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Conserved domains on  [gi|18411222|ref|NP_567150|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
79-425 7.34e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 7.34e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222  79 LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDAssksfKFLRinlPAGGHP---TAVAFADDASSIVvachhm 155
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----KLLR---TLTGHSgavTSVAFSPDGKLLA------ 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 156 SGSSlymygedkqkDQQGKLplpsikWDhhhIHEKRSVLTISGATAT-YGTA---DGSvVIASCSEGTDIVLWHGKTGRN 231
Cdd:COG2319 179 SGSD----------DGTVRL------WD---LATGKLLRTLTGHTGAvRSVAfspDGK-LLASGSADGTVRLWDLATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 232 LGHVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIvyqKDGSVKEVsrvmqLKGHKSAVTWLCFSPNSEQIITASKDG 311
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL---ATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDG 310

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 312 SIRVWNInvryhldEDPKTLKVFPiplcdsgGNPLHYDRLSLCPEGKILA-ASHGSTLQWLCAETGNVLDTAeKAHEGDI 390
Cdd:COG2319 311 TVRLWDL-------ATGKLLRTLT-------GHTGAVRSVAFSPDGKTLAsGSDDGTVRLWDLATGELLRTL-TGHTGAV 375

                       330       340       350
                ....*....|....*....|....*....|....*
gi 18411222 391 TCISWAPKaitvGERhamvLGTSGDDKKVKLWEAP 425
Cdd:COG2319 376 TSVAFSPD----GRT----LASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
79-425 7.34e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 7.34e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222  79 LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDAssksfKFLRinlPAGGHP---TAVAFADDASSIVvachhm 155
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----KLLR---TLTGHSgavTSVAFSPDGKLLA------ 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 156 SGSSlymygedkqkDQQGKLplpsikWDhhhIHEKRSVLTISGATAT-YGTA---DGSvVIASCSEGTDIVLWHGKTGRN 231
Cdd:COG2319 179 SGSD----------DGTVRL------WD---LATGKLLRTLTGHTGAvRSVAfspDGK-LLASGSADGTVRLWDLATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 232 LGHVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIvyqKDGSVKEVsrvmqLKGHKSAVTWLCFSPNSEQIITASKDG 311
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL---ATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDG 310

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 312 SIRVWNInvryhldEDPKTLKVFPiplcdsgGNPLHYDRLSLCPEGKILA-ASHGSTLQWLCAETGNVLDTAeKAHEGDI 390
Cdd:COG2319 311 TVRLWDL-------ATGKLLRTLT-------GHTGAVRSVAFSPDGKTLAsGSDDGTVRLWDLATGELLRTL-TGHTGAV 375

                       330       340       350
                ....*....|....*....|....*....|....*
gi 18411222 391 TCISWAPKaitvGERhamvLGTSGDDKKVKLWEAP 425
Cdd:COG2319 376 TSVAFSPD----GRT----LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-423 1.11e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 1.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222  81 TLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDASSKSFKflrinlpaGGHP---TAVAFADDASSIVVAchhmsg 157
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL--------KGHTgpvRDVAASADGTYLASG------ 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 158 sslymyGEDKQkdqqgklplpsIK-WDhhhIHEKRSVLTISGATATYGTADGSV---VIASCSEGTDIVLWHGKTGRNL- 232
Cdd:cd00200  70 ------SSDKT-----------IRlWD---LETGECVRTLTGHTSYVSSVAFSPdgrILSSSSRDKTIKVWDVETGKCLt 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 233 ---GHVDT-NQLknhmaAVSPNGRFLAAAAFTADVKVWEIVYQKdgsvkevsRVMQLKGHKSAVTWLCFSPNSEQIITAS 308
Cdd:cd00200 130 tlrGHTDWvNSV-----AFSPDGTFVASSSQDGTIKLWDLRTGK--------CVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 309 KDGSIRVWNINVRYHLdedpKTLKVFPIPLCDsggnplhydrLSLCPEGKILA-ASHGSTLQWLCAETGNVLDTAeKAHE 387
Cdd:cd00200 197 SDGTIKLWDLSTGKCL----GTLRGHENGVNS----------VAFSPDGYLLAsGSEDGTIRVWDLRTGECVQTL-SGHT 261

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 18411222 388 GDITCISWAPKAITvgerhamvLGTSGDDKKVKLWE 423
Cdd:cd00200 262 NSVTSLAWSPDGKR--------LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 282-317 7.22e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 7.22e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 18411222    282 VMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWN 317
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
280-317 9.08e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 9.08e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18411222   280 SRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWN 317
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 282-348 2.23e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 2.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18411222  282 VMQLKGHKSAVTWLCFSP-NSEQIITASKDGSIRVWNINvryHLDEDPKTLKvfpIPLCDSGG----------NPLHY 348
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIP---HNDESVKEIK---DPQCILKGhkkkisiidwNPMNY 138
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
79-425 7.34e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 7.34e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222  79 LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDAssksfKFLRinlPAGGHP---TAVAFADDASSIVvachhm 155
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-----KLLR---TLTGHSgavTSVAFSPDGKLLA------ 178

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 156 SGSSlymygedkqkDQQGKLplpsikWDhhhIHEKRSVLTISGATAT-YGTA---DGSvVIASCSEGTDIVLWHGKTGRN 231
Cdd:COG2319 179 SGSD----------DGTVRL------WD---LATGKLLRTLTGHTGAvRSVAfspDGK-LLASGSADGTVRLWDLATGKL 238

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 232 LGHVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWEIvyqKDGSVKEVsrvmqLKGHKSAVTWLCFSPNSEQIITASKDG 311
Cdd:COG2319 239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL---ATGELLRT-----LTGHSGGVNSVAFSPDGKLLASGSDDG 310

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 312 SIRVWNInvryhldEDPKTLKVFPiplcdsgGNPLHYDRLSLCPEGKILA-ASHGSTLQWLCAETGNVLDTAeKAHEGDI 390
Cdd:COG2319 311 TVRLWDL-------ATGKLLRTLT-------GHTGAVRSVAFSPDGKTLAsGSDDGTVRLWDLATGELLRTL-TGHTGAV 375

                       330       340       350
                ....*....|....*....|....*....|....*
gi 18411222 391 TCISWAPKaitvGERhamvLGTSGDDKKVKLWEAP 425
Cdd:COG2319 376 TSVAFSPD----GRT----LASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
79-424 2.44e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 2.44e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222  79 LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDAssksfKFLRINLPAGGHPTAVAFADDASSIVVAchhmsgs 158
Cdd:COG2319  71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG-----LLLRTLTGHTGAVRSVAFSPDGKTLASG------- 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 159 slymyGEDKqkdqqgklplpSIK-WDhhhIHEKRSVLTISGATATYGT----ADGSvVIASCSEGTDIVLWHGKTGRNLG 233
Cdd:COG2319 139 -----SADG-----------TVRlWD---LATGKLLRTLTGHSGAVTSvafsPDGK-LLASGSDDGTVRLWDLATGKLLR 198

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 234 HVDTNQLKNHMAAVSPNGRFLAAAAFTADVKVWeivyqkdgSVKEVSRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSI 313
Cdd:COG2319 199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW--------DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 314 RVWNInvryhldEDPKTLKVFPIplcdsggnplHYDR---LSLCPEGKILA-ASHGSTLQWLCAETGNVLDTAeKAHEGD 389
Cdd:COG2319 271 RLWDL-------ATGELLRTLTG----------HSGGvnsVAFSPDGKLLAsGSDDGTVRLWDLATGKLLRTL-TGHTGA 332

                       330       340       350
                ....*....|....*....|....*....|....*
gi 18411222 390 ITCISWAPKaitvGERhamvLGTSGDDKKVKLWEA 424
Cdd:COG2319 333 VRSVAFSPD----GKT----LASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-423 1.11e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 1.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222  81 TLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDDASSKSFKflrinlpaGGHP---TAVAFADDASSIVVAchhmsg 157
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL--------KGHTgpvRDVAASADGTYLASG------ 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 158 sslymyGEDKQkdqqgklplpsIK-WDhhhIHEKRSVLTISGATATYGTADGSV---VIASCSEGTDIVLWHGKTGRNL- 232
Cdd:cd00200  70 ------SSDKT-----------IRlWD---LETGECVRTLTGHTSYVSSVAFSPdgrILSSSSRDKTIKVWDVETGKCLt 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 233 ---GHVDT-NQLknhmaAVSPNGRFLAAAAFTADVKVWEIVYQKdgsvkevsRVMQLKGHKSAVTWLCFSPNSEQIITAS 308
Cdd:cd00200 130 tlrGHTDWvNSV-----AFSPDGTFVASSSQDGTIKLWDLRTGK--------CVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 309 KDGSIRVWNINVRYHLdedpKTLKVFPIPLCDsggnplhydrLSLCPEGKILA-ASHGSTLQWLCAETGNVLDTAeKAHE 387
Cdd:cd00200 197 SDGTIKLWDLSTGKCL----GTLRGHENGVNS----------VAFSPDGYLLAsGSEDGTIRVWDLRTGECVQTL-SGHT 261

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 18411222 388 GDITCISWAPKAITvgerhamvLGTSGDDKKVKLWE 423
Cdd:cd00200 262 NSVTSLAWSPDGKR--------LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
182-430 6.46e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 6.46e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 182 WDHHHIHEKRSVLTISGATATYGTADGSVVIASCSEGTDIVLWHGKTGRNLGHVDTNQLKNHMAAVSPNGRFLAAAAFTA 261
Cdd:COG2319  21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 262 DVKVWeivyqkdgSVKEVSRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWNInvryhldEDPKTLKVFPiplcds 341
Cdd:COG2319 101 TVRLW--------DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL-------ATGKLLRTLT------ 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 342 gGNPLHYDRLSLCPEGKILA-ASHGSTLQWLCAETGNVLDTAeKAHEGDITCISWAPKaitvGERhamvLGTSGDDKKVK 420
Cdd:COG2319 160 -GHSGAVTSVAFSPDGKLLAsGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPD----GKL----LASGSADGTVR 229

                       250
                ....*....|
gi 18411222 421 LWEAPKSQSL 430
Cdd:COG2319 230 LWDLATGKLL 239
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-317 7.51e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 83.54  E-value: 7.51e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222  79 LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDdasskSFKFLRInlpAGGHP---TAVAFADDASSIVVACHhm 155
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-----TGKCLTT---LRGHTdwvNSVAFSPDGTFVASSSQ-- 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 156 sgsslymygedkqkDQQGKLplpsikWDhhhIHEKRSVLTISG----ATATYGTADGSVVIASCSEGTdIVLWHGKTGRN 231
Cdd:cd00200 156 --------------DGTIKL------WD---LRTGKCVATLTGhtgeVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKC 211

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 232 LGhvdtnQLKNHMAAV-----SPNGRFLAAAAFTADVKVWeivyqkdgSVKEVSRVMQLKGHKSAVTWLCFSPNSEQIIT 306
Cdd:cd00200 212 LG-----TLRGHENGVnsvafSPDGYLLASGSEDGTIRVW--------DLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278

                       250
                ....*....|.
gi 18411222 307 ASKDGSIRVWN 317
Cdd:cd00200 279 GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 284-430 8.07e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 8.07e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 284 QLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWNinvrYHLDEDPKTLKVFPIPLcdsggnplhyDRLSLCPEGK-ILAA 362
Cdd:cd00200   4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD----LETGELLRTLKGHTGPV----------RDVAASADGTyLASG 69

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18411222 363 SHGSTLQWLCAETGNVLDTAEkAHEGDITCISWAPKaitvgeRHamVLGTSGDDKKVKLWEAPKSQSL 430
Cdd:cd00200  70 SSDKTIRLWDLETGECVRTLT-GHTSYVSSVAFSPD------GR--ILSSSSRDKTIKVWDVETGKCL 128
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 282-317 7.22e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 7.22e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 18411222    282 VMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWN 317
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
280-317 9.08e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 9.08e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18411222   280 SRVMQLKGHKSAVTWLCFSPNSEQIITASKDGSIRVWN 317
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
79-117 2.14e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 2.14e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18411222  79 LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFKLDD 117
Cdd:COG2319 365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-114 2.65e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.65e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 18411222     79 LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVFK 114
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
79-113 2.98e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 2.98e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 18411222    79 LNTLKGHGDAVTGLCFSSDGKSLATACADGVIRVF 113
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
77-366 4.02e-05

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 45.28  E-value: 4.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222  77 LDLNTLKGHGDAVTGLCFSSDGKSL--ATACADGVIRVFKLDDASSKsFKFLRINLPAGGHPTAVAFADDASSIVVACHH 154
Cdd:COG2706  35 LTLLGLVAALGNPSFLALSPDGRFLyaVNEVDDGGVSAFRIDPADGT-LTLLNTVSSGGASPCHLSVDPDGRFLFVANYG 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 155 mSGS-SLYMYGEDkqkdqqGKL--PLPSIKWDHHHIHEKRSvlTISGATATYGTADGSVVIASCSeGTD-IVLWH--GKT 228
Cdd:COG2706 114 -GGSvSVFPIDAD------GSLgePVQVIQHEGSGPNPERQ--EGPHAHSVVFDPDGRFLYVPDL-GTDrIYVYRldPAT 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 229 GRnLGHVDTNQLKN-----HMaAVSPNGRFLAAA-AFTADVKVWEIVyQKDGSVKEVSRVMQL----KGHKSAvTWLCFS 298
Cdd:COG2706 184 GK-LPEPPEVSLPPgsgprHL-AFHPNGRFAYVInELDSTVSVYAYD-AATGTLTLIQTVSTLpedfTGENWA-ADIHIS 259

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18411222 299 PNSEQIITA-SKDGSIRVwninvrYHLDEDPKTLKvfPIPLCDSGGN-PLHydrLSLCPEGK-ILAASHGS 366
Cdd:COG2706 260 PDGRFLYVSnRGHNSIAV------FAIDADGGKLT--LVGHVPTGGKwPRD---FAIDPDGRfLLVANQKS 319
PTZ00420 PTZ00420
coronin; Provisional
 282-348 2.23e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 2.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18411222  282 VMQLKGHKSAVTWLCFSP-NSEQIITASKDGSIRVWNINvryHLDEDPKTLKvfpIPLCDSGG----------NPLHY 348
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIP---HNDESVKEIK---DPQCILKGhkkkisiidwNPMNY 138
PTZ00420 PTZ00420
coronin; Provisional
 214-318 5.70e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.24  E-value: 5.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222  214 SCSEGTDIVLWHGKTGRNLGHVD-TNQ--------LKNHMAAV---SPNGRF---LAAAAFTADVKVWEIVYQkDGSVKE 278
Cdd:PTZ00420  35 ACSSGFVAVPWEVEGGGLIGAIRlENQmrkppvikLKGHTSSIldlQFNPCFseiLASGSEDLTIRVWEIPHN-DESVKE 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 18411222  279 VSRVM-QLKGHKSAVTWLCFSPNSEQIITASK-DGSIRVWNI 318
Cdd:PTZ00420 114 IKDPQcILKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDI 155
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 295-396 7.51e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 38.41  E-value: 7.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222   295 LCFSPNSEQIITASKDGSIRVWNINVRyhldedpktlKVFPIPLCDSGGNPLHydrLSLCPEGKILAASHGS-TLQWLCA 373
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRLNWQ----------RVWTLSPDKEDLEVTS---LAWRPDGKLLAVGYSDgTVRLLDA 67

                          90       100
                  ....*....|....*....|...
gi 18411222   374 ETGNVLDTAeKAHEGDITCISWA 396
Cdd:pfam12894  68 ENGKIVHHF-SAGSDLITCLGWG 89
FHA_KIF16A_STARD9 cd22731
forkhead associated (FHA) domain found in StAR-related lipid transfer protein 9 (StARD9); ...
 136-230 2.56e-03

forkhead associated (FHA) domain found in StAR-related lipid transfer protein 9 (StARD9); StARD9, also called START domain-containing protein 9, or kinesin-like protein KIF16A, is a microtubule-dependent motor protein required for spindle pole assembly during mitosis. It is required to stabilize the pericentriolar material (PCM). The FHA domain is a small phosphopeptide recognition module, but this group may lack the conserved residues that are required for binding phosphothreonine.


Pssm-ID: 438783 [Multi-domain]  Cd Length: 119  Bit Score: 37.83  E-value: 2.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411222 136 PTAVAFADDASSIVVACHHMSGSSLYMYGEDKQKDQQGKLPLPSIKWDHHHIHEKRSVLTISGATATYGTADGSVVIASC 215
Cdd:cd22731   9 PHLIAMDDDILSTGVVLYHLREGTTKIGRSDSEQEQDIVLQGPWIERDHCMIHNECGVVTLRPAQGAQCTVNGREVTESC 88

                        90
                ....*....|....*..
gi 18411222 216 --SEGTDIVLwhGKTGR 230
Cdd:cd22731  89 rlSQGAVIVL--GKTHK 103
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 82-113 3.84e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 3.84e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 18411222    82 LKGHGDAVTGLCFSSDGKSLATACADGVIRVF 113
Cdd:pfam12894  34 PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLL 65
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
86-159 6.54e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 6.54e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18411222  86 GDAVTGLCFSSDGKSLATACADG----VIrVFKLDdasSKSFKFLRiNLPAGGHPTAVAFADDASSIVVACHHmSGSS 159
Cdd:COG3391 151 GAGPHGIAVDPDGKRLYVANSGSntvsVI-VSVID---TATGKVVA-TIPVGGGPVGVAVSPDGRRLYVANRG-SNTS 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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