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Conserved domains on  [gi|18411065|ref|NP_565129|]
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O-fucosyltransferase family protein [Arabidopsis thaliana]

Protein Classification

O-fucosyltransferase family protein( domain architecture ID 10181944)

O-fucosyltransferase family protein may be involved in glycan metabolism by O-fucosylation of protein substrates; similar to O-fucosyltransferases which are involved in glycan metabolism

EC:  2.4.1.-
Gene Ontology:  GO:0016757|GO:0046922|GO:0036066

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
O-FucT_plant cd11299
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
109-429 4.34e-154

GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


:

Pssm-ID: 211385  Cd Length: 290  Bit Score: 443.16  E-value: 4.34e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 109 YLVIATSGGLNQQRTGIVDAVVAARILNATLVVPKLDQKSYWKDASDFSHIFDVDWFISFLSGDVRIIKQLP--LKGGRT 186
Cdd:cd11299   1 YLLVSANGGLNQQRSQICDAVAVARLLNATLVLPELDKNSVWGDSSKFGDIYDVDHFIKSLKDDVRVVKKLPeeLASKKP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 187 WSTSrMRVPRKCNERCYINRVLPVLLKRHAVQLNKFDYRLSNKLSD-DLQKLRCRVNYHALKFTDPILTMGNELVRRMRL 265
Cdd:cd11299  81 EITV-KRVPSRSSPSYYLEEVLPLLKKHGVIRLAPFDSRLANDLLPpEIQRLRCRVNFHALRFVPEIEELGDKLVDRLRE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 266 RSKHFIALHLRYEPDMLAFSGCyygggdkerrelaairrrwktlhinnpekqrrqGRCPLTPEEVGLMLRALGYGSDVHI 345
Cdd:cd11299 160 AGGPFLALHLRFEKDMLAFSGC---------------------------------GKCPLTPEEVGLLLRALGFPRSTRI 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 346 YVASGEVYGGEESLAPLKALFPHFYSKDTIATKEELEPFSSYSSRMAALDFLVCDESDVFVTNNNGNMAKILAGRRRYLG 425
Cdd:cd11299 207 YLAAGEIYGGERRLDPLRSIFPNLYTKETLATAEELAPFSGHSSRLAALDYIVCLESDVFVPTYGGNFAKAVAGHRRYLG 286

                ....
gi 18411065 426 HKPT 429
Cdd:cd11299 287 HRKT 290
 
Name Accession Description Interval E-value
O-FucT_plant cd11299
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
109-429 4.34e-154

GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211385  Cd Length: 290  Bit Score: 443.16  E-value: 4.34e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 109 YLVIATSGGLNQQRTGIVDAVVAARILNATLVVPKLDQKSYWKDASDFSHIFDVDWFISFLSGDVRIIKQLP--LKGGRT 186
Cdd:cd11299   1 YLLVSANGGLNQQRSQICDAVAVARLLNATLVLPELDKNSVWGDSSKFGDIYDVDHFIKSLKDDVRVVKKLPeeLASKKP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 187 WSTSrMRVPRKCNERCYINRVLPVLLKRHAVQLNKFDYRLSNKLSD-DLQKLRCRVNYHALKFTDPILTMGNELVRRMRL 265
Cdd:cd11299  81 EITV-KRVPSRSSPSYYLEEVLPLLKKHGVIRLAPFDSRLANDLLPpEIQRLRCRVNFHALRFVPEIEELGDKLVDRLRE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 266 RSKHFIALHLRYEPDMLAFSGCyygggdkerrelaairrrwktlhinnpekqrrqGRCPLTPEEVGLMLRALGYGSDVHI 345
Cdd:cd11299 160 AGGPFLALHLRFEKDMLAFSGC---------------------------------GKCPLTPEEVGLLLRALGFPRSTRI 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 346 YVASGEVYGGEESLAPLKALFPHFYSKDTIATKEELEPFSSYSSRMAALDFLVCDESDVFVTNNNGNMAKILAGRRRYLG 425
Cdd:cd11299 207 YLAAGEIYGGERRLDPLRSIFPNLYTKETLATAEELAPFSGHSSRLAALDYIVCLESDVFVPTYGGNFAKAVAGHRRYLG 286

                ....
gi 18411065 426 HKPT 429
Cdd:cd11299 287 HRKT 290
O-FucT pfam10250
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
109-424 6.54e-83

GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.


Pssm-ID: 463023 [Multi-domain]  Cd Length: 247  Bit Score: 259.15  E-value: 6.54e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065   109 YLVIA-TSGGLNQQRTGIVDAVVAARILNATLVVPKLDQKSYWKDASD----FSHIFDVdwFISFLsgdvriikqlplkg 183
Cdd:pfam10250   1 YLLYCpCNGGFNQQRDHICDAVAFARLLNATLVLPPWDQLYHWRDPSTdqipFSDIFDE--FIESL-------------- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065   184 grtwstsrmrvprkcnerCyinrvlpvllkrhavqlnkfdyrlsnkLSDDLQKLRCRVNYHALKFTDPILTMGNELVRRM 263
Cdd:pfam10250  65 ------------------C---------------------------RSKQGNFGPFWVNFHALRFSPEIEELGDKLVDRL 99
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065   264 RLRskHFIALHLRYEPDMLAFSGCYYGGGDKERRElaairrrwktlhinNPEKQRRQGRCPLTPEE-----VGLMLRALG 338
Cdd:pfam10250 100 LKG--PYLALHLRREKDMLAASGCAEGGGDEEAEE--------------DPEERRRNGLCPLTPEEclpslVGILLQALG 163
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065   339 YGSDV-HIYVASGEVYGGEEsLAPLKALFPHFYSKDTIATKEELEPFSSYSSrmAALDFLVCDESDVFVTNNNGNMAKIL 417
Cdd:pfam10250 164 FVKKLtRIYVATDEIYGGEE-LAPLKSMFPNLVTKESLASVEELEPFKDGSS--AALDYIICLHSDVFIGTCVSNFSAFV 240

                  ....*..
gi 18411065   418 AGRRRYL 424
Cdd:pfam10250 241 KGERRYL 247
 
Name Accession Description Interval E-value
O-FucT_plant cd11299
GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this ...
109-429 4.34e-154

GDP-fucose protein O-fucosyltransferase, plant specific subfamily; Some members of this plant-specific family of O-fucosyltransferases have been annotated as auxin-independent growth promotors. The function of the protein seems unclear. O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211385  Cd Length: 290  Bit Score: 443.16  E-value: 4.34e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 109 YLVIATSGGLNQQRTGIVDAVVAARILNATLVVPKLDQKSYWKDASDFSHIFDVDWFISFLSGDVRIIKQLP--LKGGRT 186
Cdd:cd11299   1 YLLVSANGGLNQQRSQICDAVAVARLLNATLVLPELDKNSVWGDSSKFGDIYDVDHFIKSLKDDVRVVKKLPeeLASKKP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 187 WSTSrMRVPRKCNERCYINRVLPVLLKRHAVQLNKFDYRLSNKLSD-DLQKLRCRVNYHALKFTDPILTMGNELVRRMRL 265
Cdd:cd11299  81 EITV-KRVPSRSSPSYYLEEVLPLLKKHGVIRLAPFDSRLANDLLPpEIQRLRCRVNFHALRFVPEIEELGDKLVDRLRE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 266 RSKHFIALHLRYEPDMLAFSGCyygggdkerrelaairrrwktlhinnpekqrrqGRCPLTPEEVGLMLRALGYGSDVHI 345
Cdd:cd11299 160 AGGPFLALHLRFEKDMLAFSGC---------------------------------GKCPLTPEEVGLLLRALGFPRSTRI 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 346 YVASGEVYGGEESLAPLKALFPHFYSKDTIATKEELEPFSSYSSRMAALDFLVCDESDVFVTNNNGNMAKILAGRRRYLG 425
Cdd:cd11299 207 YLAAGEIYGGERRLDPLRSIFPNLYTKETLATAEELAPFSGHSSRLAALDYIVCLESDVFVPTYGGNFAKAVAGHRRYLG 286

                ....
gi 18411065 426 HKPT 429
Cdd:cd11299 287 HRKT 290
O-FucT pfam10250
GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing ...
109-424 6.54e-83

GDP-fucose protein O-fucosyltransferase; This is a family of conserved proteins representing the enzyme responsible for adding O-fucose to EGF (epidermal growth factor-like) repeats. Six highly conserved cysteines are present in O-FucT-1 as well as a DXD-like motif (ERD), conserved in mammals, Drosophila, and C. elegans. Both features are characteriztic of several glycosyltransferase families. The enzyme is a membrane-bound protein released by proteolysis and, as for most glycosyltransferases, is strongly activated by manganese.


Pssm-ID: 463023 [Multi-domain]  Cd Length: 247  Bit Score: 259.15  E-value: 6.54e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065   109 YLVIA-TSGGLNQQRTGIVDAVVAARILNATLVVPKLDQKSYWKDASD----FSHIFDVdwFISFLsgdvriikqlplkg 183
Cdd:pfam10250   1 YLLYCpCNGGFNQQRDHICDAVAFARLLNATLVLPPWDQLYHWRDPSTdqipFSDIFDE--FIESL-------------- 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065   184 grtwstsrmrvprkcnerCyinrvlpvllkrhavqlnkfdyrlsnkLSDDLQKLRCRVNYHALKFTDPILTMGNELVRRM 263
Cdd:pfam10250  65 ------------------C---------------------------RSKQGNFGPFWVNFHALRFSPEIEELGDKLVDRL 99
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065   264 RLRskHFIALHLRYEPDMLAFSGCYYGGGDKERRElaairrrwktlhinNPEKQRRQGRCPLTPEE-----VGLMLRALG 338
Cdd:pfam10250 100 LKG--PYLALHLRREKDMLAASGCAEGGGDEEAEE--------------DPEERRRNGLCPLTPEEclpslVGILLQALG 163
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065   339 YGSDV-HIYVASGEVYGGEEsLAPLKALFPHFYSKDTIATKEELEPFSSYSSrmAALDFLVCDESDVFVTNNNGNMAKIL 417
Cdd:pfam10250 164 FVKKLtRIYVATDEIYGGEE-LAPLKSMFPNLVTKESLASVEELEPFKDGSS--AALDYIICLHSDVFIGTCVSNFSAFV 240

                  ....*..
gi 18411065   418 AGRRRYL 424
Cdd:pfam10250 241 KGERRYL 247
O-FucT_like cd11296
GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like ...
240-425 6.97e-13

GDP-fucose protein O-fucosyltransferase and related proteins; O-fucosyltransferase-like proteins are GDP-fucose dependent enzymes with similarities to the family 1 glycosyltransferases (GT1). They are soluble ER proteins that may be proteolytically cleaved from a membrane-associated preprotein, and are involved in the O-fucosylation of protein substrates, the core fucosylation of growth factor receptors, and other processes.


Pssm-ID: 211383  Cd Length: 206  Bit Score: 67.83  E-value: 6.97e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 240 RVNYHALKFTDPILTMGNELVRRMR-LRSKHFIALHLRYEPDmlafsgcyygggdkerrelaairrrWKTLHINNPEKQR 318
Cdd:cd11296  43 RLVGKHLRFSPEIRKLADRFVRKLLgLPGGPYLAVHLRRGDF-------------------------EVECCHLAKWMGE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18411065 319 RQGRCPLTPEEVGLMLRALGY-GSDVHIYVASGEvYGGEESLAPLKALFPHFYSKDTIATKEELEPFSSYSS-RMAALDF 396
Cdd:cd11296  98 YLEECLLSAEEIAEKIKELMAeRKLKVVYVATDE-ADREELREELRKAGIRVVTKDDLLEDAELLELEKLDNyLLSLVDQ 176
                       170       180
                ....*....|....*....|....*....
gi 18411065 397 LVCDESDVFVTNNNGNMAKILAGRRRYLG 425
Cdd:cd11296 177 EICSRADVFIGTGFSTFSSNVALLRRWRG 205
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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