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Conserved domains on  [gi|18400968|ref|NP_564485|]
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tubby like protein 5 [Arabidopsis thaliana]

Protein Classification

tubby-like F-box protein( domain architecture ID 17778958)

tubby-like F-box protein may participate in the abscisic acid (ABA) signaling pathway in plants

CATH:  1.20.1280.50
Gene Ontology:  GO:0006511|GO:0019005|GO:0005515
PubMed:  29109004|36589128|31898225|11178263
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
117-424 1.59e-134

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 386.16  E-value: 1.59e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400968   117 KQPGPRDGIIQCYIKRDKSNM----TYHLYLSLSPailVESGKFLLSAKRSRRATYTEYVISMDADNISRSSSTYIGKLK 192
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGMgltpTYHLYLELSP---GDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400968   193 SNFLGTKFIVYDTAPAYNSSqilSPPNRSRSFNSKKVSPkvpsGSYNIAQVTYELNLLGTRGPRRMNCIMHSIPSLALEp 272
Cdd:pfam01167  78 SNFLGTKFTLYDNQPPYNGA---NPSKSRSSFGSKKVSP----GRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQ- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400968   273 ggtVPSQPEFLQRSLDesfrsigsskivnhsgDFTRPKEEEgkvrPLVLKTKPPRWLQPLRCWCLNFKGRVTVASVKNFQ 352
Cdd:pfam01167 150 ---VPIQPQSESSLLE----------------DFKSGRLDE----LLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQ 206

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18400968   353 LMSAatvqpgsgsdggalatrpslspqqpeqSNHDKIILHFGKVGKDMFTMDYRYPLSAFQAFAISLSTFDT 424
Cdd:pfam01167 207 LVAP---------------------------EDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLSSFDT 251
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 55-99 2.59e-24

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438924  Cd Length: 45  Bit Score: 94.42  E-value: 2.59e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18400968  55 WANLPAALLRDVMKKLDESESTWPARKQVVACAGVCKTWRLMCKD 99
Cdd:cd22153   1 WANLPPELLRDIIQRVEESESAWPSRKNVVACASVCKSWREITKE 45
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
117-424 1.59e-134

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 386.16  E-value: 1.59e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400968   117 KQPGPRDGIIQCYIKRDKSNM----TYHLYLSLSPailVESGKFLLSAKRSRRATYTEYVISMDADNISRSSSTYIGKLK 192
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGMgltpTYHLYLELSP---GDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400968   193 SNFLGTKFIVYDTAPAYNSSqilSPPNRSRSFNSKKVSPkvpsGSYNIAQVTYELNLLGTRGPRRMNCIMHSIPSLALEp 272
Cdd:pfam01167  78 SNFLGTKFTLYDNQPPYNGA---NPSKSRSSFGSKKVSP----GRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQ- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400968   273 ggtVPSQPEFLQRSLDesfrsigsskivnhsgDFTRPKEEEgkvrPLVLKTKPPRWLQPLRCWCLNFKGRVTVASVKNFQ 352
Cdd:pfam01167 150 ---VPIQPQSESSLLE----------------DFKSGRLDE----LLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQ 206

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18400968   353 LMSAatvqpgsgsdggalatrpslspqqpeqSNHDKIILHFGKVGKDMFTMDYRYPLSAFQAFAISLSTFDT 424
Cdd:pfam01167 207 LVAP---------------------------EDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLSSFDT 251
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 55-99 2.59e-24

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438924  Cd Length: 45  Bit Score: 94.42  E-value: 2.59e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18400968  55 WANLPAALLRDVMKKLDESESTWPARKQVVACAGVCKTWRLMCKD 99
Cdd:cd22153   1 WANLPPELLRDIIQRVEESESAWPSRKNVVACASVCKSWREITKE 45
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 55-106 7.62e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.05  E-value: 7.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 18400968    55 WANLPAALLRDVMKKLDesestwpaRKQVVACAGVCKTWRlmckDIVKSPEF 106
Cdd:pfam00646   1 LLDLPDDLLLEILSRLD--------PKDLLRLSLVSKRWR----SLVDSLKL 40
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
117-424 1.59e-134

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 386.16  E-value: 1.59e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400968   117 KQPGPRDGIIQCYIKRDKSNM----TYHLYLSLSPailVESGKFLLSAKRSRRATYTEYVISMDADNISRSSSTYIGKLK 192
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGMgltpTYHLYLELSP---GDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400968   193 SNFLGTKFIVYDTAPAYNSSqilSPPNRSRSFNSKKVSPkvpsGSYNIAQVTYELNLLGTRGPRRMNCIMHSIPSLALEp 272
Cdd:pfam01167  78 SNFLGTKFTLYDNQPPYNGA---NPSKSRSSFGSKKVSP----GRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQ- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400968   273 ggtVPSQPEFLQRSLDesfrsigsskivnhsgDFTRPKEEEgkvrPLVLKTKPPRWLQPLRCWCLNFKGRVTVASVKNFQ 352
Cdd:pfam01167 150 ---VPIQPQSESSLLE----------------DFKSGRLDE----LLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQ 206

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18400968   353 LMSAatvqpgsgsdggalatrpslspqqpeqSNHDKIILHFGKVGKDMFTMDYRYPLSAFQAFAISLSTFDT 424
Cdd:pfam01167 207 LVAP---------------------------EDQDKVILQFGKVGKDMFTMDYRYPLSAFQAFAICLSSFDT 251
F-box_AtTLP-like cd22153
F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; ...
 55-99 2.59e-24

F-box domain found in Arabidopsis thaliana TUBBY-like proteins (AtTLPs) and similar proteins; The TUBBY-like protein gene family of Arabidopsis has 11 members, AtTLP1-11. They have conserved C-terminal tubby domains. All AtTLP members except AtTLP8 also contain a conserved F-box domain. AtTLPs are involved in responses to stress. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438924  Cd Length: 45  Bit Score: 94.42  E-value: 2.59e-24
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18400968  55 WANLPAALLRDVMKKLDESESTWPARKQVVACAGVCKTWRLMCKD 99
Cdd:cd22153   1 WANLPPELLRDIIQRVEESESAWPSRKNVVACASVCKSWREITKE 45
F-box_AtSKIP19-like cd22164
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar ...
 55-99 5.20e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 19 (AtSKIP19) and similar proteins; AtSKIP19, also called F-box protein SKIP19, or F-box/LRR-repeat protein 20 (FBL20), is a component of SCF (SPK1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with CUL1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438935 [Multi-domain]  Cd Length: 47  Bit Score: 34.88  E-value: 5.20e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 18400968  55 WANLPAALLRDVMKKLDESESTWPARKqvvacagVCKTWRLMCKD 99
Cdd:cd22164   2 WLDLPDDLTASILSRLGAIDILTNAQK-------VCKLWRRICKD 39
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 55-106 7.62e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 34.05  E-value: 7.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 18400968    55 WANLPAALLRDVMKKLDesestwpaRKQVVACAGVCKTWRlmckDIVKSPEF 106
Cdd:pfam00646   1 LLDLPDDLLLEILSRLD--------PKDLLRLSLVSKRWR----SLVDSLKL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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