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Conserved domains on  [gi|18401993|ref|NP_564519|]
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myb domain protein 112 [Arabidopsis thaliana]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 999994)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03091 super family cl33633
hypothetical protein; Provisional
 31-145 4.24e-46

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 159.37  E-value: 4.24e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401993   31 EIRRGPWTVEEDMKLVSYISLHGEGRWNSLSRSAGLNRTGKSCRLRWLNYLRPDIRRGDISLQEQFIILELHSRWGNRWS 110
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 18401993  111 KIAQHLPGRTDNEIKNYWRTRVQKHAKLLKCDVNS 145
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNT 125
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 31-145 4.24e-46

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 159.37  E-value: 4.24e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401993   31 EIRRGPWTVEEDMKLVSYISLHGEGRWNSLSRSAGLNRTGKSCRLRWLNYLRPDIRRGDISLQEQFIILELHSRWGNRWS 110
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 18401993  111 KIAQHLPGRTDNEIKNYWRTRVQKHAKLLKCDVNS 145
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNT 125
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 87-130 5.46e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 61.37  E-value: 5.46e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 18401993    87 RGDISLQEQFIILELHSRWGNRWSKIAQHLPGRTDNEIKNYWRT 130
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 30-128 8.73e-12

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 64.04  E-value: 8.73e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401993  30 IEIRRGPWTVEEDMKLVSYISLHGEGRWNSLSRSAGLnRTGKSCRLRWLNYLRPDIRRGDISLQEQFIILELHSRWGNRW 109
Cdd:COG5147  16 TKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQW 94

                        90
                ....*....|....*....
gi 18401993 110 SKIAQHLPGRTDNEIKNYW 128
Cdd:COG5147  95 STIADYKDRRTAQQCVERY 113
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
34-83 5.50e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 56.08  E-value: 5.50e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 18401993     34 RGPWTVEEDMKLVSYISLHGEGRWNSLSRSAGlNRTGKSCRLRWLNYLRP 83
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 36-81 3.21e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.12  E-value: 3.21e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 18401993  36 PWTVEEDMKLVSYISLHGEGRWNSLSRSAGlNRTGKSCRLRWLNYL 81
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP-GRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
PLN03091 PLN03091
hypothetical protein; Provisional
 31-145 4.24e-46

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 159.37  E-value: 4.24e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401993   31 EIRRGPWTVEEDMKLVSYISLHGEGRWNSLSRSAGLNRTGKSCRLRWLNYLRPDIRRGDISLQEQFIILELHSRWGNRWS 110
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 18401993  111 KIAQHLPGRTDNEIKNYWRTRVQKHAKLLKCDVNS 145
Cdd:PLN03091  91 QIAAQLPGRTDNEIKNLWNSCLKKKLRQRGIDPNT 125
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 32-149 2.26e-45

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 152.15  E-value: 2.26e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401993   32 IRRGPWTVEEDMKLVSYISLHGEGRWNSLSRSAGLNRTGKSCRLRWLNYLRPDIRRGDISLQEQFIILELHSRWGNRWSK 111
Cdd:PLN03212  23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLLRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSL 102

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 18401993  112 IAQHLPGRTDNEIKNYWRTRVQKhaKLLKCDVNSKQFK 149
Cdd:PLN03212 103 IAGRIPGRTDNEIKNYWNTHLRK--KLLRQGIDPQTHK 138
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 87-130 5.46e-13

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 61.37  E-value: 5.46e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 18401993    87 RGDISLQEQFIILELHSRWGNRWSKIAQHLPGRTDNEIKNYWRT 130
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 34-81 2.29e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 59.82  E-value: 2.29e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 18401993    34 RGPWTVEEDMKLVSYISLHGeGRWNSLSRSAGlNRTGKSCRLRWLNYL 81
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLP-GRTDNQCKNRWQNYL 46
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 30-128 8.73e-12

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 64.04  E-value: 8.73e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401993  30 IEIRRGPWTVEEDMKLVSYISLHGEGRWNSLSRSAGLnRTGKSCRLRWLNYLRPDIRRGDISLQEQFIILELHSRWGNRW 109
Cdd:COG5147  16 TKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLIS-STGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQW 94

                        90
                ....*....|....*....
gi 18401993 110 SKIAQHLPGRTDNEIKNYW 128
Cdd:COG5147  95 STIADYKDRRTAQQCVERY 113
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
34-83 5.50e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 56.08  E-value: 5.50e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 18401993     34 RGPWTVEEDMKLVSYISLHGEGRWNSLSRSAGlNRTGKSCRLRWLNYLRP 83
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 36-81 3.21e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.12  E-value: 3.21e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 18401993  36 PWTVEEDMKLVSYISLHGEGRWNSLSRSAGlNRTGKSCRLRWLNYL 81
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELP-GRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 37-94 1.56e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 50.00  E-value: 1.56e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 18401993    37 WTVEEDMKLVSYISLHGeGRWNSLSRSAGlNRTGKSCRLRWLNYLRPDIRRGDISLQE 94
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELG-RRTPKQCFDRWRRKLNPKISRGPWSKEE 56
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 91-130 1.91e-08

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 49.11  E-value: 1.91e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 18401993  91 SLQEQFIILELHSRWG-NRWSKIAQHLPGRTDNEIKNYWRT 130
Cdd:cd00167   3 TEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWRN 43
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
87-130 4.43e-08

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 48.37  E-value: 4.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 18401993     87 RGDISLQEQFIILELHSRWG-NRWSKIAQHLPGRTDNEIKNYWRT 130
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRN 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 91-130 6.25e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 36.90  E-value: 6.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18401993    91 SLQEQFIILELHSRWGNRWSKIAQHLPGRTDNEIKNYWRT 130
Cdd:pfam13921   2 TEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRR 41
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 36-79 2.47e-03

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 35.24  E-value: 2.47e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 18401993  36 PWTVEEDMKLVSYISLHGEGRWNS--LSRSAGLNRTGKSCRLRWLN 79
Cdd:cd11660   2 KWTDEEDEALVEGVEKYGVGNWAKilKDYFFVNNRTSVDLKDKWRN 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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