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Conserved domains on  [gi|18415244|ref|NP_567575|]
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S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 12042358)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; similar to Arabidopsis thaliana methyltransferase PMTs

CATH:  2.20.25.110
EC:  2.1.1.-
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Methyltransf_29 pfam03141
Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative ...
79-587 0e+00

Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase.


:

Pssm-ID: 335237 [Multi-domain]  Cd Length: 506  Bit Score: 807.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244    79 DYTPCTDPRKWKKY--GTHRLTFMERHCPPVFDRKQCLVPPPDGYKPPIRWPKSKDECWYRNVPYDWINKQKSNQNWLRK 156
Cdd:pfam03141   1 DYIPCLDNKRAIKFllSRERMEHRERHCPPPEEKLNCLVPPPDGYKTPIPWPKSRDKVWYANVPHTKLAEEKGGQNWVKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   157 EGEKFIFPGGGTMFPHGVSAYVDLMQDLIPEM-KDGTIRTAIDTGCGVASWGGDLLDRGILTVSLAPRDNHEAQVQFALE 235
Cdd:pfam03141  81 EGDKFTFPGGGTQFPHGADQYIDFIAQMIPDIaWGGRVRTALDVGCGVASFGAYLLSRDVLTMSFAPKDVHEAQVQFALE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   236 RGIPAILGIISTQRLPFPSNSFDMAHCSRCLIPWTEFGGVYLLEVHRILRPGGFWVLSGPPVNyenrwkgwDTTIEEQRS 315
Cdd:pfam03141 161 RGIPAMLGVLGTKRLPYPSRSFDLAHCSRCRIPWTANDGILLLEVDRVLRPGGYFVLSGPPVY--------ARTEEDLQE 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   316 NYEKLQELLSSMCFKMYAKKDDIAVWQKSPDNLCYNKlsNDPDAYPPKCDDSLEPDSAWYTPLRPCVVVPSPKLKKTDLE 395
Cdd:pfam03141 233 IWKEMEDLTKSLCWKLVAKKGDIAIWQKPLNNSCYNK--REPGKKPPLCKDSDDPDAAWYVPMEACITPLPEVSHEVGGG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   396 STPKWPERLHTTPERISD--VPGGNGNVFKHDDSKWKTRAKHYKKLL-PAIGSDKIRNVMDMNTAYGGLAAALVNDPLWV 472
Cdd:pfam03141 311 WPEPWPARLTAVPPRLSSgqIGGVSPESFKADTELWKKRVNKYKRLLkLGIDWGKVRNVMDMNAGFGGFAAALIDLPVWV 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   473 MNVVSSYAANTLPVVFDRGLIGTYHDWCEAFSTYPRTYDLLHVDGLFTSESQRCDMKYVMLEMDRILRPSGYAIIRESSY 552
Cdd:pfam03141 391 MNVVPVDSPNTLPVIYDRGLIGIYHDWCEAFSTYPRTYDLLHADHLFSLYKKRCNLVDILLEMDRILRPEGFVIIRDSVD 470
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 18415244   553 FADSIASVAKELRWSCRKEQTESAS-ANEKLLICQK 587
Cdd:pfam03141 471 VLDKVKKIAKAMRWEVRMTDTEDGPhVPEKILIAQK 506
 
Name Accession Description Interval E-value
Methyltransf_29 pfam03141
Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative ...
79-587 0e+00

Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase.


Pssm-ID: 335237 [Multi-domain]  Cd Length: 506  Bit Score: 807.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244    79 DYTPCTDPRKWKKY--GTHRLTFMERHCPPVFDRKQCLVPPPDGYKPPIRWPKSKDECWYRNVPYDWINKQKSNQNWLRK 156
Cdd:pfam03141   1 DYIPCLDNKRAIKFllSRERMEHRERHCPPPEEKLNCLVPPPDGYKTPIPWPKSRDKVWYANVPHTKLAEEKGGQNWVKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   157 EGEKFIFPGGGTMFPHGVSAYVDLMQDLIPEM-KDGTIRTAIDTGCGVASWGGDLLDRGILTVSLAPRDNHEAQVQFALE 235
Cdd:pfam03141  81 EGDKFTFPGGGTQFPHGADQYIDFIAQMIPDIaWGGRVRTALDVGCGVASFGAYLLSRDVLTMSFAPKDVHEAQVQFALE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   236 RGIPAILGIISTQRLPFPSNSFDMAHCSRCLIPWTEFGGVYLLEVHRILRPGGFWVLSGPPVNyenrwkgwDTTIEEQRS 315
Cdd:pfam03141 161 RGIPAMLGVLGTKRLPYPSRSFDLAHCSRCRIPWTANDGILLLEVDRVLRPGGYFVLSGPPVY--------ARTEEDLQE 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   316 NYEKLQELLSSMCFKMYAKKDDIAVWQKSPDNLCYNKlsNDPDAYPPKCDDSLEPDSAWYTPLRPCVVVPSPKLKKTDLE 395
Cdd:pfam03141 233 IWKEMEDLTKSLCWKLVAKKGDIAIWQKPLNNSCYNK--REPGKKPPLCKDSDDPDAAWYVPMEACITPLPEVSHEVGGG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   396 STPKWPERLHTTPERISD--VPGGNGNVFKHDDSKWKTRAKHYKKLL-PAIGSDKIRNVMDMNTAYGGLAAALVNDPLWV 472
Cdd:pfam03141 311 WPEPWPARLTAVPPRLSSgqIGGVSPESFKADTELWKKRVNKYKRLLkLGIDWGKVRNVMDMNAGFGGFAAALIDLPVWV 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   473 MNVVSSYAANTLPVVFDRGLIGTYHDWCEAFSTYPRTYDLLHVDGLFTSESQRCDMKYVMLEMDRILRPSGYAIIRESSY 552
Cdd:pfam03141 391 MNVVPVDSPNTLPVIYDRGLIGIYHDWCEAFSTYPRTYDLLHADHLFSLYKKRCNLVDILLEMDRILRPEGFVIIRDSVD 470
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 18415244   553 FADSIASVAKELRWSCRKEQTESAS-ANEKLLICQK 587
Cdd:pfam03141 471 VLDKVKKIAKAMRWEVRMTDTEDGPhVPEKILIAQK 506
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
174-300 1.57e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 59.62  E-value: 1.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244 174 VSAYVDLMQDLIPEMKDGTIRTAIDTGCGvaswggdlldRGILTVSLAPR-------DNHEAQVQFALERGIPAILGI-- 244
Cdd:COG2226   4 VAARYDGREALLAALGLRPGARVLDLGCG----------TGRLALALAERgarvtgvDISPEMLELARERAAEAGLNVef 73
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244 245 --ISTQRLPFPSNSFDMAHCSRCLIPWTEFGGVyLLEVHRILRPGGFWVLS--GPPVNYE 300
Cdd:COG2226  74 vvGDAEDLPFPDGSFDLVISSFVLHHLPDPERA-LAEIARVLKPGGRLVVVdfSPPDLAE 132
 
Name Accession Description Interval E-value
Methyltransf_29 pfam03141
Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative ...
79-587 0e+00

Putative S-adenosyl-L-methionine-dependent methyltransferase; This family is a putative S-adenosyl-L-methionine (SAM)-dependent methyltransferase.


Pssm-ID: 335237 [Multi-domain]  Cd Length: 506  Bit Score: 807.30  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244    79 DYTPCTDPRKWKKY--GTHRLTFMERHCPPVFDRKQCLVPPPDGYKPPIRWPKSKDECWYRNVPYDWINKQKSNQNWLRK 156
Cdd:pfam03141   1 DYIPCLDNKRAIKFllSRERMEHRERHCPPPEEKLNCLVPPPDGYKTPIPWPKSRDKVWYANVPHTKLAEEKGGQNWVKV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   157 EGEKFIFPGGGTMFPHGVSAYVDLMQDLIPEM-KDGTIRTAIDTGCGVASWGGDLLDRGILTVSLAPRDNHEAQVQFALE 235
Cdd:pfam03141  81 EGDKFTFPGGGTQFPHGADQYIDFIAQMIPDIaWGGRVRTALDVGCGVASFGAYLLSRDVLTMSFAPKDVHEAQVQFALE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   236 RGIPAILGIISTQRLPFPSNSFDMAHCSRCLIPWTEFGGVYLLEVHRILRPGGFWVLSGPPVNyenrwkgwDTTIEEQRS 315
Cdd:pfam03141 161 RGIPAMLGVLGTKRLPYPSRSFDLAHCSRCRIPWTANDGILLLEVDRVLRPGGYFVLSGPPVY--------ARTEEDLQE 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   316 NYEKLQELLSSMCFKMYAKKDDIAVWQKSPDNLCYNKlsNDPDAYPPKCDDSLEPDSAWYTPLRPCVVVPSPKLKKTDLE 395
Cdd:pfam03141 233 IWKEMEDLTKSLCWKLVAKKGDIAIWQKPLNNSCYNK--REPGKKPPLCKDSDDPDAAWYVPMEACITPLPEVSHEVGGG 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   396 STPKWPERLHTTPERISD--VPGGNGNVFKHDDSKWKTRAKHYKKLL-PAIGSDKIRNVMDMNTAYGGLAAALVNDPLWV 472
Cdd:pfam03141 311 WPEPWPARLTAVPPRLSSgqIGGVSPESFKADTELWKKRVNKYKRLLkLGIDWGKVRNVMDMNAGFGGFAAALIDLPVWV 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   473 MNVVSSYAANTLPVVFDRGLIGTYHDWCEAFSTYPRTYDLLHVDGLFTSESQRCDMKYVMLEMDRILRPSGYAIIRESSY 552
Cdd:pfam03141 391 MNVVPVDSPNTLPVIYDRGLIGIYHDWCEAFSTYPRTYDLLHADHLFSLYKKRCNLVDILLEMDRILRPEGFVIIRDSVD 470
                         490       500       510
                  ....*....|....*....|....*....|....*.
gi 18415244   553 FADSIASVAKELRWSCRKEQTESAS-ANEKLLICQK 587
Cdd:pfam03141 471 VLDKVKKIAKAMRWEVRMTDTEDGPhVPEKILIAQK 506
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
174-300 1.57e-10

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 59.62  E-value: 1.57e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244 174 VSAYVDLMQDLIPEMKDGTIRTAIDTGCGvaswggdlldRGILTVSLAPR-------DNHEAQVQFALERGIPAILGI-- 244
Cdd:COG2226   4 VAARYDGREALLAALGLRPGARVLDLGCG----------TGRLALALAERgarvtgvDISPEMLELARERAAEAGLNVef 73
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244 245 --ISTQRLPFPSNSFDMAHCSRCLIPWTEFGGVyLLEVHRILRPGGFWVLS--GPPVNYE 300
Cdd:COG2226  74 vvGDAEDLPFPDGSFDLVISSFVLHHLPDPERA-LAEIARVLKPGGRLVVVdfSPPDLAE 132
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
197-289 8.18e-09

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 53.05  E-value: 8.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   197 IDTGCGVASWGGDLLDRGILTVSLaprDNHEAQVQFALERGIPAILGII--STQRLPFPSNSFDMAHCSRCLiPWTEFGG 274
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGV---DISPEMLELAREKAPREGLTFVvgDAEDLPFPDNSFDLVLSSEVL-HHVEDPE 76
                          90
                  ....*....|....*
gi 18415244   275 VYLLEVHRILRPGGF 289
Cdd:pfam08241  77 RALREIARVLKPGGI 91
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
200-288 1.81e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 49.48  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244   200 GCGVASWGGDLLDRGILTVSLAprDNHEAQVQFALERGIPAILGIISTQ----RLPFPSNSFDMAHCSRCL--IPWTEFG 273
Cdd:pfam13649   5 GCGTGRLTLALARRGGARVTGV--DLSPEMLERARERAAEAGLNVEFVQgdaeDLPFPDGSFDLVVSSGVLhhLPDPDLE 82
                          90
                  ....*....|....*
gi 18415244   274 GVyLLEVHRILRPGG 288
Cdd:pfam13649  83 AA-LREIARVLKPGG 96
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
247-295 3.92e-05

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 44.47  E-value: 3.92e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 18415244 247 TQRLPFPSNSFDMAHCSRCL--IPWTEFGGVyLLEVHRILRPGGFWVLSGP 295
Cdd:COG4627  37 TDPLPFPDNSVDAIYSSHVLehLDYEEAPLA-LKECYRVLKPGGILRIVVP 86
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
194-295 1.17e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 41.93  E-value: 1.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244 194 RTAIDTGCGVaswggdlldrGILTVSLAPR-------DNHEAQVQFALER----GIPAILGiiSTQRLPFPSNSFDMAHC 262
Cdd:COG2227  26 GRVLDVGCGT----------GRLALALARRgadvtgvDISPEALEIARERaaelNVDFVQG--DLEDLPLEDGSFDLVIC 93
                        90       100       110
                ....*....|....*....|....*....|...
gi 18415244 263 SRCLIpWTEFGGVYLLEVHRILRPGGFWVLSGP 295
Cdd:COG2227  94 SEVLE-HLPDPAALLRELARLLKPGGLLLLSTP 125
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
177-294 1.12e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 40.67  E-value: 1.12e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18415244 177 YVDLMQDLIPEMKDGtiRTAIDTGCGvaswggdlldRGILTVSLAPR--------DNHEAQVQFALERGIPAILGIIS-- 246
Cdd:COG0500  13 GLAALLALLERLPKG--GRVLDLGCG----------TGRNLLALAARfggrvigiDLSPEAIALARARAAKAGLGNVEfl 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 18415244 247 ----TQRLPFPSNSFD--MAHCSRCLIPwTEFGGVYLLEVHRILRPGGFWVLSG 294
Cdd:COG0500  81 vadlAELDPLPAESFDlvVAFGVLHHLP-PEEREALLRELARALKPGGVLLLSA 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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