKRLYKDILKEQPLLIRALHGLAMVMHKTHDtsvFDMLIEAME--VARQGNRVteerNIQVLIGQ 248
Cdd:COG2956  12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGE---YDRAIRIHQklLERDPDRA----EALLELAQ 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 18420460 249 MHIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFE 298
Cdd:COG2956  85 DYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLE 134
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 119-175 3.01e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.37  E-value: 3.01e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 18420460 119 EKMFEKLLENEPENMEA--MKAVVYkkMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEAL 175
Cdd:COG4235  71 EELLERALALDPDNPEAlyLLGLAA--FQQGDYAEAIAAWQKLLALLPADAPARLLEAS 127
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 69-298 3.98e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 3.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460    69 LLSSKDFVQMLA--RKAAILlvgsfvflGFCSSKPALALPTATVVSQAELEDEKMFEKLLENEPENMEA--MKAVVykKM 144
Cdd:TIGR02917 203 LLSLGNIELALAayRKAIAL--------RPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAhyLKALV--DF 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   145 RRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQPLLIRALHGLAMVMHKTHDTsvfdmli 224
Cdd:TIGR02917 273 QKKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRLGRV------- 345

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18420460   225 eaMEVARQGNRV--TEERNIQVL--IGQMHIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFE 298
Cdd:TIGR02917 346 --DEAIATLSPAlgLDPDDPAALslLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLE 421
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 119-294 1.14e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.84  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   119 EKMFEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQP 198
Cdd:TIGR02917 485 REAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNP 564

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   199 LLIRALHGLAMVMHKTHDtsvfdmLIEAMEVAR--QGNRVTEERNIQVLiGQMHIVEGQFEEGLKIFQQMVNDNPRDFRP 276
Cdd:TIGR02917 565 QEIEPALALAQYYLGKGQ------LKKALAILNeaADAAPDSPEAWLML-GRAQLAAGDLNKAVSSFKKLLALQPDSALA 637

                         170
                  ....*....|....*...
gi 18420460   277 YLCQGIVYSLMDKKEEAA 294
Cdd:TIGR02917 638 LLLLADAYAVMKNYAKAI 655
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 102-305 1.30e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.45  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   102 ALALPTATVVSQAELED-EKMFEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETM 180
Cdd:TIGR02917 127 LLALRGLAYLGLGQLELaQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTADPGNVDALLLKGDLLLSL 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   181 GELSKAKRLYKDILKEQPLLIRALHGLAMVMHKTHDtsvFDMLIEAMEVARQgnRVTEERNIQVLIGQMHIVEGQFEEGL 260
Cdd:TIGR02917 207 GNIELALAAYRKAIALRPNNIAVLLALATILIEAGE---FEEAEKHADALLK--KAPNSPLAHYLKALVDFQKKNYEDAR 281

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 18420460   261 KIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVP 305
Cdd:TIGR02917 282 ETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAP 326
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
176-275 1.43e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 1.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 176 CYETMGELSKAKRLYKDILKEQPLLIRALHGLAMVMHKTHDTSvfdmliEAMEVARQGNRVTEERNIQVLIGQMHIVEGQ 255
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYD------EAIALEKALKLDPNNAEALLNLAELLLELGD 74

                        90       100
                ....*....|....*....|
gi 18420460 256 FEEGLKIFQQMVNDNPRDFR 275
Cdd:COG3063  75 YDEALAYLERALELDPSALR 94
PknG_TPR pfam16918
Protein kinase G tetratricopeptide repeat; This domain is found at the C-terminus of protein ...
 250-337 1.68e-03

Protein kinase G tetratricopeptide repeat; This domain is found at the C-terminus of protein kinase G and contains a tetratricopeptide repeat (TPR).


Pssm-ID: 435652 [Multi-domain]  Cd Length: 340  Bit Score: 39.68  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   250 HIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVPGEFPQKgflddVALAAQAksrERL 329
Cdd:pfam16918 104 HLDLGDVAKARRLLDRLAPTVGGDWRLDWYRGIAELLAGDYEEAFAHFDEVLAALPGEIAPK-----LALAATA---ELA 175


                  ....*...
gi 18420460   330 QNTFKAKF 337
Cdd:pfam16918 176 GETDEHKY 183
TPR_19 pfam14559
Tetratricopeptide repeat;
147-198 2.02e-03

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 36.02  E-value: 2.02e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 18420460   147 GKNEDAVKYVEKLMKLEPHEVEWKLLEALCYETMGELSKAKRLYKDILKEQP 198
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADP 53
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
250-305 2.42e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 38.74  E-value: 2.42e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18420460 250 HIVEGQFEEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVP 305
Cdd:COG4785 117 YLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDP 172
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 119-198 2.90e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.89  E-value: 2.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460 119 EKMFEKLLENEPENMEA-----MKAVVYkkMRRGKNEDAVKYVEKLMKLEPH-----EVEWKLleALCYETMGELSKAKR 188
Cdd:COG1729  13 IAAFKAFLKRYPNSPLApdalyWLGEAY--YALGDYDEAAEAFEKLLKRYPDspkapDALLKL--GLSYLELGDYDKARA 88

                        90
                ....*....|
gi 18420460 189 LYKDILKEQP 198
Cdd:COG1729  89 TLEELIKKYP 98
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 101-331 4.05e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   101 PALALPTATVVSQAELED-EKMFEKLLENEPENMEAMKAVVYKKMRRGKNEDAVKYVEKLMKLEPheVEWKLLEALCYET 179
Cdd:TIGR02917 296 PALLLAGASEYQLGNLEQaYQYLNQILKYAPNSHQARRLLASIQLRLGRVDEAIATLSPALGLDP--DDPAALSLLGEAY 373

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18420460   180 M--GELSKAKRLYKDILKEQPLLIRALHGLAMV-MHKTHDTSVFDMLIEAMEVARQGNRVteerniQVLIGQMHIVEGQF 256
Cdd:TIGR02917 374 LalGDFEKAAEYLAKATELDPENAAARTQLGISkLSQGDPSEAIADLETAAQLDPELGRA------DLLLILSYLRSGQF 447

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18420460   257 EEGLKIFQQMVNDNPRDFRPYLCQGIVYSLMDKKEEAAQQFEIYWSLVPGEFPQKGFLDDVALAAQ--AKSRERLQN 331
Cdd:TIGR02917 448 DKALAAAKKLEKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGnpDDAIQRFEK 524
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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