NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|18400571|ref|NP_565572|]
View 

Galactose oxidase/kelch repeat superfamily protein [Arabidopsis thaliana]

Protein Classification

F-box/kelch-repeat protein( domain architecture ID 17778853)

F-box/kelch-repeat protein may be a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50|2.120.10.80
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515|GO:0016567
PubMed:  10603472|31898225|11178263|31442578|24959344|10581972
SCOP:  4001927|3000448

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
81-332 4.57e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.98  E-value: 4.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571  81 YLFVF-AFNKSTARIQWQSLDLASGRWFVLPPMPnsFTKISSPHALSCasmprQGKLFVLGGGDVN-------RSAVVYT 152
Cdd:COG3055  24 KVYVAgGLSGGSASNSFEVYDPATNTWSELAPLP--GPPRHHAAAVAQ-----DGKLYVFGGFTGAnpsstplNDVYVYD 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571 153 ALTNRWSCISPMMSPRTYFVSGNVNGKIMAVGGSVGGNgeATTEVESYDPDNDTWTVVKKLPMVLAKYDSAVIGK-EMCV 231
Cdd:COG3055  97 PATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILV 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571 232 TEgwawpfmfppmGQVYDSDEGTWREMSGGMKEGWTGVSVVIRDRLFVISEHGDFPMKVYCSD--DDTWRYVsGEKLQGe 309
Cdd:COG3055 175 IG-----------GRNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDpaTNTWTAL-GELPTP- 241

                       250       260
                ....*....|....*....|...
gi 18400571 310 kmRRPFAVTGADDRVFVVASGIN 332
Cdd:COG3055 242 --RHGHAAVLTDGKVYVIGGETK 262
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 28-68 5.51e-13

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438923  Cd Length: 45  Bit Score: 62.59  E-value: 5.51e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 18400571  28 LISGLPNDIAELCLLRLPYPYHALYRSVSSSWNKTITNPRF 68
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPEL 41
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
81-332 4.57e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.98  E-value: 4.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571  81 YLFVF-AFNKSTARIQWQSLDLASGRWFVLPPMPnsFTKISSPHALSCasmprQGKLFVLGGGDVN-------RSAVVYT 152
Cdd:COG3055  24 KVYVAgGLSGGSASNSFEVYDPATNTWSELAPLP--GPPRHHAAAVAQ-----DGKLYVFGGFTGAnpsstplNDVYVYD 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571 153 ALTNRWSCISPMMSPRTYFVSGNVNGKIMAVGGSVGGNgeATTEVESYDPDNDTWTVVKKLPMVLAKYDSAVIGK-EMCV 231
Cdd:COG3055  97 PATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILV 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571 232 TEgwawpfmfppmGQVYDSDEGTWREMSGGMKEGWTGVSVVIRDRLFVISEHGDFPMKVYCSD--DDTWRYVsGEKLQGe 309
Cdd:COG3055 175 IG-----------GRNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDpaTNTWTAL-GELPTP- 241

                       250       260
                ....*....|....*....|...
gi 18400571 310 kmRRPFAVTGADDRVFVVASGIN 332
Cdd:COG3055 242 --RHGHAAVLTDGKVYVIGGETK 262
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 28-68 5.51e-13

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 62.59  E-value: 5.51e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 18400571  28 LISGLPNDIAELCLLRLPYPYHALYRSVSSSWNKTITNPRF 68
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPEL 41
PHA03098 PHA03098
kelch-like protein; Provisional
 97-217 3.99e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 51.69  E-value: 3.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571   97 QSLDLASGRWFVLPPMPNSftkisspHALSCAsMPRQGKLFVLGG----GDVNRSAVV--YTALTNRWSCISPMMSPRTY 170
Cdd:PHA03098 409 ECFSLNTNKWSKGSPLPIS-------HYGGCA-IYHDGKIYVIGGisyiDNIKVYNIVesYNPVTNKWTELSSLNFPRIN 480

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 18400571  171 FVSGNVNGKIMAVGGSVggNGEATTEVESYDPDNDTWTVVKKLPMVL 217
Cdd:PHA03098 481 ASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFPKVI 525
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 167-214 1.26e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.91  E-value: 1.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18400571   167 PRTYFVSGNVNGKIMAVGGSVGGNGEATteVESYDPDNDTWTVVKKLP 214
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNS--VEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
179-227 5.92e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.93  E-value: 5.92e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 18400571    179 KIMAVGGSVGGNGEATteVESYDPDNDTWTVVKKLPMVLAKYDSAVIGK 227
Cdd:smart00612   1 KIYVVGGFDGGQRLKS--VEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 29-70 2.77e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.99  E-value: 2.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18400571    29 ISGLPNDIAELCLLRLPYPYHALYRSVSSSWNKTITNPRFLF 70
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
FBOX smart00256
A Receptor for Ubiquitination Targets;
32-70 1.28e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 18400571     32 LPNDIAELCLLRLPYPYHALYRSVSSSWNKTITNPRFLF 70
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
81-332 4.57e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 85.98  E-value: 4.57e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571  81 YLFVF-AFNKSTARIQWQSLDLASGRWFVLPPMPnsFTKISSPHALSCasmprQGKLFVLGGGDVN-------RSAVVYT 152
Cdd:COG3055  24 KVYVAgGLSGGSASNSFEVYDPATNTWSELAPLP--GPPRHHAAAVAQ-----DGKLYVFGGFTGAnpsstplNDVYVYD 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571 153 ALTNRWSCISPMMSPRTYFVSGNVNGKIMAVGGSVGGNgeATTEVESYDPDNDTWTVVKKLPMVLAKYDSAVIGK-EMCV 231
Cdd:COG3055  97 PATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG--NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILV 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571 232 TEgwawpfmfppmGQVYDSDEGTWREMSGGMKEGWTGVSVVIRDRLFVISEHGDFPMKVYCSD--DDTWRYVsGEKLQGe 309
Cdd:COG3055 175 IG-----------GRNGSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDEVEAYDpaTNTWTAL-GELPTP- 241

                       250       260
                ....*....|....*....|...
gi 18400571 310 kmRRPFAVTGADDRVFVVASGIN 332
Cdd:COG3055 242 --RHGHAAVLTDGKVYVIGGETK 262
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
51-214 2.32e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.50  E-value: 2.32e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571  51 LYRSVSSSWNKTITNPRFLFSKQSLSISSPYLFVFAFNKSTARIQWQSLDLASGRWFVLPPMPNsftkissPHALSCASM 130
Cdd:COG3055  94 VYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPT-------PRDHLAAAV 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571 131 PRQGKLFVLGGGDVNRSavvytalTNRWSCISPMMSPRTYFVSGNVNGKIMAVGGSVGgngeATTEVESYDPDNDTWTVV 210
Cdd:COG3055 167 LPDGKILVIGGRNGSGF-------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG----FSDEVEAYDPATNTWTAL 235


                ....
gi 18400571 211 KKLP 214
Cdd:COG3055 236 GELP 239
F-box_AtAFR-like cd22152
F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and ...
 28-68 5.51e-13

F-box domain found in Arabidopsis thaliana protein ATTENUATED FAR-RED RESPONSE (AtAFR) and similar proteins; AtAFR, also called SKP1-interacting partner 29 (AtSKIP29), or F-box protein AFR, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It is part of the phyA-mediated signaling transduction pathway leading to the regulation of gene expression and hypocotyl elongation in response to red and far-red light exposure. This subfamily also includes many other Arabidopsis thaliana SKP1-interacting partner proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438923  Cd Length: 45  Bit Score: 62.59  E-value: 5.51e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 18400571  28 LISGLPNDIAELCLLRLPYPYHALYRSVSSSWNKTITNPRF 68
Cdd:cd22152   1 LIPGLPDDIALQCLARVPRSSHPSLSLVSKSWRSLLSSPEL 41
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
158-347 3.93e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 60.17  E-value: 3.93e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571 158 WSCISPMMSPRTYFVSGNVNGKIMAVGGSvgGNGEATTEVESYDPDNDTWTVVKKLPMVlAKYDSA--VIGKEMCVTEGW 235
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGL--SGGSASNSFEVYDPATNTWSELAPLPGP-PRHHAAavAQDGKLYVFGGF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571 236 AWpfmFPPMGQ------VYDSDEGTWREMSGGMKEGWTGVSVVIRDRLFVISEHGDFP----MKVYCSDDDTWRyvsgek 305
Cdd:COG3055  80 TG---ANPSSTplndvyVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGnvawVEVYDPATGTWT------ 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 18400571 306 lQGEKMRRP-FAVTGA---DDRVFVVAsginvaeGRVSEGQNGDFS 347
Cdd:COG3055 151 -QLAPLPTPrDHLAAAvlpDGKILVIG-------GRNGSGFSNTWT 188
PHA03098 PHA03098
kelch-like protein; Provisional
 97-217 3.99e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 51.69  E-value: 3.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571   97 QSLDLASGRWFVLPPMPNSftkisspHALSCAsMPRQGKLFVLGG----GDVNRSAVV--YTALTNRWSCISPMMSPRTY 170
Cdd:PHA03098 409 ECFSLNTNKWSKGSPLPIS-------HYGGCA-IYHDGKIYVIGGisyiDNIKVYNIVesYNPVTNKWTELSSLNFPRIN 480

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 18400571  171 FVSGNVNGKIMAVGGSVggNGEATTEVESYDPDNDTWTVVKKLPMVL 217
Cdd:PHA03098 481 ASLCIFNNKIYVVGGDK--YEYYINEIEVYDDKTNTWTLFCKFPKVI 525
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 167-214 1.26e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.91  E-value: 1.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18400571   167 PRTYFVSGNVNGKIMAVGGSVGGNGEATteVESYDPDNDTWTVVKKLP 214
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNS--VEVYDPETNTWSKLPSMP 46
PHA03098 PHA03098
kelch-like protein; Provisional
 22-215 2.65e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 49.00  E-value: 2.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571   22 RTKSQPLISGLPNDIAELCLLRLPYPYHALYRSVSSSWNKTITNPrFLFSKQSLSISSPYLFVFAFNKSTARI-QWQSLD 100
Cdd:PHA03098 239 LNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIH-YVYCFGSVVLNNVIYFIGGMNKNNLSVnSVVSYD 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571  101 LASGRWFVLPPM--PNSFtkissphalsCASMPRQGKLFVLGG--GDVNRSAVVYTALT-NRWSCISPMMSPRTYFVSGN 175
Cdd:PHA03098 318 TKTKSWNKVPELiyPRKN----------PGVTVFNNRIYVIGGiyNSISLNTVESWKPGeSKWREEPPLIFPRYNPCVVN 387

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 18400571  176 VNGKIMAVGGsVGGNGEATTEVESYDPDNDTWTVVKKLPM 215
Cdd:PHA03098 388 VNNLIYVIGG-ISKNDELLKTVECFSLNTNKWSKGSPLPI 426
Kelch smart00612
Kelch domain;
179-227 5.92e-06

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 42.93  E-value: 5.92e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 18400571    179 KIMAVGGSVGGNGEATteVESYDPDNDTWTVVKKLPMVLAKYDSAVIGK 227
Cdd:smart00612   1 KIYVVGGFDGGQRLKS--VEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
PHA03098 PHA03098
kelch-like protein; Provisional
 119-225 7.11e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 47.84  E-value: 7.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571  119 ISSPHALSCASMPRQGKLFVLGGGDVN----RSAVVYTALTNRWSCISPMMSPRTYFVSGNVNGKIMAVGGSvgGNGEAT 194
Cdd:PHA03098 280 IDIHYVYCFGSVVLNNVIYFIGGMNKNnlsvNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI--YNSISL 357

                         90       100       110
                 ....*....|....*....|....*....|.
gi 18400571  195 TEVESYDPDNDTWTvvKKLPMVLAKYDSAVI 225
Cdd:PHA03098 358 NTVESWKPGESKWR--EEPPLIFPRYNPCVV 386
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 29-70 2.77e-05

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 40.99  E-value: 2.77e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 18400571    29 ISGLPNDIAELCLLRLPYPYHALYRSVSSSWNKTITNPRFLF 70
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
PHA02790 PHA02790
Kelch-like protein; Provisional
 98-207 3.15e-04

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 42.72  E-value: 3.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571   98 SLDLASGRWFVLPPMpnsftkiSSPHaLSCASMPRQGKLFVLGGGDVNRSAVVYTALTNRWSCISPMMSPRTYFVSGNVN 177
Cdd:PHA02790 291 AVNYISNNWIPIPPM-------NSPR-LYASGVPANNKLYVVGGLPNPTSVERWFHGDAAWVNMPSLLKPRCNPAVASIN 362

                         90       100       110
                 ....*....|....*....|....*....|
gi 18400571  178 GKIMAvggsVGGNGEATTEVESYDPDNDTW 207
Cdd:PHA02790 363 NVIYV----IGGHSETDTTTEYLLPNHDQW 388
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
 30-68 4.52e-04

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 37.44  E-value: 4.52e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18400571  30 SGLPNDIAELCLLRLPYPYHALYRSVSSSWNKTITNPRF 68
Cdd:cd22157   1 SSLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
PHA02713 PHA02713
hypothetical protein; Provisional
 123-234 4.98e-04

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 41.92  E-value: 4.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571  123 HALSCASMPRQGKLFVLGGGDVNRSAV--VYTALTNRWSCIS--PMMSPRTYFVSGNVNGKIMAVGGSVGGNGEATteVE 198
Cdd:PHA02713 293 HIINYASAIVDNEIIIAGGYNFNNPSLnkVYKINIENKIHVElpPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERT--IE 370

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 18400571  199 SYDPDNDTWTVVKKLPMVLAKYDSAVIGKEMCVTEG 234
Cdd:PHA02713 371 CYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGG 406
FBOX smart00256
A Receptor for Ubiquitination Targets;
32-70 1.28e-03

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 36.26  E-value: 1.28e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 18400571     32 LPNDIAELCLLRLPYPYHALYRSVSSSWNKTITNPRFLF 70
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39
PHA02790 PHA02790
Kelch-like protein; Provisional
 127-301 3.45e-03

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 39.26  E-value: 3.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571  127 CASMPRQGKLFVLGG---GDVNRSAVVYTALTNRWSCISPMMSPRTYFVSGNVNGKIMAVGGSvggngEATTEVESYDPD 203
Cdd:PHA02790 265 CTSTHVGEVVYLIGGwmnNEIHNNAIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGL-----PNPTSVERWFHG 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400571  204 NDTWTVVKKLPMVLAKYDSAVIGKEMCVTEGWA-----WPFMFPpmgqvydsDEGTWREMSGGMKEGWTGVSVVIRDRLF 278
Cdd:PHA02790 340 DAAWVNMPSLLKPRCNPAVASINNVIYVIGGHSetdttTEYLLP--------NHDQWQFGPSTYYPHYKSCALVFGRRLF 411

                        170       180
                 ....*....|....*....|...
gi 18400571  279 VISEHGDFpmkvYCSDDDTWRYV 301
Cdd:PHA02790 412 LVGRNAEF----YCESSNTWTLI 430
Kelch_3 pfam13415
Galactose oxidase, central domain;
177-215 6.13e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.57  E-value: 6.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18400571   177 NGKIMAVGGSVGGNGEATTEVESYDPDNDTWTVVKKLPM 215
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDLPP 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH