|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
193-670 |
3.97e-116 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 371.09 E-value: 3.97e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRsiqetartHYKTTGLD-TALIVCHVSIIAQWIKELNQW 271
Cdd:COG0553 241 TLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLL--------ELKERGLArPVLIVAPTSLVGNWQRELAKF 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 272 FPKARVFLLHshcstgrqedyvGSIFRklQRRRKEYPDGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCS 351
Cdd:COG0553 313 APGLRVLVLD------------GTRER--AKGANPFEDADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIKNPATKRA 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 352 IAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGanlncSPEAAAkayeclvALHIAVK 431
Cdd:COG0553 379 KAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG-----DEEALE-------RLRRLLR 446
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 432 PLILRRLQEDHKEvlQLPEKQEIVLSCELSKRQRRLYMEYGNS--HQVNEI--IERRLKAFVGINHLTNICNHPGIYRSL 507
Cdd:COG0553 447 PFLLRRTKEDVLK--DLPEKTEETLYVELTPEQRALYEAVLEYlrRELEGAegIRRRGLILAALTRLRQICSHPALLLEE 524
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 508 SPASPKfgsikDSGKVEMTFKLFDDWFKSPtNRVILFTQRRTVITMMEYFLAEKGIKCVSLTGADSAAARPKIIKKFEDD 587
Cdd:COG0553 525 GAELSG-----RSAKLEALLELLEELLAEG-EKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEG 598
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 588 VSIKVFLMTTRAGGLGLNLTCANKVIIFDPDWNPQADNQAKNRIYRMGQTNDVAIYRLVSNGTIEDlKFFK-QVQKENLA 666
Cdd:COG0553 599 PEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEE-KILElLEEKRALA 677
|
....
gi 71991518 667 ARLL 670
Cdd:COG0553 678 ESVL 681
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
194-386 |
5.70e-103 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 318.88 E-value: 5.70e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARthykttGLDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKL------GLGPSLIVCPATVLKQWVKEFHRWWP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFLLHSHCSTGRQEDYVGSIFRKLQRRRKEYPDGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCSIA 353
Cdd:cd18000 75 PFRVVVLHSSGSGTGSEEKLGSIERKSQLIRKVVGDGGILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLA 154
|
170 180 190
....*....|....*....|....*....|...
gi 71991518 354 MRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHP 386
Cdd:cd18000 155 CKQLRTPHRLILSGTPIQNNLKELWSLFDFVFP 187
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
193-653 |
1.84e-64 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 235.85 E-value: 1.84e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQEtartHYKTTGldTALIVCHVSIIAQWIKELNQWF 272
Cdd:PLN03142 169 KMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHE----YRGITG--PHMVVAPKSTLGNWMNEIRRFC 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 273 PKARVFLLHshcstGRQEDyvgsifRKLQRRRKEYPDG-AIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCS 351
Cdd:PLN03142 243 PVLRAVKFH-----GNPEE------RAHQREELLVAGKfDVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLS 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 352 IAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFThiiNAGANlncspeaaaKAYECLVALHIAVK 431
Cdd:PLN03142 312 KTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWFQ---ISGEN---------DQQEVVQQLHKVLR 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 432 PLILRRLQEDHKEvlQLPEKQEIVLSCELSKRQRRLY--MEYGNSHQVNEIIER-RLKAFVgiNHLTNICNHPGIYRSLS 508
Cdd:PLN03142 380 PFLLRRLKSDVEK--GLPPKKETILKVGMSQMQKQYYkaLLQKDLDVVNAGGERkRLLNIA--MQLRKCCNHPYLFQGAE 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 509 PASPKFGS---IKDSGKVEMTFKLFDDwFKSPTNRVILFTQRRTVITMMEYFLAEKGIKCVSLTGADSAAARPKIIKKFE 585
Cdd:PLN03142 456 PGPPYTTGehlVENSGKMVLLDKLLPK-LKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFN 534
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 71991518 586 DDVSIK-VFLMTTRAGGLGLNLTCANKVIIFDPDWNPQADNQAKNRIYRMGQTNDVAIYRLVSNGTIED 653
Cdd:PLN03142 535 KPGSEKfVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEE 603
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
198-504 |
5.26e-61 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 209.46 E-value: 5.26e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 198 QQEGVEWL-QKKTDHRSGGILADEMGLGKTIQSVVFLRSIQetartHYKTTGLDTALIVCHVSIIAQWIKELNQW--FPK 274
Cdd:pfam00176 2 QIEGVNWMlSLENNLGRGGILADEMGLGKTLQTISLLLYLK-----HVDKNWGGPTLIVVPLSLLHNWMNEFERWvsPPA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 275 ARVFLLHSHCSTGRQedyvgsiFRKLQRRRKEYPdgaIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCSIAM 354
Cdd:pfam00176 77 LRVVVLHGNKRPQER-------WKNDPNFLADFD---VVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKAL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 355 RKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFThiinaganlncSPEAAAKAYECLVALHIAVKPLI 434
Cdd:pfam00176 147 KSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFD-----------RPIERGGGKKGVSRLHKLLKPFL 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71991518 435 LRRLQedhKEV-LQLPEKQEIVLSCELSKRQRRLYMEYGNSHQVNEI----IERRLKA--FVGINHLTNICNHPGIY 504
Cdd:pfam00176 216 LRRTK---KDVeKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIktgeGGREIKAslLNILMRLRKICNHPGLI 289
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
194-386 |
2.98e-52 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 180.84 E-value: 2.98e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIqetartHYKTTGLDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYL------LKEGKERGPVLVVCPLSVLENWEREFEKWTP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFLLHshcstGRQEDyvgsifRKLQRRRKEYPDGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCSIA 353
Cdd:cd17919 75 DLRVVVYH-----GSQRE------RAQIRAKEKLDKFDVVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLSKA 143
|
170 180 190
....*....|....*....|....*....|...
gi 71991518 354 MRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHP 386
Cdd:cd17919 144 LKALRAKRRLLLTGTPLQNNLEELWALLDFLDP 176
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
192-438 |
2.64e-51 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 179.68 E-value: 2.64e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 192 NKLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttgldTALIVCHVSIIAQWIKELNQW 271
Cdd:cd18012 3 ATLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKG-------PSLVVAPTSLIYNWEEEAAKF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 272 FPKARVFLLHShcsTGRQedyvgsifRKLQRRRKEYpdgAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCS 351
Cdd:cd18012 76 APELKVLVIHG---TKRK--------REKLRALEDY---DLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNPQTKTA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 352 IAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANlncspeaaAKAYECLVALhiaVK 431
Cdd:cd18012 142 KAVKALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGD--------EEALEELKKL---IS 210
|
....*..
gi 71991518 432 PLILRRL 438
Cdd:cd18012 211 PFILRRL 217
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
194-437 |
3.66e-49 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 174.10 E-value: 3.66e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIqetarthYKTTGLDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGM-------FDSGLIKSVLVVMPTSLIPHWVKEFAKWTP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFLLHSHCSTGRQEDyvgsiFRKLQRRrkeypdGAIILTTYSLFTKLKKPIV-----KHLWQVVILDEGHYIRNENT 348
Cdd:cd18001 74 GLRVKVFHGTSKKERERN-----LERIQRG------GGVLLTTYGMVLSNTEQLSaddhdEFKWDYVILDEGHKIKNSKT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 349 KCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGR-LSDSATFHRNFTHIINAGANLNCSPEAAAKAYECLVALH 427
Cdd:cd18001 143 KSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFACNGSlLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAENLR 222
|
250
....*....|
gi 71991518 428 IAVKPLILRR 437
Cdd:cd18001 223 QIIKPYFLRR 232
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
520-646 |
1.18e-47 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 166.11 E-value: 1.18e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 520 SGKVEMTFKLFDDWFKsPTNRVILFTQRRTVITMMEYFLAEKGIKCVSLTGADSAAARPKIIKKFEDDVSIKVFLMTTRA 599
Cdd:cd18793 10 SGKLEALLELLEELRE-PGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKA 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 71991518 600 GGLGLNLTCANKVIIFDPDWNPQADNQAKNRIYRMGQTNDVAIYRLV 646
Cdd:cd18793 89 GGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
194-437 |
1.98e-46 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 166.37 E-value: 1.98e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHYKTTGLdTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILASDHHKRANSFNSENL-PSLVVCPPTLVGHWVAEIKKYFP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFLLHshcstgrqedYVGSiFRKLQRRRKEYPDGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCSIA 353
Cdd:cd17999 80 NAFLKPLA----------YVGP-PQERRRLREQGEKHNVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLSKA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 354 MRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANLNCSP---EAAAKAYEclvALHIAV 430
Cdd:cd17999 149 VKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAkeqEAGALALE---ALHKQV 225
|
....*..
gi 71991518 431 KPLILRR 437
Cdd:cd17999 226 LPFLLRR 232
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
194-437 |
1.86e-40 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 149.45 E-value: 1.86e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSI---------------QETARTHYKTTGLdTALIVCHV 258
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAAVlgktgtrrdrennrpRFKKKPPASSAKK-PVLIVAPL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 259 SIIAQWIKELNQW--FpkaRVFLLHShcsTGRQEDYVGsifrKLQRRRKEypdgaIILTTYSLFTKLKKPIVKHLWQVVI 336
Cdd:cd18005 80 SVLYNWKDELDTWghF---EVGVYHG---SRKDDELEG----RLKAGRLE-----VVVTTYDTLRRCIDSLNSINWSAVI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 337 LDEGHYIRNENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANLNCSPEAA 416
Cdd:cd18005 145 ADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATAREL 224
|
250 260
....*....|....*....|.
gi 71991518 417 AKAYECLVALHIAVKPLILRR 437
Cdd:cd18005 225 RLGRKRKQELAVKLSKFFLRR 245
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
194-437 |
2.07e-40 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 149.36 E-value: 2.07e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWL-----QKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARthYKTTGLDTALIVCHVSIIAQWIKEL 268
Cdd:cd18004 1 LRPHQREGVQFLydcltGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGP--YGKPTAKKALIVCPSSLVGNWKAEF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 269 NQWFPKARVFLLHSHCSTgrQEDYVGSIFRKLQRRRKeypdgaIILTTYSLFTKL-KKPIVKHLWQVVILDEGHYIRNEN 347
Cdd:cd18004 79 DKWLGLRRIKVVTADGNA--KDVKASLDFFSSASTYP------VLIISYETLRRHaEKLSKKISIDLLICDEGHRLKNSE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 348 TKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANLNCSPEAAAKAYECLVALH 427
Cdd:cd18004 151 SKTTKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELS 230
|
250
....*....|
gi 71991518 428 IAVKPLILRR 437
Cdd:cd18004 231 ELTSRFILRR 240
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
194-414 |
6.14e-40 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 147.82 E-value: 6.14e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWL-------QKKTDHRSGGILADEMGLGKTIQSVVFLRSIQetarTHYKTTglDTALIVCHVSIIAQWIK 266
Cdd:cd18007 1 LKPHQVEGVRFLwsnlvgtDVGSDEGGGCILAHTMGLGKTLQVITFLHTYL----AAAPRR--SRPLVLCPASTLYNWED 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 267 ELNQWFPK-ARVFLLHSHCSTGRQEDyvgSIFRKLQRRRKEypdGAIILTTYSLFTKL-----KKPIVKHL---WQ---- 333
Cdd:cd18007 75 EFKKWLPPdLRPLLVLVSLSASKRAD---ARLRKINKWHKE---GGVLLIGYELFRNLasnatTDPRLKQEfiaALldpg 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 334 --VVILDEGHYIRNENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANLNC 411
Cdd:cd18007 149 pdLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDS 228
|
...
gi 71991518 412 SPE 414
Cdd:cd18007 229 TEE 231
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
194-437 |
8.37e-40 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 147.43 E-value: 8.37e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKtdhrsGGILADEMGLGKTIQSVV----------------FLRSIQETARTHYKTTgldtaLIVCH 257
Cdd:cd18008 1 LLPYQKQGLAWMLPR-----GGILADEMGLGKTIQALAlilatrpqdpkipeelEENSSDPKKLYLSKTT-----LIVVP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 258 VSIIAQWIKELNQ--WFPKARVFLLHSHcstGRQEDyvgsiFRKLQRrrkeyPDgaIILTTYSLFT-------------- 321
Cdd:cd18008 71 LSLLSQWKDEIEKhtKPGSLKVYVYHGS---KRIKS-----IEELSD-----YD--IVITTYGTLAsefpknkkgggrds 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 322 --KLKKPIVKHLWQVVILDEGHYIRNENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNF 399
Cdd:cd18008 136 keKEASPLHRIRWYRVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDI 215
|
250 260 270
....*....|....*....|....*....|....*...
gi 71991518 400 THIINAGANLNcspeaaakayecLVALHIAVKPLILRR 437
Cdd:cd18008 216 SKPFSKNDRKA------------LERLQALLKPILLRR 241
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
193-439 |
1.63e-39 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 146.38 E-value: 1.63e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETarthyKTTGldTALIVCHVSIIAQWIKELNQWF 272
Cdd:cd18009 3 VMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRER-----GVWG--PFLVIAPLSTLPNWVNEFARFT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 273 PKARVFLLHshcstGRQEdYVGSIFRKLQRRRKEYPDGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCSI 352
Cdd:cd18009 76 PSVPVLLYH-----GTKE-ERERLRKKIMKREGTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 353 AMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHR--NFTHIINAGANLNCSPEAAAKayECLVALHIAV 430
Cdd:cd18009 150 ELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESwfDFSSLSDNAADISNLSEEREQ--NIVHMLHAIL 227
|
....*....
gi 71991518 431 KPLILRRLQ 439
Cdd:cd18009 228 KPFLLRRLK 236
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
191-439 |
2.02e-35 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 134.37 E-value: 2.02e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 191 WNKLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQetartHYKT-TGldTALIVCHVSIIAQWIKELN 269
Cdd:cd17997 1 GGTMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLK-----HYKNiNG--PHLIIVPKSTLDNWMREFK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 270 QWFPKARVFLLHSHCSTgRQEdyvgSIFRKLQRRRKEypdgaIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTK 349
Cdd:cd17997 74 RWCPSLRVVVLIGDKEE-RAD----IIRDVLLPGKFD-----VCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSK 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 350 CSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFThiINAGANLNcspeaaakaYECLVALHIA 429
Cdd:cd17997 144 LSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFN--VNNCDDDN---------QEVVQRLHKV 212
|
250
....*....|
gi 71991518 430 VKPLILRRLQ 439
Cdd:cd17997 213 LRPFLLRRIK 222
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
194-437 |
5.49e-35 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 133.14 E-value: 5.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIqetaRTHYKTTGldTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHL----YQVEGIRG--PFLVIAPLSTIPNWQREFETWTD 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 kARVFLLHShcSTGRQEdyvgsIFRKLQRRRKEYPDGA--------IILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRN 345
Cdd:cd17995 75 -MNVVVYHG--SGESRQ-----IIQQYEMYFKDAQGRKkkgvykfdVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKN 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 346 ENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAganlncspeaaakayECLVA 425
Cdd:cd17995 147 RNSKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFGDLKTA---------------EQVEK 211
|
250
....*....|..
gi 71991518 426 LHIAVKPLILRR 437
Cdd:cd17995 212 LQALLKPYMLRR 223
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
194-437 |
5.39e-33 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 127.47 E-value: 5.39e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLrsiqetARTHYKTTGLDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALL------AHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFLlhshcstgrqedYVGSIfRKLQRRRKEY--PDG-AIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKC 350
Cdd:cd18003 75 GFKILT------------YYGSA-KERKLKRQGWmkPNSfHVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNFKSQR 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 351 SIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGAnlncspEAAAKAYECLVA-LHIA 429
Cdd:cd18003 142 WQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNPLTAMS------EGSQEENEELVRrLHKV 215
|
....*...
gi 71991518 430 VKPLILRR 437
Cdd:cd18003 216 LRPFLLRR 223
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
193-438 |
2.10e-32 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 125.94 E-value: 2.10e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttglDTALIVCHVSIIAQWIKELNQWF 272
Cdd:cd17996 3 TLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNN------GPYLVIVPLSTLSNWVSEFEKWA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 273 PKARVFLlhshcstgrqedYVGS-IFRKLQRRRKEYPDGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCS 351
Cdd:cd17996 77 PSVSKIV------------YKGTpDVRKKLQSQIRAGKFNVLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQSKLT 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 352 IAMRKLMTTQ-RFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNF-THIINAGA--NLNCSPEaaakayECLVA-- 425
Cdd:cd17996 145 QTLNTYYHARyRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFnTPFANTGEqvKIELNEE------ETLLIir 218
|
250
....*....|....
gi 71991518 426 -LHIAVKPLILRRL 438
Cdd:cd17996 219 rLHKVLRPFLLRRL 232
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
194-386 |
9.61e-32 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 122.49 E-value: 9.61e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETART--HykttgldtaLIVCHVSIIAQWIKELNQW 271
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIGIPgpH---------LVVVPSSTLDNWLREFKRW 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 272 FPKARVFLLHshcstGRQEDyvgsifRKLQRRR--KEYPDGAIILTTYSLFT--KLKKPIVKHL-WQVVILDEGHYIRNE 346
Cdd:cd17998 72 CPSLKVEPYY-----GSQEE------RKHLRYDilKGLEDFDVIVTTYNLATsnPDDRSFFKRLkLNYVVYDEGHMLKNM 140
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 71991518 347 NtkcSIAMRKLMTTQ---RFILTGTPFQNRLSEFWKLVDFVHP 386
Cdd:cd17998 141 T---SERYRHLMTINanfRLLLTGTPLQNNLLELMSLLNFIMP 180
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
193-437 |
9.82e-32 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 123.62 E-value: 9.82e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttglDTALIVCHVSIIAQWIKELNQWF 272
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQY------GPFLVVVPLSTMPAWQREFAKWA 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 273 PKARVFLlhshcstgrqedYVGSIF-RKLQRRRKEYPDGA------IILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRN 345
Cdd:cd17993 75 PDMNVIV------------YLGDIKsRDTIREYEFYFSQTkklkfnVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKN 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 346 ENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFhrNFTHiinaganlncsPEAAAKAYEclvA 425
Cdd:cd17993 143 DESLLYEALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPGKFDIWEEF--EEEH-----------DEEQEKGIA---D 206
|
250
....*....|..
gi 71991518 426 LHIAVKPLILRR 437
Cdd:cd17993 207 LHKELEPFILRR 218
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
208-414 |
1.90e-30 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 120.31 E-value: 1.90e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 208 KTDHRSGGILADEMGLGKTIQSVVFLrsiqETARTHyktTGLDTALIVCHVSIIAQWIKELNQWFPKA-----------R 276
Cdd:cd18069 24 KGSSGFGCILAHSMGLGKTLQVISFL----DVLLRH---TGAKTVLAIVPVNTLQNWLSEFNKWLPPPealpnvrprpfK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 277 VFLLHSHCSTGRQEDYVGSIFRKlqrrrkeypDGAIILTTYSLFTKLKKPivkhlwQVVILDEGHYIRNENTKCSIAMRK 356
Cdd:cd18069 97 VFILNDEHKTTAARAKVIEDWVK---------DGGVLLMGYEMFRLRPGP------DVVICDEGHRIKNCHASTSQALKN 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 71991518 357 LMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANLNCSPE 414
Cdd:cd18069 162 IRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQ 219
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
194-437 |
2.06e-30 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 119.46 E-value: 2.06e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFL---RSIQETARTHykttgldtaLIVCHVSIIAQWIKELNQ 270
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLwylAGRLKLLGPF---------LVLCPLSVLDNWKEELNR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 271 WFPKARVFllhshCSTGRQEDYVgsifrKLQRRRKEYPDGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKC 350
Cdd:cd18006 72 FAPDLSVI-----TYMGDKEKRL-----DLQQDIKSTNRFHVLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLL 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 351 SIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSAtfhrnFTHIINAGANLNCSPEAAAKayeclvaLHIAV 430
Cdd:cd18006 142 HKTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFPKDK-----LDDFIKAYSETDDESETVEE-------LHLLL 209
|
....*..
gi 71991518 431 KPLILRR 437
Cdd:cd18006 210 QPFLLRR 216
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
191-452 |
9.53e-30 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 118.61 E-value: 9.53e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 191 WNKLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQetartHYKTTGlDTALIVCHVSIIAQWIKELNQ 270
Cdd:cd18064 13 WGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMK-----HYRNIP-GPHMVLVPKSTLHNWMAEFKR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 271 WFPKARvfllhSHCSTGRQEDYVGSIfrklqrRRKEYP-DGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTK 349
Cdd:cd18064 87 WVPTLR-----AVCLIGDKDQRAAFV------RDVLLPgEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 350 CSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFThiinagaNLNCSPEAaakayECLVALHIA 429
Cdd:cd18064 156 LSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWFD-------TNNCLGDQ-----KLVERLHMV 223
|
250 260
....*....|....*....|...
gi 71991518 430 VKPLILRRLQEDHKEvlQLPEKQ 452
Cdd:cd18064 224 LRPFLLRRIKADVEK--SLPPKK 244
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
194-397 |
2.13e-29 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 116.54 E-value: 2.13e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEW-LQkktdhRSGGIL-ADEMGLGKTIQSVVFLRsiqetartHYKTTGldTALIVCHVSIIAQWIKELNQW 271
Cdd:cd18010 1 LLPFQREGVCFaLR-----RGGRVLiADEMGLGKTVQAIAIAA--------YYREEW--PLLIVCPSSLRLTWADEIERW 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 272 FPKARVfllhshcstgrqeDYVGSIFRKlqRRRKEYPDGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCS 351
Cdd:cd18010 66 LPSLPP-------------DDIQVIVKS--KDGLRDGDAKVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNSKAKRT 130
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 71991518 352 -IAMRKLMTTQRFI-LTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHR 397
Cdd:cd18010 131 kAALPLLKRAKRVIlLSGTPALSRPIELFTQLDALDPKLFGRFHDFGR 178
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
213-413 |
2.62e-28 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 114.60 E-value: 2.62e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 213 SGGILADEMGLGKTIQSVVFLrsiqETARTHYKTTGLDTALIVCHVSIIAQWIKELNQWFPKARvfllhshcstgRQED- 291
Cdd:cd18068 29 SGCILAHCMGLGKTLQVVTFL----HTVLLCEKLENFSRVLVVCPLNTVLNWLNEFEKWQEGLK-----------DEEKi 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 292 --YVGSIFRKLQRRR----KEYPDGAIILTTYSLF------------TKLKKPIVKHLWQ----VVILDEGHYIRNENTK 349
Cdd:cd18068 94 evNELATYKRPQERSyklqRWQEEGGVMIIGYDMYrilaqernvksrEKLKEIFNKALVDpgpdFVVCDEGHILKNEASA 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71991518 350 CSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANLNCSP 413
Cdd:cd18068 174 VSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQCADSTL 237
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
194-437 |
2.70e-28 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 114.49 E-value: 2.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHR-----SGGILADEMGLGKTIQSV----VFLRSIQETARThykttgLDTALIVCHVSIIAQW 264
Cdd:cd18067 1 LRPHQREGVKFLYRCVTGRrirgsHGCIMADEMGLGKTLQCItlmwTLLRQSPQCKPE------IDKAIVVSPSSLVKNW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 265 IKELNQWFpKARVFLLHSHCSTGRQEDYVGSIFRKLQRRRKEYPdgaIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIR 344
Cdd:cd18067 75 ANELGKWL-GGRLQPLAIDGGSKKEIDRKLVQWASQQGRRVSTP---VLIISYETFRLHVEVLQKGEVGLVICDEGHRLK 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 345 NENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANLNCSPEAAAKAYECLV 424
Cdd:cd18067 151 NSDNQTYQALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQ 230
|
250
....*....|...
gi 71991518 425 ALHIAVKPLILRR 437
Cdd:cd18067 231 ELISIVNRCIIRR 243
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
194-437 |
3.32e-28 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 113.79 E-value: 3.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQ-----KKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHYKTTgLDTALIVCHVSIIAQWIKEL 268
Cdd:cd18066 1 LRPHQREGIEFLYecvmgMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKPV-IKRALIVTPGSLVKNWKKEF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 269 NQWFPKAR--VFLLHShcsTGRQEDYVGSIFRklqrrrkeypdgAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNE 346
Cdd:cd18066 80 QKWLGSERikVFTVDQ---DHKVEEFIASPLY------------SVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNT 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 347 NTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIINAGANLNCSP------EAAAKAY 420
Cdd:cd18066 145 SIKTTTALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPeekklgEARAAEL 224
|
250
....*....|....*..
gi 71991518 421 ECLVALhiavkpLILRR 437
Cdd:cd18066 225 TRLTGL------FILRR 235
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
171-397 |
3.28e-27 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 111.02 E-value: 3.28e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 171 MVTSEEYGKSSKPWKVNAGVW-NKLHKFQQEgvewlqKKTDHRSGGILADEMGLGKTIQSVvflrSIQETARThykttgl 249
Cdd:cd18071 12 MVSRENSQDLPPFWEEAVGLFlNTITNFSQK------KRPELVRGGILADDMGLGKTLTTI----SLILANFT------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 250 dtaLIVCHVSIIAQWIKELNQwfpkarvfllhsHCSTGRQEDYVgsiFRKLQRRR--KEYPDGAIILTTYSLFT-----K 322
Cdd:cd18071 75 ---LIVCPLSVLSNWETQFEE------------HVKPGQLKVYT---YHGGERNRdpKLLSKYDIVLTTYNTLAsdfgaK 136
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71991518 323 LKKPIVKHLWQVVILDEGHYIRNENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHR 397
Cdd:cd18071 137 GDSPLHTINWLRVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLLSFLHLKPFSNPEYWRR 211
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
194-439 |
9.34e-27 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 110.15 E-value: 9.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQEtartHYKTTGldTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18063 24 LKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLME----HKRLNG--PYLIIVPLSTLSNWTYEFDKWAP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KArVFLLHSHCSTGRQedyvgSIFRKLQRRRKEypdgaIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCSIA 353
Cdd:cd18063 98 SV-VKISYKGTPAMRR-----SLVPQLRSGKFN-----VLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 354 MRK-LMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTH-IINAGANLNCSPEaaaKAYECLVALHIAVK 431
Cdd:cd18063 167 LNThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNApFAMTGERVDLNEE---ETILIIRRLHKVLR 243
|
....*...
gi 71991518 432 PLILRRLQ 439
Cdd:cd18063 244 PFLLRRLK 251
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
194-439 |
9.74e-27 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 110.13 E-value: 9.74e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttglDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18062 24 LKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRIN------GPFLIIVPLSTLSNWVYEFDKWAP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KarVFLLHSHCSTGRQEDYVGsifrklQRRRKEYpdgAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCSIA 353
Cdd:cd18062 98 S--VVKVSYKGSPAARRAFVP------QLRSGKF---NVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 354 MRK-LMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTH-IINAGANLNCSPEaaaKAYECLVALHIAVK 431
Cdd:cd18062 167 LNThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNApFAMTGEKVDLNEE---ETILIIRRLHKVLR 243
|
....*...
gi 71991518 432 PLILRRLQ 439
Cdd:cd18062 244 PFLLRRLK 251
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
194-437 |
3.17e-26 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 107.98 E-value: 3.17e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQEtartHYKTTGldTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAE----EHNIWG--PFLVIAPASTLHNWQQEISRFVP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFllhshcstgrqeDYVGS-----IFRKLQRRRKEYPDGA---IILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRN 345
Cdd:cd18002 75 QFKVL------------PYWGNpkdrkVLRKFWDRKNLYTRDApfhVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKS 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 346 ENtkcSIAMRKLMTTQ---RFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHII--NAGANLNCSPEAaakay 420
Cdd:cd18002 143 SS---SSRWKTLLSFHcrnRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIesHAENKTGLNEHQ----- 214
|
250
....*....|....*..
gi 71991518 421 ecLVALHIAVKPLILRR 437
Cdd:cd18002 215 --LKRLHMILKPFMLRR 229
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
194-439 |
3.86e-26 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 107.80 E-value: 3.86e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQetartHYKTTGlDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18065 16 LRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLK-----HYRNIP-GPHMVLVPKSTLHNWMNEFKRWVP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFllhshCSTGRQEDYVGSIfrklqrrRKEYPDGA--IILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCS 351
Cdd:cd18065 90 SLRAV-----CLIGDKDARAAFI-------RDVMMPGEwdVCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 352 IAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFThiinagaNLNCSPEAaakayECLVALHIAVK 431
Cdd:cd18065 158 EIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWFD-------TKNCLGDQ-----KLVERLHAVLK 225
|
....*...
gi 71991518 432 PLILRRLQ 439
Cdd:cd18065 226 PFLLRRIK 233
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
194-437 |
1.81e-25 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 106.03 E-value: 1.81e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHR-SGGILADEMGLGKT---IQSVVFLRSIQETAR---THYKTTGLD----------TALIVC 256
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKpRGGILADDMGLGKTltmIALILAQKNTQNRKEeekEKALTEWESkkdstlvpsaGTLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 257 HVSIIAQWIKELNQWFP--KARVFLLHshcstGRQEDYVGSIFRklqrrrkeypDGAIILTTYSLFTK-LKK-------- 325
Cdd:cd18072 81 PASLVHQWKNEVESRVAsnKLRVCLYH-----GPNRERIGEVLR----------DYDIVITTYSLVAKeIPTykeesrss 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 326 PIVKHLWQVVILDEGHYIRNENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNfthiINA 405
Cdd:cd18072 146 PLFRIAWARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLRCSPFDDLKVWKKQ----VDN 221
|
250 260 270
....*....|....*....|....*....|..
gi 71991518 406 GanlncspeaAAKAYEclvALHIAVKPLILRR 437
Cdd:cd18072 222 K---------SRKGGE---RLNILTKSLLLRR 241
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
194-437 |
3.05e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 105.11 E-value: 3.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIqetarthYKTTGLDTALIVCHVSIIAQWIKELNQWfP 273
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEI-------YLKGIHGPFLVIAPLSTIPNWEREFRTW-T 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFLLHSHCSTGRQEDYVGSIFRKLQRR--RKEYPDGAIILTTYSLFTKLkkPIVKHL-WQVVILDEGHYIRNENTKC 350
Cdd:cd18059 73 ELNVVVYHGSQASRRTIQLYEMYFKDPQGRviKGSYKFHAIITTFEMILTDC--PELRNIpWRCVVIDEAHRLKNRNCKL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 351 SIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIinaganlncspeaaaKAYECLVALHIAV 430
Cdd:cd18059 151 LEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDL---------------KTEEQVQKLQAIL 215
|
....*..
gi 71991518 431 KPLILRR 437
Cdd:cd18059 216 KPMMLRR 222
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
194-437 |
3.39e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 104.70 E-value: 3.39e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIqetarthYKTTGLDTALIVCHVSIIAQWIKELNQWfP 273
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEI-------LLTGIRGPFLIIAPLSTIANWEREFRTW-T 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFLLHSHCSTGRQEDYVGSIFRKLQRR--RKEYPDGAIIlTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKCS 351
Cdd:cd18061 73 DLNVVVYHGSLISRQMIQQYEMYFRDSQGRiiRGAYRFQAII-TTFEMILGGCPELNAIDWRCVIIDEAHRLKNKNCKLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 352 IAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIinaganlncspeaaaKAYECLVALHIAVK 431
Cdd:cd18061 152 EGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEFGDL---------------KTEEQVQKLQAILK 216
|
....*.
gi 71991518 432 PLILRR 437
Cdd:cd18061 217 PMMLRR 222
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
194-437 |
1.72e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 102.82 E-value: 1.72e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIqetarthYKTTGLDTALIVCHVSIIAQWIKELNQWfP 273
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEV-------YNVGIHGPFLVIAPLSTITNWEREFNTW-T 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFLLHSHCSTgRQEDYVGSIFRKLQRRR---KEYPDGAIIlTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENTKC 350
Cdd:cd18060 73 EMNTIVYHGSLAS-RQMIQQYEMYCKDSRGRlipGAYKFDALI-TTFEMILSDCPELREIEWRCVIIDEAHRLKNRNCKL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 351 SIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIinaganlncspeaaaKAYECLVALHIAV 430
Cdd:cd18060 151 LDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDL---------------KTEEQVQKLQAIL 215
|
....*..
gi 71991518 431 KPLILRR 437
Cdd:cd18060 216 KPMMLRR 222
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
193-437 |
1.96e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 103.16 E-value: 1.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttglDTALIVCHVSIIAQWIKELNQWF 272
Cdd:cd18054 20 ELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLY------GPFLLVVPLSTLTSWQREFEIWA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 273 PKARVFL----LHSHcSTGRQEDYVGSifrklQRRRKEYpdgAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNENT 348
Cdd:cd18054 94 PEINVVVyigdLMSR-NTIREYEWIHS-----QTKRLKF---NALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 349 KCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSdsatFHRNFTHIINAGANlncspeaaaKAYEclvALHI 428
Cdd:cd18054 165 LLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFE----FWEDFEEDHGKGRE---------NGYQ---SLHK 228
|
....*....
gi 71991518 429 AVKPLILRR 437
Cdd:cd18054 229 VLEPFLLRR 237
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
194-402 |
2.46e-24 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 101.36 E-value: 2.46e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttglDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSK------GPFLVSAPLSTIINWEREFEMWAP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVFllhshcstgrqeDYVGSifrklqrrrkeypdgAIILTTYSLFTkLKKPIVKHL-WQVVILDEGHYIRNENTKCSI 352
Cdd:cd17994 75 DFYVV------------TYVGD---------------HVLLTSYELIS-IDQAILGSIdWAVLVVDEAHRLKNNQSKFFR 126
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 71991518 353 AMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHI 402
Cdd:cd17994 127 ILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFADI 176
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
194-437 |
2.39e-23 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 99.35 E-value: 2.39e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIqetarthyKTTGLDTA-LIVCHVSIIAQWIKELNQWF 272
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEI--------FLMGIRGPfLIIAPLSTITNWEREFRTWT 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 273 PKARVFLLHSHCSTGRQEDYvgsifRKLQRRRKEYPDGAI-----ILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRNEN 347
Cdd:cd18058 73 EMNAIVYHGSQISRQMIQQY-----EMYYRDEQGNPLSGIfkfqvVITTFEMILADCPELKKINWSCVIIDEAHRLKNRN 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 348 TKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHIinaganlncspeaaaKAYECLVALH 427
Cdd:cd18058 148 CKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEFGDL---------------KTEEQVKKLQ 212
|
250
....*....|
gi 71991518 428 IAVKPLILRR 437
Cdd:cd18058 213 SILKPMMLRR 222
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
193-390 |
1.88e-22 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 96.02 E-value: 1.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVEWLqkkTDHRSGGILADEMGLGKTIQSVVFlrsiqetARTHYKTTGLDTALIVCH-VSIIAQWIKELNQW 271
Cdd:smart00487 8 PLRPYQKEAIEAL---LSGLRDVILAAPTGSGKTLAALLP-------ALEALKRGKGGRVLVLVPtRELAEQWAEELKKL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 272 FPKARVFLLhshcstgrqeDYVGSIFRKLQRRRKEYPDGAIILTTYSLFTKL--KKPIVKHLWQVVILDEGHYIRNENTK 349
Cdd:smart00487 78 GPSLGLKVV----------GLYGGDSKREQLRKLESGKTDILVTTPGRLLDLleNDKLSLSNVDLVILDEAHRLLDGGFG 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 71991518 350 C---SIAMRKLMTTQRFILTGTP---FQNRLSEFWKLVDFVHPGRLS 390
Cdd:smart00487 148 DqleKLLKLLPKNVQLLLLSATPpeeIENLLELFLNDPVFIDVGFTP 194
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
194-402 |
2.53e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 96.62 E-value: 2.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttglDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTK------GPFLVSAPLSTIINWEREFQMWAP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 K-----------ARVFLLHSHCSTgrQEDYVGSIFRKLQRRRKEYPDGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHY 342
Cdd:cd18055 75 DfyvvtytgdkdSRAIIRENEFSF--DDNAVKGGKKAFKMKREAQVKFHVLLTSYELVTIDQAALGSIRWACLVVDEAHR 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 343 IRNENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHI 402
Cdd:cd18055 153 LKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI 212
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
194-402 |
1.27e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 94.75 E-value: 1.27e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttglDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSK------GPYLVSAPLSTIINWEREFEMWAP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 KARVfLLHSHCSTGRQ---------EDYVGSIFRKLQRRRKEYP-DGAIILTTYSLFTKLKKPIVKHLWQVVILDEGHYI 343
Cdd:cd18057 75 DFYV-VTYTGDKESRSvirenefsfEDNAIRSGKKVFRMKKEAQiKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRL 153
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 71991518 344 RNENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHI 402
Cdd:cd18057 154 KNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFADI 212
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
194-402 |
5.84e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 92.82 E-value: 5.84e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttglDTALIVCHVSIIAQWIKELNQWFP 273
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSK------GPFLVSAPLSTIINWEREFEMWAP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 274 K-----------ARVFLLHSHCSTgrqEDYVGSIFRKLQRRRKEYP-DGAIILTTYSLFTKLKKPIVKHLWQVVILDEGH 341
Cdd:cd18056 75 DmyvvtyvgdkdSRAIIRENEFSF---EDNAIRGGKKASRMKKEASvKFHVLLTSYELITIDMAILGSIDWACLIVDEAH 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71991518 342 YIRNENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRNFTHI 402
Cdd:cd18056 152 RLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFADI 212
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
193-437 |
9.65e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 92.42 E-value: 9.65e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVEWLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIQETARTHykttglDTALIVCHVSIIAQWIKELNQWF 272
Cdd:cd18053 20 ELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLY------GPFLLVVPLSTLTSWQREIQTWA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 273 PKARVFLlhshcstgrqedYVGSIFRKLQRRRKEY--PDGA-----IILTTYSLFTKLKKPIVKHLWQVVILDEGHYIRN 345
Cdd:cd18053 94 PQMNAVV------------YLGDINSRNMIRTHEWmhPQTKrlkfnILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 346 ENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHrnfthiinaganlncspEAAAKAYEC-LV 424
Cdd:cd18053 162 DDSLLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFE-----------------EEHGKGREYgYA 224
|
250
....*....|...
gi 71991518 425 ALHIAVKPLILRR 437
Cdd:cd18053 225 SLHKELEPFLLRR 237
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
521-635 |
7.26e-20 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 85.73 E-value: 7.26e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 521 GKVEMTFKLFDdwfKSPTNRVILFTQRRTVItMMEYFLAEKGIKCVSLTGADSAAARPKIIKKFEDDVSIkvFLMTTRAG 600
Cdd:pfam00271 1 EKLEALLELLK---KERGGKVLIFSQTKKTL-EAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKID--VLVATDVA 74
|
90 100 110
....*....|....*....|....*....|....*
gi 71991518 601 GLGLNLTCANKVIIFDPDWNPQADNQAKNRIYRMG 635
Cdd:pfam00271 75 ERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
554-635 |
1.02e-16 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 75.71 E-value: 1.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 554 MEYFLAEKGIKCVSLTGADSAAARPKIIKKFEDDVSikVFLMTTRAGGLGLNLTCANKVIIFDPDWNPQADNQAKNRIYR 633
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 71991518 634 MG 635
Cdd:smart00490 81 AG 82
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
194-391 |
4.88e-16 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 78.92 E-value: 4.88e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQKktdhrSGGILADEMGLGKTI---------------QSVVFLRSIQETARTHY------KTTGldTA 252
Cdd:cd18070 1 LLPYQRRAVNWMLV-----PGGILADEMGLGKTVevlalillhprpdndLDAADDDSDEMVCCPDClvaetpVSSK--AT 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 253 LIVCHVSIIAQWIKELNQWFPKA-RVFL---------LHSHC--------------STGRQEDYVGSIFRKLQRRRKEYP 308
Cdd:cd18070 74 LIVCPSAILAQWLDEINRHVPSSlKVLTyqgvkkdgaLASPApeilaeydivvttyDVLRTELHYAEANRSNRRRRRQKR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 309 DGAIilttyslftklKKPIVKHLWQVVILDEGHYIRNENTKCSIAMRKLMTTQRFILTGTPFQNRLSEFWKLVDF--VHP 386
Cdd:cd18070 154 YEAP-----------PSPLVLVEWWRVCLDEAQMVESSTSKAAEMARRLPRVNRWCVSGTPIQRGLDDLFGLLSFlgVEP 222
|
....*
gi 71991518 387 GRLSD 391
Cdd:cd18070 223 FCDSD 227
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
194-398 |
1.00e-13 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 71.17 E-value: 1.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVewlQKKTDHRSGG-ILADEMGLGKTIQSVVFLRsiQETARthyktTGLDTALIVCHVSIIAQWIKELNQWF 272
Cdd:cd18011 1 PLPHQIDAV---LRALRKPPVRlLLADEVGLGKTIEAGLIIK--ELLLR-----GDAKRVLILCPASLVEQWQDELQDKF 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 273 PKARVFLLHSHCSTGRQE---------DYVGSIFRklqRRRKEYPDGAIILTTYSLftklkkpivkhlwqvVILDEGHYI 343
Cdd:cd18011 71 GLPFLILDRETAAQLRRLignpfeefpIVIVSLDL---LKRSEERRGLLLSEEWDL---------------VVVDEAHKL 132
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 71991518 344 RNEN----TKCSIAMRKL--MTTQRFILTGTPFQNRLSEFWKLVDFVHPGRLSDSATFHRN 398
Cdd:cd18011 133 RNSGggkeTKRYKLGRLLakRARHVLLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFLRL 193
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
194-398 |
2.71e-08 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 55.43 E-value: 2.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVEWLQkktDHRSGGILADeMGLGKTIQSVVFLRSIQETARTHykttgldtalivcHVSIIA-------QWIK 266
Cdd:cd18013 1 PHPYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQLDDFTR-------------RVLVIAplrvarsTWPD 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 267 ELNQWfpkarvfllhSHCstgRQEDYVGSIFRKLQRRRKEYPDGAIILTTYSLFTKLKKPIVKH-LWQVVILDEGHYIRN 345
Cdd:cd18013 64 EVEKW----------NHL---RNLTVSVAVGTERQRSKAANTPADLYVINRENLKWLVNKSGDPwPFDMVVIDELSSFKS 130
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 71991518 346 ENTKCSIAMRKLM-TTQRFI-LTGTPFQNRLSEFWKLVDFVHPG-RLSDSATFHRN 398
Cdd:cd18013 131 PRSKRFKALRKVRpVIKRLIgLTGTPSPNGLMDLWAQIALLDQGeRLGRSITAYRE 186
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
193-617 |
3.56e-08 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 57.34 E-value: 3.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVE-WLQKKTDHRSGGILADEMGLGKTiqsVVFLRSIQETARthykttgLDTALIVCHV-SIIAQWIKELNQ 270
Cdd:COG1061 80 ELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKT---VLALALAAELLR-------GKRVLVLVPRrELLEQWAEELRR 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 271 WFPKARVfllhshcsTGRQEDyvgsifrklqrrrkeyPDGAIILTTY-SLFTKLKKPIVKHLWQVVILDEGHYIRNENTK 349
Cdd:COG1061 150 FLGDPLA--------GGGKKD----------------SDAPITVATYqSLARRAHLDELGDRFGLVIIDEAHHAGAPSYR 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 350 csiAMRKLMTTQRFI-LTGTPFqnRLSEFWKLVDFvhpgrlsdsatfhrnFTHIInaganlncspeaaakaYEclvalhi 428
Cdd:COG1061 206 ---RILEAFPAAYRLgLTATPF--RSDGREILLFL---------------FDGIV----------------YE------- 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 429 avkpLILRRLQEDHkeVLQLPEKQEIvlSCELSKRQRRlYMEYGnshqvnEIIERRLkafvginhltnicnhpgiyrsls 508
Cdd:COG1061 243 ----YSLKEAIEDG--YLAPPEYYGI--RVDLTDERAE-YDALS------ERLREAL----------------------- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 509 paspkfgsikDSGKVEMTFKLFDDWFKSPTN-RVILFTQR-RTVITMMEYFLaEKGIKCVSLTGADSAAARPKIIKKFED 586
Cdd:COG1061 285 ----------AADAERKDKILRELLREHPDDrKTLVFCSSvDHAEALAELLN-EAGIRAAVVTGDTPKKEREEILEAFRD 353
|
410 420 430
....*....|....*....|....*....|.
gi 71991518 587 DvSIKVfLMTTRAGGLGLNLTCANKVIIFDP 617
Cdd:COG1061 354 G-ELRI-LVTVDVLNEGVDVPRLDVAILLRP 382
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
213-341 |
3.20e-06 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 47.78 E-value: 3.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 213 SGGILADEMGLGKTIqsVVFLRSIQETARTHYKTtgldtaLIVCHVSIIA-QWIKELNQWF-PKARVFLLHShcstgrqe 290
Cdd:cd00046 2 ENVLITAPTGSGKTL--AALLAALLLLLKKGKKV------LVLVPTKALAlQTAERLRELFgPGIRVAVLVG-------- 65
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 71991518 291 DYvgsifRKLQRRRKEYPDGAIILTTYSLFTKLKKPIVKHL---WQVVILDEGH 341
Cdd:cd00046 66 GS-----SAEEREKNKLGDADIIIATPDMLLNLLLREDRLFlkdLKLIIVDEAH 114
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
194-369 |
2.48e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 44.99 E-value: 2.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 194 LHKFQQEGVE-WLQKKTDHRsgGILADEMGLGKTiqsVVFLRSIQETARTHykttgldtALIVCH-VSIIAQWIKELNQW 271
Cdd:cd17926 1 LRPYQEEALEaWLAHKNNRR--GILVLPTGSGKT---LTALALIAYLKELR--------TLIVVPtDALLDQWKERFEDF 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 272 FPKARVFLLHShcstgrqedyvgsifrklqRRRKEYPDGAIILTTY-SLFTKLKKPI-VKHLWQVVILDEGHYIRNENTK 349
Cdd:cd17926 68 LGDSSIGLIGG-------------------GKKKDFDDANVVVATYqSLSNLAEEEKdLFDQFGLLIVDEAHHLPAKTFS 128
|
170 180
....*....|....*....|
gi 71991518 350 CSIAMRKlmTTQRFILTGTP 369
Cdd:cd17926 129 EILKELN--AKYRLGLTATP 146
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
535-758 |
4.02e-05 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 47.42 E-value: 4.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 535 KSPTNRVILFTQ-RRTVITMMEyFLAEKGIKCVSLTG-ADSAAA-------RPKIIKKFEDDVsIKVfLMTTRAGGLGLN 605
Cdd:COG1111 350 TNPDSRIIVFTQyRDTAEMIVE-FLSEPGIKAGRFVGqASKEGDkgltqkeQIEILERFRAGE-FNV-LVATSVAEEGLD 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 606 LTCANKVIIFDPDWNPQADNQAKNRIYRMGQTNdvaIYRLVSNGTIEDLKFFKQVQKENLAARLLHNaeIDQFVPNNTLA 685
Cdd:COG1111 427 IPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGR---VVVLIAKGTRDEAYYWSSRRKEKKMKSILKK--LKKLLDKQEKE 501
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71991518 686 DLFRLKPKGLEGseigvYLDGEIAREGSKKQKRDKVEKKAAKKRMKNKLAGFEDKKLLLSLFDDDKLVAMREH 758
Cdd:COG1111 502 KLKESAQATLDE-----FESIKELAEDEINEKDLDEIESSENGAHVDWREPVLLQVIVSTLAESLELRELGEK 569
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
193-370 |
6.03e-05 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 44.59 E-value: 6.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 193 KLHKFQQEGVE-WLQKKTDHRSGGILADEMGLGKTIQSVVFLRSIqetarthYKTTGLDTALIVCH-VSIIAQWIKELNQ 270
Cdd:pfam04851 3 ELRPYQIEAIEnLLESIKNGQKRGLIVMATGSGKTLTAAKLIARL-------FKKGPIKKVLFLVPrKDLLEQALEEFKK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71991518 271 WFPKArvfllHSHCstgrqEDYVGsifrklQRRRKEYPDGAIILTTY-SLFTKLK---KPIVKHLWQVVILDEGHYIRne 346
Cdd:pfam04851 76 FLPNY-----VEIG-----EIISG------DKKDESVDDNKIVVTTIqSLYKALElasLELLPDFFDVIIIDEAHRSG-- 137
|
170 180
....*....|....*....|....*...
gi 71991518 347 ntkcSIAMRKLM----TTQRFILTGTPF 370
Cdd:pfam04851 138 ----ASSYRNILeyfkPAFLLGLTATPE 161
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
581-643 |
2.76e-04 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 40.38 E-value: 2.76e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 71991518 581 IKKFEDDVSIKVFLMTTRAGGLGLNLTCANKVIIFDPDWNPQADNQAKNRIYRMGQTNDVAIY 643
Cdd:cd18785 13 IEHAEEIASSLEILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
|
|
| DpdE |
NF041062 |
protein DpdE; |
217-283 |
1.83e-03 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 42.27 E-value: 1.83e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71991518 217 LADEMGLGKTIQSVVFLRS--IQETARthykttgldTALIVCHVSIIAQWIKELNQWF-----PKARVFLLhSH 283
Cdd:NF041062 175 LADEVGLGKTIEAGLVIRQhlLDNPDA---------RVLVLVPDALVRQWRRELRDKFflddfPGARVRVL-SH 238
|
|
| |
