BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  139 LVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET-PCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGES 217
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 21955241  218 LQVRG 222
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  139 LVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET-PCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGES 217
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 21955241  218 LQVRG 222
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241     141 DVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC--KHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESL 218
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                    ....*...
gi 21955241     219 QVRGLVES 226
Cdd:smart00225   81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  139 LVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET-PCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGES 217
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETpPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 21955241  218 LQVRG 222
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241     141 DVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC--KHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESL 218
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                    ....*...
gi 21955241     219 QVRGLVES 226
Cdd:smart00225   81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  122 HQNHILRAFDALL---KTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVF----AETPCKHpvIVLKDFRGWVVQAIVD 194
Cdd:cd18235    1 NPQHTQKAFDVMNelrKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFtgdlSESRANR--VTLQDVDGKALLLLID 78

                         90       100
                 ....*....|....*....|....*
gi 21955241  195 FMYRGEISVPQQRLQTLIQAGESLQ 219
Cdd:cd18235   79 YVYTAEIQVTEENVQVLLPAANLLQ 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  122 HQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFA--ETPCKHPVIVLKDFRGWVVQAIVDFMYRG 199
Cdd:cd18338    4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTgeMSESRAKRVRIKEVDGWTLKMLIDYVYTA 83

                         90       100
                 ....*....|....*....|..
gi 21955241  200 EISVPQQRLQTLIQAGESLQVR 221
Cdd:cd18338   84 EIQVTEENVQVLLPAAGLLQLQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  125 HILRAFDAL--LKTK-TLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC--KHPVIVLKDFRGWVVQAIVDFMYRG 199
Cdd:cd18339    4 HMKKAFKVMneLRSKqLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSesKAKKIEIKDVDGQTLSKLIDYIYTA 83

                         90       100
                 ....*....|....*....|.
gi 21955241  200 EISVPQQRLQTLIQAGESLQV 220
Cdd:cd18339   84 EIEVTEENVQVLLPAASLLQL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  122 HQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCK--HPVIVLKDFRGWVVQAIVDFMYRG 199
Cdd:cd18257    1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEkeNSEVEFQCIDETALQAIVEYAYTG 80

                         90       100
                 ....*....|....*....|..
gi 21955241  200 EISVPQQRLQTLIQAGESLQVR 221
Cdd:cd18257   81 TVFISQATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  120 NNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVF----AETpcKHPVIVLKDFRGWVVQAIVDF 195
Cdd:cd18242    2 NSHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFtsemSEK--GKSEVELQGLTASTMEILLDF 79

                         90       100
                 ....*....|....*....|....*..
gi 21955241  196 MYRGEISVPQQRLQTLIQAGESLQVRG 222
Cdd:cd18242   80 VYTETVHVTVENVQELLPAACLLQLKG 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  118 RWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFA----ETPCKHPVIVLKDFRGwvVQAIV 193
Cdd:cd18266    4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTigmrEAHQKEVELVGASYIG--LKAVI 81

                         90       100       110
                 ....*....|....*....|....*....|..
gi 21955241  194 DFMYRGEISVPQQRLQTLIQAGESLQVRGLVE 225
Cdd:cd18266   82 DFLYSSELPLDGGNIDYVLETAHLLQIWKVVD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  121 NHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFA----ETPCKhpVIVLKDFRGWVVQAIVDFM 196
Cdd:cd18256    2 KHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAggmsESSKD--VVQIHGVEPDIFHILLDFI 79

                         90       100
                 ....*....|....*....|....*....
gi 21955241  197 YRGEISVPQQRLQTLIQAGESLQVRGLVE 225
Cdd:cd18256   80 YTGVVEVTVSNVQELLVAADMLQLTEVVE 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  139 LVDVTLVCAETSIRAHKMVLSACSPFFQRVF----AEtpCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQA 214
Cdd:cd18247   19 LCDVTLKVGDQKFSAHRIVLAATIPYFHAMFthdmVE--SKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVG 96

                         90
                 ....*....|.
gi 21955241  215 GESLQVRGLVE 225
Cdd:cd18247   97 ASFLQLQSVKD 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  122 HQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVF--AETPCKHPVIVLKDFRGWVVQAIVDFMYRG 199
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFtgGMRESSQDEIELKGVSAKGLKHILDFAYTS 80

                         90       100
                 ....*....|....*....|....*.
gi 21955241  200 EISVPQQRLQTLIQAGESLQVRGLVE 225
Cdd:cd18255   81 ELTLDLDCIQDVLGAAVHLQMLPVVE 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  141 DVTLVCAETSIRAHKMVLSACSPFF-QRVFAETP--CKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGES 217
Cdd:cd18293   17 DVLLQAEGESVPAHCCVLSACSPYLtERLSSEPPpaGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAARR 96

                 ....*..
gi 21955241  218 LQVRGLV 224
Cdd:cd18293   97 LQISELE 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  122 HQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETpCKHPVIVLK-----DFRGwvVQAIVDFM 196
Cdd:cd18332    2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGR-VGEGVSVLTlpsglEARG--FQLLLDFM 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 21955241  197 YRGEISVPQQRLQTLIQAGESLQVRGLVES 226
Cdd:cd18332   79 YTSRLPLTPRTVPAVLAAATYLQMEHVVET 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  122 HQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHPVIVLKDF-RGWVVQAIVDFMYRGE 200
Cdd:cd18204    1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDFlRSDIFEEVLNYMYTAK 80

                         90       100
                 ....*....|....*....|...
gi 21955241  201 ISVPQQRLQTLIQAGESLQVRGL 223
Cdd:cd18204   81 ISVKKEDVNLMMSSGQILGIRFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  122 HQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETpCKHPVIVLKDFRGwVVQAIVDFMYRGEI 201
Cdd:cd18232    1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDG-TSGSVVLPESFAE-VFGLLLDFFYTGEL 78

                         90       100
                 ....*....|....*....|....
gi 21955241  202 SVPQQRLQTLIQAGESLQVRGLVE 225
Cdd:cd18232   79 ALTRENRDRVLLAAKELRVPEAVE 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  122 HQNHILRAFDALLKTKTLVDVTLVCAETSI-RAHKMVLSACSPFFQRVF-AETPCK-HPVIVLKDFRGWVVQAIVDFMYR 198
Cdd:cd18252    4 HPADFLDAFRTFYLDGLFTDITLQCASGQIfHCHKAALAACSSYFKVMFtADMKEKsNNVIKLSGIDHDILEALVNYVYT 83

                         90       100
                 ....*....|....*....|.
gi 21955241  199 GEISVPQQRLQTLIQAGESLQ 219
Cdd:cd18252   84 SQICITERNVQSLLEAADLLQ 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  121 NHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET--PCKHPVIVLKDFRGWVVQAIVDFMYR 198
Cdd:cd18336    1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDvrEAKQEEIKMEGVDPDALKALVHYAYT 80

                         90       100
                 ....*....|....*....|....*..
gi 21955241  199 GEISVPQQRLQTLIQAGESLQVRGLVE 225
Cdd:cd18336   81 GVLELKEDTIESLLAAACLLQLSQVID 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  133 LLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVF--AETPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQT 210
Cdd:cd18269   21 LLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFlsDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQD 100

                         90
                 ....*....|
gi 21955241  211 LIQAGESLQV 220
Cdd:cd18269  101 IFALASRFQI 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  115 YSLRWNNHQNHILRA-FDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAET--PCKHPVIVLKDFRGWVVQA 191
Cdd:cd18272    7 YTFTDRSHSSRVAQSiMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNlkEARNRVIELKDVSESVFQL 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 21955241  192 IVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVE 225
Cdd:cd18272   87 LVDYIYHGTVKLRVEELQETYEVADMYQLTALFE 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  126 ILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHP----VIVLKDFRGWVVQAIVDFMYRGEI 201
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQI 80

                         90
                 ....*....|....*..
gi 21955241  202 SVPQQRLQTLIQAGESL 218
Cdd:cd18245   81 KLSEDNIQDIVQAADLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  121 NHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFA----ETPCKHpvIVLKDFRGWVVQAIVDFM 196
Cdd:cd18259   14 SHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTgdfvESISAR--VEIKDVDPAVMESLIDFA 91

                         90       100
                 ....*....|....*....|...
gi 21955241  197 YRGEISVPQQRLQTLIQAGESLQ 219
Cdd:cd18259   92 YTGKLTINQGNVEALIRTSNRLQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  115 YSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQR--VFAETPCKHPVIVLKDfrgwVVQAI 192
Cdd:cd18208    1 HSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDklLLGYSDIEIPSVVSVQ----SVQKL 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 21955241  193 VDFMYRGEISVPQQRLQTLIQAGESLQVRGLVE 225
Cdd:cd18208   77 IDFMYSGVLRVSQSEALQILTAASILQIKTVID 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  141 DVTLVCAETSIRAHKMVLSACSPFFQR--VFAETPCKHPVIVLKDfrgwVVQAIVDFMYRGEISVPQQRLQTLIQAGESL 218
Cdd:cd18229   20 DVTVRIHDASLRAHRCVLAAGSPFFHDklLLGHSEIEVPPVVPAQ----TVRQLVEFMYSGSLVVAQSEALQILTAASIL 95

                 ....*..
gi 21955241  219 QVRGLVE 225
Cdd:cd18229   96 QIKTVID 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  121 NHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC--KHPVIVLKDFRGWVVQAIVDFMYR 198
Cdd:cd18335    1 HHAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCeaKQEEIKMEGIDPNALWDLVQFAYT 80

                         90       100
                 ....*....|....*....|....*..
gi 21955241  199 GEISVPQQRLQTLIQAGESLQVRGLVE 225
Cdd:cd18335   81 GCLELKEDTIENLLAAACLLQLSQVVE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  122 HQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHpVIVLKDFRGWVVQAIVDFMYRGEI 201
Cdd:cd18260    1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQ-RVELNDISPLGLATVITYAYTGKL 79

                         90       100
                 ....*....|....*....|...
gi 21955241  202 SVPQQRLQTLIQAGESLQVRGLV 224
Cdd:cd18260   80 TLSLYTIGSTISAASYLQIHALV 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  139 LVDVTLVCAETSIR----AHKMVLSACSPFFQRVFAE---TPCKHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTL 211
Cdd:cd18211   25 LCDVTVQVEHQGSKeefsAHKAVLAASSKYFKEVFLNekiSDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRM 104

                         90
                 ....*....|....
gi 21955241  212 IQAGESLQVRGLVE 225
Cdd:cd18211  105 LEIAEKLKCLDLSE 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  121 NHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVF----AETPCKhpVIVLKDFRGWVVQAIVDFM 196
Cdd:cd18287    4 DHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmRESQQS--EIELKDTNAEAFKALLKYI 81

                 ....*..
gi 21955241  197 YRGEISV 203
Cdd:cd18287   82 YTGRLTL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21955241  139 LVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPC--KHPVIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGE 216
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVReaTEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                         90
                 ....*....|
gi 21955241  217 SLQVRGLVES 226
Cdd:cd18234   81 LLQLSEVVEA 90