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Conserved domains on  [gi|42563078|ref|NP_564970|]
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S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 11454891)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  2.20.25.110
EC:  2.1.-.-
Gene Ontology:  GO:0032259|GO:0008757|GO:1904047|GO:0008168
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 120-209 5.03e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


:

Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.00  E-value: 5.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563078 120 DLNASFYDPFLENDRSFSCFMFV-----LFGKIAEYKRKLFEKLAGKA-ETVLEIGVGTGPNLKYFAGNENVCVFGMDPN 193
Cdd:COG2230   4 DLGNDFYRLFLDPTMTYSCAYFEdpddtLEEAQEAKLDLILRKLGLKPgMRVLDIGCGWGGLALYLARRYGVRVTGVTLS 83

                        90
                ....*....|....*.
gi 42563078 194 HKMEKYACESAREAGM 209
Cdd:COG2230  84 PEQLEYARERAAEAGL 99
 
Name Accession Description Interval E-value
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 120-209 5.03e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.00  E-value: 5.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563078 120 DLNASFYDPFLENDRSFSCFMFV-----LFGKIAEYKRKLFEKLAGKA-ETVLEIGVGTGPNLKYFAGNENVCVFGMDPN 193
Cdd:COG2230   4 DLGNDFYRLFLDPTMTYSCAYFEdpddtLEEAQEAKLDLILRKLGLKPgMRVLDIGCGWGGLALYLARRYGVRVTGVTLS 83

                        90
                ....*....|....*.
gi 42563078 194 HKMEKYACESAREAGM 209
Cdd:COG2230  84 PEQLEYARERAAEAGL 99
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 165-219 1.16e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 42.55  E-value: 1.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 42563078   165 VLEIGVGTGPNLKYFAGNENVCVFGMDPNHKMEKYACESAREAGMkpeNFRFMHG 219
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL---NVEFVQG 52
PRK08317 PRK08317
hypothetical protein; Provisional
 147-227 1.83e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 44.16  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563078  147 IAEYKRKLFEKLAGKA-ETVLEIGVGTGPNLKYFA---GNENVcVFGMDPNHKMEKYACEsaREAGMKPeNFRFMHGVSK 222
Cdd:PRK08317   4 FRRYRARTFELLAVQPgDRVLDVGCGPGNDARELArrvGPEGR-VVGIDRSEAMLALAKE--RAAGLGP-NVEFVRGDAD 79


                 ....*
gi 42563078  223 LLCFD 227
Cdd:PRK08317  80 GLPFP 84
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 164-219 8.33e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.10  E-value: 8.33e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 42563078 164 TVLEIGVGTGPNLKYFAGNENVCVFGMDPNHKMEKYACESAREAgmKPENFRFMHG 219
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAAL--LADNVEVLKG 54
 
Name Accession Description Interval E-value
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 120-209 5.03e-07

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 48.00  E-value: 5.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563078 120 DLNASFYDPFLENDRSFSCFMFV-----LFGKIAEYKRKLFEKLAGKA-ETVLEIGVGTGPNLKYFAGNENVCVFGMDPN 193
Cdd:COG2230   4 DLGNDFYRLFLDPTMTYSCAYFEdpddtLEEAQEAKLDLILRKLGLKPgMRVLDIGCGWGGLALYLARRYGVRVTGVTLS 83

                        90
                ....*....|....*.
gi 42563078 194 HKMEKYACESAREAGM 209
Cdd:COG2230  84 PEQLEYARERAAEAGL 99
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 165-219 1.16e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 42.55  E-value: 1.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 42563078   165 VLEIGVGTGPNLKYFAGNENVCVFGMDPNHKMEKYACESAREAGMkpeNFRFMHG 219
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGL---NVEFVQG 52
PRK08317 PRK08317
hypothetical protein; Provisional
 147-227 1.83e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 44.16  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563078  147 IAEYKRKLFEKLAGKA-ETVLEIGVGTGPNLKYFA---GNENVcVFGMDPNHKMEKYACEsaREAGMKPeNFRFMHGVSK 222
Cdd:PRK08317   4 FRRYRARTFELLAVQPgDRVLDVGCGPGNDARELArrvGPEGR-VVGIDRSEAMLALAKE--RAAGLGP-NVEFVRGDAD 79


                 ....*
gi 42563078  223 LLCFD 227
Cdd:PRK08317  80 GLPFP 84
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 144-219 2.09e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 43.06  E-value: 2.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42563078 144 FGKIAEY---KRKLFEKLAGKA-ETVLEIGVGTGPNLKYFAgNENVCVFGMDPNHKMEKYACESAREAGMkpeNFRFMHG 219
Cdd:COG2226   1 FDRVAARydgREALLAALGLRPgARVLDLGCGTGRLALALA-ERGARVTGVDISPEMLELARERAAEAGL---NVEFVVG 76
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 154-219 1.99e-03

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 37.97  E-value: 1.99e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42563078 154 LFEKLAGKAeTVLEIGVGTGPNLKYFAGNENVCVFGMDPNHKMEKYACESAREAGMKpeNFRFMHG 219
Cdd:COG0500  20 LLERLPKGG-RVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAKAGLG--NVEFLVA 82
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 152-208 3.64e-03

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 36.15  E-value: 3.64e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 42563078 152 RKLFEKLAGKAETVLEIGVGTGPNLKYFAGnENVCVFGMDPNHKMEKYACESAREAG 208
Cdd:COG2227  15 AALLARLLPAGGRVLDVGCGTGRLALALAR-RGADVTGVDISPEALEIARERAAELN 70
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 164-219 8.33e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.10  E-value: 8.33e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 42563078 164 TVLEIGVGTGPNLKYFAGNENVCVFGMDPNHKMEKYACESAREAgmKPENFRFMHG 219
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAAL--LADNVEVLKG 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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