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Conserved domains on  [gi|18409299|ref|NP_564969|]
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S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 112-244 1.80e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 101.22  E-value: 1.80e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 112 DYKMKLFDNL-VGKAEKVLEIGIGTGPNFKYYTDIpNVSVIGIDPNAKMESYARKSATEAGLKpeeFTFVHALGESIPLE 190
Cdd:COG2226   9 DGREALLAALgLRPGARVLDLGCGTGRLALALAER-GARVTGVDISPEMLELARERAAEAGLN---VEFVVGDAEDLPFP 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 18409299 191 DASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGGIYIFIEHVAAEDGTFLRLVQ 244
Cdd:COG2226  85 DGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLA 138
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 112-244 1.80e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 101.22  E-value: 1.80e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 112 DYKMKLFDNL-VGKAEKVLEIGIGTGPNFKYYTDIpNVSVIGIDPNAKMESYARKSATEAGLKpeeFTFVHALGESIPLE 190
Cdd:COG2226   9 DGREALLAALgLRPGARVLDLGCGTGRLALALAER-GARVTGVDISPEMLELARERAAEAGLN---VEFVVGDAEDLPFP 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 18409299 191 DASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGGIYIFIEHVAAEDGTFLRLVQ 244
Cdd:COG2226  85 DGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLA 138
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 129-228 9.33e-24

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 92.73  E-value: 9.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   129 LEIGIGTGPNFKYYTDIPNvSVIGIDPNAKMESYARKSATEAGLkpeefTFVHALGESIPLEDASVDAVVGTLVLCSVTD 208
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDISPEMLELAREKAPREGL-----TFVVGDAEDLPFPDNSFDLVLSSEVLHHVED 74

                          90       100
                  ....*....|....*....|
gi 18409299   209 VTQTLKEIKRILRPGGIYIF 228
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 113-224 6.21e-16

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 75.36  E-value: 6.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299  113 YKMKLFDNL-VGKAEKVLEIGIGTGPNFKYYTDI--PNVSVIGIDPNAKMESYARKSATEAGLKpeeFTFVHALGESIPL 189
Cdd:PRK08317   7 YRARTFELLaVQPGDRVLDVGCGPGNDARELARRvgPEGRVVGIDRSEAMLALAKERAAGLGPN---VEFVRGDADGLPF 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 18409299  190 EDASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGG 224
Cdd:PRK08317  84 PDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGG 118
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 127-229 1.05e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 65.91  E-value: 1.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 127 KVLEIGIGTGPNFKYYTDIPNVSVIGIDPNAKMESYARKSAteAGLKPEEFTFVHA-LGESIPLEDASVDAVVGTLVL-C 204
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAA--AALLADNVEVLKGdAEELPPEADESFDVIISDPPLhH 78

                        90       100
                ....*....|....*....|....*
gi 18409299 205 SVTDVTQTLKEIKRILRPGGIYIFI 229
Cdd:cd02440  79 LVEDLARFLEEARRLLKPGGVLVLT 103
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 108-228 7.58e-12

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 63.84  E-value: 7.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   108 KEVSDYKMKLFDNLVG-KAEKVLEIGIGTGPNFKYYTD-IPNVSVIGIDPNAKMESYARKsateagLKPEEFTFVHALGE 185
Cdd:TIGR02072  17 REMAKRLLALLKEKGIfIPASVLDIGCGTGYLTRALLKrFPQAEFIALDISAGMLAQAKT------KLSENVQFICGDAE 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 18409299   186 SIPLEDASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGGIYIF 228
Cdd:TIGR02072  91 KLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAF 133
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 112-244 1.80e-26

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 101.22  E-value: 1.80e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 112 DYKMKLFDNL-VGKAEKVLEIGIGTGPNFKYYTDIpNVSVIGIDPNAKMESYARKSATEAGLKpeeFTFVHALGESIPLE 190
Cdd:COG2226   9 DGREALLAALgLRPGARVLDLGCGTGRLALALAER-GARVTGVDISPEMLELARERAAEAGLN---VEFVVGDAEDLPFP 84

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 18409299 191 DASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGGIYIFIEHVAAEDGTFLRLVQ 244
Cdd:COG2226  85 DGSFDLVISSFVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLA 138
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 129-228 9.33e-24

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 92.73  E-value: 9.33e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   129 LEIGIGTGPNFKYYTDIPNvSVIGIDPNAKMESYARKSATEAGLkpeefTFVHALGESIPLEDASVDAVVGTLVLCSVTD 208
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDISPEMLELAREKAPREGL-----TFVVGDAEDLPFPDNSFDLVLSSEVLHHVED 74

                          90       100
                  ....*....|....*....|
gi 18409299   209 VTQTLKEIKRILRPGGIYIF 228
Cdd:pfam08241  75 PERALREIARVLKPGGILII 94
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 128-224 3.93e-22

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 88.39  E-value: 3.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   128 VLEIGIGTGPNFKYYTDIPNVSVIGIDPNAKMESYARKSATEAGLKpeeFTFVHALGESIPLEDASVDAVV--GTLVLCS 205
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEMLERARERAAEAGLN---VEFVQGDAEDLPFPDGSFDLVVssGVLHHLP 77

                          90
                  ....*....|....*....
gi 18409299   206 VTDVTQTLKEIKRILRPGG 224
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 116-228 7.47e-17

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 75.05  E-value: 7.47e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 116 KLFDNLVGKAEKVLEIGIGTGPNFKYYTDIpNVSVIGIDPNAKMESYARKSATEAGLkpeefTFVHALGESIPLEDASVD 195
Cdd:COG2227  16 ALLARLLPAGGRVLDVGCGTGRLALALARR-GADVTGVDISPEALEIARERAAELNV-----DFVQGDLEDLPLEDGSFD 89

                        90       100       110
                ....*....|....*....|....*....|...
gi 18409299 196 AVVGTLVLCSVTDVTQTLKEIKRILRPGGIYIF 228
Cdd:COG2227  90 LVICSEVLEHLPDPAALLRELARLLKPGGLLLL 122
PRK08317 PRK08317
hypothetical protein; Provisional
 113-224 6.21e-16

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 75.36  E-value: 6.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299  113 YKMKLFDNL-VGKAEKVLEIGIGTGPNFKYYTDI--PNVSVIGIDPNAKMESYARKSATEAGLKpeeFTFVHALGESIPL 189
Cdd:PRK08317   7 YRARTFELLaVQPGDRVLDVGCGPGNDARELARRvgPEGRVVGIDRSEAMLALAKERAAGLGPN---VEFVRGDADGLPF 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 18409299  190 EDASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGG 224
Cdd:PRK08317  84 PDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGG 118
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 90-257 3.91e-14

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 69.56  E-value: 3.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299  90 WYEEFFAWSMNSEVESYEKEVSDYKmklfdnlvgKAEKVLEIGIGTGPNFKYYTDIPNVSVIGIDPNAKMESYARKSATE 169
Cdd:COG0500   1 PWDSYYSDELLPGLAALLALLERLP---------KGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAIALARARAAK 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 170 AGLKPEEFtFVHALGESIPLEDASVDAVVGTLVLCSV--TDVTQTLKEIKRILRPGGIYIFIEHVAAEDGTFLRLVQTVL 247
Cdd:COG0500  72 AGLGNVEF-LVADLAELDPLPAESFDLVVAFGVLHHLppEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLAT 150

                       170
                ....*....|
gi 18409299 248 DPLQQVVADG 257
Cdd:COG0500 151 ASLLELLLLL 160
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 127-229 1.05e-13

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 65.91  E-value: 1.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 127 KVLEIGIGTGPNFKYYTDIPNVSVIGIDPNAKMESYARKSAteAGLKPEEFTFVHA-LGESIPLEDASVDAVVGTLVL-C 204
Cdd:cd02440   1 RVLDLGCGTGALALALASGPGARVTGVDISPVALELARKAA--AALLADNVEVLKGdAEELPPEADESFDVIISDPPLhH 78

                        90       100
                ....*....|....*....|....*
gi 18409299 205 SVTDVTQTLKEIKRILRPGGIYIFI 229
Cdd:cd02440  79 LVEDLARFLEEARRLLKPGGVLVLT 103
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 123-236 1.30e-12

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 64.36  E-value: 1.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   123 GKAEKVLEIGIGTG--PNFKYYTDIPNVSVIGIDPNAKMESYARKSATEAGLKpeEFTFVHALGESIP--LEDASVDAVV 198
Cdd:pfam13847   2 DKGMRVLDLGCGTGhlSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFD--NVEFEQGDIEELPelLEDDKFDVVI 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 18409299   199 GTLVLCSVTDVTQTLKEIKRILRPGGIYIFIEHVAAED 236
Cdd:pfam13847  80 SNCVLNHIPDPDKVLQEILRVLKPGGRLIISDPDSLAE 117
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 122-224 1.77e-12

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 65.56  E-value: 1.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299  122 VGKAEKVLEIGIGTGpnfkyytDI---------PNVSVIGIDPNAKMESYARKSATEAGLKPEeFTFVHALGESIPLEDA 192
Cdd:PRK00216  49 VRPGDKVLDLACGTG-------DLaialakavgKTGEVVGLDFSEGMLAVGREKLRDLGLSGN-VEFVQGDAEALPFPDN 120

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 18409299  193 SVDAVV---GtlvLCSVTDVTQTLKEIKRILRPGG 224
Cdd:PRK00216 121 SFDAVTiafG---LRNVPDIDKALREMYRVLKPGG 152
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 108-228 7.58e-12

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 63.84  E-value: 7.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   108 KEVSDYKMKLFDNLVG-KAEKVLEIGIGTGPNFKYYTD-IPNVSVIGIDPNAKMESYARKsateagLKPEEFTFVHALGE 185
Cdd:TIGR02072  17 REMAKRLLALLKEKGIfIPASVLDIGCGTGYLTRALLKrFPQAEFIALDISAGMLAQAKT------KLSENVQFICGDAE 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 18409299   186 SIPLEDASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGGIYIF 228
Cdd:TIGR02072  91 KLPLEDSSFDLIVSNLALQWCDDLSQALSELARVLKPGGLLAF 133
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
104-239 4.09e-11

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 60.78  E-value: 4.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 104 ESYEKEV---SDYKM--KLFDNLV-----GKAEKVLEIGIGTGPNFKYYTDIPNvSVIGIDPNAKMESYARKsateaglK 173
Cdd:COG4976  16 DSYDAALvedLGYEApaLLAEELLarlppGPFGRVLDLGCGTGLLGEALRPRGY-RLTGVDLSEEMLAKARE-------K 87

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 18409299 174 PEEFTFVHALGESIPLEDASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGGIYIFIEHVAAEDGTF 239
Cdd:COG4976  88 GVYDRLLVADLADLAEPDGRFDLIVAADVLTYLGDLAAVFAGVARALKPGGLFIFSVEDADGSGRY 153
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 129-225 9.87e-11

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 57.38  E-value: 9.87e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   129 LEIGIGTGPNFKYY-TDIPNVSVIGIDPNAKMESYARKsaTEAGLKPEEFTFVHALGESIPLED-ASVDAVVGTLVLCSV 206
Cdd:pfam08242   1 LEIGCGTGTLLRALlEALPGLEYTGLDISPAALEAARE--RLAALGLLNAVRVELFQLDLGELDpGSFDVVVASNVLHHL 78

                          90
                  ....*....|....*....
gi 18409299   207 TDVTQTLKEIKRILRPGGI 225
Cdd:pfam08242  79 ADPRAVLRNIRRLLKPGGV 97
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
112-230 7.78e-10

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 57.83  E-value: 7.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   112 DYKMKLFDNLVGkaEKVLEIGIGTGP-NFKYYTDI-PNVSVIGIDPNAKMESYARKSATEAGLKPEEFtfVHALGESIPL 189
Cdd:pfam01209  32 DFTMKCMGVKRG--NKFLDVAGGTGDwTFGLSDSAgSSGKVVGLDINENMLKEGEKKAKEEGKYNIEF--LQGNAEELPF 107

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 18409299   190 EDASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGGIYIFIE 230
Cdd:pfam01209 108 EDDSFDIVTISFGLRNFPDYLKVLKEAFRVLKPGGRVVCLE 148
arsM PRK11873
arsenite methyltransferase;
150-224 1.14e-09

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 58.04  E-value: 1.14e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18409299  150 VIGIDPNAKMESYARKSATEAGLKPEEFTfvhaLG--ESIPLEDASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGG 224
Cdd:PRK11873 105 VIGVDMTPEMLAKARANARKAGYTNVEFR----LGeiEALPVADNSVDVIISNCVINLSPDKERVFKEAFRVLKPGG 177
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
124-228 1.61e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 54.06  E-value: 1.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 124 KAEKVLEIGIGTGpnfkYYTD-----IPNVSVIGIDPNAKMESYARKSATEAglkpeefTFVHALGESIPLEdASVDAVV 198
Cdd:COG4106   1 PPRRVLDLGCGTG----RLTAllaerFPGARVTGVDLSPEMLARARARLPNV-------RFVVADLRDLDPP-EPFDLVV 68

                        90       100       110
                ....*....|....*....|....*....|
gi 18409299 199 GTLVLCSVTDVTQTLKEIKRILRPGGIYIF 228
Cdd:COG4106  69 SNAALHWLPDHAALLARLAAALAPGGVLAV 98
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 107-237 1.76e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 52.82  E-value: 1.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   107 EKEVSDYKMKLFDNLvGKAEKVLEIGIGTGPNFKYYTDIPnVSVIGIDPNAKMESYARKSATEAGLKPEEFTFvhalges 186
Cdd:pfam13489   6 ERLLADLLLRLLPKL-PSPGRVLDFGCGTGIFLRLLRAQG-FSVTGVDPSPIAIERALLNVRFDQFDEQEAAV------- 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 18409299   187 iplEDASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGGiYIFIEHVAAEDG 237
Cdd:pfam13489  77 ---PAGKFDVIVAREVLEHVPDPPALLRQIAALLKPGG-LLLLSTPLASDE 123
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 126-228 3.80e-06

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 46.08  E-value: 3.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 126 EKVLEIGIGTGPNFKYYTDIPNVSVIGIDPNAKMESYARKSATEAGLkPEEFTFVHALGESIPlEDASVDAVVGTLVLCS 205
Cdd:COG2230  53 MRVLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEYARERAAEAGL-ADRVEVRLADYRDLP-ADGQFDAIVSIGMFEH 130

                        90       100
                ....*....|....*....|....*
gi 18409299 206 VTD--VTQTLKEIKRILRPGGIYIF 228
Cdd:COG2230 131 VGPenYPAYFAKVARLLKPGGRLLL 155
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 124-228 1.24e-05

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 44.79  E-value: 1.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 124 KAEKVLEIGIGTGpnfkyYTDI-------PNVSVIGIDPNAKMESYARKSATEAGLkPEEFTFVH--ALgESIP-LEDAS 193
Cdd:COG4122  16 GAKRILEIGTGTG-----YSTLwlaralpDDGRLTTIEIDPERAAIARENFARAGL-ADRIRLILgdAL-EVLPrLADGP 88

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 18409299 194 VDavvgtLVLC--SVTDVTQTLKEIKRILRPGGIYIF 228
Cdd:COG4122  89 FD-----LVFIdaDKSNYPDYLELALPLLRPGGLIVA 120
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
180-225 3.35e-05

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 43.32  E-value: 3.35e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 18409299 180 VHALGESIPLEDASVDAVVGTLVL--CSVTDVTQTLKEIKRILRPGGI 225
Cdd:COG4627  33 VGDLTDPLPFPDNSVDAIYSSHVLehLDYEEAPLALKECYRVLKPGGI 80
Methyltransf_8 pfam05148
Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic ...
 187-225 5.18e-05

Hypothetical methyltransferase; This family consists of several uncharacterized eukaryotic proteins which are related to methyltransferases pfam01209.


Pssm-ID: 398698  Cd Length: 214  Bit Score: 43.65  E-value: 5.18e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18409299   187 IPLEDASVDAVVGTLVLCsVTDVTQTLKEIKRILRPGGI 225
Cdd:pfam05148 111 VPLEDESVDVAVFCLSLM-GTNIADFLKEANRILKNGGL 148
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 150-229 1.38e-04

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 41.86  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 150 VIGIDPNAKMESYARKSATEAGLkpEEFTFVHALGESIPLEDASVDAVV-----GTLVLCSVTD----VTQTLKEIKRIL 220
Cdd:COG1041  51 VIGSDIDPKMVEGARENLEHYGY--EDADVIRGDARDLPLADESVDAIVtdppyGRSSKISGEEllelYEKALEEAARVL 128


                ....*....
gi 18409299 221 RPGGIYIFI 229
Cdd:COG1041 129 KPGGRVVIV 137
PRK10258 PRK10258
biotin biosynthesis protein BioC; Provisional
 128-275 1.89e-04

biotin biosynthesis protein BioC; Provisional


Pssm-ID: 182340 [Multi-domain]  Cd Length: 251  Bit Score: 42.05  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299  128 VLEIGIGTGPNFKYYTDIPNVsVIGIDPNAKMESYARKsateaglKPEEFTFVHALGESIPLEDASVDAVVGTLVLCSVT 207
Cdd:PRK10258  46 VLDAGCGPGWMSRYWRERGSQ-VTALDLSPPMLAQARQ-------KDAADHYLAGDIESLPLATATFDLAWSNLAVQWCG 117

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18409299  208 DVTQTLKEIKRILRPGGIyifiehVAaedgtFLRLVQTVLDPLQQ---VVADGCHLTRHTGESILEARFNG 275
Cdd:PRK10258 118 NLSTALRELYRVVRPGGV------VA-----FTTLVQGSLPELHQawqAVDERPHANRFLPPDAIEQALNG 177
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
127-236 3.50e-04

Predicted methyltransferase [General function prediction only];


Pssm-ID: 443826  Cd Length: 274  Bit Score: 41.44  E-value: 3.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299 127 KVLEIGIGTGpnfkYYTDI------PNVSVIG--IDPNAKMESYARKSATEAGLK----PEEF---TFVHALGESIPLED 191
Cdd:COG4798  69 TVVEIWPGGG----WYTEIlapylgPKGKVYAanFDPDSEPPEYAKRSREAFSAKlaadPALYgnvRVTAFAPPDDPIAP 144

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 18409299 192 A-SVDAVvgtLVLCSV------TDVTQTLKEIKRILRPGGIYIFIEHVAAED 236
Cdd:COG4798 145 PgSADLV---LTFRNYhnwyraGDAAAMFAAFFKALKPGGVLGVVDHRAPPG 193
methyltr_grsp TIGR04188
methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are ...
 122-225 1.00e-03

methyltransferase, ATP-grasp peptide maturase system; Members of this protein family are predicted SAM-dependent methyltransferases that regularly occur in the context of a putative peptide modification ATP-grasp enzyme (TIGR04187, related to enzymes of microviridin maturation) and a putative ribosomal peptide modification target (TIGR04186).


Pssm-ID: 275041  Cd Length: 363  Bit Score: 40.42  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299   122 VGKAEKVLEIGIGTGpnfkYYTDI-------PNVSVIGIDPnaKMESYARKSATEAGLKPeefTFVHALGESIPLEDASV 194
Cdd:TIGR04188 105 VEDGHRVLEIGTGTG----YSAALlchrlgdDNVTSVEVDP--GLAARAASALAAAGYAP---TVVTGDGLLGHPPRAPY 175

                          90       100       110
                  ....*....|....*....|....*....|.
gi 18409299   195 DAVVGTlvlCSVTDVTQTLkeiKRILRPGGI 225
Cdd:TIGR04188 176 DRIIAT---CAVRRVPPAW---LRQTRPGGV 200
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 115-227 7.35e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 37.52  E-value: 7.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18409299  115 MKLFDNLVG--KAEKVLEIGIGTGPNFKYYTDI--PNVSVIGIDPNAKMESYARKSATEAGLkpEEFTFVHALGESIPLE 190
Cdd:PRK13943  69 MALFMEWVGldKGMRVLEIGGGTGYNAAVMSRVvgEKGLVVSVEYSRKICEIAKRNVRRLGI--ENVIFVCGDGYYGVPE 146

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 18409299  191 DASVDAVVGTLvlcSVTDVTQT----LKEIKRILRPGGIYI 227
Cdd:PRK13943 147 FAPYDVIFVTV---GVDEVPETwftqLKEGGRVIVPINLKL 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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