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Conserved domains on  [gi|17864534|ref|NP_524871|]
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lethal-(2)-denticleless [Drosophila melanogaster]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-393 3.80e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 3.80e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  52 PIFSAKFANCdgyRHILAIANEDGKITLQDTtqrNHQPEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVA 131
Cdd:cd00200  11 GVTCVAFSPD---GKLLATGSGDGTIKVWDL---ETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 132 GSGIrgLNSYVGHTRSVKSAAFKRTDPaVFATGGRDGAILIWDIRANlnmdltsrvdNCIYS--GHTGgpgtpvsqrkqr 209
Cdd:cd00200  82 TGEC--VRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG----------KCLTTlrGHTD------------ 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 210 trtpkmaggttssSITGLAFQDNDTLISCGAGDGVIKVWDLRRNYTAYkkeplprhklpyagssTFRGFTN----LIVDA 285
Cdd:cd00200 137 -------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA----------------TLTGHTGevnsVAFSP 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 286 SGTRLYANCMDNTIYCYNLAsySQRPLACYKGLLNSTFYIksCLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTV 365
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLR-TGECVQTLSGHTN 262

                       330       340
                ....*....|....*....|....*...
gi 17864534 366 EVTCVAWgSSHDCPIVTCSDDARHKIWR 393
Cdd:cd00200 263 SVTSLAW-SPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-393 3.80e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 3.80e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  52 PIFSAKFANCdgyRHILAIANEDGKITLQDTtqrNHQPEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVA 131
Cdd:cd00200  11 GVTCVAFSPD---GKLLATGSGDGTIKVWDL---ETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 132 GSGIrgLNSYVGHTRSVKSAAFKRTDPaVFATGGRDGAILIWDIRANlnmdltsrvdNCIYS--GHTGgpgtpvsqrkqr 209
Cdd:cd00200  82 TGEC--VRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG----------KCLTTlrGHTD------------ 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 210 trtpkmaggttssSITGLAFQDNDTLISCGAGDGVIKVWDLRRNYTAYkkeplprhklpyagssTFRGFTN----LIVDA 285
Cdd:cd00200 137 -------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA----------------TLTGHTGevnsVAFSP 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 286 SGTRLYANCMDNTIYCYNLAsySQRPLACYKGLLNSTFYIksCLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTV 365
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLR-TGECVQTLSGHTN 262

                       330       340
                ....*....|....*....|....*...
gi 17864534 366 EVTCVAWgSSHDCPIVTCSDDARHKIWR 393
Cdd:cd00200 263 SVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
65-394 3.51e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 3.51e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  65 RHILAIANEDGKITLQDTTQRnhqpeeQSLVGPQCHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAgSGiRGLNSYVGH 144
Cdd:COG2319  90 GRLLASASADGTVRLWDLATG------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TG-KLLRTLTGH 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 145 TRSVKSAAFkRTDPAVFATGGRDGAILIWDIRANlnmdltsrvdNCI--YSGHTGgpgtpvsqrkqrtrtpkmaggttss 222
Cdd:COG2319 162 SGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATG----------KLLrtLTGHTG------------------------- 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 223 SITGLAFQDNDTLISCGAGDGVIKVWDLRRNytaykkEPLprhklpyagsSTFRGFTNLIVDAS----GTRLYANCMDNT 298
Cdd:COG2319 206 AVRSVAFSPDGKLLASGSADGTVRLWDLATG------KLL----------RTLTGHSGSVRSVAfspdGRLLASGSADGT 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 299 IYCYNLAsySQRPLACYKGLLNSTFYIksCLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTVEVTCVAWgSSHDC 378
Cdd:COG2319 270 VRLWDLA--TGELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAF-SPDGK 343

                       330
                ....*....|....*.
gi 17864534 379 PIVTCSDDARHKIWRI 394
Cdd:COG2319 344 TLASGSDDGTVRLWDL 359
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 118-305 2.83e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 2.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  118 SASGDHTARLWEVAGSGIrgLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILIWDIRANLNMDLTSRVDN--CIYSGH 195
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQL--VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANicCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  196 TGGPGTPVSQRKQRT-----RTPKMAGGTT---SSSITGLAFQDNDTLIScGAGDGVIKVWDLRRNYTAYKKEPLprHKl 267
Cdd:PLN00181 628 ESGRSLAFGSADHKVyyydlRNPKLPLCTMighSKTVSYVRFVDSSTLVS-SSTDNTLKLWDLSMSISGINETPL--HS- 703

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 17864534  268 pYAGSSTFRGFTNLIVD----ASGTRlyancmDNTIYCYNLA 305
Cdd:PLN00181 704 -FMGHTNVKNFVGLSVSdgyiATGSE------TNEVFVYHKA 738
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 355-392 2.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 17864534    355 EPLVALAGHTVEVTCVAWgSSHDCPIVTCSDDARHKIW 392
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
355-392 7.89e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17864534   355 EPLVALAGHTVEVTCVAWGSSHDCpIVTCSDDARHKIW 392
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-393 3.80e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 3.80e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  52 PIFSAKFANCdgyRHILAIANEDGKITLQDTtqrNHQPEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVA 131
Cdd:cd00200  11 GVTCVAFSPD---GKLLATGSGDGTIKVWDL---ETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 132 GSGIrgLNSYVGHTRSVKSAAFKRTDPaVFATGGRDGAILIWDIRANlnmdltsrvdNCIYS--GHTGgpgtpvsqrkqr 209
Cdd:cd00200  82 TGEC--VRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETG----------KCLTTlrGHTD------------ 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 210 trtpkmaggttssSITGLAFQDNDTLISCGAGDGVIKVWDLRRNYTAYkkeplprhklpyagssTFRGFTN----LIVDA 285
Cdd:cd00200 137 -------------WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA----------------TLTGHTGevnsVAFSP 187

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 286 SGTRLYANCMDNTIYCYNLAsySQRPLACYKGLLNSTFYIksCLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTV 365
Cdd:cd00200 188 DGEKLLSSSSDGTIKLWDLS--TGKCLGTLRGHENGVNSV--AFSPDGYLLASGSEDGTIRVWDLR-TGECVQTLSGHTN 262

                       330       340
                ....*....|....*....|....*...
gi 17864534 366 EVTCVAWgSSHDCPIVTCSDDARHKIWR 393
Cdd:cd00200 263 SVTSLAW-SPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
65-394 3.51e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 3.51e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  65 RHILAIANEDGKITLQDTTQRnhqpeeQSLVGPQCHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAgSGiRGLNSYVGH 144
Cdd:COG2319  90 GRLLASASADGTVRLWDLATG------LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA-TG-KLLRTLTGH 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 145 TRSVKSAAFkRTDPAVFATGGRDGAILIWDIRANlnmdltsrvdNCI--YSGHTGgpgtpvsqrkqrtrtpkmaggttss 222
Cdd:COG2319 162 SGAVTSVAF-SPDGKLLASGSDDGTVRLWDLATG----------KLLrtLTGHTG------------------------- 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 223 SITGLAFQDNDTLISCGAGDGVIKVWDLRRNytaykkEPLprhklpyagsSTFRGFTNLIVDAS----GTRLYANCMDNT 298
Cdd:COG2319 206 AVRSVAFSPDGKLLASGSADGTVRLWDLATG------KLL----------RTLTGHSGSVRSVAfspdGRLLASGSADGT 269

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 299 IYCYNLAsySQRPLACYKGLLNSTFYIksCLSPDGKYLLSGSSDERAYIWNLDhAEEPLVALAGHTVEVTCVAWgSSHDC 378
Cdd:COG2319 270 VRLWDLA--TGELLRTLTGHSGGVNSV--AFSPDGKLLASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAF-SPDGK 343

                       330
                ....*....|....*.
gi 17864534 379 PIVTCSDDARHKIWRI 394
Cdd:COG2319 344 TLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
62-351 2.03e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 2.03e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  62 DGyrHILAIANEDGKITLQDTTQRNhqpEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAGSgiRGLNSY 141
Cdd:COG2319 173 DG--KLLASGSDDGTVRLWDLATGK---LLRTLTG---HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTL 242

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 142 VGHTRSVKSAAFkRTDPAVFATGGRDGAILIWDiranlnmdLTSRVDNCIYSGHTGGpgtpvsqrkqrtrtpkmaggtts 221
Cdd:COG2319 243 TGHSGSVRSVAF-SPDGRLLASGSADGTVRLWD--------LATGELLRTLTGHSGG----------------------- 290

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 222 ssITGLAF-QDNDTLIScGAGDGVIKVWDLRRNytaykkEPLprhklpyagsSTFRGFTNLIVDAS----GTRLYANCMD 296
Cdd:COG2319 291 --VNSVAFsPDGKLLAS-GSDDGTVRLWDLATG------KLL----------RTLTGHTGAVRSVAfspdGKTLASGSDD 351

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 17864534 297 NTIYCYNLASysQRPLACYKGllnSTFYIKS-CLSPDGKYLLSGSSDERAYIWNLD 351
Cdd:COG2319 352 GTVRLWDLAT--GELLRTLTG---HTGAVTSvAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
100-394 6.95e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 6.95e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 100 HFNAVFDLEWAPGQMRFVSASGDHTARLWEVAGSgiRGLNSYVGHTRSVKSAAFKRtDPAVFATGGRDGAILIWDiranl 179
Cdd:COG2319  35 LAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG--ALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWD----- 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 180 nmdLTSRVDNCIYSGHTGgpgtpvsqrkqrtrtpkmaggttssSITGLAFQDNDTLISCGAGDGVIKVWDLRRnytaykK 259
Cdd:COG2319 107 ---LATGLLLRTLTGHTG-------------------------AVRSVAFSPDGKTLASGSADGTVRLWDLAT------G 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 260 EPLprhklpyagsSTFRGFTNLIVDAS----GTRLYANCMDNTIYCYNLASysQRPLACYKGllnSTFYIKS-CLSPDGK 334
Cdd:COG2319 153 KLL----------RTLTGHSGAVTSVAfspdGKLLASGSDDGTVRLWDLAT--GKLLRTLTG---HTGAVRSvAFSPDGK 217

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17864534 335 YLLSGSSDERAYIWNLDhAEEPLVALAGHTVEVTCVAWgsSHDCP-IVTCSDDARHKIWRI 394
Cdd:COG2319 218 LLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAF--SPDGRlLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
196-394 6.82e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 6.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 196 TGGPGTPVSQRKQRTRTPKMAGGTTSSSITGLAFQDNDTLISCGAGDGVIKVWDLRRNytaykkeplprhKLPYAGSSTF 275
Cdd:COG2319  11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG------------ALLATLLGHT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534 276 RGFTNLIVDASGTRLYANCMDNTIYCYNLASysQRPLACYKGLlnsTFYIKSC-LSPDGKYLLSGSSDERAYIWNLDHAE 354
Cdd:COG2319  79 AAVLSVAFSPDGRLLASASADGTVRLWDLAT--GLLLRTLTGH---TGAVRSVaFSPDGKTLASGSADGTVRLWDLATGK 153

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 17864534 355 EpLVALAGHTVEVTCVAWgsSHD-CPIVTCSDDARHKIWRI 394
Cdd:COG2319 154 L-LRTLTGHSGAVTSVAF--SPDgKLLASGSDDGTVRLWDL 191
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 118-305 2.83e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.86  E-value: 2.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  118 SASGDHTARLWEVAGSGIrgLNSYVGHTRSVKSAAFKRTDPAVFATGGRDGAILIWDIRANLNMDLTSRVDN--CIYSGH 195
Cdd:PLN00181 550 SSNFEGVVQVWDVARSQL--VTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANicCVQFPS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17864534  196 TGGPGTPVSQRKQRT-----RTPKMAGGTT---SSSITGLAFQDNDTLIScGAGDGVIKVWDLRRNYTAYKKEPLprHKl 267
Cdd:PLN00181 628 ESGRSLAFGSADHKVyyydlRNPKLPLCTMighSKTVSYVRFVDSSTLVS-SSTDNTLKLWDLSMSISGINETPL--HS- 703

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 17864534  268 pYAGSSTFRGFTNLIVD----ASGTRlyancmDNTIYCYNLA 305
Cdd:PLN00181 704 -FMGHTNVKNFVGLSVSdgyiATGSE------TNEVFVYHKA 738
WD40 COG2319
WD40 repeat [General function prediction only];
62-132 1.19e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.19e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17864534  62 DGyrHILAIANEDGKITLQDTTQRnhqPEEQSLVGpqcHFNAVFDLEWAPGQMRFVSASGDHTARLWEVAG 132
Cdd:COG2319 341 DG--KTLASGSDDGTVRLWDLATG---ELLRTLTG---HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 355-392 2.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 17864534    355 EPLVALAGHTVEVTCVAWgSSHDCPIVTCSDDARHKIW 392
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAF-SPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
355-392 7.89e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 7.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 17864534   355 EPLVALAGHTVEVTCVAWGSSHDCpIVTCSDDARHKIW 392
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
221-249 8.45e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 8.45e-04
                          10        20
                  ....*....|....*....|....*....
gi 17864534   221 SSSITGLAFQDNDTLISCGAGDGVIKVWD 249
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 138-174 1.27e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.27e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 17864534    138 LNSYVGHTRSVKSAAFKRTDPaVFATGGRDGAILIWD 174
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 221-249 1.57e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.57e-03
                           10        20
                   ....*....|....*....|....*....
gi 17864534    221 SSSITGLAFQDNDTLISCGAGDGVIKVWD 249
Cdd:smart00320  12 TGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-129 1.63e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 1.63e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 17864534     98 QCHFNAVFDLEWAPGQMRFVSASGDHTARLWE 129
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
138-174 2.52e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.52e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 17864534   138 LNSYVGHTRSVKSAAFKRtDPAVFATGGRDGAILIWD 174
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
98-129 9.92e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 9.92e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 17864534    98 QCHFNAVFDLEWAPGQMRFVSASGDHTARLWE 129
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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