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Conserved domains on  [gi|18401331|ref|NP_565638|]
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HSP20-like chaperones superfamily protein [Arabidopsis thaliana]

Protein Classification

Hsp20/alpha crystallin family protein( domain architecture ID 10084732)

Hsp20/alpha crystallin family protein is a small, stress-induced protein, between 12-43 kDa, which functions as an ATP-independent chaperone that prevents aggregation and protects against cell stress, induced by heat, osmotic, or acid shock

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 32-100 1.26e-12

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


:

Pssm-ID: 107219  Cd Length: 80  Bit Score: 61.07  E-value: 1.26e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18401331  32 LTIYLPGFRKEQLKVQVTTtRKLRVMGDRPAGANKWI---RFRKEFPIPPNIDVDSVSAKFEGANLVVRLPR 100
Cdd:cd00298  10 VTVDLPGVKKEDIKVEVED-NVLTISGKREEEEERERsygEFERSFELPEDVDPEKSKASLENGVLEITLPK 80
 
Name Accession Description Interval E-value
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 32-100 1.26e-12

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 61.07  E-value: 1.26e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18401331  32 LTIYLPGFRKEQLKVQVTTtRKLRVMGDRPAGANKWI---RFRKEFPIPPNIDVDSVSAKFEGANLVVRLPR 100
Cdd:cd00298  10 VTVDLPGVKKEDIKVEVED-NVLTISGKREEEEERERsygEFERSFELPEDVDPEKSKASLENGVLEITLPK 80
IbpA COG0071
Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, ...
 23-114 3.30e-10

Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439841  Cd Length: 105  Bit Score: 55.54  E-value: 3.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401331  23 WKTEQGFEaLTIYLPGFRKEQLKVQVTTTRkLRVMGDR----PAGANKWIR-------FRKEFPIPPNIDVDSVSAKFEG 91
Cdd:COG0071   5 EETDDAYV-ITADLPGVDKEDIDVTVEGNV-LTISGERkeeeEEEGENYLRrerrygsFERSFTLPDDVDVDKIEASYEN 82

                        90       100
                ....*....|....*....|...
gi 18401331  92 ANLVVRLPRTEPMGKQPSPIGTA 114
Cdd:COG0071  83 GVLTITLPKAEEAKPRKIEIKAG 105
HSP20 pfam00011
Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and ...
 23-111 5.34e-06

Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts.


Pssm-ID: 459629  Cd Length: 100  Bit Score: 43.75  E-value: 5.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401331    23 WKTEQGFEaLTIYLPGFRKEQLKVQVTTTRkLRVMGDRPAG--ANKWIR-------FRKEFPIPPNIDVDSVSAKFEGAN 93
Cdd:pfam00011   3 KEDEDAFE-VRLDVPGFKPEELKVKVEDNR-LLVKGEHEEEkeDDHGLRsersygsFSRKFTLPENADPDKVKASLKDGV 80

                          90
                  ....*....|....*...
gi 18401331    94 LVVRLPRTEPmGKQPSPI 111
Cdd:pfam00011  81 LTVTVPKLEP-EPKERRI 97
PRK11597 PRK11597
heat shock chaperone IbpB; Provisional
 16-117 2.38e-03

heat shock chaperone IbpB; Provisional


Pssm-ID: 183223  Cd Length: 142  Bit Score: 37.03  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401331   16 EFEPLSNWKTEQGFEALTIYLPGFRKEQLKVQVTTTRkLRVMG--DRPAGANKWIR-------FRKEFPIPPNIDVDsvS 86
Cdd:PRK11597  31 SFPPYNIEKSDDNHYRITLALAGFRQEDLDIQLEGTR-LTVKGtpEQPEKEVKWLHqglvnqpFSLSFTLAENMEVS--G 107

                         90       100       110
                 ....*....|....*....|....*....|.
gi 18401331   87 AKFEGANLVVRLPRTEPMGKQPSPIGTATKP 117
Cdd:PRK11597 108 ATFVNGLLHIDLIRNEPEAIAPQRIAISERP 138
 
Name Accession Description Interval E-value
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 32-100 1.26e-12

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 61.07  E-value: 1.26e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18401331  32 LTIYLPGFRKEQLKVQVTTtRKLRVMGDRPAGANKWI---RFRKEFPIPPNIDVDSVSAKFEGANLVVRLPR 100
Cdd:cd00298  10 VTVDLPGVKKEDIKVEVED-NVLTISGKREEEEERERsygEFERSFELPEDVDPEKSKASLENGVLEITLPK 80
ACD_sHsps-like cd06464
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). ...
 25-100 4.53e-12

Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.


Pssm-ID: 107221  Cd Length: 88  Bit Score: 59.88  E-value: 4.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401331  25 TEQGFEaLTIYLPGFRKEQLKVQVTTtRKLRVMGDRPA---GANKWIR-------FRKEFPIPPNIDVDSVSAKFEGANL 94
Cdd:cd06464   5 TDDAYV-VEADLPGFKKEDIKVEVED-GVLTISGEREEeeeEEENYLRrersygsFSRSFRLPEDVDPDKIKASLENGVL 82


                ....*.
gi 18401331  95 VVRLPR 100
Cdd:cd06464  83 TITLPK 88
IbpA COG0071
Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, ...
 23-114 3.30e-10

Small heat shock protein IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 439841  Cd Length: 105  Bit Score: 55.54  E-value: 3.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401331  23 WKTEQGFEaLTIYLPGFRKEQLKVQVTTTRkLRVMGDR----PAGANKWIR-------FRKEFPIPPNIDVDSVSAKFEG 91
Cdd:COG0071   5 EETDDAYV-ITADLPGVDKEDIDVTVEGNV-LTISGERkeeeEEEGENYLRrerrygsFERSFTLPDDVDVDKIEASYEN 82

                        90       100
                ....*....|....*....|...
gi 18401331  92 ANLVVRLPRTEPMGKQPSPIGTA 114
Cdd:COG0071  83 GVLTITLPKAEEAKPRKIEIKAG 105
ACD_ScHsp26_like cd06472
Alpha crystallin domain (ACD) found in Saccharomyces cerevisiae (Sc) small heat shock protein ...
 36-100 2.39e-08

Alpha crystallin domain (ACD) found in Saccharomyces cerevisiae (Sc) small heat shock protein (Hsp)26 and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers consisting of multiple subunits. ScHsp26 is temperature-regulated, it switches from an inactive to a chaperone-active form upon elevation in temperature. It associates into large 24-mers storage forms which upon heat shock disassociate into dimers. These dimers initiate the interaction with non-native substrate proteins and re-assemble into large globular assemblies having one monomer of substrate bound per dimer. This group also contains Arabidopsis thaliana (Ath) Hsp15.7, a peroxisomal matrix protein which can complement the morphological phenotype of S. cerevisiae mutants deficient in Hsps26. AthHsp15.7 is minimally expressed under normal conditions and is strongly induced by heat and oxidative stress. Also belonging to this group is wheat HSP16.9 which differs in quaternary structure from the shell-type particles of ScHsp26, it assembles as a dodecameric double disc, with each disc organized as a trimer of dimers.


Pssm-ID: 107229  Cd Length: 92  Bit Score: 50.00  E-value: 2.39e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18401331  36 LPGFRKEQLKVQVTTTRKLRVMGDR----PAGANKWIR-------FRKEFPIPPNIDVDSVSAKFEGANLVVRLPR 100
Cdd:cd06472  17 VPGVKKEDVKVEVEDGRVLRISGERkkeeEKKGDDWHRverssgrFVRRFRLPENADADEVKAFLENGVLTVTVPK 92
HSP20 pfam00011
Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and ...
 23-111 5.34e-06

Hsp20/alpha crystallin family; Not only do small heat-shock-proteins occur in eukaryotes and prokaryotes but they have also now been shown to occur in cyanobacterial phages as well as their bacterial hosts.


Pssm-ID: 459629  Cd Length: 100  Bit Score: 43.75  E-value: 5.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401331    23 WKTEQGFEaLTIYLPGFRKEQLKVQVTTTRkLRVMGDRPAG--ANKWIR-------FRKEFPIPPNIDVDSVSAKFEGAN 93
Cdd:pfam00011   3 KEDEDAFE-VRLDVPGFKPEELKVKVEDNR-LLVKGEHEEEkeDDHGLRsersygsFSRKFTLPENADPDKVKASLKDGV 80

                          90
                  ....*....|....*...
gi 18401331    94 LVVRLPRTEPmGKQPSPI 111
Cdd:pfam00011  81 LTVTVPKLEP-EPKERRI 97
PRK11597 PRK11597
heat shock chaperone IbpB; Provisional
 16-117 2.38e-03

heat shock chaperone IbpB; Provisional


Pssm-ID: 183223  Cd Length: 142  Bit Score: 37.03  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401331   16 EFEPLSNWKTEQGFEALTIYLPGFRKEQLKVQVTTTRkLRVMG--DRPAGANKWIR-------FRKEFPIPPNIDVDsvS 86
Cdd:PRK11597  31 SFPPYNIEKSDDNHYRITLALAGFRQEDLDIQLEGTR-LTVKGtpEQPEKEVKWLHqglvnqpFSLSFTLAENMEVS--G 107

                         90       100       110
                 ....*....|....*....|....*....|.
gi 18401331   87 AKFEGANLVVRLPRTEPMGKQPSPIGTATKP 117
Cdd:PRK11597 108 ATFVNGLLHIDLIRNEPEAIAPQRIAISERP 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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