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Conserved domains on  [gi|17570095|ref|NP_510626|]
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Fork-head domain-containing protein [Caenorhabditis elegans]

Protein Classification

forkhead box transcription factor( domain architecture ID 10646668)

forkhead box transcription factor contains a forkhead/winged helix DNA-binding domain and is involved in regulating diverse biological processes

Gene Ontology:  GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 21-105 2.95e-22

FORKHEAD; FORKHEAD, also known as a "winged helix"


:

Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 84.21  E-value: 2.95e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570095     21 MPKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKVFHDmyKWEfvNHVAWVLDTELCFRRE-----RDVRSGLWA 95
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRA--GWQ--NSIRHNLSLNDCFVKVpregdRPGKGSYWT 76

                           90
                   ....*....|
gi 17570095     96 YEDGNKDILD 105
Cdd:smart00339  77 LDPAAENMFE 86
 
Name Accession Description Interval E-value
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 21-105 2.95e-22

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 84.21  E-value: 2.95e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570095     21 MPKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKVFHDmyKWEfvNHVAWVLDTELCFRRE-----RDVRSGLWA 95
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRA--GWQ--NSIRHNLSLNDCFVKVpregdRPGKGSYWT 76

                           90
                   ....*....|
gi 17570095     96 YEDGNKDILD 105
Cdd:smart00339  77 LDPAAENMFE 86
FH_FOXA1 cd20038
Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, ...
 20-83 3.39e-05

Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, also called hepatocyte nuclear factor 3-alpha (HNF-3-alpha or HNF-3A) or transcription factor 3A (TCF-3A), acts as a transcription factor that is essential for epithelial lineage differentiation. It has been found to be upregulated in numerous cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410812 [Multi-domain]  Cd Length: 112  Bit Score: 40.50  E-value: 3.39e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17570095  20 AMPKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKvfHDMYKWEfvNHVAWVLDTELCF 83
Cdd:cd20038  13 AKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYR--QNQQRWQ--NSIRHSLSFNDCF 72
 
Name Accession Description Interval E-value
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 21-105 2.95e-22

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 84.21  E-value: 2.95e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17570095     21 MPKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKVFHDmyKWEfvNHVAWVLDTELCFRRE-----RDVRSGLWA 95
Cdd:smart00339   1 KPPYSYIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRA--GWQ--NSIRHNLSLNDCFVKVpregdRPGKGSYWT 76

                           90
                   ....*....|
gi 17570095     96 YEDGNKDILD 105
Cdd:smart00339  77 LDPAAENMFE 86
FH_FOXA1 cd20038
Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, ...
 20-83 3.39e-05

Forkhead (FH) domain found in Forkhead box protein A1 (FOXA1) and similar proteins; FOXA1, also called hepatocyte nuclear factor 3-alpha (HNF-3-alpha or HNF-3A) or transcription factor 3A (TCF-3A), acts as a transcription factor that is essential for epithelial lineage differentiation. It has been found to be upregulated in numerous cancers. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410812 [Multi-domain]  Cd Length: 112  Bit Score: 40.50  E-value: 3.39e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17570095  20 AMPKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKvfHDMYKWEfvNHVAWVLDTELCF 83
Cdd:cd20038  13 AKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYR--QNQQRWQ--NSIRHSLSFNDCF 72
FH_FOXA2 cd20039
Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins; FOXA2, ...
 20-83 1.40e-04

Forkhead (FH) domain found in Forkhead box protein A2 (FOXA2) and similar proteins; FOXA2, also called hepatocyte nuclear factor 3-beta (HNF-3-beta or HNF-3B) or transcription factor 3B (TCF-3B), acts as a core transcription factor that controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis. It may also have an important role in bone metabolism. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410813 [Multi-domain]  Cd Length: 104  Bit Score: 38.94  E-value: 1.40e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17570095  20 AMPKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKvfHDMYKWEfvNHVAWVLDTELCF 83
Cdd:cd20039   4 AKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFPFYR--QNQQRWQ--NSIRHSLSFNDCF 63
FH_FOXA3 cd20040
Forkhead (FH) domain found in Forkhead box protein A3 (FOXA3) and similar proteins; FOXA3, ...
 20-83 1.55e-04

Forkhead (FH) domain found in Forkhead box protein A3 (FOXA3) and similar proteins; FOXA3, also called hepatocyte nuclear factor 3-gamma (HNF-3-gamma or HNF-3G), fork head-related protein FKH H3, or transcription factor 3G (TCF-3G), acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410814 [Multi-domain]  Cd Length: 102  Bit Score: 38.55  E-value: 1.55e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17570095  20 AMPKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKvfHDMYKWEfvNHVAWVLDTELCF 83
Cdd:cd20040   2 AKPPYSYISLITMAIQQAPSKMLTLNEIYQWIMDLFPYYR--ENQQRWQ--NSIRHSLSFNDCF 61
FH_FOXP2 cd20065
Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2); FOXP2, also called CAG repeat ...
 22-98 1.47e-03

Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2); FOXP2, also called CAG repeat protein 44, or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal, and cardiovascular tissues. An arginine-to-histidine missense mutation (R553H) in the FOXP2 Forkhead domain has been linked to a severe speech and language disorder. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410839 [Multi-domain]  Cd Length: 82  Bit Score: 35.44  E-value: 1.47e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17570095  22 PKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKvfHDMYKWEfvNHVAWVLDTELCFRRERDVRSGLWAYED 98
Cdd:cd20065   3 PPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFR--RNAATWK--NAVRHNLSLHKCFVRVENVKGAVWTVDE 75
FH_FOXA cd20015
Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily ...
 22-85 6.14e-03

Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily includes three winged helix transcription factors, FOXA1 (also called hepatocyte nuclear factor 3-alpha or transcription factor 3A), FOXA2 (also called hepatocyte nuclear factor 3-beta or transcription factor 3B), and FOXA3 (also called hepatocyte nuclear factor 3-gamma or transcription factor 3G). FOXA1 is essential for epithelial lineage differentiation and has been found to be upregulated in numerous cancers. FOXA2 controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis and may also have an important role in bone metabolism. FOXA3 acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. This subfamily also includes Xenopus tropicalis FOXA4, Drosophila melanogaster protein fork head (dFKH), and similar proteins. FOXA4 is only present in amphibians, where it is required for the correct regionalization and maintenance of the central nervous system. dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410789 [Multi-domain]  Cd Length: 97  Bit Score: 34.14  E-value: 6.14e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17570095  22 PKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKvfHDMYKWEfvNHVAWVLDTELCFRR 85
Cdd:cd20015   2 PPYSYISLITMAIQQSPSKMLTLSEIYQWIMDLFPYYR--QNQQRWQ--NSIRHSLSFNDCFVK 61
FH_FOXP4 cd20067
Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, ...
 22-98 7.13e-03

Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is not required for T cell development, but is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.


Pssm-ID: 410841 [Multi-domain]  Cd Length: 87  Bit Score: 33.94  E-value: 7.13e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17570095  22 PKFKMVALVSAAMEEADDVFPEIEVVVKWITDLFPYYKvfHDMYKWEfvNHVAWVLDTELCFRRERDVRSGLWAYED 98
Cdd:cd20067   2 PPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFR--RNTATWK--NAVRHNLSLHKCFVRVENVKGAVWTVDE 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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