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Conserved domains on  [gi|17647957|ref|NP_523853|]
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sialyltransferase, isoform B [Drosophila melanogaster]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 199-469 2.55e-137

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467696  Cd Length: 266  Bit Score: 395.87  E-value: 2.55e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 199 TCLVMEAGVRVLRRKDAPFNK-LPFGRLFPRQKLFRNVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHE 277
Cdd:cd23968   5 LCRLKKAAPFSTLRKTTSPFKdLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 278 VDVGSKTTIRVVNSQVVTKPEFDFTRAPIFRNVTIAAWDPGKYNGTLEDWLTSADYDLFSNYELYRRRYPKSRAFLIDPH 357
Cdd:cd23968  85 KDVGSKTTLRLINSQILSKPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYLIDPR 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 358 SVWRLWQSLQMFAGNRpISKNPPSSGFIGLALLLPHCPQVDFVEYVPSTRLNGRCHYYSKEMNSACTFGSWHPLAAEKLM 437
Cdd:cd23968 165 FLWRLWDILQEYTPEK-IKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAEKLL 243

                       250       260       270
                ....*....|....*....|....*....|..
gi 17647957 438 ALDMNMAEDDDmsvfqfgilRIRRPDKLLCGF 469
Cdd:cd23968 244 VRHLNVGSDDD---------IFRKGRATLPGF 266
 
Name Accession Description Interval E-value
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 199-469 2.55e-137

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 395.87  E-value: 2.55e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 199 TCLVMEAGVRVLRRKDAPFNK-LPFGRLFPRQKLFRNVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHE 277
Cdd:cd23968   5 LCRLKKAAPFSTLRKTTSPFKdLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 278 VDVGSKTTIRVVNSQVVTKPEFDFTRAPIFRNVTIAAWDPGKYNGTLEDWLTSADYDLFSNYELYRRRYPKSRAFLIDPH 357
Cdd:cd23968  85 KDVGSKTTLRLINSQILSKPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYLIDPR 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 358 SVWRLWQSLQMFAGNRpISKNPPSSGFIGLALLLPHCPQVDFVEYVPSTRLNGRCHYYSKEMNSACTFGSWHPLAAEKLM 437
Cdd:cd23968 165 FLWRLWDILQEYTPEK-IKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAEKLL 243

                       250       260       270
                ....*....|....*....|....*....|..
gi 17647957 438 ALDMNMAEDDDmsvfqfgilRIRRPDKLLCGF 469
Cdd:cd23968 244 VRHLNVGSDDD---------IFRKGRATLPGF 266
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 224-437 1.35e-24

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 102.30  E-value: 1.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957   224 RLFPRQKLFRNvKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVN--SQVVTKPEFDF 301
Cdd:pfam00777  30 ELLPKVSPFDN-KRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957   302 TRAPIFRNVTIAAwDPGKYNGTLedWLTSA--------DYDLFSNYELYRRRYPKSRAFLIDP---HSVWRLWQSLQMFA 370
Cdd:pfam00777 109 FSHPRDPFVEFVL-VPFKGRDLL--WLPAFltkgnvsrSLRVLYTLKEVKIPVDPDKVLFLHPdflRYVANFWLRSHGLK 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957   371 GNRpisknpPSSGFIGLALLLPHCPQVD---FVEYVPSTRLngRCHYYSKEMNSACTFGSWHPLAAEKLM 437
Cdd:pfam00777 186 GRR------PSTGLLMLSLALHLCDEVSlygFGPFLDSRGN--SHHYYDNVLMKKGGFYGVHDMPFEFKL 247
 
Name Accession Description Interval E-value
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 199-469 2.55e-137

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 395.87  E-value: 2.55e-137
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 199 TCLVMEAGVRVLRRKDAPFNK-LPFGRLFPRQKLFRNVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHE 277
Cdd:cd23968   5 LCRLKKAAPFSTLRKTTSPFKdLLSLRYPFPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 278 VDVGSKTTIRVVNSQVVTKPEFDFTRAPIFRNVTIAAWDPGKYNGTLEDWLTSADYDLFSNYELYRRRYPKSRAFLIDPH 357
Cdd:cd23968  85 KDVGSKTTLRLINSQILSKPEFNFLTDPLYRNVTLLVWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFYLIDPR 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 358 SVWRLWQSLQMFAGNRpISKNPPSSGFIGLALLLPHCPQVDFVEYVPSTRLNGRCHYYSKEMNSACTFGSWHPLAAEKLM 437
Cdd:cd23968 165 FLWRLWDILQEYTPEK-IKPNPPSSGFIGIVLMLHLCDWVDVYEYVPSVRQTDRCHYYDVEKDLACTLGAWHPLAAEKLL 243

                       250       260       270
                ....*....|....*....|....*....|..
gi 17647957 438 ALDMNMAEDDDmsvfqfgilRIRRPDKLLCGF 469
Cdd:cd23968 244 VRHLNVGSDDD---------IFRKGRATLPGF 266
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 207-455 1.49e-84

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 261.18  E-value: 1.49e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 207 VRVLRRKDAPFNKLPFGRLFPRQKLFRNVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTI 286
Cdd:cd23985  14 VSMLEGTDFPFNTSEWEGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTI 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 287 RVVNSQVVTKPEFDFTRAPIFRNVTIAAWDPGKYNGTLEDWLTSADYDLFSNYELYRRRYPKSRAFLIDPHSVWRLWQSL 366
Cdd:cd23985  94 RLINSQLVTTEKHKFLKDSLYNEGILIVWDPAPYHSDIPEWYKNPDYNFFENYKTYRRLNPNQPFYILHPQMQWELWDII 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 367 QMFAGNRpISKNPPSSGFIGLALLLPHCPQVDFVEYVPSTRLNGRCHYYSKEMNSACTFGSWHPLAAEKLMALDMNMAED 446
Cdd:cd23985 174 QENSPEE-IQPNPPSSGMLGIILMMTLCDQVDVYEFLPSKRKTDVCHYYQKFFDRACTMGAYHPLLYEKNLVKHLNQGTD 252


                ....*....
gi 17647957 447 DDmsVFQFG 455
Cdd:cd23985 253 ED--IYLLG 259
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 207-449 3.07e-83

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 257.84  E-value: 3.07e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 207 VRVLRRKDAPFNKLPFGRLFPR---QKLFRNVkdIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSK 283
Cdd:cd23986  17 VRTLDGKEAPFSALGWEKYVPKiplSKLHLRG--FRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNK 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 284 TTIRVVNSQVVTKPEFDFTRAPIFRNVTIAAWDPGKYNGTLEDWLTSADYDLFSNYELYRRRYPKSRAFLIDPHSVWRLW 363
Cdd:cd23986  95 TTIRIINSQILTNPNHHFIDSSLYKDVILVAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNQPFYILHPKFIWQLW 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 364 QSLQMfAGNRPISKNPPSSGFIGLALLLPHCPQVDFVEYVPSTRLNGRCHYYSKEMNSACTFGSWHPLAAEKLMALDMNM 443
Cdd:cd23986 175 DIIQE-NTQEKIQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHERYYDAACTLGAYHPLLYEKLLIQRMNK 253


                ....*.
gi 17647957 444 AEDDDM 449
Cdd:cd23986 254 GTEDDL 259
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 241-437 9.55e-35

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 128.25  E-value: 9.55e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 241 CAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKpefdftrapiFRNVTIAAWDPGKY 320
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGF----------YLRGPRCGCHPLPL 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 321 NGTLEDWLTSADYDLFSNYELYRRRYPKSRAFLIDP-HSVWRLWQSLQMFAGNRP-ISKNPPSSGFIGLALLLPHCPQVD 398
Cdd:cd19952  71 EEEVVLILSRAAAADFKRLKRRKKRHDNAVLLLTDPaPDLLSYVRKRLEKLGLKSfFGGNAPSSGLLAVLLALQLCDSVD 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 17647957 399 ---FvEYVPSTRLNGRCHYYSKEMNSActFGSWHPLAAEKLM 437
Cdd:cd19952 151 lygF-GVDSGHAPKVPYHYYDLVEAEE--GTAVHSFDLEAEL 189
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 224-437 1.35e-24

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 102.30  E-value: 1.35e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957   224 RLFPRQKLFRNvKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVN--SQVVTKPEFDF 301
Cdd:pfam00777  30 ELLPKVSPFDN-KRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNpeSAIDSKYGNLG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957   302 TRAPIFRNVTIAAwDPGKYNGTLedWLTSA--------DYDLFSNYELYRRRYPKSRAFLIDP---HSVWRLWQSLQMFA 370
Cdd:pfam00777 109 FSHPRDPFVEFVL-VPFKGRDLL--WLPAFltkgnvsrSLRVLYTLKEVKIPVDPDKVLFLHPdflRYVANFWLRSHGLK 185

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957   371 GNRpisknpPSSGFIGLALLLPHCPQVD---FVEYVPSTRLngRCHYYSKEMNSACTFGSWHPLAAEKLM 437
Cdd:pfam00777 186 GRR------PSTGLLMLSLALHLCDEVSlygFGPFLDSRGN--SHHYYDNVLMKKGGFYGVHDMPFEFKL 247
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 239-441 1.36e-20

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 89.66  E-value: 1.36e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 239 KTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVnsqvvtKPEFDFTrapifrnvtiaawDPG 318
Cdd:cd23967   3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMF------YPESAFR-------------DPE 63

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 319 KYNGtleDWL------TSADYDLFsnYELYRRRYPKSRAF-----------------LIDPHSVWRLWQSLQMFAGNRPI 375
Cdd:cd23967  64 EYDS---DWLlvlvpfKSMDLLWL--QAVIKGKKPNGKGGfwkkiatsvpkppkkirILNPYILQEAAFDLIGLPMNGKQ 138

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17647957 376 SKNPPSSGFIGLALLLPHCPQVDFVEY-VPSTRLNGRCHYYSKEMNSACTFGSWHPLAAEKLMALDM 441
Cdd:cd23967 139 GKNVPTTGIIAIVMALHYCDEVDIAGFgYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 224-434 1.81e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 82.31  E-value: 1.81e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 224 RLFPRQKLFRNvKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKpefdftR 303
Cdd:cd23963  50 ELLPKTSPFSH-KRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKR------R 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 304 APIFRNVTiaawDPGKYNGTLED------WLTSADYD-----LFSNYELYRRRYPKSRAFLIDP---HSVWRLWqslqmf 369
Cdd:cd23963 123 YNSLKKNR----DRDKFLNRLKEyngsilWYPKFSFKsstnlLLKAARALKKNGLNLTVVYSNPehfLAVQKFW------ 192

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17647957 370 agNRPISKNPPSSGFIGLALLLPHCPQVD------FveyvpSTRLNGR---CHYYSKEMNSacTFGSWHPLAAE 434
Cdd:cd23963 193 --KRRGLEKRPSTGLYLVSLALTFCDEIHlygfwpF-----PTDPNGRpvpYHYYDDLSPS--TKNKVHNMPEE 257
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 239-289 4.62e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 79.98  E-value: 4.62e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 17647957 239 KTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVV 289
Cdd:cd23965   2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV 52
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 231-289 1.13e-15

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 76.94  E-value: 1.13e-15
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17647957 231 LFRNVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVV 289
Cdd:cd23966  70 RTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM 128
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 239-441 2.02e-15

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 74.70  E-value: 2.02e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 239 KTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIR-------VVNSQVVTKPEFDFTRAPiFRNVT 311
Cdd:cd23982   3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRlfypesaQFDPGIENDPDTLLVLVP-FKPLD 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 312 IaawdpgkyngtleDWLtsadYDLFSNYELYRR----------RYPKSRAFLIDPHSVWRLWQSLQMFAGNRPiSKNPPS 381
Cdd:cd23982  82 F-------------YWL----YEILSNEKRVRKgfwkqppriwDANPKQIRILNPYYTYVAATKLLQVPGQRK-KKQKPT 143

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17647957 382 SGFIGLALLLPHCPQVDFV--EYVPSTRLNGRCHYYSKE-MNSacTFGSWHPLAAEKLMALDM 441
Cdd:cd23982 144 TGLLAITLALHLCDEVHIAgfGYPDNGNSNQPIHYYNQItLKS--MANSGHNLNAEAQAIQRL 204
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 237-437 1.15e-14

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 72.85  E-value: 1.15e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 237 DIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKPEFDFTR-----APIFRNVT 311
Cdd:cd23983   1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPtslfvAVLFKSVD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 312 IAAWDPGKYNGTLEDW--------------LTSADYDLFsNYELYRR------RYPKsraflidPHSVWRLWQslqmfag 371
Cdd:cd23983  81 FAWLKAMVKKEPLSFWsrlffwkevadsipLKPSQFRIL-NPLIIKEtaldilQYPE-------PQSRLWGWD------- 145

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17647957 372 nrpisKNPPSSGFIGLALLLPHCPQVDFVEY-----VPSTRLngrcHYYSKEMNSACTFGSWHPLAAEKLM 437
Cdd:cd23983 146 -----KNVPTLGVTAVVLATHLCDEVSLAGFgydlsQPHAPL----HYYDSVCMAAMNTQTMHNVTKETKF 207
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 241-424 1.35e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 72.97  E-value: 1.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 241 CAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVN----SQVVTKPEFDFTRAPifrNVTIAAWD 316
Cdd:cd23978   4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAhssvYRVLRRPQEFLNRTP---ETTLIFWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 317 PgkYNGTLEDWLTSAdydlfsnYELYRRR---YPKSRAFLIDPHSVWRLWQSLQMFAG-NRPISKNPPSSGFIGLALLLP 392
Cdd:cd23978  81 P--PNKMQKDGKSNL-------FRIIQRAsmtFPNMSAFVVSPRRMRQFDDLFRGETGrDRKKSHSWLSTGWFTMVIAVE 151

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 17647957 393 HCPQVDFVEYVPSTRLNGRC-------HYYSKEMNSACT 424
Cdd:cd23978 152 LCDNVHVYGMVPPNYCSKRPtpkkmpyHYYEPKGPDECV 190
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 239-397 1.44e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 72.97  E-value: 1.44e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 239 KTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVV-----TKPEFdFTRApifRNVTIA 313
Cdd:cd23977   2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVplllrNQGYF-FQQS---RDTKYV 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 314 AWDPGKYNGTLEDWLTsadydlFSNYELYRRRYPKSRAFLIDPHSVWRLWQSLQMFAG-NRPISKNPPSSGFIGLALLLP 392
Cdd:cd23977  78 IWGPERNMDRDGGGKT------YRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGkNRMKSGSFLSTGWFTMILALE 151


                ....*
gi 17647957 393 HCPQV 397
Cdd:cd23977 152 LCEEI 156
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 239-436 1.63e-13

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 69.39  E-value: 1.63e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 239 KTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKPEFDFTRAPIfrnVTIAAWDPg 318
Cdd:cd23984   3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTT---VVLIPFKP- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 319 kyngtlED--WLTSA-DYDLFSNYELYRR-----RYPKSRAFLIDPHSVWRLWQSLQMFAGNRPISKNP--PSSGFIGLA 388
Cdd:cd23984  79 ------HDlrWLLDLlMGKKVSAKGFWKKpalnlIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPkhPTTGIIAIT 152

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 17647957 389 LLLPHCPQVDFVEYVPS-TRLNGRCHYYSKEMNSACTFGSWHPLAAEKL 436
Cdd:cd23984 153 LALHICNEVHIAGFKYDfSNLNSTLHYYGNETMSVMTKNEYHNISAEQK 201
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 239-435 3.81e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 69.13  E-value: 3.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 239 KTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVV---NSQVVTKPEFDF---TRAPIFrnvti 312
Cdd:cd23976  16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIahsSIQRILRNRNELlnvSQGTVF----- 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 313 AAWDPGKYNGTLEDWLtsadydLFSNYELYRRRYPKSRAFLIDPHSVWRLWQSLQMFAG-NRPISKNPPSSGFIGLALLL 391
Cdd:cd23976  91 IFWGPSNYMRRDGKGL------VYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGkDRKISNTWLSTGWFTMIIAL 164

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17647957 392 PHCPQVDFVEYVPSTRLNGR------CHYYSKEMNSACTF---------GSWHPLAAEK 435
Cdd:cd23976 165 ELCDRINVYGMVPPDFCRDPnhpsvpYHYYEPSGPDECTMyishergrkGSHHRFITEK 223
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 240-285 5.58e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 69.21  E-value: 5.58e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 17647957 240 TCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTT 285
Cdd:cd23964  84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTS 129
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 222-296 1.27e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 68.19  E-value: 1.27e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17647957 222 FGRLFPRQKLFRNvKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTK 296
Cdd:cd23970  53 LRSLLPEVSPFQN-KHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEK 126
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 219-305 3.60e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 67.16  E-value: 3.60e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 219 KLPFGRLFPrQKLFRnvkdiktCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKT-----TIRVVNSQV 293
Cdd:cd23972  71 KLFFPRDTP-GKCIR-------CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTsfygfTVNTMKNSL 142

                        90
                ....*....|..
gi 17647957 294 VTKPEFDFTRAP 305
Cdd:cd23972 143 ISYWNLGFTRTP 154
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 225-421 4.80e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 66.28  E-value: 4.80e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 225 LFPRQKLFRNvKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKPEFDFTRA 304
Cdd:cd23969  52 LLPEVSPLKG-KHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNA 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 305 PIFR---------NVTIaAWDPGKYNGTLED---WLTsadyDLFSNYEL-YRRRYPKSRAFlidpHSVWRLWQSlqmfAG 371
Cdd:cd23969 131 TDKEkfverlrqlGDSI-LWIPAFVSKGGEEhvqWTN----EIILKHKLnVKTAYPPLRLN----HAIRGYWLT----TK 197

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17647957 372 NRPiskNPPSSGFIGLALLLPHCPQVDFVEYVP-STRLNGRC---HYY-SKEMNS 421
Cdd:cd23969 198 FRI---KRPSTGLLMYTLATRFCDEIHLYGFYPfSEDGNGRAvkyHYYdNRKYLT 249
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 241-317 7.88e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 64.95  E-value: 7.88e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 241 CAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVV----TKPEFDFTRApifrNVTI-AAW 315
Cdd:cd23975   4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVplllKNPDYFFKET----NETIyVIW 79


                ..
gi 17647957 316 DP 317
Cdd:cd23975  80 GP 81
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 224-296 1.57e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 64.96  E-value: 1.57e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17647957 224 RLFPRQKLFRNvKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTK 296
Cdd:cd23987  51 ELLPRTSPLKN-KHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQR 122
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 239-298 1.59e-11

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 63.40  E-value: 1.59e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17647957 239 KTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQ-VVTKPE 298
Cdd:cd23981   3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEgAIQKPE 63
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 227-418 1.84e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 64.77  E-value: 1.84e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 227 PRQKLFRNVKDIK----TCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTKP----- 297
Cdd:cd23973  68 KEQQLLALSPPGGdgciRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSlmilq 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 298 EFDFTRAPIFRNVtiaawdpgKYNGTLE-----DWLTSADYDLFSNYELYRRRYPKSR---AFliDPHSVWRLWQSLQMF 369
Cdd:cd23973 148 KRGFKNIPQDKDI--------KYILFPEgprdyQWLEALLKNKTIPSGAYYGRRPRSYfsgDF--TEDKYLVLHPDFLRY 217

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17647957 370 AGNRPISKNP----------PSSGFIGLALLLPHCPQVDFVEYVPSTRLNGRCHYYSKE 418
Cdd:cd23973 218 VKNRFLRSKTlkgkywaiyrPTTGAFLLLTALHLCDTVSAYGFITEDYRKYPDHYYDKK 276
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 239-285 3.01e-11

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 64.13  E-value: 3.01e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 17647957 239 KTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTT 285
Cdd:cd23980  82 RRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTT 128
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 232-285 2.59e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 61.04  E-value: 2.59e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 17647957 232 FRNVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTT 285
Cdd:cd23979  74 SWDPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTT 127
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 224-312 3.46e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 60.54  E-value: 3.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 224 RLFPRQKLFRnVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHE-VDVGSKTTIRVVNSQVVTKP--EFD 300
Cdd:cd23991  51 RMFPKSQPFR-GYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGNIsKDVGSKTNLVTANPSIISIKyaKLN 129

                        90
                ....*....|..
gi 17647957 301 FTRAPIFRNVTI 312
Cdd:cd23991 130 ERRKPFLETVSV 141
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 211-296 1.94e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 58.42  E-value: 1.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 211 RRKDAPFNKLPFgRLFPRQKLFRNvKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEvDVGSKTTIRVVN 290
Cdd:cd23971  39 RKKTITVNEKLF-SMLPKESPFSN-KPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLNDSK-DVGSKTNLVTAN 115


                ....*.
gi 17647957 291 SQVVTK 296
Cdd:cd23971 116 PSILRE 121
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 225-296 3.76e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 57.66  E-value: 3.76e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17647957 225 LFPRQKLFRNvKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTTIRVVNSQVVTK 296
Cdd:cd23988  52 LLPEVSPMKN-RRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQR 122
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 223-285 1.07e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 56.68  E-value: 1.07e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17647957 223 GRLFPRQKLFRNVKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAPTQGHEVDVGSKTT 285
Cdd:cd23974  69 GQMFDWWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTS 131
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 225-436 2.11e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 49.06  E-value: 2.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 225 LFPRQKLFRnvKDIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAP-TQGHEVDVGSKTTIRVVNSQVVTK--PEFDF 301
Cdd:cd23989  52 LFPQDTPLQ--LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLVTANPSIIDKrfQNLLW 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647957 302 TRAPIFRNVTI--------------AAWDPgkyngTLEDWLTSADYD-----LFSNYELYRRrypksraflidphsvwrl 362
Cdd:cd23989 130 SRKSFVESMKVygrsyiympafsmkTGTDP-----SLRVYYTLADVGanqtvLFANPNFLRN------------------ 186

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17647957 363 wqsLQMFAGNRPISKNPPSSGFIGLALLLPHCPQVDFVEYVP-STRLNGRC---HYYSKEMnsacTFGSWHPLAAEKL 436
Cdd:cd23989 187 ---VGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPfSVDLDERTishHYYDNVL----PDSGFHAMPEEFL 257
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 224-296 3.52e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 48.68  E-value: 3.52e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17647957 224 RLFPRQKLFRNVKdIKTCAIVSSAGSLAGSKLGRFIDTHDIVMRFNHAP-TQGHEVDVGSKTTIRVVNSQVVTK 296
Cdd:cd23990  51 KMFPKDMPYSRSQ-FKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTINPSIITE 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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