|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
44-499 |
1.60e-115 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 347.24 E-value: 1.60e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 44 DPIASLVDTAFIGQIG-PVELAAVGVSIALFNQVSRIAIFPLVSiTTSFVAEEdacssqqdtvrdhkecieIGINNptee 122
Cdd:cd13136 19 VPLLGLVDTAVVGHLGsAAYLGAVALGTTIFNTLFWLFGFLRMG-TTGLVAQA------------------LGAGD---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 123 tielipekhkdslsdefktsssifsiskppaKKRNIPSASSALIIGGVLGLFQAVFLISAAKPLLSFMGvkHDSPMMRPS 202
Cdd:cd13136 76 -------------------------------REEAIALLVRALLLALAIGLLLILLQSPLLALALLLLG--ASAAVAALA 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 203 QRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGDVTNIILDPIFIFVFRLGVTGAATAHVISQYLMCGILLWK 282
Cdd:cd13136 123 RQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVGNVVNIVLDPLFVFGLGWGVAGAALATVIAQYLGALLGLWL 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 283 LMGQVDIFNMS-----TKHLQFCRFMKNGFLLLMRVIAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAV 357
Cdd:cd13136 203 LRRRVRLLGKSlsrrlPSKAALKRLFKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAY 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 358 AGQAILASAFAKKDYKRAAATASRVLQLGLVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFV 437
Cdd:cd13136 283 AAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFV 362
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42562670 438 FDGVNFGASDFGYAAASLVMVAIVSILCLLFLSSTHGFIGLWFGLTIYMSLRAAVGFWRIGT 499
Cdd:cd13136 363 LDGIFIGATDTRYLRNSMLVSLAVFLPLLFLLVPLWGNHGLWLALILFMLLRGLTLALRLPR 424
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
44-426 |
9.09e-75 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 239.45 E-value: 9.09e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 44 DPIASLVDTAFIGQIGPVELAAVGVSiALFNQVSRIAIFPLVSITTSFVAEEDACSSQQdtvrdhkecieiginnpteet 123
Cdd:TIGR00797 9 QPLLGLVDTAFVGHLGPVDLAAVSLG-SSVFMFLFSILMGLGTATTALVAQAVGAGNYQ--------------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 124 ielipekhkdslsdefktsssifsiskppakkRNIPSASSALIIGGVLGLFQAVFLISAAKPLLSFMGvkHDSPMMRPSQ 203
Cdd:TIGR00797 67 --------------------------------RLGRQAQQSLLLALLLGLPVLLVGYFFIDPLLSLMG--ADGEVAELAQ 112
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 204 RYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGDVTNIILDPIFIF-VFR-LGVTGAATAHVISQYLMCGILLW 281
Cdd:TIGR00797 113 DYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNYILIFgKFGfLGIVGAALATVISYWLMFLLLLY 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 282 KLMGQVDI-----FNMSTKHLQFCRFMKNGFLLLMRVIAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYA 356
Cdd:TIGR00797 193 YIKKAKKIglkweGLLKPDWEVLKRLLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFG 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 357 VAGQAILASAFAKKDYKRAAATASRVLQLGLVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVA 426
Cdd:TIGR00797 273 IAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
45-496 |
6.73e-57 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 195.36 E-value: 6.73e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 45 PIASLVDTAFIGQIGPVELAAVGVSIALFNQVSRIAIFpLVSITTSFVAeedacssqqdtvrdhkecIEIGINNPTEeti 124
Cdd:COG0534 25 SLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIG-LGVGGTALVA------------------QALGAGDREE--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 125 elipekhkdslsdefktsssifsiskppAKKrnipSASSALIIGGVLGLFQAVFLISAAKPLLSFMGVkhDSPMMRPSQR 204
Cdd:COG0534 83 ----------------------------ARR----VLGQALLLALLLGLLLTLLGLLFAPPLLRLLGA--DPEVLALARD 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 205 YLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGDVTNIILDPIFIFVFRLGVTGAATAHVISQYLMCGILLWKLM 284
Cdd:COG0534 129 YLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLIGNVLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLF 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 285 GQVDIFNMSTKHLQFC-----RFMKNGFLLLMRVIAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAG 359
Cdd:COG0534 209 RKRSLLRLRLRDLRPDrkilkRILRIGLPAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAA 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 360 QAILASAFAKKDYKRAAATASRVLQLGLVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFD 439
Cdd:COG0534 289 QPLVGQNLGAGDYDRARRAARLALLLALGIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLS 368
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 42562670 440 GVNFGASDFGYAA-ASLVMVAIVSILCLLFLSSTH-GFIGLWFGLTIYMSLRAAVGFWR 496
Cdd:COG0534 369 GALRGAGDTRFPMiISLLRLWLVRLPLAYLLAFLGlGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
161-496 |
3.47e-38 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 144.96 E-value: 3.47e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 161 ASSALIIGGVLGLFQAVFLISAAKPLLSFMGVkhDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATV 240
Cdd:cd13137 80 LGQSLLLALLLSLPLALLGLLFAEPLLRLLGA--DPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMI 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 241 IGDVTNIILDPIFIF----VFRLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHLqfcRFMKNGFLLLMRV--- 313
Cdd:cd13137 158 IVNVLNIVLDYVLIFglwgFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGF---RLDRKIIKKLLRIglp 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 314 -----IAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLV 388
Cdd:cd13137 235 agleqLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVL 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 389 LGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASD-FGYAAASLVMVAIVSILCLL 467
Cdd:cd13137 315 FMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDtRPPLIINLISMWLVRLPLAY 394
|
330 340 350
....*....|....*....|....*....|.
gi 42562670 468 FLSSTHGF--IGLWFGLTIYMSLRAAVGFWR 496
Cdd:cd13137 395 LLGFVLGLglTGIWLAMFVDTIVRAILLLYR 425
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
160-481 |
1.08e-29 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 120.64 E-value: 1.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 160 SASSALIIGGVLGLFQAVFLISAAKPLLSFMGVKHDSpmMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFAT 239
Cdd:cd13138 82 AVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEI--LELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFV 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 240 VIGDVTNIILDPIFIFVFRLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHLQFCR-----FMKNGFLLLMRVI 314
Cdd:cd13138 160 IIACVLNIILDLLFIAVFHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKeilkeILKIGLPSALQQS 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 315 AVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVLGFVLA 394
Cdd:cd13138 240 LVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGLIII 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 395 VILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGasdFGYAAASLVM----VAIVSILCLLFLS 470
Cdd:cd13138 320 LLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRG---LGKTKFPMIIsilrLWLVRIPLAYLLS 396
|
330
....*....|...
gi 42562670 471 ST--HGFIGLWFG 481
Cdd:cd13138 397 RLtgLGLFGIWLA 409
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
161-494 |
4.82e-27 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 113.19 E-value: 4.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 161 ASSALIIGGVLGLFQAVFLISAAKPLLSFMGVkhDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATV 240
Cdd:cd12082 74 LVQSIVLAILLGLLLAALLLFFSPLILSLLGA--EEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISV 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 241 IGDVTNIILDPIFIFVF---RLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHLQFC-----RFMKNGFLLLMR 312
Cdd:cd12082 152 LSNLLNILLDPLLIFGLgppELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDlellrRLLRIGLPSAIQ 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 313 VIAVTFCVTLSASLAAR-EGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVLGF 391
Cdd:cd12082 232 NSLLSLGLLIIVAIVAAfGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGA 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 392 VLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASDFGYAAASLVMVAIVSILCLLFLSS 471
Cdd:cd12082 312 VLGLLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLA 391
|
330 340
....*....|....*....|....*
gi 42562670 472 THGF--IGLWFGLTIYMSLRAAVGF 494
Cdd:cd12082 392 YLGLglYGIWLALVISLILAALVLL 416
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
161-484 |
4.09e-26 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 110.29 E-value: 4.09e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 161 ASSALIIGGVLGLFQAVFLISAAKPLLSFMGVkhDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATV 240
Cdd:cd13143 84 FSTALLLSLILGLLLTILGLLFLDPLLRLLGA--SGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGML 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 241 IGDVTNIILDPIFIFVFRLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHLQFCR-----FMKNGFLLLMRVIA 315
Cdd:cd13143 162 IGAVLNIILDPLFIFVLGLGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLkiikeILALGFPSFLMQLS 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 316 VTFCVTL-SASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVLGFVLA 394
Cdd:cd13143 242 SSVVTIVlNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALIYGLVLF 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 395 VILGAGLHFGARVFTKDDKVLHLISIGLpfvagtqPINALAFVFDGVNFGASDF----GYAAASLVMVA----IVSILCL 466
Cdd:cd13143 322 LILLLFPEQIVSLFTDDPELIALAARIL-------RIFLLAFPLAGINIVLSGYfqaiGKAKRAALLSLlrqgLFLIPLL 394
|
330
....*....|....*...
gi 42562670 467 LFLSSTHGFIGLWFGLTI 484
Cdd:cd13143 395 LILPRLFGLDGIWLAFPL 412
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
161-416 |
1.42e-25 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 108.77 E-value: 1.42e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 161 ASSALIIGGVLGLFQAVFLISAAKPLLSFMGVKhDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATV 240
Cdd:cd13140 84 ARNALQLNLLLGILYGLLLLLFAKPLIGFFNLG-DAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINA 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 241 IGDVTNIILDPIFIFVF----RLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHLQFCR-FMKN----GFLLLM 311
Cdd:cd13140 163 IGLVLNIILDPLLIFGFgpfpALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRkYIKEilklGLPVAL 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 312 RVIAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVLGF 391
Cdd:cd13140 243 QSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGL 322
|
250 260
....*....|....*....|....*
gi 42562670 392 VLAVILGAGLHFGARVFTKDDKVLH 416
Cdd:cd13140 323 FATLLLFFFGEPLFSLFIPDPETIA 347
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
161-497 |
6.46e-24 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 104.12 E-value: 6.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 161 ASSALIIGGVLGLFQAVFLISAAKPLLSFMGVkhDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATV 240
Cdd:cd13134 82 AGVALLFNLLLGLVFSLLLLFFGAELLRLMGL--PPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSL 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 241 IGDVTNIILDPIFIFVF----RLGVTGAATAHVISQYLMCGILLW-------KLMGQVDIFNMSTKHLQfcRFMKNGFLL 309
Cdd:cd13134 160 IMNILNIVGNYLLIFGWfglpKLGVAGVAISTVISRAVGLVLLFIllfrklkIRFRLKDLRPFPKKLLK--KILKIGLPS 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 310 LMRVIAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVL 389
Cdd:cd13134 238 AGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLV 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 390 GFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASD--FGYAAASLVMVAI-VSILCL 466
Cdd:cd13134 318 SLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDarFPVLIGIISMWGIsVPLAYL 397
|
330 340 350
....*....|....*....|....*....|.
gi 42562670 467 LFLSSTHGFIGLWFGLTIYMSLRAAVGFWRI 497
Cdd:cd13134 398 LGIVLGLGLLGVWIAFAADEWVRGIIMLWRW 428
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
159-496 |
2.88e-22 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 99.14 E-value: 2.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 159 PSASSALIIGGVLGLFQAVFLISAAKPLLSFMGvkHDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFA 238
Cdd:cd13133 82 RVLWQGLYFSLLLAPLLALLSALAAPLLFLLLG--HSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVA 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 239 TVIGDVTNIILDPIFIF----VFRLGVTGAATAHVISQYLMCGILLWKLMGQVDIfnMSTKHLQFCRFMKNGFLLLMRV- 313
Cdd:cd13133 160 NLVMVVVNIVLDYALIFgklgFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNR--RRFGLRRAWRFDRELLRRILRLg 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 314 --IAVTFCVTLSA-----SLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLG 386
Cdd:cd13133 238 lpSGLQFFLDVGAftvffLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLA 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 387 LVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLP---FVAGTQPINALAFVFDGVNFGASD--FGYAAASLVMVAIV 461
Cdd:cd13133 318 LAYMLLLGILFLLFPELLLSIFTPGADFALIAELAVPllrFVAAYILFDALALVFAGALRGAGDtrFVMLAELIVAWLYL 397
|
330 340 350
....*....|....*....|....*....|....*
gi 42562670 462 SILCLLFLSSTHGFIGLWFGLTIYMSLRAAVGFWR 496
Cdd:cd13133 398 LPPAYLLVVLGAGLAGAWTVETVYVIVLALIFLLR 432
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
160-484 |
3.76e-18 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 86.86 E-value: 3.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 160 SASSALIIGGVLGLFQAVFLISAAKPLL-SFMGVkhdSPMMRP-SQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLF 237
Cdd:cd13142 89 VAGQTFSFVIILSLILAVLGYILSRPLLlLLIGA---PEEVYPlALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTPMK 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 238 ATVIGDVTNIILDPIFIFVF----RLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHLQFCRFM-----KNGFL 308
Cdd:cd13142 166 IMFGSVLLNVILDPLLIFGIgpfpGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLRDLKPDWEWlkkifRIGLP 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 309 LLMRVIAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVA-----GQAILASAFakKDYKRAAATASRVL 383
Cdd:cd13142 246 SSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARAtstmvGQNLGAGQI--DRAEEIVKKAALLI 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 384 QLGLVLGFVLAVILGAGLhfgARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASDFGYAAA-SLVMVAIVS 462
Cdd:cd13142 324 FLILVIGGVLAFLFAEPI---VRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIiSILRLWVIR 400
|
330 340
....*....|....*....|....
gi 42562670 463 ILCLLFLS--STHGFIGLWFGLTI 484
Cdd:cd13142 401 IPLAYLLAyvLGLGVTGIWIAMAI 424
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
160-494 |
5.20e-17 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 83.36 E-value: 5.20e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 160 SASSALIIGGVLGLFQAVFLISAAKPLLSFMGvkhDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFAT 239
Cdd:cd13147 87 AAVHSILLGLIISIILTIVLLPFLEPILVLMG---AGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAM 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 240 VIGDVTNIILDPIFIFVFRLGVTGAATAHVISQYLMCGILL-WKLMGQVDIFNMSTKHLQFCRFMKNGFL---------- 308
Cdd:cd13147 164 VAGSILNIILDPIFIYTLGLGIAGAAWATVISMLISSLVLLyWFFVKKDTYVSLSLKNFKFDKKIVKDILkvgipasleq 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 309 LLMRViaVTFCVTLSASLAAreGSTSMAAFQVCLQ-VWLATSLLAdGYAVAGQAILASAFAKKDYKRAAATASRVLQLGL 387
Cdd:cd13147 244 LIMSV--LMIILNLILVIVA--GTDGVAVYTAGWRiVSFAIIPLI-GIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGL 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 388 VLGFVLAVILGAGLHFGARVFTKDD----------KVLHLISIGLPFVAgtqPINALAFVFDGVNFGASDFgyAAASLVM 457
Cdd:cd13147 319 IIELIIAILIFIFAPQIAYLFTYSEesahlapeivAFLRIMCLFLPFVP---FGMMSSSMFQGIGKGLTSL--IITILRE 393
|
330 340 350
....*....|....*....|....*....|....*...
gi 42562670 458 VAIVSILCLLF-LSSTHGFIGLWFGLTIYMSLRAAVGF 494
Cdd:cd13147 394 LIFQVLFAYLFaIVLGLGLFGVWWGIVLGNAIGSIVGY 431
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
48-496 |
8.22e-17 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 82.55 E-value: 8.22e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 48 SLVDTAFIGQIGPVELAAVGVSIALFNQVSrIAIFPLVSITTSFVAEEdacssqqdtvrdhkecieIGINNPTEetielI 127
Cdd:cd13131 23 GFVDTVMAGRLGADDLAAVALGSSLWFPVF-TFGMGLLLAVTPLVAQA------------------HGAGDRRR-----I 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 128 PekhkdslsdefktsssifsiskppakkrniPSASSALIIGGVLGLFQAVFLIsAAKPLLSFMGVKHDspMMRPSQRYLS 207
Cdd:cd13131 79 R------------------------------RAVRQGLWLALLLSLPLMLLLW-LAPPILPLMGQEPE--VAAIARGYLL 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 208 LRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGDVTNIILDPIFIF----VFRLGVTGAATAHVISQYLMCGILLW-- 281
Cdd:cd13131 126 ALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVLNIPLNYVLIFgkfgLPALGGAGAGLATAIVYWLMFLALAFyi 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 282 KLMGQVDIFNMSTKHLQFCRFMKNGFLLLMRVIAVTFCV-----TLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYA 356
Cdd:cd13131 206 RRHKRFRRYRLFARFWRPDWARLKELLRLGLPIGLTIFFevslfAAVALLMGRLGTTVLAAHQIALNFASLLFMVPLGIS 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 357 VAGQAILASAFAKKDYKRAAATASRVLQLGLVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAF 436
Cdd:cd13131 286 MAATVRVGFALGAGDPADARRAGLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQV 365
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 42562670 437 VFDGVNFGASD----FGYAAASLVMVAIVSILCLLFLSSTHGFiGLWFGLTIYMSLRAAVGFWR 496
Cdd:cd13131 366 VAAGALRGYKDtrvpFLLALISYWGIGLPLGYLLAFTTGLGAF-GVWIGLIIGLALAAILLLWR 428
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
161-482 |
1.98e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 78.21 E-value: 1.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 161 ASSALIIGGVLGLFQAVFLISAAKPLLSFMGVKHDSPMMRPSQRYLSLrsLGAPAVLLSLAAQGVFRGFKDTTTPLFATV 240
Cdd:cd13146 90 ADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSL--PGVPFIMLIGVLMGVLQGEGRTKYMMMAML 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 241 IGDVTNIILDPIFIFVFRLGVTGAATAHVISQYLMCGILLWKLMG-------QVDIFNMSTKhlQFCRFMKNGFLLLMRV 313
Cdd:cd13146 168 IGTVVNIVLDPILIFVFDMGVKGAALATVLAQAISLLYLLYVFLIgksnvtiHIKLSNISSS--VIVEILRVGLPQMLLQ 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 314 IAVTFCVTLSASLAAREGSTSMAAFQVCLQvwLATSLLADGYAVAGQ--AILASAFAKKDYKRAAAT--ASRVLQLGLVL 389
Cdd:cd13146 246 LISSISFLIYNRIIIDIDPVAMTAFTLVGR--LDQFILIPIFAISSAllTIAGQNWGRGNYDRMLQIlmTAVILGIVVVL 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 390 GFVLAVILGAGLHFGArvFTKDDKVLHlisiglpfVAGTQ-PINALAFVFDGVNFGASDF----GYAAASLVMVAI---- 460
Cdd:cd13146 324 VLVLGYVLVAPWLFSL--FTTVPEVVA--------YAVLQvRTMALALPFVAISILVTEFfqaiGKAWPSLLLTLIrhvf 393
|
330 340
....*....|....*....|....
gi 42562670 461 --VSILCLLFLSSTHGFIGLWFGL 482
Cdd:cd13146 394 lsVPVVYLLAYVFGKGITGVYFGI 417
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
46-495 |
2.31e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 78.11 E-value: 2.31e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 46 IASLVDTAFIGQIGPVELAAVGVsialfnqvsriaIFPLVSITTSFvaeedacssqqdtvrdhkeCIEIGINnpteetie 125
Cdd:cd13149 27 IFNLTDTFFVGKLGTKELAAISF------------TFPVVLFLNSL-------------------TIGLGIG-------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 126 lipekhkdslsdefktSSSIfsISKPPAKKRNIPS---ASSALIIGGVLGLFQAVFLISAAKPLLSFMGVkhDSPMMRPS 202
Cdd:cd13149 68 ----------------ASAV--ISRAIGAGDRNKAkrlATDSLILSLLLSVIVSLLGLFTIPPLFSLLGA--SGEILPLI 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 203 QRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGDVTNIILDPIFIFVF----RLGVTGAATAHVISQYLMCGI 278
Cdd:cd13149 128 VEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVMLGAALVNVILDPILIFGFgpipGMGIAGAAIATVISRALGLGA 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 279 ---LLWKLMGQVDIFNMSTKHLQFC--RFMKNGFLLLMRVIAVTFCVTLSASLAAREGSTSMAAFQVC--LQVWLATSLL 351
Cdd:cd13149 208 alyFLHYHHRLIDFSEPSLKALFRSwkDILSIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVAtrIESFAFIIVM 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 352 ADGYAVAgqAILASAFAKKDYKRAAATASRVLQLGLVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVA---GT 428
Cdd:cd13149 288 ALSSALG--PFVGQNWGAGQYERVQEGLKISLKFSLIYGAILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPigyGG 365
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 42562670 429 QPINALAfvfdgvNFGASDFGYAAASLVMVAIVSILCLLFL----SSTHGFIGLWFGLTIYMSLRAAVGFW 495
Cdd:cd13149 366 LGILIIT------SASFNALGKPLYSLGLNLIRVFLLYIPLayvgSHLLGFAGVFIGALAGNLIAGILAYF 430
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
171-495 |
1.17e-14 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 76.07 E-value: 1.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 171 LGLFQAVFLISAAKPLLSFMGVKHDspMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGDVTNIILD 250
Cdd:cd13132 92 LCCVPISLLWLNTEPILLLLGQDPE--IARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLVALLLNILLN 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 251 PIFIFVFRLGVTGAATAHVISQYLMCGILL---WKLMGQVDIFNMSTKHLqFCR---FMK----NGFLLLMRVIAVTFCV 320
Cdd:cd13132 170 YLLVFVLGLGFIGAALATSISYWLIVVLLLlyiFFSKGHKATWGGFSREA-FRGwgpFLKlaipSALMLCLEWWAFEILV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 321 TLSASLaarEGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVLGFVLAVILGAG 400
Cdd:cd13132 249 LLAGLL---PGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALILSLVIGVVVAILLLVL 325
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 401 LHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASDFGYAAAS------LVMVAIVSILCLLFlssTHG 474
Cdd:cd13132 326 RDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVnlvayyLIGLPVGLLLAFVL---GLG 402
|
330 340
....*....|....*....|.
gi 42562670 475 FIGLWFGLTIYMSLRAAVGFW 495
Cdd:cd13132 403 LKGLWIGLIAGLILQAVILLL 423
|
|
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
161-497 |
7.47e-14 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 73.42 E-value: 7.47e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 161 ASSALIIGGVLGLFQAVFLISAAKPLLSFMGVkhDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATV 240
Cdd:cd13144 87 ANNGLLLALLSYLLFLLLGLFGVKPFFRLFTD--DPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQL 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 241 IGDVTNIILDPIFIFVF----RLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHlqfcrfmKNGFLLLMRVI-A 315
Cdd:cd13144 165 IGAIINIILDPILIFGLfgfpAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRL-------FRPSLRIIKEIyA 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 316 VTFCVTLSASLA-----------AREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATasrvLQ 384
Cdd:cd13144 238 VGLPSIIMQAISsvmvfglnkilAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREA----IK 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 385 LGLVLGFVLAVILGAGLHFGA----RVFTKDDKVLhliSIGLPFVagtqPINALAFVFDGVNFGASDF----GYAAASLV 456
Cdd:cd13144 314 YAILIAVVIMLAGGLLFQLFPdqllGLFNASEEML---AIGVPAL----RIISLSFLFAALSIILSGLfqalGRGVYSLI 386
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 42562670 457 MVAIVSILCLL----FLSSTHGFIGLWFGLTIYMSLRAAVG---FWRI 497
Cdd:cd13144 387 ISVARQLVVLLplawLLAKMFGLNGVWWSFPIAEIVSFLLSllfLKRL 434
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
160-426 |
1.56e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 69.56 E-value: 1.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 160 SASSALIIGGVLGLFQAVFLISAAKPLLSFMGVkhdSPM-MRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFA 238
Cdd:cd13139 92 AAVQAILLGVALSLILSILGYFFAEDILSLMGA---SPAvIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMRS 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 239 TVIGDVTNIILDPIFIF----VFRLGVTGAATAHVISQYLMCGILLWKLMgqvdifnMSTKHLQFCR-FMKNGFLLLMRV 313
Cdd:cd13139 169 LWLANGLNIILDPLFIFglgpIPAMGVTGAAIATTIGRSIGVLYQLYHLF-------KGKGRIQIRRrHLKLDWAIIKKI 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 314 IAVTFCVTL-----SAS------LAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRV 382
Cdd:cd13139 242 IKIAVGGILqfliaSSSwiflvrIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRA 321
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 42562670 383 LQLGLVLGFVLAVILGAGLHFGARVFTKDDKV-------LHLISIGLPFVA 426
Cdd:cd13139 322 GKYNMVFLGIVSLVFFLFAEPLVSFFTTDPEViaiaveaLRIISLGYIFYG 372
|
|
| PRK10367 |
PRK10367 |
DNA-damage-inducible SOS response protein; Provisional |
156-504 |
6.23e-12 |
|
DNA-damage-inducible SOS response protein; Provisional
Pssm-ID: 182413 [Multi-domain] Cd Length: 441 Bit Score: 67.46 E-value: 6.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 156 RNIPSASSALIIGGVLGLFQAVFLISAAKPL--LSFMGVKHDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTT 233
Cdd:PRK10367 80 KNPQALARALVQPLLLALGAGALIALLRTPLidLALHIVGGSEAVLEQARRFLEIRWLSAPASLANLVLLGWLLGVQYAR 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 234 TPLFATVIGDVTNIILDPIFIFVFRLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHLQ------FCRFMKNGF 307
Cdd:PRK10367 160 APVILLVVGNILNIVLDLWLVMGLHMNVQGAALATVIAEYATLLIGLLMVRKVLKLRGISLEMLKtawrgnFRRLLALNR 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 308 LLLMRVIAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAA---TASRvlQ 384
Cdd:PRK10367 240 DIMLRSLLLQLCFGAITVLGARLGSDIIAVNAVLMTLLTFTAYALDGFAYAVEAHSGQAYGARDGSQLLDvwrAACR--Q 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 385 LGLV-LGFVLAVILgAGLHFGArVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASDFGYAAASLVMVAIVSI 463
Cdd:PRK10367 318 SGIVaLLFSLVYAL-AGEHIIA-LLTSLPQIQQLADRYLIWQVILPLVGVWCYLLDGMFIGATRAAEMRNSMAVAAAGFA 395
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 42562670 464 LCLLFLSSThGFIGLWFGLTIYMSLRA-AVGF-WRIGTGTGPW 504
Cdd:PRK10367 396 LTLLTLPWL-GNHGLWLALTVFLALRGlSLAAiWRRHWRNGTW 437
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
161-495 |
8.40e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 67.24 E-value: 8.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 161 ASSALIIGGVLGLFQAVFLISAAKPLLSFMGVKHDSPMMrpSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATV 240
Cdd:cd13145 88 AAQGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDL--ALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLI 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 241 IGDVTNIILDPIFIF----VFRLGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHL-----QFCRFMKNGF--LL 309
Cdd:cd13145 166 IGFFLNIILDPLFIFggggIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFiprldVYKEILKQGFpaSL 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 310 LMRVIAVTFCVTLSAslAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVL 389
Cdd:cd13145 246 NMMTIGLGIFVITYF--VGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVI 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 390 GFVLAVILGAGLHFGARVFTKDDKVlhlISIGlpfvAGTQPINALAFVFDGVNFGASDFGYAAASLVMVAIVSIL----- 464
Cdd:cd13145 324 MVVATVFLLFFAEPLMSLFTNDPAV---IAIG----AGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYrqlvg 396
|
330 340 350
....*....|....*....|....*....|....*.
gi 42562670 465 -CLLF--LSSTHGF--IGLWFGLTIYMSLRAAVGFW 495
Cdd:cd13145 397 pALVFwlLVNVLGLgvTGIWWGIFTIVWSAAIIALL 432
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
313-464 |
5.43e-10 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 57.96 E-value: 5.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 313 VIAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVLGFV 392
Cdd:pfam01554 6 NLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGLLLSLP 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 42562670 393 LAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGAsdfGYAAASLVMVAIVSIL 464
Cdd:pfam01554 86 IALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQ---GDTKPPMYINIISLLL 154
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
164-283 |
1.94e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 53.43 E-value: 1.94e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 164 ALIIGGVLGLFQAVFLISAAKPLLSFMGVKHDSpmMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGD 243
Cdd:cd13148 95 ALVIALAGGLVFSLLFLLFGPALYRLLGGRGEA--LDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLVGA 172
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 42562670 244 VTNIILDPIFIFVF----RLGVTGAATAHVISQYLMCGILLWKL 283
Cdd:cd13148 173 VVQIPLSPGLILGWgplpRLGVAGAAVAAVLYYALAALVLLRYL 216
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
160-252 |
2.32e-07 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 50.64 E-value: 2.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 160 SASSALIIGGVLGLFQAVFLISAAKPLLSFMGvkHDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFAT 239
Cdd:pfam01554 71 ALRQGLILGLLLSLPIALLVLLFSEPILSLFG--QDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYIN 148
|
90
....*....|...
gi 42562670 240 VIGDVTNIILDPI 252
Cdd:pfam01554 149 IISLLLNIPLNYL 161
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
166-438 |
3.61e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 49.21 E-value: 3.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 166 IIGGVLGLFqavFLISAaKPLLSFMGVkhDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGDVT 245
Cdd:cd13135 89 IIGVILFLL---WLFGA-RIIFVLFGV--DGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 246 NIILDPIFIF----VFRLGVTGAATAHVISQYLMCGILLwklmgqvdIFNMSTKHLQFCRFMKNgfLLLMRVIAVTFCVT 321
Cdd:cd13135 163 NVILDYVLIFgnfgFPRLGIIGAAIATTIANVLNLIILV--------YLCRKIKKLTFKLSNTK--VLKANIRPYKFTIK 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 322 LSASLAARE-----------------GSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQ 384
Cdd:cd13135 233 LGLPLGGEEflwnignlavirilnriGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLG 312
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 42562670 385 LGLVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVF 438
Cdd:cd13135 313 LGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVY 366
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
142-278 |
4.60e-06 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 48.84 E-value: 4.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 142 SSSIFSIS---KPPAKKRNIPSASSALIIGgvLGLFQAVFLISAAKPLLSFMGVKHDSPMMrpSQRYLSLRSLGAPAVLL 218
Cdd:PRK09575 72 TGSLLSIKrgeGDLEKAKRILTTGLLLLLL--LGPIVSVILFLFADDFLRAQGAEGRTLEL--ALQYIQVLIWGCLFTLG 147
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 42562670 219 SLAAQGVFRgfkDTTTPLFAT---VIGDVTNIILDPIFIFVFRLGVTGAATAHVISQYLMCGI 278
Cdd:PRK09575 148 AIALPFLLR---NDESPNLATglmVIGALINIVLDYLFIGWLDWGLTGAAIATALAQLVVTVL 207
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
162-495 |
1.19e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 47.70 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 162 SSALIIGGVLGLFQAVFLISAAKPLLSFMGVKHDSPMMRPSQRYLSLRSLGAPAVLLSLAAqgVFRGFKDTTTPLFATVI 241
Cdd:cd13141 91 NQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYWFIPSLALQFILTVLGA--ALRGTGIVKPFMVIQIL 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 242 GDVTNIILDPIFIF---VFR-LGVTGAATAHVISQYLMCGILLWKLMGQVDIFNMSTKHLQ-----FCRFMKNG------ 306
Cdd:cd13141 169 AVLLNIILAPILITgwgTGRaLGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWRpdlptWKRLLKIGlpsgge 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 307 FLLLMRVIAVTFCVTlsaslaAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLG 386
Cdd:cd13141 249 FLLTFVYMAVIYWAL------RPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILT 322
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 387 LVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASDFGYAAASLVMVAIVSILCL 466
Cdd:cd13141 323 TALMLVLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFALPV 402
|
330 340 350
....*....|....*....|....*....|.
gi 42562670 467 LFLSSTHGF--IGLWFGLTIYMSLRAAVGFW 495
Cdd:cd13141 403 IWLSAQPDFriEQIWYLSVATTILQAALSLL 433
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
162-283 |
2.50e-05 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 46.68 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 162 SSALIIGGVLGLFQAVFLISAAKPLLS--FMGVK---HDSPMMRPSQRYLSLrslGAPAVLLSLAAQGVFRGFKDTTTPL 236
Cdd:COG0728 303 SRGLRLVLLLTLPAAVGLIVLAEPIVRllFERGAftaEDTALTALALAAYAL---GLPAFALVKVLARAFYARQDTRTPV 379
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 42562670 237 FATVIGDVTNIILDpiFIFVFRLGVTGAATAHVISQYLMCGILLWKL 283
Cdd:COG0728 380 RIAVIAVVVNIVLN--LLLVPPLGHAGLALATSLSALVNALLLLVLL 424
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
162-283 |
1.12e-04 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 44.37 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 162 SSALIIGGVLGLFQAVFLISAAKPLLS--FMGVKHDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFAT 239
Cdd:cd13123 296 SRGLRLVLFLLLPAAVGLIVLAEPIVRllFERGAFTAEDTLMTASALAAYALGLPAFALVKLLSRAFYALKDTKTPVKIA 375
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 42562670 240 VIGDVTNIILDpiFIFVFRLGVTGAATAHVISQYLMCGILLWKL 283
Cdd:cd13123 376 VIAVAVNILLN--LLLIKPLGHVGLALATSLSAWVNALLLLVLL 417
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
154-509 |
2.33e-04 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 43.57 E-value: 2.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 154 KKRNIPSASSALIIGGVLGLFQAVFLISAAKPLLSFMGVKHDSPMMRPSQRYLSLRSLGAPAVLLSLAAQGVFRGFKDTT 233
Cdd:PRK10189 101 RRRARAAARQSLVIMTLFAVLLAVLIHFFGEQIIDLVAGDATPEVKALALTYLELTVWSYPAAAITLIGSGALRGAGNTK 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 234 TPLFATVIGDVTNIILDPIFIF-VFR---LGVTGAATAHVISQYLMCGILLWKLM-GQVDIFNMSTKHLqfcrFMKNGFL 308
Cdd:PRK10189 181 IPLLINGGMNILNIIISSILIYgLFSwqgLGFVGAGLGLTISRYIGAVAIIWVLMiGFNPALRISLKSY----FKPLNFA 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 309 LLMRVIAVTFCVTLSASL-----------AAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAA 377
Cdd:PRK10189 257 IIWEVMGIGIPASIESVLfnggklltqmfVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLGKGQIAQAER 336
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 378 TASRVLQLGLVLGFVLAVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASDFGYAaaslVM 457
Cdd:PRK10189 337 QLRHVFWLSTLGLTAIAWLSAPFAGLLASFYTQDPDVKHVVKILIWLNALFMPIWAASWVLPAGLKGARDARYA----MW 412
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 42562670 458 VAIVSILC-------LLFLSSTHGFIGLWFGLTIYMSLRAAVGFWRIGTGTGPWSFLRS 509
Cdd:PRK10189 413 VSMLGMWGcrvvagyILGIMLGFGVVGVWMGMFLDWAVRGVLFYWRMVSGRWLWKYPRP 471
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
314-478 |
1.66e-03 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 40.69 E-value: 1.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 314 IAVTFCVTLSASLAAREGSTSMAAFQVCLQVWLATSLLADGYAVAGQAILASAFAKKDYKRAAATASRVLQLGLVLGFVL 393
Cdd:TIGR00797 7 ILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLALLLGLPV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 394 AVILGAGLHFGARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASDFGYAA-ASLVMVAIVSILCLLFLSST 472
Cdd:TIGR00797 87 LLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMyITLIGNVINIILNYILIFGK 166
|
....*.
gi 42562670 473 HGFIGL 478
Cdd:TIGR00797 167 FGFLGI 172
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
164-497 |
2.00e-03 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 40.57 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 164 ALIIGGVLGLFQAVFLISAAKPLLSFMGVkhDSPMMRPSQRYLSLRSLGAPAVLLSLaaqgVFRGFKD----TTTPLFAT 239
Cdd:PRK01766 94 GLWLALFLSVLIMLVLYNAVPPILNMMNL--EPEVADIAVGYLHALLWGIPAYLLYQ----VLRSFIDglgkTKPTMVIG 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 240 VIGDVTNIILDPIFIF----VFRLGVTGAATAHVISQYLMCGILLWKLMgqvdiFNMSTKHLQ-FCRFMKNGFLLLMRV- 313
Cdd:PRK01766 168 FLGLLINIPLNYIFIYgkfgFPELGGVGCGVATAIVYWVMFLAMLIYIK-----RARRFRDFRlFKGLYKPDWAVIKRLl 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 314 -----IAVTFC--VTLSAS---LAAREGSTSMAAFQVCLQVwlaTSL---LADGYAVAGQAILASAFAKKDYKRaAATAS 380
Cdd:PRK01766 243 klglpIGLAIFfeVSLFAVvtlLVSPLGTVTVAAHQIALNF---SSLlfmLPLSLAMALTIRVGFELGAGRTLD-ARQYA 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42562670 381 RVlqlGLVLGFVLAVILGAGLHFG----ARVFTKDDKVLHLISIGLPFVAGTQPINALAFVFDGVNFGASDfgyaAASLV 456
Cdd:PRK01766 319 YI---GLAVGLGMALLTAIFLVLFreqiALLYTDDPEVVALASHLLLFAALFQFSDAIQVIGSGALRGYKD----TRVIF 391
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 42562670 457 MVAIVS-------ILCLLFLSSTHGFIGLWFGLTIYMSLRAAVGFWRI 497
Cdd:PRK01766 392 FITFIAywvlglpLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRL 439
|
|
| murJ_mviN |
TIGR01695 |
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously ... |
206-283 |
2.14e-03 |
|
murein biosynthesis integral membrane protein MurJ; This model represents MurJ (previously MviN), a family of integral membrane proteins predicted to have ten or more transmembrane regions. Members have been suggested to act as a lipid II flippase, translocated a precursor of murein. However, it appears FtsW has that activity. Flippase activity for MurJ has not been shown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273763 [Multi-domain] Cd Length: 502 Bit Score: 40.77 E-value: 2.14e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 42562670 206 LSLRSLGAPAVLLSLAAQGVFRGFKDTTTPLFATVIGDVTNIILDPIFIFVFRLGvtGAATAHVISQYLMCGILLWKL 283
Cdd:TIGR01695 350 LAAYGLGLIFYSLQKVLLRAFYARKDTRTPFINSVISVVLNALLSLLLIFPLGLV--GIALATSAASMVSSVLLYLML 425
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