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Conserved domains on  [gi|18400003|ref|NP_564469|]
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Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
216-398 1.83e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 1.83e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 216 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 294
Cdd:COG2319 172 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 295 ASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 374
Cdd:COG2319 251 SVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329
                       170       180
                ....*....|....*....|....
gi 18400003 375 FGEIAGISFSPDTEALYVGVADRT 398
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGSDDGT 353
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
216-398 1.83e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 1.83e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 216 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 294
Cdd:COG2319 172 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 295 ASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 374
Cdd:COG2319 251 SVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329
                       170       180
                ....*....|....*....|....
gi 18400003 375 FGEIAGISFSPDTEALYVGVADRT 398
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGSDDGT 353
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
215-398 5.46e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 5.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 215 DPSGSLrLITANNDCKIRVFDAQSFTRVSEF--ALDWsVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDY 292
Cdd:cd00200  18 SPDGKL-LATGSGDGTIKVWDLETGELLRTLkgHTGP-VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 293 SFASAWHPNGLILATGNQDTACRLWDIRNPSESFaVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEI 372
Cdd:cd00200  96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG----KCV 170
                       170       180       190
                ....*....|....*....|....*....|
gi 18400003 373 DLF----GEIAGISFSPDTEALYVGVADRT 398
Cdd:cd00200 171 ATLtghtGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
279-318 2.66e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.66e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18400003    279 SGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 318
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
280-318 1.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18400003   280 GKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 318
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
223-364 1.22e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 40.41  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003   223 ITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAV-VGDSTECLISDSHSGKVISSLRGHKD-YSFAsaWHP 300
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPVGQRPRGITFSKDGKLLYVcASDSDTIQVIDPATGEVLHTLPSGPDpEQFA--LHP 92
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18400003   301 NGLILATGNQDTA-CRLWDIrnpsESFAVLKG-NMGA-IRGLKFTPEGRFLA-MAEPADFVHIFDTQS 364
Cdd:TIGR03866  93 NGKILYIANEDDAlVTVIDI----ETRKVLAQiDVGVePEGMAVSPDGKIVVnTSETTNMAHWIDTAT 156
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
216-398 1.83e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 1.83e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 216 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 294
Cdd:COG2319 172 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 295 ASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 374
Cdd:COG2319 251 SVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGH 329
                       170       180
                ....*....|....*....|....
gi 18400003 375 FGEIAGISFSPDTEALYVGVADRT 398
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGSDDGT 353
WD40 COG2319
WD40 repeat [General function prediction only];
216-398 2.58e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 2.58e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 216 PSGSlRLITANNDCKIRVFDAQSFTRVSEFAL-DWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 294
Cdd:COG2319 214 PDGK-LLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVN 292
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 295 ASAWHPNGLILATGNQDTACRLWDIRNPsESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDL 374
Cdd:COG2319 293 SVAFSPDGKLLASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGH 371
                       170       180
                ....*....|....*....|....
gi 18400003 375 FGEIAGISFSPDTEALYVGVADRT 398
Cdd:COG2319 372 TGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
221-398 9.32e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 9.32e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 221 RLITANNDCKIRVFDAQS-FTRVSEFALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWH 299
Cdd:COG2319  92 LLASASADGTVRLWDLATgLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 300 PNGLILATGNQDTACRLWDIRNPSEsFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEIDLF---- 375
Cdd:COG2319 172 PDGKLLASGSDDGTVRLWDLATGKL-LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG----KLLRTLtghs 246
                       170       180
                ....*....|....*....|...
gi 18400003 376 GEIAGISFSPDTEALYVGVADRT 398
Cdd:COG2319 247 GSVRSVAFSPDGRLLASGSADGT 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
215-398 5.46e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 5.46e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 215 DPSGSLrLITANNDCKIRVFDAQSFTRVSEF--ALDWsVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDY 292
Cdd:cd00200  18 SPDGKL-LATGSGDGTIKVWDLETGELLRTLkgHTGP-VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 293 SFASAWHPNGLILATGNQDTACRLWDIRNPSESFaVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEI 372
Cdd:cd00200  96 VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG----KCV 170
                       170       180       190
                ....*....|....*....|....*....|
gi 18400003 373 DLF----GEIAGISFSPDTEALYVGVADRT 398
Cdd:cd00200 171 ATLtghtGEVNSVAFSPDGEKLLSSSSDGT 200
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
172-398 2.64e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 2.64e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 172 NLILLGGFDGelLCKCVNQPGVAFCTRLSTEDNAItNTVDIyrDPSGSLrLITANNDCKIRVFDAQSFTRVSEFA--LDW 249
Cdd:cd00200  64 TYLASGSSDK--TIRLWDLETGECVRTLTGHTSYV-SSVAF--SPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRghTDW 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 250 sVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIRNPSESfAVL 329
Cdd:cd00200 138 -VNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL-GTL 215
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18400003 330 KGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQeidLFG---EIAGISFSPDTEALYVGVADRT 398
Cdd:cd00200 216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQT---LSGhtnSVTSLAWSPDGKRLASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
248-398 5.90e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 5.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 248 DWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIRNPsESFA 327
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG-KLLR 156
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18400003 328 VLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEIDLF----GEIAGISFSPDTEALYVGVADRT 398
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG----KLLRTLtghtGAVRSVAFSPDGKLLASGSADGT 227
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
215-361 1.00e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 1.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 215 DPSGSLrLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYS 293
Cdd:cd00200 144 SPDGTF-VASSSQDGTIKLWDLRTGKCVATLtGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18400003 294 FASAWHPNGLILATGNQDTACRLWDIRNPSESfAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFD 361
Cdd:cd00200 223 NSVAFSPDGYLLASGSEDGTIRVWDLRTGECV-QTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
217-398 5.75e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.76  E-value: 5.75e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 217 SGSLRLITANNDCKIRVFDAQSFTRVSEFALD----WSVnntSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDY 292
Cdd:cd00200  61 ADGTYLASGSSDKTIRLWDLETGECVRTLTGHtsyvSSV---AFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW 137
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 293 SFASAWHPNGLILATGNQDTACRLWDIRNPSeSFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQei 372
Cdd:cd00200 138 VNSVAFSPDGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT-- 214
                       170       180
                ....*....|....*....|....*....
gi 18400003 373 dLFG---EIAGISFSPDTEALYVGVADRT 398
Cdd:cd00200 215 -LRGhenGVNSVAFSPDGYLLASGSEDGT 242
WD40 COG2319
WD40 repeat [General function prediction only];
216-321 1.55e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 1.55e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 216 PSGSlRLITANNDCKIRVFDAQSFTRVSEF-ALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSF 294
Cdd:COG2319 298 PDGK-LLASGSDDGTVRLWDLATGKLLRTLtGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT 376
                        90       100
                ....*....|....*....|....*..
gi 18400003 295 ASAWHPNGLILATGNQDTACRLWDIRN 321
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
214-398 1.62e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 1.62e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 214 RDPSGSLRLITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYS 293
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 294 FASAWHPNGLILATGNQDTACRLWDIRNPSEsFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDTQSGflqsQEID 373
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLL-LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG----KLLR 156
                       170       180
                ....*....|....*....|....*....
gi 18400003 374 LF----GEIAGISFSPDTEALYVGVADRT 398
Cdd:COG2319 157 TLtghsGAVTSVAFSPDGKLLASGSDDGT 185
WD40 COG2319
WD40 repeat [General function prediction only];
255-398 2.82e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 2.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 255 SVSPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIRNPSESfAVLKGNMG 334
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL-ATLLGHTA 79
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18400003 335 AIRGLKFTPEGRFLAMAEPADFVHIFDTQSGFLQSQEIDLFGEIAGISFSPDTEALYVGVADRT 398
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGT 143
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
283-398 4.11e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.26  E-value: 4.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 283 ISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDIrNPSESFAVLKGNMGAIRGLKFTPEGRFLAMAEPADFVHIFDT 362
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 18400003 363 QSGFLQSQEIDLFGEIAGISFSPDTEALYVGVADRT 398
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
279-318 2.66e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 2.66e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18400003    279 SGKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 318
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
280-318 1.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.21e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18400003   280 GKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWD 318
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
257-291 1.58e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 40.34  E-value: 1.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 18400003   257 SPDGKLLAVVGDSTECLISDSHSGKVISSLRGHKD 291
Cdd:pfam12894  47 RPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
197-286 4.68e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.60  E-value: 4.68e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003 197 TRLSTEDNAITNTVD-------IYRDPSGSLRLITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAVV--- 266
Cdd:COG3391  93 SVIDLATGKVVATIPvgggprgLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVAnsg 172
                        90       100
                ....*....|....*....|..
gi 18400003 267 GDSTECLIS--DSHSGKVISSL 286
Cdd:COG3391 173 SNTVSVIVSviDTATGKVVATI 194
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
223-364 1.22e-03

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 40.41  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003   223 ITANNDCKIRVFDAQSFTRVSEFALDWSVNNTSVSPDGKLLAV-VGDSTECLISDSHSGKVISSLRGHKD-YSFAsaWHP 300
Cdd:TIGR03866  15 VSNEKDNTISVIDTATLKVTRTFPVGQRPRGITFSKDGKLLYVcASDSDTIQVIDPATGEVLHTLPSGPDpEQFA--LHP 92
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 18400003   301 NGLILATGNQDTA-CRLWDIrnpsESFAVLKG-NMGA-IRGLKFTPEGRFLA-MAEPADFVHIFDTQS 364
Cdd:TIGR03866  93 NGKILYIANEDDAlVTVIDI----ETRKVLAQiDVGVePEGMAVSPDGKIVVnTSETTNMAHWIDTAT 156
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
230-376 4.05e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.64  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003  230 KIRVFDAQSFTRVseFALDWSvnntsvsPDGKLLAVVGDSTECLISDSHSGK---VISSLRGHKDYSFasAWHPNGLILA 306
Cdd:COG4946  379 EPKQLTLGDLGRV--FNPVWS-------PDGKKIAFTDNRGRLWVVDLASGKvrkVDTDGYGDGISDL--AWSPDSKWLA 447
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003  307 ----TGNQDTACRLWDIRNpSESFAVLKGNMGAIRgLKFTPEGRFLAMA-----EPA----DFVHIFDTQSG----FLQS 369
Cdd:COG4946  448 yskpGPNQLSQIFLYDVET-GKTVQLTDGRYDDGS-PAFSPDGKYLYFLssrdfNPTygdlDFDLAFPRTTRiyavPLRK 525

                 ....*..
gi 18400003  370 QEIDLFG 376
Cdd:COG4946  526 DAPSPFA 532
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
255-418 4.50e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 39.25  E-value: 4.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003  255 SVSPDGKLLAVVGDST--ECL----ISDSHSGKVISSLrGHKDYsFASAWHPNGLILATGNQDTacRLW--DIRNPSESf 326
Cdd:COG4946  349 AWSPDGKSIAYFSDASgeYELyiapADGSGEPKQLTLG-DLGRV-FNPVWSPDGKKIAFTDNRG--RLWvvDLASGKVR- 423
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18400003  327 AVLKGNMGA-IRGLKFTPEGRFLAMAEPADF----VHIFDTQSGflQSQEI--DLFGEIAGIsFSPDTEALYVgVADRTY 399
Cdd:COG4946  424 KVDTDGYGDgISDLAWSPDSKWLAYSKPGPNqlsqIFLYDVETG--KTVQLtdGRYDDGSPA-FSPDGKYLYF-LSSRDF 499
                        170
                 ....*....|....*....
gi 18400003  400 GSLLeykrrkDNHYMDSFY 418
Cdd:COG4946  500 NPTY------GDLDFDLAF 512
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
280-319 5.10e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 38.90  E-value: 5.10e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18400003   280 GKVISSLRGHKDYSFASAWHPNGLILATGNQDTACRLWDI 319
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEV 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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