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Conserved domains on  [gi|18404840|ref|NP_565894|]
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AMMECR1 family [Arabidopsis thaliana]

Protein Classification

AMMECR1 domain-containing protein( domain architecture ID 10486934)

AMMECR1 domain-containing protein such as human nuclear protein AMMECR1 that is implicated in the AMME complex, an X-linked contiguous gene deletion syndrome characterized by glomerulonephritis, sensorineural hearing loss, intellectual disability, midface hypoplasia, and elliptocytosis

PubMed:  10049589|17715145

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
11-183 1.66e-62

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


:

Pssm-ID: 460368  Cd Length: 167  Bit Score: 191.90  E-value: 1.66e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840    11 YCFDTLVSHYNNEET-----PPPAFEEaNHPLFVTWKKIvnggEPRLRGCIGTLEARR-LISGFKDYALTSALRDRRFPP 84
Cdd:pfam01871   2 LAREAIESYLKGGKPpppeePPELLKE-KRGVFVTLKKK----GGELRGCIGTFEPVRpLAEEIIENAIAAAFRDPRFPP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840    85 IQAKELPSLQCTVSVLTDYEDAEDYLDWEVGKHGIIIEftepetNTKRSATYLPEVPAHEGWTKIEAIDSLVRKAGYNGv 164
Cdd:pfam01871  77 LTPEELPSLSIEVSVLTPPEPIESPEDLEPGKHGLIIE------KGGRSGTLLPQVAVEQGWDPEEFLDHLCRKAGLPP- 149
                         170
                  ....*....|....*....
gi 18404840   165 iTEAVRRRINLTRYQSTLF 183
Cdd:pfam01871 150 -DAWRDEDVKLYRFEAEVF 167
 
Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
11-183 1.66e-62

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


Pssm-ID: 460368  Cd Length: 167  Bit Score: 191.90  E-value: 1.66e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840    11 YCFDTLVSHYNNEET-----PPPAFEEaNHPLFVTWKKIvnggEPRLRGCIGTLEARR-LISGFKDYALTSALRDRRFPP 84
Cdd:pfam01871   2 LAREAIESYLKGGKPpppeePPELLKE-KRGVFVTLKKK----GGELRGCIGTFEPVRpLAEEIIENAIAAAFRDPRFPP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840    85 IQAKELPSLQCTVSVLTDYEDAEDYLDWEVGKHGIIIEftepetNTKRSATYLPEVPAHEGWTKIEAIDSLVRKAGYNGv 164
Cdd:pfam01871  77 LTPEELPSLSIEVSVLTPPEPIESPEDLEPGKHGLIIE------KGGRSGTLLPQVAVEQGWDPEEFLDHLCRKAGLPP- 149
                         170
                  ....*....|....*....
gi 18404840   165 iTEAVRRRINLTRYQSTLF 183
Cdd:pfam01871 150 -DAWRDEDVKLYRFEAEVF 167
AMMECR1 COG2078
Predicted RNA modification protein, AMMECR1 domain [General function prediction only];
24-160 4.15e-31

Predicted RNA modification protein, AMMECR1 domain [General function prediction only];


Pssm-ID: 441681  Cd Length: 184  Bit Score: 112.14  E-value: 4.15e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840  24 ETPPPAFEEaNHPLFVTWKKivNGgepRLRGCIGTLEARR-LISGFKDYALTSALRDRRFPPIQAKELPSLQCTVSVLTD 102
Cdd:COG2078  32 EDLPEALKE-RRGVFVTLKK--DG---ELRGCIGTLEPVRpLAEAVIENAIAAAFEDPRFPPVTPEELDDLTIEVSVLSP 105
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18404840 103 YEDAEDYL-DWEVGKHGIIIEftepetntK--RSATYLPEVPAHEGWTKIEAIDSLVRKAG 160
Cdd:COG2078 106 PEPIEDLLeELEPGRDGLIVE--------KggRRGLLLPQVAWEGLWDPEEFLAHLCRKAG 158
TIGR00296 TIGR00296
uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein ...
37-183 1.02e-28

uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein family have been crystallized from Pyrococcus Horikoshii, Methanosarcina Mazei, and Sulfolobus Tokodaii. [Unknown function, General]


Pssm-ID: 273002  Cd Length: 200  Bit Score: 106.44  E-value: 1.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840    37 LFVTWKKivnGGEPRLRGCIGTLE-ARRLISGFKDYALTSALRDRRFPPIQAKELPSLQCTVSVLTDYE------DAEDY 109
Cdd:TIGR00296  46 VFITLKK---KGNKHLRGCIGTPEpVMPLIEAIEEAAISAATEDPRFPPVQLEELDDIKVEVSILTPPEtifvggPKDYP 122
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18404840   110 LDWEVGKHGIIIEFtepetnTKRSATYLPEVPAHEGWTKIEAIDSLVRKAGYNGVITEAVRRRInlTRYQSTLF 183
Cdd:TIGR00296 123 FDIEIGRHGLIVEF------GPKRGLLLPQVAVEYGWDAEEFLANLCMKAGLPPDCFLTYGIEV--YRFEGQIF 188
PRK00801 PRK00801
hypothetical protein; Provisional
27-160 9.44e-15

hypothetical protein; Provisional


Pssm-ID: 234839  Cd Length: 201  Bit Score: 69.70  E-value: 9.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840   27 PPAFEEaNHPLFVTWKKivnGGEprLRGCIG-TLEARRLISGFKDYALTSALRDRRFPPIQAKELPSLQCTVSVLTDYED 105
Cdd:PRK00801  37 PPVFWE-KRGVFVTLNK---HGV--LRGCIGfPYPDSPLVEAIIDSAISAATRDPRFPPVKLEEMDEITVEVTVLTPPEL 110
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18404840  106 AE-------DYLdwEVGKHGIIIEftepetNTKRSATYLPEVPAHEGWTKIEAIDSLVRKAG 160
Cdd:PRK00801 111 IEgppeelpEKI--EVGRHGLIVK------KGIYSGLLLPQVAPEWGFDSEEFLSHTCLKAG 164
 
Name Accession Description Interval E-value
AMMECR1 pfam01871
AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. ...
11-183 1.66e-62

AMMECR1; This family consists of several AMMECR1 as well as several uncharacterized proteins. The contiguous gene deletion syndrome AMME is characterized by Alport syndrome, midface hypoplasia, mental retardation and elliptocytosis and is caused by a deletion in Xq22.3, comprising several genes including COL4A5, FACL4 and AMMECR1. This family contains sequences from several eukaryotic species as well as archaebacteria and it has been suggested that the AMMECR1 protein may have a basic cellular function, potentially in either the transcription, replication, repair or translation machinery.


Pssm-ID: 460368  Cd Length: 167  Bit Score: 191.90  E-value: 1.66e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840    11 YCFDTLVSHYNNEET-----PPPAFEEaNHPLFVTWKKIvnggEPRLRGCIGTLEARR-LISGFKDYALTSALRDRRFPP 84
Cdd:pfam01871   2 LAREAIESYLKGGKPpppeePPELLKE-KRGVFVTLKKK----GGELRGCIGTFEPVRpLAEEIIENAIAAAFRDPRFPP 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840    85 IQAKELPSLQCTVSVLTDYEDAEDYLDWEVGKHGIIIEftepetNTKRSATYLPEVPAHEGWTKIEAIDSLVRKAGYNGv 164
Cdd:pfam01871  77 LTPEELPSLSIEVSVLTPPEPIESPEDLEPGKHGLIIE------KGGRSGTLLPQVAVEQGWDPEEFLDHLCRKAGLPP- 149
                         170
                  ....*....|....*....
gi 18404840   165 iTEAVRRRINLTRYQSTLF 183
Cdd:pfam01871 150 -DAWRDEDVKLYRFEAEVF 167
AMMECR1 COG2078
Predicted RNA modification protein, AMMECR1 domain [General function prediction only];
24-160 4.15e-31

Predicted RNA modification protein, AMMECR1 domain [General function prediction only];


Pssm-ID: 441681  Cd Length: 184  Bit Score: 112.14  E-value: 4.15e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840  24 ETPPPAFEEaNHPLFVTWKKivNGgepRLRGCIGTLEARR-LISGFKDYALTSALRDRRFPPIQAKELPSLQCTVSVLTD 102
Cdd:COG2078  32 EDLPEALKE-RRGVFVTLKK--DG---ELRGCIGTLEPVRpLAEAVIENAIAAAFEDPRFPPVTPEELDDLTIEVSVLSP 105
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18404840 103 YEDAEDYL-DWEVGKHGIIIEftepetntK--RSATYLPEVPAHEGWTKIEAIDSLVRKAG 160
Cdd:COG2078 106 PEPIEDLLeELEPGRDGLIVE--------KggRRGLLLPQVAWEGLWDPEEFLAHLCRKAG 158
TIGR00296 TIGR00296
uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein ...
37-183 1.02e-28

uncharacterized protein, PH0010 family; Members of this functionally uncharacterized protein family have been crystallized from Pyrococcus Horikoshii, Methanosarcina Mazei, and Sulfolobus Tokodaii. [Unknown function, General]


Pssm-ID: 273002  Cd Length: 200  Bit Score: 106.44  E-value: 1.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840    37 LFVTWKKivnGGEPRLRGCIGTLE-ARRLISGFKDYALTSALRDRRFPPIQAKELPSLQCTVSVLTDYE------DAEDY 109
Cdd:TIGR00296  46 VFITLKK---KGNKHLRGCIGTPEpVMPLIEAIEEAAISAATEDPRFPPVQLEELDDIKVEVSILTPPEtifvggPKDYP 122
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18404840   110 LDWEVGKHGIIIEFtepetnTKRSATYLPEVPAHEGWTKIEAIDSLVRKAGYNGVITEAVRRRInlTRYQSTLF 183
Cdd:TIGR00296 123 FDIEIGRHGLIVEF------GPKRGLLLPQVAVEYGWDAEEFLANLCMKAGLPPDCFLTYGIEV--YRFEGQIF 188
AmmeMemoSam_A TIGR04335
AmmeMemoRadiSam system protein A; Members of this protein family belong to the same domain ...
24-183 1.76e-28

AmmeMemoRadiSam system protein A; Members of this protein family belong to the same domain family as AMMECR1, a mammalian protein named for AMME - Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis. Members of the present family occur as part of a three gene system with a homolog of the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility), and an uncharacterized radical SAM enzyme.


Pssm-ID: 275134  Cd Length: 174  Bit Score: 104.97  E-value: 1.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840    24 ETPPPAFEEANhPLFVTWKKivNGgepRLRGCIGTLEARR-LISGFKDYALTSALRDRRFPPIQAKELPSLQCTVSVLT- 101
Cdd:TIGR04335  24 SPGPPKLNEKG-GCFVTLHK--NG---ELRGCIGTIEADRpLVEDVAENAIAAAFKDPRFPPLTEDELDRLTIEVSVLSp 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840   102 ----DYEDAEDYL-DWEVGKHGIIIEftepetNTKRSATYLPEVPAHEGwTKIEAIDSLVRKAGYNGvitEAVRRRINLT 176
Cdd:TIGR04335  98 peplPVEDEEELLeELRPGRDGLILE------DGGRRGLFLPQVWEELP-DPEEFLRHLCLKAGLPP---DAWRDDVTIY 167

                  ....*..
gi 18404840   177 RYQSTLF 183
Cdd:TIGR04335 168 RFTVEVF 174
PRK00801 PRK00801
hypothetical protein; Provisional
27-160 9.44e-15

hypothetical protein; Provisional


Pssm-ID: 234839  Cd Length: 201  Bit Score: 69.70  E-value: 9.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18404840   27 PPAFEEaNHPLFVTWKKivnGGEprLRGCIG-TLEARRLISGFKDYALTSALRDRRFPPIQAKELPSLQCTVSVLTDYED 105
Cdd:PRK00801  37 PPVFWE-KRGVFVTLNK---HGV--LRGCIGfPYPDSPLVEAIIDSAISAATRDPRFPPVKLEEMDEITVEVTVLTPPEL 110
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18404840  106 AE-------DYLdwEVGKHGIIIEftepetNTKRSATYLPEVPAHEGWTKIEAIDSLVRKAG 160
Cdd:PRK00801 111 IEgppeelpEKI--EVGRHGLIVK------KGIYSGLLLPQVAPEWGFDSEEFLSHTCLKAG 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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