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Conserved domains on  [gi|18379248|ref|NP_563702|]
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Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTWD_Cns1-like cd21377
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 170-351 5.79e-70

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


:

Pssm-ID: 439173  Cd Length: 159  Bit Score: 216.05  E-value: 5.79e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248 170 KACLSAIENRGVKIGKAMYR-ELTGLKKPMLDKNNILHWPVLLLYAEAMTSDFVEDFCETDMFATHLDMMFSEDSPPLPW 248
Cdd:cd21377   1 KALLSALKSRGIKLGPPLYDeELTGERKPYLDEDGELHWPVLLLYPEVGQSDFIEDFSEDDTLGDHLDVMFPEPAPPLPW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248 249 DKNNEYSRDVIELYYEASSGTPLPRsrvlqyllegtkgsqaettgeedtsatKTPSYLKGSSGMVKVNERRTLHDVLKEP 328
Cdd:cd21377  81 DTEGEYTRDNLEVYYETNAVKPLPS---------------------------ESSKAGPKEKKWVRVDPDTTLGDVLAHP 133

                       170       180
                ....*....|....*....|....
gi 18379248 329 KF-VIPEIPVFYIVSKRSKFYKDF 351
Cdd:cd21377 134 DYyVIPGIPVFYVVPKGSPFEKRF 157
PLN03088 super family cl33632
SGT1, suppressor of G2 allele of SKP1; Provisional
 39-189 5.20e-11

SGT1, suppressor of G2 allele of SKP1; Provisional


The actual alignment was detected with superfamily member PLN03088:

Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 63.27  E-value: 5.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248   39 NECVRKGKK-----HYSEAIDCYTKAIsqgvLSDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAK 113
Cdd:PLN03088   3 KDLEDKAKEafvddDFALAVDLYTQAI----DLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  114 ASMSLDLLNEAKSYCEKGIENDPSNEDMKKLLKLVNSKKQEKE----QHEAQASQAVVEAKACLSAIENRGVKIGKAMYR 189
Cdd:PLN03088  79 ACMKLEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAEEEkdlvQPVPSDLPSSVTAPPVEEADATPVVPPSKPKYR 158
 
Name Accession Description Interval E-value
CTWD_Cns1-like cd21377
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 170-351 5.79e-70

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


Pssm-ID: 439173  Cd Length: 159  Bit Score: 216.05  E-value: 5.79e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248 170 KACLSAIENRGVKIGKAMYR-ELTGLKKPMLDKNNILHWPVLLLYAEAMTSDFVEDFCETDMFATHLDMMFSEDSPPLPW 248
Cdd:cd21377   1 KALLSALKSRGIKLGPPLYDeELTGERKPYLDEDGELHWPVLLLYPEVGQSDFIEDFSEDDTLGDHLDVMFPEPAPPLPW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248 249 DKNNEYSRDVIELYYEASSGTPLPRsrvlqyllegtkgsqaettgeedtsatKTPSYLKGSSGMVKVNERRTLHDVLKEP 328
Cdd:cd21377  81 DTEGEYTRDNLEVYYETNAVKPLPS---------------------------ESSKAGPKEKKWVRVDPDTTLGDVLAHP 133

                       170       180
                ....*....|....*....|....
gi 18379248 329 KF-VIPEIPVFYIVSKRSKFYKDF 351
Cdd:cd21377 134 DYyVIPGIPVFYVVPKGSPFEKRF 157
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 199-351 3.83e-15

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 70.71  E-value: 3.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248   199 LDKNNILHWPVLLLYAEAMTSDFVEDFCETDMFATHLDMMFseDSPPlPWDKNNEYSRDVIELYYEASSGtplprsrvlq 278
Cdd:pfam18972   3 DDPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVF--PSPP-PWDTKKEYTPKNVEVYMETRTG---------- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18379248   279 yllegtkgsqaettgeedtsatktpsylkgssGMVKVNERRTLHDVLK-EPKF-VIPEIPVFYIV--SKRSKFYKDF 351
Cdd:pfam18972  70 --------------------------------GLVKVGKKVPLRKVLSsAPKVeLVDGLLRIYVVpkGKAQKWIEDW 114
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 39-189 5.20e-11

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 63.27  E-value: 5.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248   39 NECVRKGKK-----HYSEAIDCYTKAIsqgvLSDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAK 113
Cdd:PLN03088   3 KDLEDKAKEafvddDFALAVDLYTQAI----DLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  114 ASMSLDLLNEAKSYCEKGIENDPSNEDMKKLLKLVNSKKQEKE----QHEAQASQAVVEAKACLSAIENRGVKIGKAMYR 189
Cdd:PLN03088  79 ACMKLEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAEEEkdlvQPVPSDLPSSVTAPPVEEADATPVVPPSKPKYR 158
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
47-181 2.62e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.02  E-value: 2.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  47 KHYSEAIDCYTKAISQgvlsDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKS 126
Cdd:COG0457  22 GRYEEAIEDYEKALEL----DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALE 97

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18379248 127 YCEKGIENDPSNEDMKKLLKLVNSKKQEKEQHEAQASQAVVEAKACLSAIENRGV 181
Cdd:COG0457  98 DYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGI 152
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 11-155 2.81e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 49.21  E-value: 2.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248    11 PTTEKEKADLEAISALKEST----AIEFKEEGNECVRKgkKHYSEAIDCYTKAISQgvlsdSETSILFSNRSHVNLLLGN 86
Cdd:TIGR00990 103 PADELPEIDESSVANLSEEErkkyAAKLKEKGNKAYRN--KDFNKAIKLYSKAIEC-----KPDPVYYSNRAACHNALGD 175

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18379248    87 YRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEA----KSYCEKGIENDPSNEDM--KKLLKLVNSKKQEK 155
Cdd:TIGR00990 176 WEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlldlTASCIIDGFRNEQSAQAveRLLKKFAESKAKEI 250
TPR_19 pfam14559
Tetratricopeptide repeat;
85-145 6.28e-05

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 40.65  E-value: 6.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18379248    85 GNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYCEKGIENDPSNEDMKKLL 145
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALL 62
 
Name Accession Description Interval E-value
CTWD_Cns1-like cd21377
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 170-351 5.79e-70

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


Pssm-ID: 439173  Cd Length: 159  Bit Score: 216.05  E-value: 5.79e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248 170 KACLSAIENRGVKIGKAMYR-ELTGLKKPMLDKNNILHWPVLLLYAEAMTSDFVEDFCETDMFATHLDMMFSEDSPPLPW 248
Cdd:cd21377   1 KALLSALKSRGIKLGPPLYDeELTGERKPYLDEDGELHWPVLLLYPEVGQSDFIEDFSEDDTLGDHLDVMFPEPAPPLPW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248 249 DKNNEYSRDVIELYYEASSGTPLPRsrvlqyllegtkgsqaettgeedtsatKTPSYLKGSSGMVKVNERRTLHDVLKEP 328
Cdd:cd21377  81 DTEGEYTRDNLEVYYETNAVKPLPS---------------------------ESSKAGPKEKKWVRVDPDTTLGDVLAHP 133

                       170       180
                ....*....|....*....|....
gi 18379248 329 KF-VIPEIPVFYIVSKRSKFYKDF 351
Cdd:cd21377 134 DYyVIPGIPVFYVVPKGSPFEKRF 157
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 173-351 1.62e-34

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 124.21  E-value: 1.62e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248 173 LSAIENRGVKIGKAMYRELTGLK------------KPMLDKNNILHWPVLLLYAEAMTSDFVEDFCETDMFATHLDMMFS 240
Cdd:cd21380   4 IKAIKERGIKLEGSKKGESDDLSllepchpelsgaRVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDTTFIDHLEVMFE 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248 241 EdspPLPWDKNNEYSRDVIELYYEASSgtplprsrvlqyllegtkgsqaettgeedtsatktpsylkgSSGMVKVNERRT 320
Cdd:cd21380  84 E---PPPWDVEKKYTPDNLNVYFEDRD-----------------------------------------KGKLVKVDPKST 119

                       170       180       190
                ....*....|....*....|....*....|..
gi 18379248 321 LHDVLKEPKFVIPE-IPVFYIVSKRSKFYKDF 351
Cdd:cd21380 120 LGEVLSHKRYVVKNgTPSFIVLVKGSEFEKEF 151
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 199-351 3.83e-15

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 70.71  E-value: 3.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248   199 LDKNNILHWPVLLLYAEAMTSDFVEDFCETDMFATHLDMMFseDSPPlPWDKNNEYSRDVIELYYEASSGtplprsrvlq 278
Cdd:pfam18972   3 DDPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVF--PSPP-PWDTKKEYTPKNVEVYMETRTG---------- 69

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18379248   279 yllegtkgsqaettgeedtsatktpsylkgssGMVKVNERRTLHDVLK-EPKF-VIPEIPVFYIV--SKRSKFYKDF 351
Cdd:pfam18972  70 --------------------------------GLVKVGKKVPLRKVLSsAPKVeLVDGLLRIYVVpkGKAQKWIEDW 114
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 208-343 6.58e-12

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439175  Cd Length: 150  Bit Score: 62.53  E-value: 6.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248 208 PVLLLYAEAMTSDFVEDFCETDMFATHLDMMFsedSPPLPWDKNNEYSRDVIELYYEASSGtplprsrvlqyllegtkgs 287
Cdd:cd21381  49 PALLLYPLHLQSDFIKAFSELSTPQEHLEYVL---PRPWDWDKHEEYTPKNVECYMETESG------------------- 106

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 18379248 288 qaettgeedtsatktpsylkgssGMVKVNERRTLHDVLKEPKfvipeIPVF------YIVSK 343
Cdd:cd21381 107 -----------------------GLVKVGKKVPLLKVLSNGK-----VPLFdgllriYVVPK 140
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 39-189 5.20e-11

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 63.27  E-value: 5.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248   39 NECVRKGKK-----HYSEAIDCYTKAIsqgvLSDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAK 113
Cdd:PLN03088   3 KDLEDKAKEafvddDFALAVDLYTQAI----DLDPNNAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  114 ASMSLDLLNEAKSYCEKGIENDPSNEDMKKLLKLVNSKKQEKE----QHEAQASQAVVEAKACLSAIENRGVKIGKAMYR 189
Cdd:PLN03088  79 ACMKLEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAEEEkdlvQPVPSDLPSSVTAPPVEEADATPVVPPSKPKYR 158
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
47-181 2.62e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 60.02  E-value: 2.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  47 KHYSEAIDCYTKAISQgvlsDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKS 126
Cdd:COG0457  22 GRYEEAIEDYEKALEL----DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALE 97

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18379248 127 YCEKGIENDPSNEDMKKLLKLVNSKKQEKEQHEAQASQAVVEAKACLSAIENRGV 181
Cdd:COG0457  98 DYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGI 152
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
21-216 1.02e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.48  E-value: 1.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  21 EAISALKESTAIEFKEE------GNECVRKGKkhYSEAIDCYTKAISQgvlsDSETSILFSNRSHVNLLLGNYRRALTDA 94
Cdd:COG0457  26 EAIEDYEKALELDPDDAealynlGLAYLRLGR--YEEALADYEQALEL----DPDDAEALNNLGLALQALGRYEEALEDY 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  95 EESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYCEKGIENDPSNEDMKKLLKLVNSKKQEKEqhEAQASQAVVEAKACLS 174
Cdd:COG0457 100 DKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYE--EALELLEKLEAAALAA 177

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 18379248 175 AIENRGVKIGKAMYRELTGLKKPMLDKNNILHWPVLLLYAEA 216
Cdd:COG0457 178 LLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAAL 219
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 47-166 1.17e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.19  E-value: 1.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  47 KHYSEAIDCYTKAISQgvlsDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKS 126
Cdd:COG4783  18 GDYDEAEALLEKALEL----DPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALA 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 18379248 127 YCEKGIENDPSNEDMKKLLKLVNSKKQEKEQHEAQASQAV 166
Cdd:COG4783  94 LLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKAL 133
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 14-136 1.46e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.34  E-value: 1.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  14 EKEKADLEAISALKESTAIEFKEEGNECVRKGKKHYSEAIDCYTKAISqgvlSDSETSILFSNRSHVNLLLGNYRRALTD 93
Cdd:COG5010  35 NNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ----LDPNNPELYYNLALLYSRSGDKDEAKEY 110

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 18379248  94 AEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYCEKGIENDP 136
Cdd:COG5010 111 YEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 11-155 2.81e-06

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 49.21  E-value: 2.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248    11 PTTEKEKADLEAISALKEST----AIEFKEEGNECVRKgkKHYSEAIDCYTKAISQgvlsdSETSILFSNRSHVNLLLGN 86
Cdd:TIGR00990 103 PADELPEIDESSVANLSEEErkkyAAKLKEKGNKAYRN--KDFNKAIKLYSKAIEC-----KPDPVYYSNRAACHNALGD 175

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18379248    87 YRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEA----KSYCEKGIENDPSNEDM--KKLLKLVNSKKQEK 155
Cdd:TIGR00990 176 WEKVVEDTTAALELDPDYSKALNRRANAYDGLGKYADAlldlTASCIIDGFRNEQSAQAveRLLKKFAESKAKEI 250
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
46-137 2.83e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.16  E-value: 2.83e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  46 KKHYSEAIDCYTKAISQgvlsDSETSILFSNRSHVNLLLGNYRRALtDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAK 125
Cdd:COG3063   5 LGDLEEAEEYYEKALEL----DPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                        90
                ....*....|..
gi 18379248 126 SYCEKGIENDPS 137
Cdd:COG3063  80 AYLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 46-138 4.23e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.95  E-value: 4.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  46 KKHYSEAIDCYTKAISqgvLSDSETSILFsNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAK 125
Cdd:COG4783  51 LGDLDEAIVLLHEALE---LDPDEPEARL-NLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAI 126

                        90
                ....*....|...
gi 18379248 126 SYCEKGIENDPSN 138
Cdd:COG4783 127 AALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 82-166 2.07e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 2.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  82 LLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYCEKGIENDPSNEDMKKLLKLVNSKKQEKEQHEAQ 161
Cdd:COG5010  65 NKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144


                ....*
gi 18379248 162 ASQAV 166
Cdd:COG5010 145 LQRAL 149
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 49-149 2.29e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.46  E-value: 2.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  49 YSEAIDCYTKAISQgvlsDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYC 128
Cdd:COG4235  33 YDEALAAYEKALRL----DPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAW 108

                        90       100
                ....*....|....*....|.
gi 18379248 129 EKGIENDPSNEDMKKLLKLVN 149
Cdd:COG4235 109 QKLLALLPADAPARLLEASIA 129
TPR_19 pfam14559
Tetratricopeptide repeat;
85-145 6.28e-05

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 40.65  E-value: 6.28e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18379248    85 GNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYCEKGIENDPSNEDMKKLL 145
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALL 62
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 49-160 1.10e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  49 YSEAIDCYTKAISQgvlsDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYC 128
Cdd:COG2956  24 PDKAIDLLEEALEL----DPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELL 99

                        90       100       110
                ....*....|....*....|....*....|..
gi 18379248 129 EKGIENDPSNEDMkkLLKLVNSKKQEKEQHEA 160
Cdd:COG2956 100 EKLLELDPDDAEA--LRLLAEIYEQEGDWEKA 129
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
31-138 1.20e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 42.98  E-value: 1.20e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  31 AIEFKEEGNECVRKGKkhYSEAIDCYTKAISqgvlSDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYR 110
Cdd:COG4785  73 AQLYYERGVAYDSLGD--YDLAIADFDQALE----LDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                        90       100
                ....*....|....*....|....*...
gi 18379248 111 AAKASMSLDLLNEAKSYCEKGIENDPSN 138
Cdd:COG4785 147 RGIALYYLGRYELAIADLEKALELDPND 174
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
76-181 2.65e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.92  E-value: 2.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  76 NRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYCEKGIENDPSNEDMKKLLKLVNSKKQEK 155
Cdd:COG0457  13 NLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRY 92

                        90       100
                ....*....|....*....|....*.
gi 18379248 156 EQHEAQASQAVVEAKACLSAIENRGV 181
Cdd:COG0457  93 EEALEDYDKALELDPDDAEALYNLGL 118
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 46-180 5.15e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 5.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  46 KKHYSEAIDCYTKAISqgvlSDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAK 125
Cdd:COG2956  89 AGLLDRAEELLEKLLE----LDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAI 164

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18379248 126 SYCEKGIENDPSNEDMKKLLKLVNSKKQEKEQHEAQASQAVVEAKACLSAIENRG 180
Cdd:COG2956 165 EALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLA 219
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 46-180 6.39e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 6.39e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  46 KKHYSEAIDCYTKAISQgvlsDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAK 125
Cdd:COG2956  55 RGEYDRAIRIHQKLLER----DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAI 130

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18379248 126 SYCEKGIENDPSNEDMKKLLKLVNSKKQEKEQHEAQASQAVVEAKACLSAIENRG 180
Cdd:COG2956 131 EVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLA 185
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 82-145 9.59e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.02  E-value: 9.59e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 18379248  82 LLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYCEKGIENDPSNEDMKKLL 145
Cdd:COG4783  15 LLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL 78
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
82-166 2.06e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.07  E-value: 2.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  82 LLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYcEKGIENDPSNEDMKKLLKLVNSKKQEKEQHEAQ 161
Cdd:COG3063   3 LKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAY 81


                ....*
gi 18379248 162 ASQAV 166
Cdd:COG3063  82 LERAL 86
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 51-140 3.62e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 37.29  E-value: 3.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379248  51 EAIDCYTKAISQgvlsDSETSILFSNRSHVNLLLGNYRRALTDAEESMRLSPHNVKAVYRAAKASMSLDLLNEAKSYCEK 130
Cdd:COG4235   1 EAIARLRQALAA----NPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLER 76

                        90
                ....*....|
gi 18379248 131 GIENDPSNED 140
Cdd:COG4235  77 ALALDPDNPE 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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