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Conserved domains on  [gi|17647667|ref|NP_523440|]
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mitochondrial ribosomal protein L10 [Drosophila melanogaster]

Protein Classification

50S ribosomal protein L10( domain architecture ID 10146583)

50S ribosomal protein L10 binds and anchors the two L7/L12 dimers to the large ribosomal subunit

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 74-227 6.98e-34

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


:

Pssm-ID: 240223  Cd Length: 157  Bit Score: 119.53  E-value: 6.98e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667  74 NPYNEIIAREVRNWLDHSRLVAFFHLSSITADDIFRVRVQLHKQNLHLKSYGSKIIEQAVKNTRYEAIVPLFHSNHCIVF 153
Cdd:cd05797   2 REKKEEIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAGVKLKVVKNTLAKRALEGTGFEDLDDLLKGPTAIAF 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17647667 154 SP-DPEKTAALLRIVRRV-PQMVLLGGIVEETMLSRNQLVAYAQMPGLHAVQAQLVQTLSQAPGHLIQQLQAHQNS 227
Cdd:cd05797  82 SEeDPVAAAKVLKDFAKEnKKLEIKGGVVEGKVLDAEEVKALAKLPSREELLAQLLGLLQAPATKLVRVLNAPASK 157
 
Name Accession Description Interval E-value
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 74-227 6.98e-34

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 119.53  E-value: 6.98e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667  74 NPYNEIIAREVRNWLDHSRLVAFFHLSSITADDIFRVRVQLHKQNLHLKSYGSKIIEQAVKNTRYEAIVPLFHSNHCIVF 153
Cdd:cd05797   2 REKKEEIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAGVKLKVVKNTLAKRALEGTGFEDLDDLLKGPTAIAF 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17647667 154 SP-DPEKTAALLRIVRRV-PQMVLLGGIVEETMLSRNQLVAYAQMPGLHAVQAQLVQTLSQAPGHLIQQLQAHQNS 227
Cdd:cd05797  82 SEeDPVAAAKVLKDFAKEnKKLEIKGGVVEGKVLDAEEVKALAKLPSREELLAQLLGLLQAPATKLVRVLNAPASK 157
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 78-237 4.50e-13

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 65.09  E-value: 4.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667  78 EIIArEVRNWLDHSRLVAFFHLSSITADDIFRVRVQLHKQNLHLKSYGSKIIEQAVKNTRYEAIVPLFHSNHCIVFSPDP 157
Cdd:COG0244   8 AVVA-ELKEKLKEAQAVVLTDYRGLTVAQMTELRRKLREAGVEYKVVKNTLARIALEGTGFEGLDDLLKGPTAIAFSYED 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667 158 EKTAAllRIVRRV----PQMVLLGGIVEETMLSRNQLVAYAQMPGLHAVQAQLVQTLsQAPG-HLIQQLQAHQNSFVQVL 232
Cdd:COG0244  87 PVAAA--KVLKDFakenEKLVIKGGVLDGKVLDAEQVKALAKLPSREELLAKLLGLL-QAPAtKLVGVLNAPPRKLARVL 163


                ....*
gi 17647667 233 DVHAK 237
Cdd:COG0244 164 KAIAE 168
rplJ PRK00099
50S ribosomal protein L10; Reviewed
 78-237 1.64e-11

50S ribosomal protein L10; Reviewed


Pssm-ID: 234632  Cd Length: 172  Bit Score: 60.92  E-value: 1.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667   78 EIIArEVRNWLDHSRLVAFFHLSSITADDIFRVRVQLHKQNLHLKSYGSKIIEQAVKNTRYEAIVPLFHSNHCIVFSP-D 156
Cdd:PRK00099   8 EIVA-ELAEKLKKAQSAVVADYRGLTVAQMTELRKKLREAGVEYKVVKNTLARRALEGTGFEGLDDLLKGPTAIAFSYeD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667  157 PektAALLRIVRRV----PQMVLLGGIVEETMLSRNQLVAYAQMPGLHAVQAQLVQTLSQAPGHLIQQLQAHQNSFVQVL 232
Cdd:PRK00099  87 P---VAAAKVLKDFakdnKKLEIKGGAIEGKVLDAEEVKALAKLPSREELLAKLLGVLQAPATKLAGVLNAPPSKLARVL 163


                 ....*
gi 17647667  233 DVHAK 237
Cdd:PRK00099 164 KALAE 168
Ribosomal_L10 pfam00466
Ribosomal protein L10;
78-164 1.44e-05

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 42.53  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667    78 EIIArEVRNWLDHSRLVAFFHLSSITADDIFRVRVQLHKQNLHLKSYGSKIIEQAVKNTRYEAIVPLFHSNHCIVFSP-D 156
Cdd:pfam00466   8 ELVE-ELKELLKEYKSVVVVDYRGLTVAQLTELRKKLRENGAELKVGKNTLMRRALEETGEEKLEDYLKGPTALLFTNeD 86


                  ....*...
gi 17647667   157 PEKTAALL 164
Cdd:pfam00466  87 PVAVAKVL 94
 
Name Accession Description Interval E-value
Ribosomal_L10 cd05797
Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and ...
 74-227 6.98e-34

Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein and forms the base of the L7/L12 stalk, while the extended C-terminal helix binds to two or three dimers of the NTD of L7/L12 (L7 and L12 are identical except for an acetylated N-terminus). The L7/L12 stalk is known to contain the binding site for elongation factors G and Tu (EF-G and EF-Tu, respectively); however, there is disagreement as to whether or not L10 is involved in forming the binding site. The stalk is believed to be associated with GTPase activities in protein synthesis. In a neuroblastoma cell line, L10 has been shown to interact with the SH3 domain of Src and to activate the binding of the Nck1 adaptor protein with skeletal proteins such as the Wiskott-Aldrich Syndrome Protein (WASP) and the WASP-interacting protein (WIP). These bacteria and eukaryotic sequences have no additional C-terminal domain, present in other eukaryotic and archaeal orthologs.


Pssm-ID: 240223  Cd Length: 157  Bit Score: 119.53  E-value: 6.98e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667  74 NPYNEIIAREVRNWLDHSRLVAFFHLSSITADDIFRVRVQLHKQNLHLKSYGSKIIEQAVKNTRYEAIVPLFHSNHCIVF 153
Cdd:cd05797   2 REKKEEIVAELKEKLKEAKSVVVADYRGLTVAQLTELRKELREAGVKLKVVKNTLAKRALEGTGFEDLDDLLKGPTAIAF 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17647667 154 SP-DPEKTAALLRIVRRV-PQMVLLGGIVEETMLSRNQLVAYAQMPGLHAVQAQLVQTLSQAPGHLIQQLQAHQNS 227
Cdd:cd05797  82 SEeDPVAAAKVLKDFAKEnKKLEIKGGVVEGKVLDAEEVKALAKLPSREELLAQLLGLLQAPATKLVRVLNAPASK 157
RplJ COG0244
Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 ...
 78-237 4.50e-13

Ribosomal protein L10 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L10 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 440014  Cd Length: 172  Bit Score: 65.09  E-value: 4.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667  78 EIIArEVRNWLDHSRLVAFFHLSSITADDIFRVRVQLHKQNLHLKSYGSKIIEQAVKNTRYEAIVPLFHSNHCIVFSPDP 157
Cdd:COG0244   8 AVVA-ELKEKLKEAQAVVLTDYRGLTVAQMTELRRKLREAGVEYKVVKNTLARIALEGTGFEGLDDLLKGPTAIAFSYED 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667 158 EKTAAllRIVRRV----PQMVLLGGIVEETMLSRNQLVAYAQMPGLHAVQAQLVQTLsQAPG-HLIQQLQAHQNSFVQVL 232
Cdd:COG0244  87 PVAAA--KVLKDFakenEKLVIKGGVLDGKVLDAEQVKALAKLPSREELLAKLLGLL-QAPAtKLVGVLNAPPRKLARVL 163


                ....*
gi 17647667 233 DVHAK 237
Cdd:COG0244 164 KAIAE 168
rplJ PRK00099
50S ribosomal protein L10; Reviewed
 78-237 1.64e-11

50S ribosomal protein L10; Reviewed


Pssm-ID: 234632  Cd Length: 172  Bit Score: 60.92  E-value: 1.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667   78 EIIArEVRNWLDHSRLVAFFHLSSITADDIFRVRVQLHKQNLHLKSYGSKIIEQAVKNTRYEAIVPLFHSNHCIVFSP-D 156
Cdd:PRK00099   8 EIVA-ELAEKLKKAQSAVVADYRGLTVAQMTELRKKLREAGVEYKVVKNTLARRALEGTGFEGLDDLLKGPTAIAFSYeD 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667  157 PektAALLRIVRRV----PQMVLLGGIVEETMLSRNQLVAYAQMPGLHAVQAQLVQTLSQAPGHLIQQLQAHQNSFVQVL 232
Cdd:PRK00099  87 P---VAAAKVLKDFakdnKKLEIKGGAIEGKVLDAEEVKALAKLPSREELLAKLLGVLQAPATKLAGVLNAPPSKLARVL 163


                 ....*
gi 17647667  233 DVHAK 237
Cdd:PRK00099 164 KALAE 168
Ribosomal_L10 pfam00466
Ribosomal protein L10;
78-164 1.44e-05

Ribosomal protein L10;


Pssm-ID: 459822 [Multi-domain]  Cd Length: 99  Bit Score: 42.53  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17647667    78 EIIArEVRNWLDHSRLVAFFHLSSITADDIFRVRVQLHKQNLHLKSYGSKIIEQAVKNTRYEAIVPLFHSNHCIVFSP-D 156
Cdd:pfam00466   8 ELVE-ELKELLKEYKSVVVVDYRGLTVAQLTELRKKLRENGAELKVGKNTLMRRALEETGEEKLEDYLKGPTALLFTNeD 86


                  ....*...
gi 17647667   157 PEKTAALL 164
Cdd:pfam00466  87 PVAVAKVL 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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