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Conserved domains on  [gi|24642365|ref|NP_523359|]
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odorant receptor 13a [Drosophila melanogaster]

Protein Classification

odorant receptor( domain architecture ID 139944)

odorant receptor (OR) found in insects similar to Drosophila ORs, novel seven-transmembrane domain proteins that can signal independently of heterotrimeric G proteins, and which show no obvious sequence homology with G protein-coupled receptors (GPCRs) and display an inverted topology with an intracellular N-terminus and an extracellular C-terminus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7tm_6 super family cl20237
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 78-399 8.62e-39

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


The actual alignment was detected with superfamily member pfam02949:

Pssm-ID: 251636  Cd Length: 313  Bit Score: 141.66  E-value: 8.62e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365    78 ENCCTTFMGVLNFVRLIHLRLNQRKFRQLIENFSYEIWIPNSSK--------NNVAAECRRRMVTFSIMTSllacliIMY 149
Cdd:pfam02949   7 TNLQVLVTSIVCLFKFLLILLKRKEIVELISLLRELDPRCLEEEeeriferlVATASRVRFLLFIIYILAY------ALF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   150 CVLPLVEIFFGpafDAQNKPFPYKMIFPYDAQSSWIRYVMTYIFTSYAGICVVTTLFAEDTILGFFITYTCGQFHLLHQR 229
Cdd:pfam02949  81 CISALVSMVLS---LERGLPLPYYLPFPFDWEASRPPYYIAYIYQVLGMTVTVLQNIGSDSLFCSFLLFLVLHLRLLQLR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   230 IAGLfaGSNAELAESIQLERLKRIVEKHNNIISFAKRLEDFFNPILLANLMISSVLICMVGFQIVTGKNmfIGDYVKFII 309
Cdd:pfam02949 158 LERL--GLDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNLLFFSG--PLQGIYYVL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   310 YISSALSQLYVLCENGDALIKQSTLTAQILYECQWEGSDRieiqsftpttkRIRNQIWFMILCSQQPVRITAFKFSTLSL 389
Cdd:pfam02949 234 YLLAMLIQLFPYCYYGNELTEASEELANAIYSSNWYDASR-----------RYRRTLLIFIMRAQRPITIKAGGFFPISL 302

                         330
                  ....*....|
gi 24642365   390 QSFTAILSTS 399
Cdd:pfam02949 303 PTFISILKFA 312
 
Name Accession Description Interval E-value
7tm_6 pfam02949
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 78-399 8.62e-39

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


Pssm-ID: 251636  Cd Length: 313  Bit Score: 141.66  E-value: 8.62e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365    78 ENCCTTFMGVLNFVRLIHLRLNQRKFRQLIENFSYEIWIPNSSK--------NNVAAECRRRMVTFSIMTSllacliIMY 149
Cdd:pfam02949   7 TNLQVLVTSIVCLFKFLLILLKRKEIVELISLLRELDPRCLEEEeeriferlVATASRVRFLLFIIYILAY------ALF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   150 CVLPLVEIFFGpafDAQNKPFPYKMIFPYDAQSSWIRYVMTYIFTSYAGICVVTTLFAEDTILGFFITYTCGQFHLLHQR 229
Cdd:pfam02949  81 CISALVSMVLS---LERGLPLPYYLPFPFDWEASRPPYYIAYIYQVLGMTVTVLQNIGSDSLFCSFLLFLVLHLRLLQLR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   230 IAGLfaGSNAELAESIQLERLKRIVEKHNNIISFAKRLEDFFNPILLANLMISSVLICMVGFQIVTGKNmfIGDYVKFII 309
Cdd:pfam02949 158 LERL--GLDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNLLFFSG--PLQGIYYVL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   310 YISSALSQLYVLCENGDALIKQSTLTAQILYECQWEGSDRieiqsftpttkRIRNQIWFMILCSQQPVRITAFKFSTLSL 389
Cdd:pfam02949 234 YLLAMLIQLFPYCYYGNELTEASEELANAIYSSNWYDASR-----------RYRRTLLIFIMRAQRPITIKAGGFFPISL 302

                         330
                  ....*....|
gi 24642365   390 QSFTAILSTS 399
Cdd:pfam02949 303 PTFISILKFA 312
 
Name Accession Description Interval E-value
7tm_6 pfam02949
7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably ...
 78-399 8.62e-39

7tm Odorant receptor; This family is composed of 7 transmembrane receptors, that are probably drosophila odorant receptors.


Pssm-ID: 251636  Cd Length: 313  Bit Score: 141.66  E-value: 8.62e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365    78 ENCCTTFMGVLNFVRLIHLRLNQRKFRQLIENFSYEIWIPNSSK--------NNVAAECRRRMVTFSIMTSllacliIMY 149
Cdd:pfam02949   7 TNLQVLVTSIVCLFKFLLILLKRKEIVELISLLRELDPRCLEEEeeriferlVATASRVRFLLFIIYILAY------ALF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   150 CVLPLVEIFFGpafDAQNKPFPYKMIFPYDAQSSWIRYVMTYIFTSYAGICVVTTLFAEDTILGFFITYTCGQFHLLHQR 229
Cdd:pfam02949  81 CISALVSMVLS---LERGLPLPYYLPFPFDWEASRPPYYIAYIYQVLGMTVTVLQNIGSDSLFCSFLLFLVLHLRLLQLR 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   230 IAGLfaGSNAELAESIQLERLKRIVEKHNNIISFAKRLEDFFNPILLANLMISSVLICMVGFQIVTGKNmfIGDYVKFII 309
Cdd:pfam02949 158 LERL--GLDPELSEEEEYQELRECVRDHQRILRLVDELNRIFSVPILVQFLLSGLVICFLLFNLLFFSG--PLQGIYYVL 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   310 YISSALSQLYVLCENGDALIKQSTLTAQILYECQWEGSDRieiqsftpttkRIRNQIWFMILCSQQPVRITAFKFSTLSL 389
Cdd:pfam02949 234 YLLAMLIQLFPYCYYGNELTEASEELANAIYSSNWYDASR-----------RYRRTLLIFIMRAQRPITIKAGGFFPISL 302

                         330
                  ....*....|
gi 24642365   390 QSFTAILSTS 399
Cdd:pfam02949 303 PTFISILKFA 312
7tm_7 pfam08395
7tm Chemosensory receptor; This family includes a number of gustatory and odorant receptors ...
 34-406 3.27e-04

7tm Chemosensory receptor; This family includes a number of gustatory and odorant receptors mainly from insect species such as A. gambiae and D. melanogaster. They are classified as G-protein-coupled receptors (GPCRs), or seven-transmembrane receptors. They show high sequence divergence, consistent with an ancient origin for the family.


Pssm-ID: 462463  Cd Length: 370  Bit Score: 42.39  E-value: 3.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365    34 WRSQSLLATAYIVWAWYVIASVGITISYQTAFLlnNLSDIIITTENCCTTFMGVLNfvrlihLRLNQRKFRQLIENFSYe 113
Cdd:pfam08395  34 LLLLLILFLLVLLLLFLISFMREFYFFRRNALL--EVVYNIQLVLNLLTVLVILLS------LLFQRRRLARLLNELLR- 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   114 iwIPNSSKNNVAAECRRRmvtFSIMTSLLACLIIMYCVLPLVEIFFGPAFDaqnkpfpykmifpydaqsSWIRYVMTYIF 193
Cdd:pfam08395 105 --LDRRLLRLGSRRNCRR---FNRLLLLLLVLIILLLLVTLVGYLLLSQYF------------------LLVLLLLLYLL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   194 TSYAGICVVTTLFAedtilgfFITYTCGQFHLLHQRIAGLFAGSNAELAESIQ----LERLKRIVEKHNNIISFAKRLED 269
Cdd:pfam08395 162 PYLVLNLLILQYFL-------LVLLIYRRLRLLNRQLKQLVRELRGLSRSGQLreccYLRLDKLLRLYRRLSDLVRELNR 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642365   270 FFNPILLANLMISSVLICMVGF-QIVTGKNMFIGDYVK-FIIYISSALSQLYVLCENGDALIKQSTLTAQILYECQWEGS 347
Cdd:pfam08395 235 CFGLQLLLILLYSFITITVLIYyLYSSLLLDSSGFTLLvFVLWLLIFLLLLLLIVYACNLISNEAKKTGLLLRRLNLSLK 314

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24642365   348 DRIEIQSFTpttkrirnqiWFMILCSQQPVRITAFKFSTLSLQSFTAILSTSISYFTLL 406
Cdd:pfam08395 315 DSRLERSIE----------KFLLQLLHQKLRFTACGLFDLDRSLLFSMFSAITTYLVIL 363
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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