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Conserved domains on  [gi|18419744|ref|NP_567992|]
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Trm112p-like protein [Arabidopsis thaliana]

Protein Classification

Trm112 family protein( domain architecture ID 10006712)

Trm112 family protein with similarity to Schizosaccharomyces pombe multifunctional methyltransferase subunit trm112, which acts as an activator of both rRNA/tRNA and protein methyltransferases

CATH:  2.20.25.10
PubMed:  28134793|30010922

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Trm112 COG2835
RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];
16-75 3.57e-14

RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 442083 [Multi-domain]  Cd Length: 60  Bit Score: 60.28  E-value: 3.57e-14
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18419744 16 IDKTLSEILVCPLSKQPLRFCEKTKSLVSDTIGVSFPIKDGIPCLVPKDGKILEEEGDAS 75
Cdd:COG2835  1 MDPRLLEILACPVCKGPLELDKEEGELVCTACGLAYPIRDGIPVLLPDEARPLSEDEEFS 60
 
Name Accession Description Interval E-value
Trm112 COG2835
RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];
16-75 3.57e-14

RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442083 [Multi-domain]  Cd Length: 60  Bit Score: 60.28  E-value: 3.57e-14
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18419744 16 IDKTLSEILVCPLSKQPLRFCEKTKSLVSDTIGVSFPIKDGIPCLVPKDGKILEEEGDAS 75
Cdd:COG2835  1 MDPRLLEILACPVCKGPLELDKEEGELVCTACGLAYPIRDGIPVLLPDEARPLSEDEEFS 60
Trm112p pfam03966
Trm112p-like protein; The function of this family is uncertain. The bacterial members are ...
17-56 7.47e-07

Trm112p-like protein; The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices.


Pssm-ID: 397869  Cd Length: 44  Bit Score: 41.38  E-value: 7.47e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 18419744   17 DKTLSEILVCPLSKQPLRFCEKTK----SLVSDTIGVSFPIKDG 56
Cdd:pfam03966  1 DLLLLEILACPLCKGPLHLLLEYDieegELVCPECGLAYPIRDG 44
PRK11827 PRK11827
protein YcaR;
16-75 4.85e-06

protein YcaR;


Pssm-ID: 183328  Cd Length: 60  Bit Score: 39.59  E-value: 4.85e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18419744  16 IDKTLSEILVCPLSKQPLRFCEKTKSLVSDTIGVSFPIKDGIPCLVPKDGKILEEEGDAS 75
Cdd:PRK11827  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
 
Name Accession Description Interval E-value
Trm112 COG2835
RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];
16-75 3.57e-14

RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442083 [Multi-domain]  Cd Length: 60  Bit Score: 60.28  E-value: 3.57e-14
                       10        20        30        40        50        60
               ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18419744 16 IDKTLSEILVCPLSKQPLRFCEKTKSLVSDTIGVSFPIKDGIPCLVPKDGKILEEEGDAS 75
Cdd:COG2835  1 MDPRLLEILACPVCKGPLELDKEEGELVCTACGLAYPIRDGIPVLLPDEARPLSEDEEFS 60
Trm112p pfam03966
Trm112p-like protein; The function of this family is uncertain. The bacterial members are ...
17-56 7.47e-07

Trm112p-like protein; The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices.


Pssm-ID: 397869  Cd Length: 44  Bit Score: 41.38  E-value: 7.47e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 18419744   17 DKTLSEILVCPLSKQPLRFCEKTK----SLVSDTIGVSFPIKDG 56
Cdd:pfam03966  1 DLLLLEILACPLCKGPLHLLLEYDieegELVCPECGLAYPIRDG 44
PRK11827 PRK11827
protein YcaR;
16-75 4.85e-06

protein YcaR;


Pssm-ID: 183328  Cd Length: 60  Bit Score: 39.59  E-value: 4.85e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18419744  16 IDKTLSEILVCPLSKQPLRFCEKTKSLVSDTIGVSFPIKDGIPCLVPKDGKILEEEGDAS 75
Cdd:PRK11827  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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