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Conserved domains on  [gi|18412879|ref|NP_565242|]
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RNI-like superfamily protein [Arabidopsis thaliana]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1563018)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 121-335 8.30e-10

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 59.26  E-value: 8.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 121 SDSDLVSIgVNFPLLEKLDI-SYPNSSPSrvsdsgvIELSSNLKGLLKINISGNSFITDKSLIALSQNCLLLREIIFRDC 199
Cdd:cd09293  17 SNISQLLR-ILHSGLEWLELyMCPISDPP-------LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRAC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 200 DFISSDCIKFVLRNSRNLESlaINgIGLRPRESLLTDAFLFA-----RCLTELDLSDSFLSDDllCLIASAKLplkklll 274
Cdd:cd09293  89 ENITDSGIVALATNCPKLQT--IN-LGRHRNGHLITDVSLSAlgkncTFLQTVGFAGCDVTDK--GVWELASG------- 156

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18412879 275 sdchgftfdgilylldKYQSLVHLNLKGANFLSDEMVMKLGMF--FRRLTFLNLSFCSKLTGL 335
Cdd:cd09293 157 ----------------CSKSLERLSLNNCRNLTDQSIPAILASnyFPNLSVLEFRGCPLITDF 203
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 386-508 5.09e-09

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 56.95  E-value: 5.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 386 DECLEKISRHCPFIESLDVAQCPGITRDGILEVWRNCGKLRSLDISR---CTGIKSLGVVDF--ELPKLESLRACGTWID 460
Cdd:cd09293  67 DEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRhrnGHLITDVSLSALgkNCTFLQTVGFAGCDVT 146

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 18412879 461 DEAL-DMISKKCRGLLHLDLQGCLNVSSRGVKEVVQS--CIRLREINLKYC 508
Cdd:cd09293 147 DKGVwELASGCSKSLERLSLNNCRNLTDQSIPAILASnyFPNLSVLEFRGC 197
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 121-335 8.30e-10

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 59.26  E-value: 8.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 121 SDSDLVSIgVNFPLLEKLDI-SYPNSSPSrvsdsgvIELSSNLKGLLKINISGNSFITDKSLIALSQNCLLLREIIFRDC 199
Cdd:cd09293  17 SNISQLLR-ILHSGLEWLELyMCPISDPP-------LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRAC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 200 DFISSDCIKFVLRNSRNLESlaINgIGLRPRESLLTDAFLFA-----RCLTELDLSDSFLSDDllCLIASAKLplkklll 274
Cdd:cd09293  89 ENITDSGIVALATNCPKLQT--IN-LGRHRNGHLITDVSLSAlgkncTFLQTVGFAGCDVTDK--GVWELASG------- 156

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18412879 275 sdchgftfdgilylldKYQSLVHLNLKGANFLSDEMVMKLGMF--FRRLTFLNLSFCSKLTGL 335
Cdd:cd09293 157 ----------------CSKSLERLSLNNCRNLTDQSIPAILASnyFPNLSVLEFRGCPLITDF 203
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 386-508 5.09e-09

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 56.95  E-value: 5.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 386 DECLEKISRHCPFIESLDVAQCPGITRDGILEVWRNCGKLRSLDISR---CTGIKSLGVVDF--ELPKLESLRACGTWID 460
Cdd:cd09293  67 DEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRhrnGHLITDVSLSALgkNCTFLQTVGFAGCDVT 146

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 18412879 461 DEAL-DMISKKCRGLLHLDLQGCLNVSSRGVKEVVQS--CIRLREINLKYC 508
Cdd:cd09293 147 DKGVwELASGCSKSLERLSLNNCRNLTDQSIPAILASnyFPNLSVLEFRGC 197
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 121-335 8.30e-10

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 59.26  E-value: 8.30e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 121 SDSDLVSIgVNFPLLEKLDI-SYPNSSPSrvsdsgvIELSSNLKGLLKINISGNSFITDKSLIALSQNCLLLREIIFRDC 199
Cdd:cd09293  17 SNISQLLR-ILHSGLEWLELyMCPISDPP-------LDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRAC 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 200 DFISSDCIKFVLRNSRNLESlaINgIGLRPRESLLTDAFLFA-----RCLTELDLSDSFLSDDllCLIASAKLplkklll 274
Cdd:cd09293  89 ENITDSGIVALATNCPKLQT--IN-LGRHRNGHLITDVSLSAlgkncTFLQTVGFAGCDVTDK--GVWELASG------- 156

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 18412879 275 sdchgftfdgilylldKYQSLVHLNLKGANFLSDEMVMKLGMF--FRRLTFLNLSFCSKLTGL 335
Cdd:cd09293 157 ----------------CSKSLERLSLNNCRNLTDQSIPAILASnyFPNLSVLEFRGCPLITDF 203
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 386-508 5.09e-09

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 56.95  E-value: 5.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 386 DECLEKISRHCPFIESLDVAQCPGITRDGILEVWRNCGKLRSLDISR---CTGIKSLGVVDF--ELPKLESLRACGTWID 460
Cdd:cd09293  67 DEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCPKLQTINLGRhrnGHLITDVSLSALgkNCTFLQTVGFAGCDVT 146

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 18412879 461 DEAL-DMISKKCRGLLHLDLQGCLNVSSRGVKEVVQS--CIRLREINLKYC 508
Cdd:cd09293 147 DKGVwELASGCSKSLERLSLNNCRNLTDQSIPAILASnyFPNLSVLEFRGC 197
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 396-505 1.67e-06

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 49.25  E-value: 1.67e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 396 CPFIESLDVAQCPGItrDGILEVWRNCGKLRSLDISRCTGIkslgvvdfelpkleslracgtwiDDEALDMISKKCRGLL 475
Cdd:cd09293  27 HSGLEWLELYMCPIS--DPPLDQLSNCNKLKKLILPGSKLI-----------------------DDEGLIALAQSCPNLQ 81

                        90       100       110
                ....*....|....*....|....*....|
gi 18412879 476 HLDLQGCLNVSSRGVKEVVQSCIRLREINL 505
Cdd:cd09293  82 VLDLRACENITDSGIVALATNCPKLQTINL 111
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 283-441 2.96e-04

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 42.70  E-value: 2.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 283 DGILYLLDKYQSLVHLNLKGANFLSDEMVMKLGMFFRRLTFLNLSFCSKLT--GLaffsiieRCVSLRCMIMVGTNFGVE 360
Cdd:cd09293  42 DPPLDQLSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITdsGI-------VALATNCPKLQTINLGRH 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 361 EytkdtkdfksgvkflylsRNHNLLDECLEKISRHCPFIESLDVAQCpGITRDGILEVWRNCGK-LRSLDISRCTGIKSL 439
Cdd:cd09293 115 R------------------NGHLITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWELASGCSKsLERLSLNNCRNLTDQ 175


                ..
gi 18412879 440 GV 441
Cdd:cd09293 176 SI 177
FBXL3_LRR-like cd23951
Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part ...
 427-507 5.92e-04

Leucine-rich repeat domain of FBXL3 and related proteins; F-box/LRR-repeat proteins are part of Skp1-Cul1-F-box-protein (SCF) ubiquitin ligase complexes. They contain an F-Box, which binds to the core complex component SKP and a leucine-rich repeat (LRR) domain which gives substrate binding specificity. FBXL3 (F-box and leucine rich repeat protein 3) and FBXL21 have been shown to bind CRY1 repressors and are involved in regulation of circadian clock.


Pssm-ID: 467830 [Multi-domain]  Cd Length: 349  Bit Score: 42.37  E-value: 5.92e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18412879 427 SLDISRCTGIKSLGVVDFELPKLESLRACGTWIDDEALD-MISKKCRGLLHLDLQGCLNVSSRGVKEVVQSCIRLREINL 505
Cdd:cd23951  74 FLDVDQSKFVSALTVVFDHSSSLSSLAIDDTPVDDPSLQtLASSSSDTLELLKMKSCPRVSPRGILAVADHCQHLRELSL 153


                ..
gi 18412879 506 KY 507
Cdd:cd23951 154 NY 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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