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Conserved domains on  [gi|22024014|ref|NP_523786|]
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ETS-domain lacking [Drosophila melanogaster]

Protein Classification

SAM domain-containing protein; ACK family non-receptor tyrosine-protein kinase( domain architecture ID 10170773)

SAM (sterile alpha motif) domain-containing protein may be involved in protein-protein interaction and in developmental regulation| ACK (activated Cdc42-associated kinase) family non-receptor tyrosine-protein kinase catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates; such as TNK1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAM_PNT-Mae cd08536
Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the ...
 103-170 9.48e-33

Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the Activity of ETS) subfamily represents a group of SAM Pointed monodomain proteins. SAM Pointed domain is a protein-protein interaction domain. It can interact with other SAM pointed domains forming head-to-tail heterodimers and also provides a kinase docking site. For example, in Drosophila Mae is required for facilitating phosphorylation of the Yan factor and for blocking phosphorylation of the ETS-2 regulator. Mae interacts with the SAM Pointed domains of Yan and ETS-2. Binding enhances access of the kinase to the Yan phosphorylation site by providing a kinase docking site, or inhibits phosphorylation of ETS-2 by blocking its docking site. This type of factors participates in regulation of kinase signaling particularly during embryogenesis.


:

Pssm-ID: 176086  Cd Length: 66  Bit Score: 111.27  E-value: 9.48e-33
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22024014 103 DPRDWTRADVWKWLINMAVSEGLEVTAelPQKFPMNGKALCLMSLDMYLCRVPVGGKMLYRDFRVRLA 170
Cdd:cd08536   1 DPRSWSREHVRTWLRWVSARYQLEVVD--LDKFLMNGKGLCLMSLEGFLYRVPVGGKLLYEDFQRRLA 66
 
Name Accession Description Interval E-value
SAM_PNT-Mae cd08536
Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the ...
 103-170 9.48e-33

Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the Activity of ETS) subfamily represents a group of SAM Pointed monodomain proteins. SAM Pointed domain is a protein-protein interaction domain. It can interact with other SAM pointed domains forming head-to-tail heterodimers and also provides a kinase docking site. For example, in Drosophila Mae is required for facilitating phosphorylation of the Yan factor and for blocking phosphorylation of the ETS-2 regulator. Mae interacts with the SAM Pointed domains of Yan and ETS-2. Binding enhances access of the kinase to the Yan phosphorylation site by providing a kinase docking site, or inhibits phosphorylation of ETS-2 by blocking its docking site. This type of factors participates in regulation of kinase signaling particularly during embryogenesis.


Pssm-ID: 176086  Cd Length: 66  Bit Score: 111.27  E-value: 9.48e-33
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22024014 103 DPRDWTRADVWKWLINMAVSEGLEVTAelPQKFPMNGKALCLMSLDMYLCRVPVGGKMLYRDFRVRLA 170
Cdd:cd08536   1 DPRSWSREHVRTWLRWVSARYQLEVVD--LDKFLMNGKGLCLMSLEGFLYRVPVGGKLLYEDFQRRLA 66
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 99-162 6.59e-11

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 55.73  E-value: 6.59e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22024014     99 GLPLDPRDWTRADVWKWLinmavsegLEVTAELP------QKFPMNGKALCLMSLDMYLCRVPVGGKMLY 162
Cdd:smart00251  12 GIPADPQLWTEDHVLEWL--------EWAVKEFSlspidfSKFDMSGKELCSMSKEEFLERAPFGGDILW 73
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
99-162 6.86e-11

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 55.76  E-value: 6.86e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22024014    99 GLPLDPRDWTRADVWKWLiNMAVSEgLEVTAELPQKFPMNGKALCLMSLDMYLCRVPVGGKMLY 162
Cdd:pfam02198  12 WIPADPRLWTKDHVLEWL-EWAVDE-FDLSKIDFSQFDMNGKALCSLGKEEFLQRAPGPGDILW 73
 
Name Accession Description Interval E-value
SAM_PNT-Mae cd08536
Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the ...
 103-170 9.48e-33

Sterile alpha motif (SAM)/Pointed domain of Mae protein homolog; Mae (Modulator of the Activity of ETS) subfamily represents a group of SAM Pointed monodomain proteins. SAM Pointed domain is a protein-protein interaction domain. It can interact with other SAM pointed domains forming head-to-tail heterodimers and also provides a kinase docking site. For example, in Drosophila Mae is required for facilitating phosphorylation of the Yan factor and for blocking phosphorylation of the ETS-2 regulator. Mae interacts with the SAM Pointed domains of Yan and ETS-2. Binding enhances access of the kinase to the Yan phosphorylation site by providing a kinase docking site, or inhibits phosphorylation of ETS-2 by blocking its docking site. This type of factors participates in regulation of kinase signaling particularly during embryogenesis.


Pssm-ID: 176086  Cd Length: 66  Bit Score: 111.27  E-value: 9.48e-33
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22024014 103 DPRDWTRADVWKWLINMAVSEGLEVTAelPQKFPMNGKALCLMSLDMYLCRVPVGGKMLYRDFRVRLA 170
Cdd:cd08536   1 DPRSWSREHVRTWLRWVSARYQLEVVD--LDKFLMNGKGLCLMSLEGFLYRVPVGGKLLYEDFQRRLA 66
SAM_PNT cd08203
Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in ...
 103-169 2.10e-20

Sterile alpha motif (SAM)/Pointed domain; Sterile alpha motif (SAM)/Pointed domain is found in about 40% of transcriptional regulators of ETS family (initially named for Erythroblastosis virus, E26-E Twenty Six). SAM Pointed domain containing proteins of this family additionally have a C-terminal ETS DNA-binding domain. In a few cases, SAM Pointed domain appears as a single domain protein. Members of this group are mostly involved in regulation of embryonic development and growth control in eukaryotes. SAM Pointed domains mediate protein-protein interactions. Depending on the subgroup, they can interact with other SAM Pointed domains forming homo or hetero dimers/oligomers and/or they can recruit a protein kinase to its target which can be a SAM Pointed domain containing protein itself or another protein that has no kinase docking site. Thus, SAM Pointed domains participate in transcriptional regulation and signal transduction. Some genes coding ETS family transcriptional regulators are proto-oncogenes. They are prone to chromosomal translocations resulting in gene fusions. Chimeric proteins with SAM Pointed domains were found in a number of different human tumors including myeloid leukemia, lymphoblastic leukemia, Ewing's sarcoma and primitive neuroectodermal tumor. Members of this family are potential targets for cancer therapy.


Pssm-ID: 188876  Cd Length: 67  Bit Score: 80.06  E-value: 2.10e-20
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22024014 103 DPRDWTRADVWKWLINMAVSEGLEvtAELPQKFPMNGKALCLMSLDMYLCRVPV-GGKMLYRDFRVRL 169
Cdd:cd08203   1 DPLEWTPEHVQQWLSWVSKKFSLD--PIDPDRFPMNGKELCALSKEDFRERAPSrGGDVLASHLALLR 66
SAM_PNT-PDEF-like cd08532
Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of ...
 99-162 5.08e-13

Sterile alpha motif (SAM)/Pointed domain of prostate-derived ETS factor; SAM Pointed domain of PDEF-like (Prostate-Derived ETS Factor) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. In human males this activator is highly expressed in the prostate gland and enhances androgen-mediated activation of the PSA promoter though interaction with the DNA binding domain of androgen receptor. PDEF may play a role in prostate cancer development as well as in goblet cell formation and mucus production in the epithelial lining of respiratory and intestinal tracts.


Pssm-ID: 188878  Cd Length: 81  Bit Score: 61.22  E-value: 5.08e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22024014  99 GLPLDPRDWTRADVWKWLINMAVSEGLevTAELPQKFPMNGKALCLMSLDMYLCRVPVGGKMLY 162
Cdd:cd08532   9 GISPDPYQWSTANVQAWLQWTEHQYRL--PPNPPRCFQMNGKTLCALSEEDFVRRAPQGGDTLH 70
SAM_PNT smart00251
SAM / Pointed domain; A subfamily of the SAM domain
 99-162 6.59e-11

SAM / Pointed domain; A subfamily of the SAM domain


Pssm-ID: 128547  Cd Length: 82  Bit Score: 55.73  E-value: 6.59e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22024014     99 GLPLDPRDWTRADVWKWLinmavsegLEVTAELP------QKFPMNGKALCLMSLDMYLCRVPVGGKMLY 162
Cdd:smart00251  12 GIPADPQLWTEDHVLEWL--------EWAVKEFSlspidfSKFDMSGKELCSMSKEEFLERAPFGGDILW 73
SAM_PNT pfam02198
Sterile alpha motif (SAM)/Pointed domain;
99-162 6.86e-11

Sterile alpha motif (SAM)/Pointed domain;


Pssm-ID: 460486  Cd Length: 83  Bit Score: 55.76  E-value: 6.86e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22024014    99 GLPLDPRDWTRADVWKWLiNMAVSEgLEVTAELPQKFPMNGKALCLMSLDMYLCRVPVGGKMLY 162
Cdd:pfam02198  12 WIPADPRLWTKDHVLEWL-EWAVDE-FDLSKIDFSQFDMNGKALCSLGKEEFLQRAPGPGDILW 73
SAM_PNT_ESE cd08757
Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM ...
 103-166 1.78e-10

Sterile alpha motif (SAM)/Pointed domain of ESE-like ETS transcriptional regulators; SAM Pointed domain of ESE-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. ETS factors are important for cell differentiation. They can be involved in regulation of gene expression in different types of epithelial cells. They are expressed in salivary gland, intestine, stomach, pancreas, lungs, kidneys, colon, mammary gland, and prostate. Members of this group are proto-oncogenes. Expression profiles of these factors are altered in epithelial cancers, which makes them potential targets for cancer therapy.


Pssm-ID: 188885  Cd Length: 69  Bit Score: 54.26  E-value: 1.78e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22024014 103 DPRDWTRADVWKWLINMAVSEGLEVTAELPQKF-PMNGKALCLMSLDMYLCRVPVGGKMLYRDFR 166
Cdd:cd08757   1 HPQHWTKNDVLDWLLFVAEQNKIDAEEINFQKFdNIDGQTLCSMSLEEFIERDGVYGNLLYAELR 65
SAM_PNT-Tel_Yan cd08535
Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; SAM Pointed domain of Tel ...
 102-162 4.31e-09

Sterile alpha motif (SAM)/Pointed domain of Tel/Yan protein; SAM Pointed domain of Tel (Translocation, Ets, Leukemia)/Yan subfamily of ETS transcriptional repressors is a protein-protein interaction domain. SAM Pointed domains of this type of regulators can interact with each other, forming head-to-tail homodimers or homooligomers, and/or interact with SAM Pointed domains of another subfamily of ETS factors forming heterodimers. The oligomeric form is able to block transcription of target genes and is involved in MAPK signaling. They participate in regulation of different processes during embryoniv development including hematopoietic differentiation and eye development. Tel/Yan transcriptional factors are frequent targets of chromosomal translocations resulting in fusions of SAM domain with new neighboring genes. Such chimeric proteins were found in different tumors. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 176085  Cd Length: 68  Bit Score: 50.46  E-value: 4.31e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22024014 102 LDPRDWTRADVWKWLiNMAVSE-GLEVTAElpQKFPMNGKALCLMSLDMYLCRVPVGGKMLY 162
Cdd:cd08535   1 LQPRQWSREDVLQWL-RWAENEfSLPPIDS--NTFEMNGKALCLLTKEDFRYRCPHAGDVLY 59
SAM_PNT-ESE-3-like cd08539
Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM ...
 104-165 1.19e-06

Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators; SAM Pointed domain of ESE-3-like (Epithelium-Specific ETS) subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. It can act as a major transactivator by providing a potential docking site for co-activators. The ESE-3 transcriptional activator is involved in regulation of glandular epithelium differentiation through the MAP kinase signaling cascade. It is found to be expressed in glandular epithelium of prostate, pancreas, salivary gland, and trachea. Additionally, ESE-3 is differentially expressed during monocyte-derived dendritic cells development. DNA binding consensus motif for ESE-3 consists of purine-rich GGAA/T core sequence. The expression profiles of these factors are altered in epithelial cancers. Members of this subfamily are potential targets for cancer therapy.


Pssm-ID: 188882  Cd Length: 78  Bit Score: 44.25  E-value: 1.19e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22024014 104 PRDWTRADVWKWLINMAVSEGLEVTAELPQKFPMNGKALCLMSLDMYLCRVPVGGKMLYRDF 165
Cdd:cd08539   9 PQYWTKFQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNL 70
SAM_PNT-ETS-1 cd08542
Sterile alpha motif (SAM)/Pointed domain of ETS-1; SAM Pointed domain of ETS-1 subfamily of ...
 99-155 9.62e-06

Sterile alpha motif (SAM)/Pointed domain of ETS-1; SAM Pointed domain of ETS-1 subfamily of ETS transcriptional activators is a protein-protein interaction domain. The ETS-1 activator is regulated by phosphorylation. It contains a docking site for the ERK2 MAP (Mitogen Activated Protein) kinase, while the ERK2 phosphorylation site is located in the N-terminal disordered region upstream of the SAM Pointed domain. Mutations of the kinase docking site residues inhibit phosphorylation. ETS-1 activators play a role in a number of different physiological processes, and they are expressed during embryonic development, including blood vessel formation, hematopoietic, lymphoid, neuronal and osteogenic differentiation. The Ets-1 gene is a proto-oncogene involved in progression of different tumors (including breast cancer, meningioma, and prostate cancer). Members of this subfamily are potential molecular targets for selective cancer therapy.


Pssm-ID: 176092  Cd Length: 88  Bit Score: 42.27  E-value: 9.62e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22024014  99 GLPLDPRDWTRADVWKWL---INMAVSEGLEVtaelpQKFPMNGKALCLMSLDMYLCRVP 155
Cdd:cd08542  14 GIPKDPREWTETHVREWVmwaVNEFSLKGVDF-----QKFCMSGAALCALGKECFLELAP 68
SAM_PNT-GABP-alpha cd08534
Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain; SAM Pointed ...
 99-155 4.50e-04

Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain; SAM Pointed domain of GA-binding protein (GABP) alpha subfamily of ETS transcriptional regulators is a putative protein-protein interaction domain. This type of transcriptional regulators forms heterotetramers containing two alpha and two beta subunits. It interacts with GA repeats (purine rich repeats). GABP transcriptional factors control gene expression in cell cycle control, apoptosis, and cellular respiration. GABP participates in regulation of transmembrane receptors and key hormones especially in myeloid cells and at the neuromuscular junction.


Pssm-ID: 176084  Cd Length: 89  Bit Score: 37.72  E-value: 4.50e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22024014  99 GLPLDPRDWTRADVWKWLInMAVSEgLEVTAELPQKFPMNGKALCLMSLDMYLCRVP 155
Cdd:cd08534  14 KIPYDPMEWTEDHVLHWLQ-WAVKE-FGLTGINLSDWNITGRELCSLTQEEFLQRVP 68
SAM_PNT-ETS-1,2 cd08533
Sterile alpha motif (SAM)/Pointed domain of ETS-1,2 family; SAM Pointed domain of ETS-1,2 ...
 101-155 1.90e-03

Sterile alpha motif (SAM)/Pointed domain of ETS-1,2 family; SAM Pointed domain of ETS-1,2 family of transcriptional activators is a protein-protein interaction domain. It carries a kinase docking site and mediates interaction between ETS transcriptional activators and protein kinases. This group of transcriptional factors is involved in the Ras/MAP kinase signaling pathway. MAP kinases phosphorylate the transcription factors. Phosphorylated factors then recruit coactivators and enhance transactivation. Members of this group play a role in regulation of different embryonic developmental processes. ETS-1,2 transcriptional activators are proto-oncogenes involved in malignant transformation and tumor progression. They are potential molecular targets for selective cancer therapy.


Pssm-ID: 188879  Cd Length: 71  Bit Score: 35.42  E-value: 1.90e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22024014 101 PLDPRDWTRADVWKWLiNMAVSE-GLEVTAelPQKFPMNGKALCLMSLDMYLCRVP 155
Cdd:cd08533   1 PKDPRQWSETQVAYWL-DWAANEfSLEGVN--LSNFCMSGRDMCALGKEAFLSLAP 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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