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Conserved domains on  [gi|18403455|ref|NP_564586|]
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F-box and associated interaction domains-containing protein [Arabidopsis thaliana]

Protein Classification

F-box protein( domain architecture ID 17779041)

F-box protein is the substrate-recognition component of an SCF (Skp1-cullin-F-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
97-333 2.65e-53

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


:

Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 176.40  E-value: 2.65e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455    97 YVDCDGLLfCTSYKfKGVLIWNPWLKQTRLF---ASNHHYPT--KYVIGYDN-KKRYKVLDYEFE----PSSKLTIYEIG 166
Cdd:TIGR01640   1 VVPCDGLI-CFSYG-KRLVVWNPSTGQSRWLptpKSRRSNKEsdTYFLGYDPiEKQYKVLCFSDRsgnrNQSEHQVYTLG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   167 lySKKVKDLESDSSWSVVQSNSVSLNGTLYWAGVDV--NNGIFIRSFSFSTERLTTFCRLPLKY-NEDNILALAVFrKDR 243
Cdd:TIGR01640  79 --SNSWRTIECSPPHHPLKSRGVCINGVLYYLAYTLktNPDYFIVSFDVSSERFKEFIPLPCGNsDSVDYLSLINY-KGK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   244 FSLLKLCNKTSKIKIWLTKNSINNReiglvedvvWIKLMTVLIPDFPKLPFRWYnrpdLTYFLdndDAKRLVICCYDETQ 323
Cdd:TIGR01640 156 LAVLKQKKDTNNFDLWVLNDAGKQE---------WSKLFTVPIPPLPDLVDDNF----LSGFT---DKGEIVLCCEDENP 219
                         250
                  ....*....|.
gi 18403455   324 -QVYIYIVRRN 333
Cdd:TIGR01640 220 fYIFYYNVGEN 230
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
5-42 4.25e-16

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438928  Cd Length: 39  Bit Score: 71.34  E-value: 4.25e-16
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 18403455   5 NLPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDNKF 42
Cdd:cd22157   2 SLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
97-333 2.65e-53

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 176.40  E-value: 2.65e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455    97 YVDCDGLLfCTSYKfKGVLIWNPWLKQTRLF---ASNHHYPT--KYVIGYDN-KKRYKVLDYEFE----PSSKLTIYEIG 166
Cdd:TIGR01640   1 VVPCDGLI-CFSYG-KRLVVWNPSTGQSRWLptpKSRRSNKEsdTYFLGYDPiEKQYKVLCFSDRsgnrNQSEHQVYTLG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   167 lySKKVKDLESDSSWSVVQSNSVSLNGTLYWAGVDV--NNGIFIRSFSFSTERLTTFCRLPLKY-NEDNILALAVFrKDR 243
Cdd:TIGR01640  79 --SNSWRTIECSPPHHPLKSRGVCINGVLYYLAYTLktNPDYFIVSFDVSSERFKEFIPLPCGNsDSVDYLSLINY-KGK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   244 FSLLKLCNKTSKIKIWLTKNSINNReiglvedvvWIKLMTVLIPDFPKLPFRWYnrpdLTYFLdndDAKRLVICCYDETQ 323
Cdd:TIGR01640 156 LAVLKQKKDTNNFDLWVLNDAGKQE---------WSKLFTVPIPPLPDLVDDNF----LSGFT---DKGEIVLCCEDENP 219
                         250
                  ....*....|.
gi 18403455   324 -QVYIYIVRRN 333
Cdd:TIGR01640 220 fYIFYYNVGEN 230
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
188-360 1.06e-40

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 141.21  E-value: 1.06e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   188 SVSLNGTLYWAGVDVNN--GIFIRSFSFSTERLTTFCRLPLKYNEDNILALAVFRKDRFSLLKLCNKTSKIKIWLTKNSI 265
Cdd:pfam07734   1 GVSLKGNTYWLAREKETneEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   266 NNreiglveDVVWIKLMTVLIPDFPKLPFRWYNrpdLTYFLDNDdaKRLVICCYDET--QQVYIYIVRRNIVKKikidlf 343
Cdd:pfam07734  81 PN-------AVSWSKFLTVDMPPLPGLFFHFFA---GSFFIDEE--KKVAVVCDKDKekKTNTIYIIGEDGYFK------ 142
                         170
                  ....*....|....*..
gi 18403455   344 EDLLDQSSPHLRTYIPS 360
Cdd:pfam07734 143 EVDSSYCSPLVCSYVPS 159
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
5-42 4.25e-16

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 71.34  E-value: 4.25e-16
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 18403455   5 NLPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDNKF 42
Cdd:cd22157   2 SLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
6-46 2.71e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 49.36  E-value: 2.71e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 18403455      6 LPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDNKFVNDH 46
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
5-42 5.28e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 45.61  E-value: 5.28e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18403455     5 NLPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDNKF 42
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
 
Name Accession Description Interval E-value
F_box_assoc_1 TIGR01640
F-box protein interaction domain; This model describes a large family of plant domains, with ...
97-333 2.65e-53

F-box protein interaction domain; This model describes a large family of plant domains, with several hundred members in Arabidopsis thaliana. Most examples are found C-terminal to an F-box (pfam00646), a 60 amino acid motif involved in ubiquitination of target proteins to mark them for degradation. Two-hybid experiments support the idea that most members are interchangeable F-box subunits of SCF E3 complexes. Some members have two copies of this domain.


Pssm-ID: 273726 [Multi-domain]  Cd Length: 230  Bit Score: 176.40  E-value: 2.65e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455    97 YVDCDGLLfCTSYKfKGVLIWNPWLKQTRLF---ASNHHYPT--KYVIGYDN-KKRYKVLDYEFE----PSSKLTIYEIG 166
Cdd:TIGR01640   1 VVPCDGLI-CFSYG-KRLVVWNPSTGQSRWLptpKSRRSNKEsdTYFLGYDPiEKQYKVLCFSDRsgnrNQSEHQVYTLG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   167 lySKKVKDLESDSSWSVVQSNSVSLNGTLYWAGVDV--NNGIFIRSFSFSTERLTTFCRLPLKY-NEDNILALAVFrKDR 243
Cdd:TIGR01640  79 --SNSWRTIECSPPHHPLKSRGVCINGVLYYLAYTLktNPDYFIVSFDVSSERFKEFIPLPCGNsDSVDYLSLINY-KGK 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   244 FSLLKLCNKTSKIKIWLTKNSINNReiglvedvvWIKLMTVLIPDFPKLPFRWYnrpdLTYFLdndDAKRLVICCYDETQ 323
Cdd:TIGR01640 156 LAVLKQKKDTNNFDLWVLNDAGKQE---------WSKLFTVPIPPLPDLVDDNF----LSGFT---DKGEIVLCCEDENP 219
                         250
                  ....*....|.
gi 18403455   324 -QVYIYIVRRN 333
Cdd:TIGR01640 220 fYIFYYNVGEN 230
FBA_1 pfam07734
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
188-360 1.06e-40

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 254394  Cd Length: 159  Bit Score: 141.21  E-value: 1.06e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   188 SVSLNGTLYWAGVDVNN--GIFIRSFSFSTERLTTFCRLPLKYNEDNILALAVFRKDRFSLLKLCNKTSKIKIWLTKNSI 265
Cdd:pfam07734   1 GVSLKGNTYWLAREKETneEDFLLSFDFTTERFGPRLPLPFQSPDLDTVSLSVVREEKLAVLLQEDDTSKIEIWVTTKIE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403455   266 NNreiglveDVVWIKLMTVLIPDFPKLPFRWYNrpdLTYFLDNDdaKRLVICCYDET--QQVYIYIVRRNIVKKikidlf 343
Cdd:pfam07734  81 PN-------AVSWSKFLTVDMPPLPGLFFHFFA---GSFFIDEE--KKVAVVCDKDKekKTNTIYIIGEDGYFK------ 142
                         170
                  ....*....|....*..
gi 18403455   344 EDLLDQSSPHLRTYIPS 360
Cdd:pfam07734 143 EVDSSYCSPLVCSYVPS 159
F-box_AtFBW1-like cd22157
F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) ...
5-42 4.25e-16

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438928  Cd Length: 39  Bit Score: 71.34  E-value: 4.25e-16
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 18403455   5 NLPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDNKF 42
Cdd:cd22157   2 SLPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISSPSF 39
FBOX smart00256
A Receptor for Ubiquitination Targets;
6-46 2.71e-08

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 49.36  E-value: 2.71e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 18403455      6 LPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDNKFVNDH 46
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWFKL 41
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
5-42 5.28e-07

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 45.61  E-value: 5.28e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18403455     5 NLPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDNKF 42
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
5-38 7.19e-06

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 42.43  E-value: 7.19e-06
                        10        20        30
                ....*....|....*....|....*....|....
gi 18403455   5 NLPWELVEEILYRVPPQSLARFRTVCKQWNSLFD 38
Cdd:cd09917   2 DLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
F-box_AtGID2-like cd22151
F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, ...
4-42 1.07e-05

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438922  Cd Length: 44  Bit Score: 42.31  E-value: 1.07e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 18403455   4 VNLPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDNKF 42
Cdd:cd22151   1 RKLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESL 39
F-box_FBA cd22083
F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box ...
6-38 1.14e-04

F-box domain found in the F-box associated (FBA) family of F-box proteins; The F-box associated (FBA) family is composed of FBXO2, FBXO6, FBXO17, FBXO27, and FBXO44, which contain a conserved G domain that mediates substrate binding. Members of this family play diverse roles in glycoprotein quality control. They bind high mannose and sulfated glycoproteins, with one FBA protein, FBXO44, failing to bind any glycans on the tested arrays. FBA proteins are components of canonical SCF (Skp1, Cullin1, and Rbx1) complexes, yet FBXO2 bound very little Cullin1, suggesting that FBXO2 may exist primarily as a heterodimer with Skp1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438855  Cd Length: 37  Bit Score: 38.91  E-value: 1.14e-04
                        10        20        30
                ....*....|....*....|....*....|....
gi 18403455   6 LPWELVEEILYRVPPQSL-ARFRTVCKQWNSLFD 38
Cdd:cd22083   4 IPEELLLEILTHVPATSLiTNCRLVCTLWRDIID 37
F-box-like pfam12937
F-box-like; This is an F-box-like family.
5-40 2.19e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 35.54  E-value: 2.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 18403455     5 NLPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDN 40
Cdd:pfam12937   3 SLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDD 38
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
6-40 6.75e-03

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 34.21  E-value: 6.75e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 18403455   6 LPWELVEEILYRVPPQSLARFRTVCKQWNSLFDDN 40
Cdd:cd22147   5 LPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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