|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
918-1203 |
7.89e-126 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 392.71 E-value: 7.89e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 918 NLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLT 997
Cdd:cd02897 4 NLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGSTWLT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 998 AYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERFG----DDGISLTAFVTLALMENVdlYPEYRNN 1073
Cdd:cd02897 84 AFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMqggvDDEVALTAYVLIALLEAG--LPSERPV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1074 INKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTaPAGEQQSPWYNATRSVNIEI 1153
Cdd:cd02897 162 VEKALSCLEAALDSISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRP-PPSEEGPSYYWQAPSAEVEM 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 24582565 1154 SAYAALALLENN--LVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMF 1203
Cdd:cd02897 241 TAYALLALLSAGgeDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
905-1200 |
3.11e-83 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 275.72 E-value: 3.11e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 905 VSAVGDLIGSLV----GNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENG 980
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 981 AFSAFGldIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERF---GDDG-ISLTAFV 1056
Cdd:pfam07678 81 SYSAFG--HSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAmkgGVDGeVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1057 TLALMENVDLY---PEYRNNINKALDFI-TRGLDGSSNLHAMAIGTYVLSRANHNAKA-AFLQRLDSMATNKDGLKWW-N 1130
Cdd:pfam07678 159 TIALLEALDINgllQRVHPSIRKALTYLeQAQLAGLTSPYTLAILAYALALAGSPETReELLKSLDAMAREEGNSRYWeR 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24582565 1131 KTAPAGEQQSPWYNATRSVNIEISAYAALALLennLVGD---ALPVLNWLMDQRNPKGGFVASQDTVVGLQAL 1200
Cdd:pfam07678 239 DEKSDPQGVPEYPPQAPSLEVETTAYALLAYL---LLGDltyADPIVKWLTSQRNSHGGFSSTQDTVVALQAL 308
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
128-1399 |
1.36e-42 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 171.42 E-value: 1.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 128 TDKSIYKPGDLVHYRVLILDANLKPARGYgRVHVDIKDSGDNIIRSykdIRLT---NSIYSNELRLSDSPRFGTWSIVVD 204
Cdd:COG2373 375 TDRGIYRPGETVHLKALLRDADGKAPAGL-PLTLELTDPDGKEVRR---QTLTlneFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 205 VSD--QEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVG-----EATLSIYPTFFGSLQPFVND 277
Cdd:COG2373 451 VDPkpALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlkvegEVTLRPARTAFPGYPGYRFG 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 278 LITRKVVPI-----------DGNAYFEFDIENELHLKQDYerQYLLDALVEEkSTGSVQNYSTVLTLHLNHYRVeAVKVP 346
Cdd:COG2373 531 DPDEEFEPEeldlgegtldaDGKASLSLPLPDAPDAPGPL--RATVEASVFE-SGGRPVTRSATVPVHPADFYV-GIRLP 606
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 347 SYYIPG----VPFEAtarIARNDGGQLRDfNPQITAYL-------TNVYGSSEMYN-----------RTAYSLDASGEIK 404
Cdd:COG2373 607 LFDGDPegapATFEV---VAVDPDGKPVA-GKGLKVELyreewryVWYKSDDGGWRyesqekeepvaEGTLTTGADGPAS 682
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 405 MKFTVP--------IGDRDEFHSIIVDYqgvisEVGKIPSKHLHSKNYItaKVLNDRPT--VNQEISVVVRSfaPIKYFM 474
Cdd:COG2373 683 LSLTPVewgryrleVKDPDGGLATSVRF-----YAGGNASWGAERPDRL--ELSLDKESykPGETAKLLIQS--PFAGRA 753
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 475 YQVVGRGDIILSRNVDVAPGTfHTIKFLASFAMMPRANLLVyTVIDGefvYDEQVIQL--------------EENLLNaV 540
Cdd:COG2373 754 LVTVERDGVLETQWVDVKGGG-TTVEIPVTEDWAPNAYVSA-TLVRP---GDSTANDMparaygvaplpvdpPARRLK-V 827
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 541 QVDAPIRAPPGQDIDIGISTKPY----SYVGLMLVDQnandlrsG-HDLTHKRLMDALRSYElsdvntpmgspGKES-GV 614
Cdd:COG2373 828 ELTAPEKLRPGETLTVTVKVKGAagkaAEVTLAAVDE-------GiLNLTGYKTPDPLDFFY-----------GKRAlGV 889
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 615 ITMSNTDYFIEKeaesNPALDREVSTGpeedklttvrktdigpahkievntlppGKGRYAFSYTPKPFwhnprvhvMRDP 694
Cdd:COG2373 890 ETRDLYGRLIGA----FGGAAGALRSG---------------------------GDGALGRGGNPKPP--------RKRF 930
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 695 ADTWLFL-NISASSDGRNSIHRRIPSEMTSWVVSAFAldpVNGLGLsppnGKLEAY----KEFYISTELPysikR----- 764
Cdd:COG2373 931 KPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVA---WSDDRF----GSAEATvtvrKPLVVRPSLP----Rflapg 999
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 765 DElIAIPFVVHNNRDSDLNVEVTFynsaldfdfpqldpKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKA 844
Cdd:COG2373 1000 DR-FELPVDVFNLTGKAGTVTVTL--------------EASGGLTLEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTV 1064
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 845 MAASSQAGDTVEQNLLVEHPGAMERINRGFLFElnsnAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLIL 924
Cdd:COG2373 1065 TATGGGESDAREVELPVRPANPLVTRATSGVLA----PGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLR 1140
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 925 LPTGCGEQTMVNFVPNLIVLRyLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDiKRSSTWLTAYVARSL 1004
Cdd:COG2373 1141 YPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWPGG-SESDPWLTAYATDFL 1218
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1005 RQA--APFTqVDSNVLQKALTYLGSVQSANGGFEERGDvferfGDDGISLTAFVTLALMENVDLYP--EYRNNINKALDF 1080
Cdd:COG2373 1219 LEAreAGYA-VPDDALDRALDYLRNYLRNPWEIEYDDA-----YRLAVRAYALYVLARAGKADLGDlrYLYDRRKDALSP 1292
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1081 ITRgldgssnlhAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWnktapageqqsPWYNATrsvnIEISAYAALA 1160
Cdd:COG2373 1293 LAK---------AQLAAALALLGDKARAEELLAAALARLRETGARDYWY-----------GDYGSP----LRDQALALAL 1348
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1161 LLENNLVGDALP-VLNWLMDQRNpKGGFVASQDTVVGLQALLMFAERfSSQGNNLQIGFHYGEGAETIINVNAENSLALQ 1239
Cdd:COG2373 1349 LAELGPDAPLAPkLARWLAKALK-SGRWLSTQETAWALLALAAYARA-AGASPDFTATLTLDGKTLPLTGRGPLARVTLP 1426
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1240 TVELPNnlKNLSVSATGRGMALAQVSYTYNTNVTSAWPR----------FVLDPTVnrnshADYLHLSACASF---VSVV 1306
Cdd:COG2373 1427 AAELLA--GPLTITNTGDGPLYYTLTLSGYPAEGPPPAAsngleierryYDLDGKP-----IDPASLKQGDLVvvrLTVT 1499
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1307 GENEQRSNMAVmEVHLPSGFVVDRDTLPT-------LESSERIKKVETqnRNTKVVIYFDYLDRREVcpTLHaYKTVKVT 1379
Cdd:COG2373 1500 APSGRVENVAV-VDPLPAGFEIENPRLATsgdlgdwLGDSWQPDHQEF--RDDRVVAAFDLDPAGTY--TFA-YLVRAVT 1573
|
1370 1380
....*....|....*....|...
gi 24582565 1380 K---HRPVAVVmYDYYDSARRAR 1399
Cdd:COG2373 1574 PgtfVLPPAQA-EDMYRPEVRAR 1595
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1311-1402 |
3.14e-31 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 118.06 E-value: 3.14e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1311 QRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNtKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYD 1390
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDDG-KVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYD 79
|
90
....*....|..
gi 24582565 1391 YYDSARRARQFY 1402
Cdd:pfam07677 80 YYEPERRATTFY 91
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
918-1203 |
7.89e-126 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 392.71 E-value: 7.89e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 918 NLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDIKRSSTWLT 997
Cdd:cd02897 4 NLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGESDKSGSTWLT 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 998 AYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERFG----DDGISLTAFVTLALMENVdlYPEYRNN 1073
Cdd:cd02897 84 AFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMqggvDDEVALTAYVLIALLEAG--LPSERPV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1074 INKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWNKTaPAGEQQSPWYNATRSVNIEI 1153
Cdd:cd02897 162 VEKALSCLEAALDSISDPYTLALAAYALTLAGSEKRPEALKKLDELAISEDGTKHWSRP-PPSEEGPSYYWQAPSAEVEM 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 24582565 1154 SAYAALALLENN--LVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMF 1203
Cdd:cd02897 241 TAYALLALLSAGgeDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
917-1203 |
7.03e-89 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 290.44 E-value: 7.03e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 917 GNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDiKRSSTWL 996
Cdd:cd02891 3 GNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNS-DSGSTWL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 997 TAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFER----FGDDGISLTAFVTLALMENVDLYPeyrN 1072
Cdd:cd02891 82 TAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHRemkgGVDDSVSLTAYVLIALAEAGKACD---A 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1073 NINKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKA-AFLQRLDSMATNKDGLKWWnktapageQQSPWYNATRSVNI 1151
Cdd:cd02891 159 SIEKALAYLETQLDGLLDPYALAILAYALALAGDSTRAdEALKKLLEAAREKGGTAHW--------SLSWPGDYGSSLRV 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 24582565 1152 EISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMF 1203
Cdd:cd02891 231 EATAYALLALLKLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
905-1200 |
3.11e-83 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 275.72 E-value: 3.11e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 905 VSAVGDLIGSLV----GNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENG 980
Cdd:pfam07678 1 ISVVGDIMGPAIqvvpENLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 981 AFSAFGldIKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERF---GDDG-ISLTAFV 1056
Cdd:pfam07678 81 SYSAFG--HSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAmkgGVDGeVSLTAYV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1057 TLALMENVDLY---PEYRNNINKALDFI-TRGLDGSSNLHAMAIGTYVLSRANHNAKA-AFLQRLDSMATNKDGLKWW-N 1130
Cdd:pfam07678 159 TIALLEALDINgllQRVHPSIRKALTYLeQAQLAGLTSPYTLAILAYALALAGSPETReELLKSLDAMAREEGNSRYWeR 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24582565 1131 KTAPAGEQQSPWYNATRSVNIEISAYAALALLennLVGD---ALPVLNWLMDQRNPKGGFVASQDTVVGLQAL 1200
Cdd:pfam07678 239 DEKSDPQGVPEYPPQAPSLEVETTAYALLAYL---LLGDltyADPIVKWLTSQRNSHGGFSSTQDTVVALQAL 308
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
917-1200 |
6.39e-70 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 236.79 E-value: 6.39e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 917 GNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQ---LTPEVELRATNNLAIGYQRILYYRHENGAFSAFGldIKRSS 993
Cdd:cd02896 3 EGLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWK--NRPSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 994 TWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERFGDDGI-------SLTAFVTLALMENVDL 1066
Cdd:cd02896 81 TWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsegdvSLTAFVLIALQEARSI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1067 YPEYRNN----INKALDFITRGLDGSSNLHAMAIGTYVLSRANHNAKAAFLQRLDSMAtNKDGLKWWNKTApagEQQSPW 1142
Cdd:cd02896 161 CPPEVQNldqsIRKAISYLENQLPNLQRPYALAITAYALALADSPLSHAANRKLLSLA-KRDGNGWYWWTI---DSPYWP 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 24582565 1143 YNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQAL 1200
Cdd:cd02896 237 VPGPSAITVETTAYALLALLKLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQAL 294
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
917-1203 |
1.97e-52 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 186.60 E-value: 1.97e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 917 GNLDSLILLPTG--------CGEQTMVNFVPNLIVLRYLgrlrqLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGlD 988
Cdd:cd00688 3 KHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLL-----AATGIRDKADENIEKGIQRLLSYQLSDGGFSGWG-G 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 989 IKRSSTWLTAYVARSLRQAAPFTQVDSNVLQKALTYLGSVQSANGGFEERGDVFERFG--DDGISLTAFVTLALMENVDL 1066
Cdd:cd00688 77 NDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIGgdESDVRLTAYALIALALLGKL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1067 YPeyRNNINKALDFITR--------GLDGSSNLHAMAIGTYVLSRANH----NAKAAfLQRLDSMATNKDGLKWWNKtap 1134
Cdd:cd00688 157 DP--DPLIEKALDYLLScqnydggfGPGGESHGYGTACAAAALALLGDldspDAKKA-LRWLLSRQRPDGGWGEGRD--- 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24582565 1135 ageqqsPWYNATRSVNIEISAYAALALLENNLVGDALPVLNWLMDQRNPKGGF-------VASQDTVVGLQALLMF 1203
Cdd:cd00688 231 ------RTNKLSDSCYTEWAAYALLALGKLGDLEDAEKLVKWLLSQQNEDGGFsskpgksYDTQHTVFALLALSLY 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
128-1399 |
1.36e-42 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 171.42 E-value: 1.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 128 TDKSIYKPGDLVHYRVLILDANLKPARGYgRVHVDIKDSGDNIIRSykdIRLT---NSIYSNELRLSDSPRFGTWSIVVD 204
Cdd:COG2373 375 TDRGIYRPGETVHLKALLRDADGKAPAGL-PLTLELTDPDGKEVRR---QTLTlneFGGYSFSFPLPEDAPTGTWRLELY 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 205 VSD--QEHTQTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVG-----EATLSIYPTFFGSLQPFVND 277
Cdd:COG2373 451 VDPkpALGSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGlkvegEVTLRPARTAFPGYPGYRFG 530
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 278 LITRKVVPI-----------DGNAYFEFDIENELHLKQDYerQYLLDALVEEkSTGSVQNYSTVLTLHLNHYRVeAVKVP 346
Cdd:COG2373 531 DPDEEFEPEeldlgegtldaDGKASLSLPLPDAPDAPGPL--RATVEASVFE-SGGRPVTRSATVPVHPADFYV-GIRLP 606
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 347 SYYIPG----VPFEAtarIARNDGGQLRDfNPQITAYL-------TNVYGSSEMYN-----------RTAYSLDASGEIK 404
Cdd:COG2373 607 LFDGDPegapATFEV---VAVDPDGKPVA-GKGLKVELyreewryVWYKSDDGGWRyesqekeepvaEGTLTTGADGPAS 682
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 405 MKFTVP--------IGDRDEFHSIIVDYqgvisEVGKIPSKHLHSKNYItaKVLNDRPT--VNQEISVVVRSfaPIKYFM 474
Cdd:COG2373 683 LSLTPVewgryrleVKDPDGGLATSVRF-----YAGGNASWGAERPDRL--ELSLDKESykPGETAKLLIQS--PFAGRA 753
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 475 YQVVGRGDIILSRNVDVAPGTfHTIKFLASFAMMPRANLLVyTVIDGefvYDEQVIQL--------------EENLLNaV 540
Cdd:COG2373 754 LVTVERDGVLETQWVDVKGGG-TTVEIPVTEDWAPNAYVSA-TLVRP---GDSTANDMparaygvaplpvdpPARRLK-V 827
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 541 QVDAPIRAPPGQDIDIGISTKPY----SYVGLMLVDQnandlrsG-HDLTHKRLMDALRSYElsdvntpmgspGKES-GV 614
Cdd:COG2373 828 ELTAPEKLRPGETLTVTVKVKGAagkaAEVTLAAVDE-------GiLNLTGYKTPDPLDFFY-----------GKRAlGV 889
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 615 ITMSNTDYFIEKeaesNPALDREVSTGpeedklttvrktdigpahkievntlppGKGRYAFSYTPKPFwhnprvhvMRDP 694
Cdd:COG2373 890 ETRDLYGRLIGA----FGGAAGALRSG---------------------------GDGALGRGGNPKPP--------RKRF 930
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 695 ADTWLFL-NISASSDGRNSIHRRIPSEMTSWVVSAFAldpVNGLGLsppnGKLEAY----KEFYISTELPysikR----- 764
Cdd:COG2373 931 KPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVA---WSDDRF----GSAEATvtvrKPLVVRPSLP----Rflapg 999
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 765 DElIAIPFVVHNNRDSDLNVEVTFynsaldfdfpqldpKATNQPKVELYRRRSLQVPGRSARSVSFIVTPKRVGPLLVKA 844
Cdd:COG2373 1000 DR-FELPVDVFNLTGKAGTVTVTL--------------EASGGLTLEGEATQTVTLAAGGRATVRFPLKAPDAGDAKVTV 1064
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 845 MAASSQAGDTVEQNLLVEHPGAMERINRGFLFElnsnAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIGSLVGNLDSLIL 924
Cdd:COG2373 1065 TATGGGESDAREVELPVRPANPLVTRATSGVLA----PGESWTLPLDLPGGLRPGTGSLTLSLSSSPPLDLAGLLRYLLR 1140
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 925 LPTGCGEQTMVNFVPNLIVLRyLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGAFSAFGLDiKRSSTWLTAYVARSL 1004
Cdd:COG2373 1141 YPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNSDGGFGLWPGG-SESDPWLTAYATDFL 1218
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1005 RQA--APFTqVDSNVLQKALTYLGSVQSANGGFEERGDvferfGDDGISLTAFVTLALMENVDLYP--EYRNNINKALDF 1080
Cdd:COG2373 1219 LEAreAGYA-VPDDALDRALDYLRNYLRNPWEIEYDDA-----YRLAVRAYALYVLARAGKADLGDlrYLYDRRKDALSP 1292
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1081 ITRgldgssnlhAMAIGTYVLSRANHNAKAAFLQRLDSMATNKDGLKWWnktapageqqsPWYNATrsvnIEISAYAALA 1160
Cdd:COG2373 1293 LAK---------AQLAAALALLGDKARAEELLAAALARLRETGARDYWY-----------GDYGSP----LRDQALALAL 1348
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1161 LLENNLVGDALP-VLNWLMDQRNpKGGFVASQDTVVGLQALLMFAERfSSQGNNLQIGFHYGEGAETIINVNAENSLALQ 1239
Cdd:COG2373 1349 LAELGPDAPLAPkLARWLAKALK-SGRWLSTQETAWALLALAAYARA-AGASPDFTATLTLDGKTLPLTGRGPLARVTLP 1426
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1240 TVELPNnlKNLSVSATGRGMALAQVSYTYNTNVTSAWPR----------FVLDPTVnrnshADYLHLSACASF---VSVV 1306
Cdd:COG2373 1427 AAELLA--GPLTITNTGDGPLYYTLTLSGYPAEGPPPAAsngleierryYDLDGKP-----IDPASLKQGDLVvvrLTVT 1499
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1307 GENEQRSNMAVmEVHLPSGFVVDRDTLPT-------LESSERIKKVETqnRNTKVVIYFDYLDRREVcpTLHaYKTVKVT 1379
Cdd:COG2373 1500 APSGRVENVAV-VDPLPAGFEIENPRLATsgdlgdwLGDSWQPDHQEF--RDDRVVAAFDLDPAGTY--TFA-YLVRAVT 1573
|
1370 1380
....*....|....*....|...
gi 24582565 1380 K---HRPVAVVmYDYYDSARRAR 1399
Cdd:COG2373 1574 PgtfVLPPAQA-EDMYRPEVRAR 1595
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1311-1402 |
3.14e-31 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 118.06 E-value: 3.14e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 1311 QRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKVETQNRNtKVVIYFDYLDRREVCPTLHAYKTVKVTKHRPVAVVMYD 1390
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDDG-KVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYD 79
|
90
....*....|..
gi 24582565 1391 YYDSARRARQFY 1402
Cdd:pfam07677 80 YYEPERRATTFY 91
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
697-788 |
5.18e-27 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 105.75 E-value: 5.18e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 697 TWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNgKLEAYKEFYISTELPYSIKRDELIAIPFVVHN 776
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPP-ELVVFKPFFVDLNLPYSVRRGEQFELKATVFN 79
|
90
....*....|..
gi 24582565 777 NRDSDLNVEVTF 788
Cdd:pfam00207 80 YLDKCLKVRVRL 91
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
445-573 |
3.11e-16 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 77.00 E-value: 3.11e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 445 ITAKVLNDRPTVNQEISVVVRS----FAPIKYFMYQVVGRGDIILSRNvdvaPGTFHTIKFLASFAMMPRANLLVYTVI- 519
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSpfdgTVERDGFTYLVLSKGQIVVVGR----GGVTTSFSLPVTAEMAPSARVVAYYVRv 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 24582565 520 ---DGEFVYDEQVIQLEENLLNAVQVD-APIRAPPGQDIDIGISTKPYSYVGLMLVDQ 573
Cdd:pfam07703 77 dlsKPEVVADSVWVDVDDTCENKLKVTlSAEKYRPGSTVELKVKADPGAYVALAAVDK 134
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
126-215 |
3.81e-15 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 72.35 E-value: 3.81e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 126 VQTDKSIYKPGDLVHYRVLILDANLKPARGYgRVHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVDV 205
Cdd:pfam01835 4 VYTDRGIYRPGETVHFKGLLRDQDLRPLAGL-PVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLRD 82
|
90
....*....|..
gi 24582565 206 SDQE--HTQTFE 215
Cdd:pfam01835 83 GAGGslGSGSFR 94
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
219-304 |
3.93e-06 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 46.11 E-value: 3.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24582565 219 HILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQPFvndLITRKVVPIDGNAYFEFDIeN 298
Cdd:pfam17791 2 YVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDDSKRKCF---ESFSKELDKDGCGSASLST-E 77
|
....*.
gi 24582565 299 ELHLKQ 304
Cdd:pfam17791 78 EFQLTF 83
|
|
| |
